Tempus Reports Third Quarter 2025 Results

Tempus Reports Third Quarter 2025 Results

CHICAGO–(BUSINESS WIRE)–
Tempus AI, Inc. (NASDAQ: TEM), a technology company leading the adoption of AI to advance precision medicine and patient care, today reported financial results for the quarter ended September 30, 2025.

  • Revenue grew 84.7% year-over-year to $334.2 million in the third quarter of 2025
  • Gross profit reached $209.9 million in the third quarter of 2025, an improvement of 98.4% year-over-year
  • 217,000 clinical tests delivered in the quarter, representing 33% year-over-year volume growth, with Oncology volume growth accelerating to 27% and Hereditary at 37%
  • Insights bookings of $150 million across multiple new contracts with year-over-year revenue growth of 37.6% in the quarter
  • Increasing full year 2025 revenue guidance to $1.265 billion, representing approximately 80% growth year-over-year
  • Ended the quarter with $764.3 million of cash and marketable securities

“Not only are we growing at an incredible rate, reaching positive adjusted EBITDA marks an important milestone and reflects the strength of our underlying business,” said Eric Lefkofsky, Founder and CEO of Tempus. “One of the hardest things to do, and a sign of business model endurance, is being able to slow down the rate of reinvesting back into the business and still maintain growth, which is exactly what we achieved this quarter.”

Third Quarter Summary Results

  • Quarterly revenue increased 84.7% year-over-year to $334.2 million in the third quarter of 2025.

    • Revenue from Genomics totaled $252.9 million in the third quarter of 2025, growing 117.2% compared to the third quarter of 2024.

      • Oncology testing (Tempus genomics) contributed $139.5 million, up 31.7% year-over-year in the third quarter of 2025, with approximately 27% volume growth.
      • Hereditary testing (Ambry genetics) contributed $102.6 million of revenue in the third quarter of 2025, an increase of 32.8% on a pro forma1 basis after giving effect to the Ambry acquisition, with approximately 37% volume growth.
    • Revenue from Data and services totaled $81.3 million in the third quarter of 2025, delivering 26.1% growth versus the third quarter of 2024, led by Insights (data licensing), which grew 37.6% year-over-year.
  • Recorded $209.9 million in quarterly gross profit, representing a 98.4% improvement year-over-year.
  • Reported a net loss of ($80.0 million) in the third quarter of 2025, including $35.0 million in stock compensation expense and related employer payroll taxes, increased amortization expense of intangibles related to the Ambry acquisition, and a one time $12.0 million expense related to the loss on debt extinguishment, compared to a net loss of ($75.8 million) in the third quarter of 2024.
  • Adjusted EBITDA of $1.5 million in the third quarter of 2025 compared to ($21.8 million) in the third quarter of 2024, an improvement of $23.3 million year-over-year.

1

The pro forma amounts have been calculated after applying the Company’s accounting policies

Third Quarter and Recent Operational Highlights

  • Acquired Paige, an AI company specializing in digital pathology, to expand our dataset and technical team, and establish a leading footprint in digital pathology.
  • Selected by Advanced Research Projects Agency for Health (ARPA-H) to provide testing and CRO services in support of the agency’s ADAPT (Advanced Analysis for Precision Cancer Therapy) program.
  • Obtained 510(k) clearance from the U.S. FDA for xR IVD (RNA NGS in vitro diagnostic device), which will support life sciences’ drug development programs.
  • Received U.S. FDA 510(k) clearance for updated Tempus Pixel, an AI-powered cardiac imaging platform and for Tempus’ ECG-Low ejection fraction software, which leverages AI to identify patients who may have a low left ventricular ejection fraction.
  • Expanded collaboration with Northwestern Medicine to integrate David, Tempus’ generative-AI clinical co-pilot within the EHR platform to transform clinical workflows.
  • Expanded Tempus Next into breast cancer, providing real-time insights to close guideline-based care gaps.

Third Quarter Financial Results

 

 

 

Three Months Ended September 30,

 

 

 

 

 

 

2025

 

 

2024

 

 

Change

 

 

 

(in thousands, except percentages and per share amounts)

 

 

 

 

 

 

(unaudited)

 

 

 

 

Revenue

 

$

334,206

 

 

$

180,929

 

 

 

84.7

%

Gross profit

 

$

209,942

 

 

$

105,839

 

 

 

98.4

%

Loss from operations

 

$

(60,996

)

 

$

(53,616

)

 

 

13.8

%

Net loss

 

$

(79,982

)

 

$

(75,840

)

 

 

5.5

%

Adjusted EBITDA

 

$

1,476

 

 

$

(21,843

)

 

 

106.8

%

Net loss per share attributable to common shareholders, basic and diluted

 

$

(0.46

)

 

$

(0.46

)

 

 

 

Non-GAAP net loss per share

 

$

(0.11

)

 

$

(0.24

)

 

 

54.2

%

Financial Outlook and Guidance

Tempus increased full year 2025 revenue guidance to approximately $1.265 billion, which represents ~80% annual growth. Given the acquisition of Paige, which we expect will increase losses by approximately $5 million per quarter, we expect Q4 Adjusted EBITDA to be ~$20 million, resulting in slightly positive Adjusted EBITDA for the full year.

For additional information on the quarter, including a letter from our CEO and CFO, please visit our investor relations site at investors.tempus.com.

Webcast and Conference Call Information

A conference call and webcast will begin today, November 4, 2025 after market close at 4:30 p.m. Eastern Time. Interested parties may access details at:

Conference ID: 5436492

Domestic Dial-in Number: (800) 715-9871

International Dial-in Number: (646) 307-1963

Live webcast: https://edge.media-server.com/mmc/p/vg3azega

The webcast may be accessed on the company’s investor relations website at investors.tempus.com. For those unable to listen to the live webcast, a recording will be made available on the company’s website after the event and will be accessible for one year. Visit the investor relations website to find the company’s latest deck, and commentary on the quarter by Eric Lefkofsky, Founder and CEO and Jim Rogers, CFO, which will be discussed on the conference call and webcast.

About Tempus

Tempus is a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare. With one of the world’s largest libraries of multimodal data, and an operating system to make that data accessible and useful, Tempus provides AI-enabled precision medicine solutions to physicians to deliver personalized patient care and in parallel facilitates discovery, development and delivery of optimal therapeutics. The goal is for each patient to benefit from the treatment of others who came before by providing physicians with tools that learn as the company gathers more data. For more information, visit tempus.com.

Non-GAAP Financial Measures

In addition to the financial information presented in this release in accordance with accounting principles generally accepted in the United States of America (GAAP), Tempus also presents adjusted non-GAAP financial measures.

Non-GAAP gross profit is defined as GAAP gross profit, excluding stock-based compensation expense and employer payroll tax related to stock-based compensation (collectively, the “stock-based compensation adjustments”). Non-GAAP gross margin is defined as gross profit, excluding the stock-based compensation adjustments, as a percentage of revenue. Non-GAAP operating expenses are calculated as the sum of technology research and development expense, research and development expense, and selling, general and administrative expense, excluding the stock-based compensation adjustments, acquisition-related expenses, amortization of intangibles due to acquisition, and franchise taxes related to our IPO. Non-GAAP loss from operations is defined as loss from operations, adjusted to exclude (i) stock-based compensation expense, (ii) employer payroll tax related to stock-based compensation expense, (iii) acquisition-related expenses, (iv) franchise taxes related to our IPO, and (v) amortization of intangibles due to acquisition. Non-GAAP net loss is defined as net loss, adjusted to exclude (i) changes in fair value of our warrant liability, warrant asset, marketable equity securities, contingent consideration liabilities and indemnity-related holdback liabilities, (ii) stock-based compensation expense, (iii) employer payroll tax related to stock-based compensation expense, (iv) acquisition-related expenses, (v) amortization of intangibles due to acquisition, (vi) (gains) losses on equity method investments, (vii) provision for (benefit from) income taxes, (viii) the payment of $2.3 million of our Series G-4 convertible preferred stock in connection with the initial public offering (the “G-4 Special Payment”), (ix) franchise taxes related to our IPO, (x) loss on debt extinguishment, and (xi) amortization of deferred other income from our IP License Agreement with SB Tempus. Non-GAAP net loss per share is defined as non-GAAP net loss divided by weighted average common shares outstanding, basic and diluted.

Adjusted EBITDA is defined as net loss, adjusted to exclude (i) interest income, (ii) interest expense, (iii) depreciation and amortization, (iv) provision for (benefit from) income taxes, (v) (gains) losses on equity method investments, (vi) changes in fair value of our warrant liability, warrant asset, marketable equity securities, contingent consideration liabilities and indemnity-related holdback liabilities, (vii) stock-based compensation expense, (viii) employer payroll tax related to stock-based compensation expense, (ix) acquisition related expenses, (x) the G-4 Special Payment, (xi) amortization of deferred other income from our IP License Agreement with SB Tempus, (xii) franchise taxes related to our IPO, and (xiii) loss on debt extinguishment.

Tempus believes these non-GAAP financial measures are useful to investors and others because they allow for additional information with respect to financial measures used by management in its financial and operational decision-making and they may be used by institutional investors and the analyst community to help them analyze the health of Tempus’ business. In particular, Adjusted EBITDA is a key measurement used by Tempus management to make operating decisions, including those related to analyzing operating expenses, evaluating performance, and performing strategic planning and annual budgeting. However, there are a number of limitations related to the use of non-GAAP financial measures, and these non-GAAP measures should be considered in addition to, not as a substitute for or in isolation from, our financial results prepared in accordance with GAAP. Other companies, including companies in our industry, may calculate these non-GAAP financial measures differently or not at all, which reduces their usefulness as comparative measures.

Tempus does not provide guidance for net loss, the most directly comparable GAAP measure to EBITDA and Adjusted EBITDA, and similarly cannot provide a reconciliation between Tempus’ forecasted Adjusted EBITDA and net loss without unreasonable effort due to the unavailability of reliable estimates for certain components of net income (loss) and the respective reconciliations. These forecasted items are not within Tempus’ control, may vary greatly between periods, and could significantly impact future financial results.

Other Key Metrics

Total Remaining Contract Value (TCV) is equal to the total potential value of signed contracts and assumes the exercise of all contract options, all discretionary opt-ins, and no early termination. Remaining TCV excludes any revenue recognized to date on these contracts or any future adjustments made to the contractual value as a result of amendments or terminations.

Net Revenue Retention compares the annual Insights product revenue generated from all customers that made an Insights purchase in one year to the annual Insights product revenue generated from the same cohort of customers in the subsequent year.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended, about Tempus and its industry that involve substantial risks and uncertainties. All statements other than statements of historical facts contained in this press release are forward-looking statements, including, but not limited to, Tempus’ expected financial results for fourth quarter and full year 2025; and Tempus ability to establish a leading footprint in digital technology. In some cases, you can identify forward-looking statements because they contain words such as “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “going to,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” or “would” or the negative of these words or other similar terms or expressions. Tempus cautions you that the foregoing may not include all of the forward-looking statements made in this press release.

You should not rely on forward-looking statements as predictions of future events. Tempus has based the forward-looking statements contained in this press release primarily on its current expectations and projections about future events and trends that it believes may affect Tempus’ business, financial condition, results of operations and prospects. These forward-looking statements are subject to risks and uncertainties related to: the intended use of Tempus’ products and services; Tempus’ financial performance; the ability to attract and retain customers and partners; managing Tempus’ growth and future expenses; competition and new market entrants; compliance with new laws, regulations and executive actions, including any evolving regulations in the artificial intelligence space; the ability to maintain, protect and enhance Tempus’ intellectual property; the ability to attract and retain qualified team members and key personnel; the ability to repay or refinance outstanding debt, or to access additional financing; future acquisitions, divestitures or investments, including Tempus’ ability to realize the expected benefits of the acquisition of Paige AI, Ambry Genetics and Deep 6 AI; the potential adverse impact of climate change, natural disasters, health epidemics, macroeconomic conditions, trade tensions and tariffs, and war or other armed conflict, as well as risks, uncertainties, and other factors described in the section titled “Risk Factors” in Tempus’ Form 10-K for the year ended December 31, 2024, filed with the Securities and Exchange Commission (“the SEC”) on February 24, 2025, as supplemented by Tempus’ Form 10-Q for the quarter ended September 30, 2025, filed with the SEC on November 4, 2025. In addition, any forward-looking statements contained in this press release are based on assumptions that Tempus believes to be reasonable as of this date. Tempus undertakes no obligation to update any forward-looking statements to reflect events or circumstances after the date of this press release or to reflect new information or the occurrence of unanticipated events, except as required by law.

Tempus AI, Inc.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS

(Unaudited)

(in thousands, except per share amounts)

 

 

 

Three Months Ended

September 30,

 

 

Nine Months Ended

September 30,

 

 

 

2025

 

 

2024

 

 

2025

 

 

2024

 

Net revenue

 

 

 

 

 

 

 

 

 

 

 

 

Genomics

 

$

252,878

 

 

$

116,422

 

 

$

688,525

 

 

$

331,315

 

Data and services(1)

 

 

81,328

 

 

 

64,507

 

 

 

216,053

 

 

 

161,403

 

Total net revenue

 

$

334,206

 

 

$

180,929

 

 

$

904,578

 

 

$

492,718

 

Cost and operating expenses

 

 

 

 

 

 

 

 

 

 

 

 

Cost of revenues, genomics

 

 

98,643

 

 

 

60,126

 

 

 

283,182

 

 

 

181,285

 

Cost of revenues, data and services

 

 

25,621

 

 

 

14,964

 

 

 

61,212

 

 

 

52,384

 

Technology research and development

 

 

38,087

 

 

 

30,680

 

 

 

105,960

 

 

 

135,655

 

Research and development

 

 

44,960

 

 

 

27,348

 

 

 

122,453

 

 

 

119,713

 

Selling, general and administrative

 

 

187,891

 

 

 

101,427

 

 

 

523,230

 

 

 

644,063

 

Total cost and operating expenses

 

 

395,202

 

 

 

234,545

 

 

 

1,096,037

 

 

 

1,133,100

 

Loss from operations

 

$

(60,996

)

 

$

(53,616

)

 

$

(191,459

)

 

$

(640,382

)

Interest income

 

 

4,600

 

 

 

4,789

 

 

 

7,506

 

 

 

7,538

 

Interest expense

 

 

(15,399

)

 

 

(13,761

)

 

 

(54,981

)

 

 

(40,294

)

Loss on debt extinguishment

 

 

(12,034

)

 

 

 

 

 

(12,034

)

 

 

 

Other income (expense), net

 

 

2,605

 

 

 

(11,522

)

 

 

16,879

 

 

 

(17,821

)

Loss before (provision for) benefit from income taxes

 

$

(81,224

)

 

$

(74,110

)

 

$

(234,089

)

 

$

(690,959

)

(Provision for) benefit from income taxes

 

 

(276

)

 

 

(38

)

 

 

45,692

 

 

 

(144

)

Gains (losses) from equity method investments

 

 

1,518

 

 

 

(1,692

)

 

 

(2,465

)

 

 

(1,692

)

Net Loss

 

$

(79,982

)

 

$

(75,840

)

 

$

(190,862

)

 

$

(692,795

)

Dividends on Series A, B, B-1, B-2, C, D, E, F, G, G-3, and G-4 preferred shares

 

 

 

 

 

 

 

 

 

 

 

(39,347

)

Cumulative undeclared dividends on Series C preferred shares

 

 

 

 

 

 

 

 

 

 

 

(1,174

)

Net loss attributable to common shareholders, basic and diluted

 

 

(79,982

)

 

 

(75,840

)

 

 

(190,862

)

 

 

(733,316

)

Net loss per share attributable to common shareholders, basic and diluted

 

$

(0.46

)

 

$

(0.46

)

 

$

(1.10

)

 

$

(7.04

)

Weighted-average shares outstanding used to compute net loss per share, basic and diluted

 

 

174,945

 

 

 

165,612

 

 

 

172,969

 

 

 

104,164

 

Comprehensive Loss, net of tax

 

 

 

 

 

 

 

 

 

 

 

 

Net loss

 

$

(79,982

)

 

$

(75,840

)

 

$

(190,862

)

 

$

(692,795

)

Foreign currency translation adjustment

 

 

(2,915

)

 

 

10,302

 

 

 

5,439

 

 

 

10,203

 

Comprehensive loss

 

$

(82,897

)

 

$

(65,538

)

 

$

(185,423

)

 

$

(682,592

)

(1)

Includes related party revenue of $25,132, $2,389, $41,671, $2,604 for the three and nine months ended September 30, 2025 and 2024, respectively.

Tempus AI, Inc.

CONDENSED CONSOLIDATED BALANCE SHEETS

(Unaudited)

(in thousands, except share and per share amounts)

 

 

 

September 30,

2025

 

 

December 31,

2024

 

Assets

 

 

 

 

 

 

Current Assets

 

 

 

 

 

 

Cash and cash equivalents

 

$

655,918

 

 

$

340,954

 

Accounts receivable(1), net of allowances of $1,583 and $1,141 at September 30, 2025 and December 31, 2024, respectively

 

 

283,626

 

 

 

154,819

 

Inventory

 

 

54,976

 

 

 

38,386

 

Related party asset

 

 

5,660

 

 

 

 

Prepaid expenses and other current assets

 

 

42,611

 

 

 

26,135

 

Marketable equity securities

 

 

103,720

 

 

 

107,309

 

Total current assets

 

$

1,146,511

 

 

$

667,603

 

Property and equipment, net

 

 

90,710

 

 

 

58,056

 

Goodwill

 

 

465,140

 

 

 

73,343

 

Intangible assets, net

 

 

372,876

 

 

 

11,716

 

Investments and other assets

 

 

20,948

 

 

 

8,305

 

Investment in joint venture

 

 

94,367

 

 

 

91,450

 

Related party asset, less current portion

 

 

19,340

 

 

 

 

Operating lease right-of-use assets

 

 

66,901

 

 

 

14,762

 

Restricted cash

 

 

4,631

 

 

 

881

 

Total Assets

 

$

2,281,424

 

 

$

926,116

 

 

 

 

 

 

 

 

Liabilities, Convertible redeemable preferred stock, and Stockholders’ equity

 

 

 

 

 

 

Current Liabilities

 

 

 

 

 

 

Accounts payable

 

 

59,553

 

 

 

53,804

 

Accrued expenses

 

 

160,773

 

 

 

130,407

 

Deferred revenue(2)

 

 

84,719

 

 

 

75,981

 

Deferred other income

 

 

15,955

 

 

 

15,955

 

Other current liabilities

 

 

11,819

 

 

 

6,964

 

Operating lease liabilities

 

 

12,417

 

 

 

6,459

 

Accrued data licensing fees

 

 

4,792

 

 

 

1,500

 

Total current liabilities

 

$

350,028

 

 

$

291,070

 

Operating lease liabilities, less current portion

 

 

77,723

 

 

 

26,199

 

Convertible promissory note

 

 

217,959

 

 

 

168,192

 

Other long-term liabilities

 

 

58,772

 

 

 

15,980

 

Revolving credit facility

 

 

100,000

 

 

 

 

Interest payable

 

 

8,739

 

 

 

70,450

 

Long-term debt, net

 

 

200,859

 

 

 

267,244

 

Convertible senior notes, net

 

 

726,863

 

 

 

 

Deferred other income, less current portion

 

 

11,966

 

 

 

23,932

 

Deferred revenue, less current portion

 

 

20,691

 

 

 

6,710

 

Total Liabilities

 

$

1,773,600

 

 

$

869,777

 

(1)

Includes related party accounts receivable of $6,639 and $4,287 as of September 30, 2025 and December 31, 2024, respectively.

(2) Includes related party deferred revenue of $19,918 and $0 as of September 30, 2025 and December 31, 2024, respectively.

Tempus AI, Inc.

CONDENSED CONSOLIDATED BALANCE SHEETS

(Unaudited)

(in thousands, except share and per share amounts)

 

Commitments and contingencies (Note 8)

 

 

 

 

 

 

Convertible redeemable preferred stock, $0.0001 par value, 20,000,000 shares authorized at September 30, 2025 and December 31, 2024, respectively, no shares issued and outstanding at September 30, 2025 and December 31, 2024

 

$

 

 

$

 

Stockholders’ equity

 

 

 

 

 

 

Class A Common Stock, $0.0001 par value, 1,000,000,000 shares authorized at September 30, 2025 and December 31, 2024, respectively; 172,779,554 and 157,076,972 shares issued and outstanding at September 30, 2025 and December 31, 2024, respectively

 

 

17

 

 

 

16

 

Class B Common Stock, $0.0001 par value, 5,500,000 shares authorized at September 30, 2025 and December 31, 2024, respectively; 5,043,789 issued and outstanding at September 30, 2025 and December 31, 2024, respectively

 

 

1

 

 

 

1

 

Non-voting Common Stock, $0.0001 par value, no shares authorized at September 30, 2025 and December 31, 2024, respectively; no shares issued and outstanding at September 30, 2025, and December 31, 2024, respectively

 

 

 

 

 

 

Treasury Stock, 145,466 shares at September 30, 2025 and December 31, 2024, at cost

 

 

(3,602

)

 

 

(3,602

)

Additional Paid-In Capital

 

 

2,847,571

 

 

 

2,210,664

 

Accumulated Other Comprehensive Income

 

 

5,533

 

 

 

94

 

Accumulated deficit

 

 

(2,341,696

)

 

 

(2,150,834

)

Total Stockholders’ equity

 

$

507,824

 

 

$

56,339

 

Total Liabilities, Convertible redeemable preferred stock, and Stockholders’ equity

 

$

2,281,424

 

 

$

926,116

 

Tempus AI, Inc.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(in thousands, except per share amounts)

 

 

Nine Months Ended

September 30,

 

 

2025

 

 

2024

 

Operating activities

 

 

 

 

 

Net loss

$

(190,862

)

 

$

(692,795

)

Adjustments to reconcile net loss to net cash used in operating activities

 

 

 

 

 

Change in fair value of warrant liability

$

 

 

$

42,400

 

Stock-based compensation

 

79,408

 

 

 

509,351

 

Gain on warrant exercise

 

 

 

 

(173

)

Gain on marketable equity securities

 

(4,731

)

 

 

(5,119

)

Loss on debt extinguishment

 

12,034

 

 

 

 

Deferred income taxes

 

(46,216

)

 

 

 

Losses from equity method investments

 

2,465

 

 

 

1,692

 

Amortization of original issue discount

 

2,615

 

 

 

1,036

 

Amortization of deferred financing fees

 

398

 

 

 

383

 

Change in fair value of contingent consideration

 

 

 

 

165

 

Change in fair value of holdback liability

 

291

 

 

 

 

Amortization of warrant contract asset

 

 

 

 

3,633

 

Depreciation and amortization

 

75,416

 

 

 

27,788

 

Provision for bad debt expense

 

767

 

 

 

545

 

Provision for obsolete inventory

 

1,135

 

 

 

 

Change in fair value of warrant asset

 

 

 

 

(18,302

)

Non-cash operating lease costs

 

7,866

 

 

 

4,670

 

Minimum accretion expense

 

109

 

 

 

85

 

PIK interest added to principal

 

8,839

 

 

 

6,567

 

Change in assets and liabilities

 

 

 

 

 

Accounts receivable(1)

 

(63,199

)

 

 

(51,699

)

Inventory

 

(6,537

)

 

 

(7,293

)

Prepaid expenses and other current assets

 

(3,991

)

 

 

(14,040

)

Investments and other assets

 

(16,700

)

 

 

(410

)

Accounts payable

 

(18,528

)

 

 

(24,776

)

Related party asset

 

(25,000

)

 

 

 

Deferred revenue(2)

 

17,398

 

 

 

(1,052

)

Deferred other income

 

(11,966

)

 

 

43,876

 

Accrued data licensing fees

 

3,730

 

 

 

(4,250

)

Accrued expenses & other

 

(5,179

)

 

 

23,371

 

Interest payable

 

10,288

 

 

 

11,208

 

Operating lease liabilities

 

(11,152

)

 

 

(6,655

)

Net cash used in operating activities

$

(181,302

)

 

$

(149,794

)

(1)

Includes increase in related party accounts receivable of $2,352 and $1,909 as of September 30, 2025 and September 30, 2024, respectively.

(2)

Includes increase in related party deferred revenue of $19,918 and $0 as of September 30, 2025 and September 30, 2024, respectively.

Tempus AI, Inc.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(in thousands, except per share amounts)

 

 

Nine Months Ended

September 30,

 

 

2025

 

 

2024

 

Investing activities

 

 

 

 

 

Purchases of property and equipment

$

(16,294

)

 

$

(14,159

)

Proceeds from sale of marketable equity securities

 

8,316

 

 

 

23,098

 

Purchases of marketable equity securities

 

 

 

 

(36,183

)

Business combinations, net of cash acquired (Note 4)

 

(375,025

)

 

 

 

Investment in joint venture

 

 

 

 

(95,186

)

Purchases of capitalized software

 

(4,635

)

 

 

 

Net cash used in investing activities

$

(387,638

)

 

$

(122,430

)

 

 

 

 

 

 

Financing activities

 

 

 

 

 

Proceeds from issuance of common stock in connection with initial public offering, net of underwriting discounts and commissions

$

 

 

$

381,951

 

Tax withholding related to net share settlement of restricted stock units

 

 

 

 

(69,918

)

Issuance of Series G-5 Preferred Stock

 

 

 

 

199,750

 

Payment of deferred offering costs

 

(501

)

 

 

(8,587

)

Dividends paid

 

 

 

 

(5,625

)

Proceeds from revolving credit facility, net of original issue discount

 

98,000

 

 

 

 

Proceeds from long-term debt, net of original issue discount

 

196,000

 

 

 

 

Proceeds from convertible senior notes, net of initial purchasers’ discount

 

726,497

 

 

 

 

Payment of deferred financing fees

 

(1,255

)

 

 

 

Payment of indemnity holdback related to acquisition

 

 

 

 

(813

)

G-4 Special Payment

 

 

 

 

(2,250

)

Principal payments on long-term debt

 

(276,892

)

 

 

 

Prepayment premium on long-term debt

 

(7,841

)

 

 

 

Purchases of capped call

 

(41,775

)

 

 

 

Proceeds from issuance of common stock in connection with at-the-market offering, net of commissions

 

195,499

 

 

 

 

Net cash provided by financing activities

$

887,732

 

 

$

494,508

 

Effect of foreign exchange rates on cash

$

(78

)

 

$

(13

)

 

 

 

 

 

 

Net increase in Cash, Cash Equivalents and Restricted Cash

$

318,714

 

 

$

222,271

 

Cash, cash equivalents and restricted cash, beginning of period

 

341,835

 

 

 

166,607

 

Cash, cash equivalents and restricted cash, end of period

$

660,549

 

 

$

388,878

 

 

 

 

 

 

 

Cash, Cash Equivalents and Restricted Cash are Comprised of:

 

 

 

 

 

Cash and cash equivalents

$

655,918

 

 

$

388,006

 

Restricted cash and cash equivalents

 

4,631

 

 

 

872

 

Total cash, cash equivalents and restricted cash

$

660,549

 

 

$

388,878

 

 

 

 

 

 

 

Supplemental disclosure of cash flow information

 

 

 

 

 

Cash paid during the year for interest

$

37,349

 

 

$

20,899

 

Cash paid for income taxes

$

573

 

 

$

127

 

Tempus AI, Inc.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(in thousands, except per share amounts)

 

 

Nine Months Ended

September 30,

 

 

2025

 

 

2024

 

Supplemental disclosure of noncash investing and financing activities

 

 

 

 

 

Dividends payable

$

 

 

$

5,487

 

Purchases of property and equipment, accrued but not paid

$

3,724

 

 

$

6,706

 

Redemption of convertible promissory note

$

22,721

 

 

$

18,664

 

Non-voting common stock issued in connection with business combinations

$

 

 

$

344

 

Deferred offering costs, accrued but not yet paid

$

320

 

 

$

179

 

Deferred financing fees, accrued but not yet paid

$

489

 

 

$

 

Reclassification of deferred offering costs to additional paid-in capital upon at-the-market offering

$

821

 

 

$

 

Operating lease liabilities arising from obtaining right-of-use assets

$

22,670

 

 

$

550

 

Conversion of redeemable convertible preferred stock to common stock in connection with initial public offering

$

 

 

$

1,348,809

 

Taxes related to net share settlement of restricted stock units not yet paid

$

 

 

$

164

 

Reclassification of deferred offering costs to additional paid-in capital upon initial public offering

$

 

 

$

12,347

 

Class A Common Stock issued in connection with business combinations

$

403,154

 

 

$

 

Class A Common Stock issued in connection with license agreement

$

1,443

 

 

$

 

Issuance of Series G-3 Preferred Stock

$

 

 

$

3,809

 

Issuance of Series G-4 Preferred Stock

$

 

 

$

611

 

Convertible promissory note principal reset due to amendment

$

72,488

 

 

$

 

Tempus AI, Inc.

RECONCILIATION OF GAAP TO NON-GAAP FINANCIAL MEASURES

(Unaudited)

(in thousands, except percentages and per share amounts)

 

Genomics Gross Profit & Gross Margin

 

 

 

Three Months Ended

September 30,

 

 

Nine Months Ended

September 30,

 

 

 

2025

 

 

2024

 

 

2025

 

 

2024

 

Genomics revenue

 

$

252,878

 

 

$

116,422

 

 

$

688,525

 

 

$

331,315

 

Cost of revenues, genomics

 

 

98,643

 

 

 

60,126

 

 

 

283,182

 

 

 

181,285

 

Gross profit, genomics

 

$

154,235

 

 

$

56,296

 

 

$

405,343

 

 

$

150,030

 

Stock-based compensation expense

 

 

1,631

 

 

 

1,083

 

 

 

4,086

 

 

 

12,410

 

Employer payroll tax related to stock-based compensation

 

 

36

 

 

 

26

 

 

 

338

 

 

 

162

 

Non-GAAP gross profit, genomics

 

$

155,902

 

 

$

57,405

 

 

$

409,767

 

 

$

162,602

 

Genomics gross margin

 

 

61.0

%

 

 

48.4

%

 

 

58.9

%

 

 

45.3

%

Stock-based compensation expense

 

 

0.6

%

 

 

0.9

%

 

 

0.6

%

 

 

3.7

%

Employer payroll tax related to stock-based compensation

 

 

0.0

%

 

 

0.0

%

 

 

0.0

%

 

 

0.0

%

Non-GAAP gross margin, genomics

 

 

61.7

%

 

 

49.3

%

 

 

59.5

%

 

 

49.1

%

Data and Services Gross Profit & Gross Margin

 

 

 

Three Months Ended

September 30,

 

 

Nine Months Ended

September 30,

 

 

 

2025

 

 

2024

 

 

2025

 

 

2024

 

Data and services revenue

 

$

81,328

 

 

$

64,507

 

 

$

216,053

 

 

$

161,403

 

Cost of revenues, data and services

 

 

25,621

 

 

 

14,964

 

 

 

61,212

 

 

 

52,384

 

Gross profit, data and services

 

$

55,707

 

 

$

49,543

 

 

$

154,841

 

 

$

109,019

 

Stock-based compensation expense

 

 

894

 

 

 

916

 

 

 

2,198

 

 

 

8,145

 

Employer payroll tax related to stock-based compensation

 

 

62

 

 

 

43

 

 

 

220

 

 

 

162

 

Non-GAAP gross profit, data and services

 

$

56,663

 

 

$

50,502

 

 

$

157,259

 

 

$

117,326

 

Gross margin, data and services

 

 

68.5

%

 

 

76.8

%

 

 

71.7

%

 

 

67.5

%

Stock-based compensation expense

 

 

1.1

%

 

 

1.4

%

 

 

1.0

%

 

 

5.0

%

Employer payroll tax related to stock-based compensation

 

 

0.1

%

 

 

0.1

%

 

 

0.1

%

 

 

0.1

%

Non-GAAP gross margin, data and services

 

 

69.7

%

 

 

78.3

%

 

 

72.8

%

 

 

72.7

%

Total Gross Profit & Gross Margin

 

 

 

Three Months Ended

September 30,

 

 

Nine Months Ended

September 30,

 

 

 

2025

 

 

2024

 

 

2025

 

 

2024

 

Net revenue

 

$

334,206

 

 

$

180,929

 

 

$

904,578

 

 

$

492,718

 

Cost of revenues

 

 

124,264

 

 

 

75,090

 

 

 

344,394

 

 

 

233,669

 

Gross profit

 

$

209,942

 

 

$

105,839

 

 

$

560,184

 

 

$

259,049

 

Stock-based compensation expense

 

 

2,525

 

 

 

1,999

 

 

 

6,284

 

 

 

20,555

 

Employer payroll tax related to stock-based compensation

 

 

98

 

 

 

69

 

 

 

558

 

 

 

324

 

Non-GAAP gross profit

 

$

212,565

 

 

$

107,907

 

 

$

567,026

 

 

$

279,928

 

Gross margin

 

 

62.8

%

 

 

58.5

%

 

 

61.9

%

 

 

52.6

%

Stock-based compensation expense

 

 

0.8

%

 

 

1.1

%

 

 

0.7

%

 

 

4.2

%

Employer payroll tax related to stock-based compensation

 

 

0.0

%

 

 

0.0

%

 

 

0.1

%

 

 

0.1

%

Non-GAAP gross margin

 

 

63.6

%

 

 

59.6

%

 

 

62.7

%

 

 

56.8

%

Operating Expenses

 

 

 

Three Months Ended

September 30,

 

 

Nine Months Ended

September 30,

 

 

 

2025

 

 

2024

 

 

2025

 

 

2024

 

Technology research and development

 

$

38,087

 

 

$

30,680

 

 

$

105,960

 

 

$

135,655

 

Stock-based compensation expense

 

 

5,463

 

 

 

3,929

 

 

 

12,067

 

 

 

54,363

 

Employer payroll tax related to stock-based compensation

 

 

278

 

 

 

192

 

 

 

1,034

 

 

 

1,441

 

Non-GAAP technology research and development

 

$

32,346

 

 

$

26,559

 

 

$

92,859

 

 

$

79,851

 

Research and development

 

$

44,960

 

 

$

27,348

 

 

$

122,453

 

 

$

119,713

 

Stock-based compensation expense

 

 

3,301

 

 

 

2,554

 

 

 

7,618

 

 

 

44,787

 

Employer payroll tax related to stock-based compensation

 

 

122

 

 

 

134

 

 

 

533

 

 

 

810

 

Non-GAAP research and development

 

$

41,537

 

 

$

24,660

 

 

$

114,302

 

 

$

74,116

 

Selling, general and administrative

 

$

187,891

 

 

$

101,427

 

 

$

523,230

 

 

$

644,063

 

Stock-based compensation expense

 

 

22,690

 

 

 

12,556

 

 

 

53,439

 

 

 

389,646

 

Employer payroll tax related to stock-based compensation

 

 

541

 

 

 

806

 

 

 

6,040

 

 

 

3,388

 

Acquisition related expenses(1)

 

 

552

 

 

 

 

 

 

6,073

 

 

 

 

Amortization of intangibles due to acquisition

 

 

16,764

 

 

 

 

 

 

44,691

 

 

 

 

Franchise taxes related to IPO

 

 

 

 

 

 

 

 

1,647

 

 

 

 

Non-GAAP selling, general and administrative

 

$

147,344

 

 

$

88,065

 

 

$

411,340

 

 

$

251,029

 

Operating expenses

 

$

270,938

 

 

$

159,455

 

 

$

751,643

 

 

$

899,431

 

Stock-based compensation expense

 

 

31,454

 

 

 

19,039

 

 

 

73,124

 

 

 

488,796

 

Employer payroll tax related to stock-based compensation

 

 

941

 

 

 

1,132

 

 

 

7,607

 

 

 

5,639

 

Acquisition related expenses(1)

 

 

552

 

 

 

 

 

 

6,073

 

 

 

 

Amortization of intangibles due to acquisition

 

 

16,764

 

 

 

 

 

 

44,691

 

 

 

 

Franchise taxes related to IPO

 

 

 

 

 

 

 

 

1,647

 

 

 

 

Non-GAAP operating expenses

 

$

221,227

 

 

$

139,284

 

 

$

618,501

 

 

$

404,996

 

(1)

Acquisition related expenses consist of legal, diligence, accounting, and financing costs incurred for acquisitions during the three and nine months ended September 30, 2025.

Earnings per Share

 

 

 

Three Months Ended

September 30,

 

 

Nine Months Ended

September 30,

 

 

 

2025

 

 

2024

 

 

2025

 

 

2024

 

Net loss

 

$

(79,982

)

 

$

(75,840

)

 

$

(190,862

)

 

$

(692,795

)

Fair value changes(1)

 

 

1,255

 

 

 

15,605

 

 

 

(4,441

)

 

 

19,885

 

Stock-based compensation expense

 

 

33,979

 

 

 

21,038

 

 

 

79,408

 

 

 

509,351

 

Employer payroll tax related to stock-based compensation

 

 

1,039

 

 

 

1,201

 

 

 

8,165

 

 

 

5,963

 

Acquisition related expenses(2)

 

 

552

 

 

 

 

 

 

6,073

 

 

 

 

Amortization of intangibles due to acquisition

 

 

16,764

 

 

 

 

 

 

44,691

 

 

 

 

(Gains) losses from equity method investments

 

 

(1,518

)

 

 

1,692

 

 

 

2,465

 

 

 

1,692

 

Provision for (benefit from) income taxes

 

 

276

 

 

 

38

 

 

 

(45,692

)

 

 

144

 

G-4 Special Payment

 

 

 

 

 

 

 

 

 

 

 

2,250

 

Franchise taxes related to IPO

 

 

 

 

 

 

 

 

1,647

 

 

 

 

Loss on debt extinguishment

 

 

12,034

 

 

 

 

 

 

12,034

 

 

 

 

Amortization of technology license

 

 

(3,989

)

 

 

(3,989

)

 

 

(11,966

)

 

 

(3,989

)

Non-GAAP net loss

 

$

(19,590

)

 

$

(40,255

)

 

$

(98,478

)

 

$

(157,499

)

Non-GAAP net loss per share

 

$

(0.11

)

 

$

(0.24

)

 

$

(0.57

)

 

$

(1.51

)

Weighted average common shares outstanding, basic and diluted

 

 

174,945

 

 

 

165,612

 

 

 

172,969

 

 

 

104,164

 

(1)

Fair value changes include gains and losses related to quarterly fair value adjustments of our warrant liability, warrant asset, marketable equity securities, contingent consideration liabilities, and indemnity-related holdback liabilities.

(2)

Acquisition related expenses consist of legal, diligence, accounting, and financing costs incurred for acquisitions during the three and nine months ended September 30, 2025.

Adjusted EBITDA

 

 

 

Three Months Ended

September 30,

 

 

Nine Months Ended

September 30,

 

 

 

2025

 

 

2024

 

 

2025

 

 

2024

 

Net loss

 

$

(79,982

)

 

$

(75,840

)

 

$

(190,862

)

 

$

(692,795

)

Interest income

 

 

(4,600

)

 

 

(4,789

)

 

 

(7,506

)

 

 

(7,538

)

Interest expense

 

 

15,399

 

 

 

13,761

 

 

 

54,981

 

 

 

40,294

 

Depreciation

 

 

8,120

 

 

 

6,788

 

 

 

24,350

 

 

 

19,472

 

Amortization

 

 

18,911

 

 

 

2,652

 

 

 

51,066

 

 

 

8,316

 

Provision for (benefit from) income taxes

 

 

276

 

 

 

38

 

 

 

(45,692

)

 

 

144

 

EBITDA

 

$

(41,876

)

 

$

(57,390

)

 

$

(113,663

)

 

$

(632,107

)

(Gains) losses on equity method investments

 

 

(1,518

)

 

 

1,692

 

 

 

2,465

 

 

 

1,692

 

Fair value changes(1)

 

 

1,255

 

 

 

15,605

 

 

 

(4,441

)

 

 

19,885

 

Stock-based compensation expense

 

 

33,979

 

 

 

21,038

 

 

 

79,408

 

 

 

509,351

 

Employer payroll tax related to stock-based compensation

 

 

1,039

 

 

 

1,201

 

 

 

8,165

 

 

 

5,963

 

Acquisition related expenses(2)

 

 

552

 

 

 

 

 

 

6,073

 

 

 

 

G-4 Special Payment

 

 

 

 

 

 

 

 

 

 

 

2,250

 

Amortization of technology license

 

 

(3,989

)

 

 

(3,989

)

 

 

(11,966

)

 

 

(3,989

)

Franchise taxes related to IPO

 

 

 

 

 

 

 

 

1,647

 

 

 

 

Loss on debt extinguishment

 

 

12,034

 

 

 

 

 

 

12,034

 

 

 

 

Adjusted EBITDA

 

$

1,476

 

 

$

(21,843

)

 

$

(20,278

)

 

$

(96,955

)

(1)

Fair value changes include gains and losses related to quarterly fair value adjustments of our warrant liability, warrant asset, marketable equity securities, contingent consideration liabilities, and indemnity-related holdback liabilities.

(2)

Acquisition related expenses consist of legal, diligence, accounting, and financing costs incurred for acquisitions of during the three and nine months ended September 30, 2025.

Loss from Operations

 

 

 

Three Months Ended

September 30,

 

 

Nine Months Ended

September 30,

 

 

 

2025

 

 

2024

 

 

2025

 

 

2024

 

Loss from operations

 

$

(60,996

)

 

$

(53,616

)

 

$

(191,459

)

 

$

(640,382

)

Stock-based compensation expense

 

 

33,979

 

 

 

21,038

 

 

 

79,408

 

 

 

509,351

 

Employer payroll tax related to stock-based compensation

 

 

1,039

 

 

 

1,201

 

 

 

8,165

 

 

 

5,963

 

Acquisition related expenses(1)

 

 

552

 

 

 

 

 

 

6,073

 

 

 

 

Franchise taxes related to IPO

 

 

 

 

 

 

 

 

1,647

 

 

 

 

Amortization of intangibles due to acquisition

 

 

16,764

 

 

 

 

 

 

44,691

 

 

 

 

Non-GAAP loss from operations

 

$

(8,662

)

 

$

(31,377

)

 

$

(51,475

)

 

$

(125,068

)

(1)

Acquisition related expenses consist of legal, diligence, accounting, and financing costs incurred for acquisitions during the three and nine months ended September 30, 2025.

 

Tempus Communications

Erin Carron

[email protected]

Tempus Investor Relations

Elizabeth Krutoholow

[email protected]

KEYWORDS: Illinois United States North America

INDUSTRY KEYWORDS: Data Management Technology Health General Health Pharmaceutical Oncology Health Technology Software Artificial Intelligence Telemedicine/Virtual Medicine Clinical Trials

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