McCormick & Company Ranked World’s 14th Most Sustainable Corporation and No. 1 in Food on Corporate Knights 2022 Global 100 Sustainability Index

PR Newswire

HUNT VALLEY, Md., Jan. 19, 2022 /PRNewswire/ — McCormick & Company, Incorporated (NYSE: MKC), a global leader in flavor, today was named the world’s 14th most sustainable corporation and No. 1 in the Food Products sector by the Corporate Knights Global 100 Sustainability Index. This year the company retained its top position among its food industry peers.

“On behalf of our 14,000 employees around the world, I am truly honored to make this prestigious list for the sixth consecutive year. This recognition underscores our continued commitment to Purpose-led Performance and doing what’s right for People, the Communities where we live, work and source and the Planet we all share,” said Lawrence E. Kurzius, Chairman, President and CEO of McCormick & Company. “As a leader in the food and flavor industry, we understand and embrace our role in driving transformational changes that will create a sustainable future for generations to come. In 2021, McCormick was also recognized as a United Nations Global Compact LEAD company and awarded the inaugural Terra Carta Seal from His Royal Highness the Prince of Wales for our industry leadership.”   

All companies in the Global 100 Sustainability Index are scored on applicable metrics relative to their peers, with 50% of the weight assigned to Clean Revenue and Clean Investment. Nine of the indicators have fixed weights; the rest are assigned weights according to each industry’s relative and total impact in relation to the overall economy. After quantitatively analyzing data for 23 key performance indicators, this year’s overall scores were converted to letter grades. The ranking is based on a rigorous assessment of 6,914 companies with more than $1 billion in U.S. revenues.

McCormick’s Purpose-led Performance report outlines the progress the company is making against its 2025 goals and commitments. To learn more about the journey, please visit our Corporate website.

About McCormick

McCormick & Company, Incorporated is a global leader in flavor. As a Fortune 500 company with over $5 billion in annual sales across 160 countries and territories, we manufacture, market and distribute spices, seasoning mixes, condiments and other flavorful products to the entire food industry including ecommerce channels, grocery, food manufacturers and foodservice businesses. Our most popular brands with trademark registrations include McCormick, French’s, Frank’s RedHot, Stubb’s, OLD BAY, Lawry’s, Zatarain’s, Ducros, Vahiné, Cholula, Schwartz, Kamis, Kohinoor, DaQiao, Club House, Aeroplane and Gourmet Garden. Every day, no matter where or what you eat or drink, you can enjoy food flavored by McCormick.

Founded in 1889 and headquartered in Hunt Valley, Maryland USA, McCormick is guided by our principles and committed to our Purpose – To Stand Together for the Future of Flavor. McCormick envisions A World United by Flavor where healthy, sustainable and delicious go hand in hand. To learn more, visit www.mccormickcorporation.com or follow McCormick & Company on Twitter, Instagram and LinkedIn.

For information contact:

Corporate Communications:
Lori Robinson[email protected]

 

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SOURCE McCormick & Company, Incorporated

House Minority Leader Kevin McCarthy Makes Rumble his Preferred Platform

McCarthy’s addition brings political heavyweight to Rumble

PR Newswire

TORONTO, Jan. 19, 2022 /PRNewswire/ — Rumble is proud to announce that U.S. House of Representatives Minority Leader Kevin McCarthy is making Rumble his preferred platform with exclusive content. McCarthy will use Rumble to make important announcements while engaging with his constituents and the American people on pressing political issues.

“Congressman McCarthy has already gained nearly ten thousand followers since joining Rumble,” said Rumble CEO Chris Pavlovski ahead of the announcement. “His choice to use Rumble as his preferred platform shows how we have rapidly become an important platform for America’s political leaders.”

“Now more than ever, freedom-minded Americans across the country find themselves looking for a platform to uninhibitedly share ideas and content,” McCarthy said. “On Rumble, I, along with every other user, can disseminate information, learn new things, and share unique ideas without fear of being censored or deplatformed. That is how it should be in America.”

McCarthy is hosting multiple live streams this week, including today and tomorrow, as he introduces himself to the Rumble community.

Rumble is a high-growth neutral video platform that is creating the rails and independent infrastructure designed to be immune to cancel culture. Rumble’s mission is to restore the Internet to its roots by making it free and open once again. Additionally, the company announced in December 2021 the execution of a definitive business combination agreement with CF Acquisition Corp. VI (NASDAQ: CFVI). See the announcement here: https://corp.rumble.com

You can find the official Kevin McCarthy video channel here: https://rumble.com/c/RepKevinMcCarthy 

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SOURCE Rumble

Jiuzi Holdings, Inc. Awarded the “2021 Annual Industry Leading Enterprise” by the 5th Boao Enterprise Asian Economy Forum

PR Newswire

HANGZHOU, China, Jan. 19, 2022 /PRNewswire/ — Jiuzi Holdings, Inc. (NASDAQ:JZXN; the “Company”; “Jiuzi New Energy”), a new energy vehicles franchisor and retailer under the brand name “Jiuzi” in China, today announced that its wholly-owned subsidiary, Zhejiang Jiuzi New Energy Vehicles Co., Ltd. (“Zhejiang Jiuzi”), has won the “2021 Annual Industry Leading Enterprise” Award during the 5th Boao Enterprise Forum held between January 8-9, 2022 in Hainan, China. Zhejiang Jiuzi has been recognized for its outstanding brand influence and strong business performance.

Mr. Qi Zhang, Chief Operation Officer of the Company, was invited to attend the Boao Enterprise Forum alongside government officials, industry scholars and leading enterprises representatives on behalf of Zhejiang Jiuzi to receive the honor and also explained the Company’s strategies including its O2O new energy vehicle (“NEV”) retail ecosystem that offers consumers one-stop vehicle retail services in its communication with interested investors and industry peers to explore opportunities for in-depth collaboration at the Boao Enterprise Forum.

The 5th Boao Enterprise Forum was jointly hosted by state media Global Times and China Enterprise Website (www.zhongqiwang.cn), with a theme of Chinese enterprises “Changes” and “Innovation”. Over 500 esteemed guests, including political leaders, experts and scholars, representatives from leading media outlets and well-known domestic firms attended the forum to exchange ideas on economic and technological development, on social issues that concern humanity. For more information on the forum, please visit: www.qiyeboao.com.

Mr. Zhang was interviewed by leading media outlets and shared: “Fossil fuel emission poses increased threat to China’s air quality in recent years that renders environment protection urgent action to take. The development of NEVs serves as one of the most effective solutions, which is exactly what Jiuzi New Energy is trying to deliver to expand our business nationally and contribute our part to China’s goal of environment protection.”

“We are very honored to receive this recognition which signifies our rapid growth and achievements in the industry during the past year. We are determined and it is also Jiuzi New Energy’s mission to build a NEV retail service ecosystem that integrates online and offline services, promote the development of NEV industry with strong strategic planning, and to make a contribution to achieve national carbon emission reduction and carbon neutral goals,” Zhang added.

About Jiuzi Holdings, Inc.

Jiuzi Holdings, Inc., headquartered in Hangzhou, China, and established in 2017, franchises and operates retail stores under the brand name “Jiuzi” to sell New Energy Vehicles (“NEVs”) in third-fourth tier cities in China. The Company mainly sells battery-operated electric vehicles, and sources NEVs through more than twenty NEV manufacturers. It has 31 operating franchise stores and one company-owned store. For more information, visit the Company’s website at http://www.zjjzxny.cn/.

Forward-Looking Statements

All statements other than statements of historical fact in this announcement are forward-looking statements. These forward-looking statements involve known and unknown risks and uncertainties and are based on current expectations and projections about future events and financial trends that the Company believes may affect its financial condition, results of operations, business strategy and financial needs. Investors can identify these forward-looking statements by words or phrases such as “may,” “will,” “expect,” “anticipate,” “aim,” “estimate,” “intend,” “plan,” “believe,” “potential,” “continue,” “is/are likely to” or other similar expressions. The Company undertakes no obligation to update forward-looking statements to reflect subsequent occurring events or circumstances, or changes in its expectations, except as may be required by law. Although the Company believes that the expectations expressed in these forward-looking statements are reasonable, it cannot assure you that such expectations will turn out to be correct, and the Company cautions investors that actual results may differ materially from the anticipated results and encourages investors to review other factors that may affect its future results in the Company’s registration statement and in its other filings with the SEC.

For more information, please contact:

Janice Wang

EverGreen Consulting Inc.
Email: [email protected]
Phone: +1 571-464-9470 (from U.S.)
            +86 13811768559 (from China)

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SOURCE Jiuzi Holdings, Inc.

Union Pacific Railroad and Schneider to Team Up for Intermodal Service in 2023

PR Newswire

OMAHA, Neb., Jan. 19, 2022 /PRNewswire/ — Union Pacific Railroad is pleased to announce it will be the primary intermodal rail transportation provider in the western U.S. for Schneider effective January 2023. The partnership creates seamless service and reliability between the railroad and Schneider, which provides the critical “first and last miles” of the supply chain.

“Schneider’s Intermodal business is a great fit for Union Pacific’s diverse network,” said Union Pacific Chairman, President and CEO Lance Fritz. “We look forward to growing in the Intermodal space together.”   

Schneider, a premier transportation and logistics provider, recently celebrated over 30 years of Intermodal service. Schneider’s intermodal network services +45 ramps in North America with over 25,000 Intermodal containers.

“We are excited to have Schneider be a part of our intermodal service offering,” said Union Pacific Executive Vice President – Marketing and Sales Kenny Rocker. “Schneider’s operational excellence and focus on growth, combined with the strength of Union Pacific’s intermodal network are a natural fit. We expect both companies to provide customer-centric solutions, utilizing Union Pacific’s unparalleled franchise and reliable intermodal service product.” 

“When we pair Union Pacific’s transcontinental rail solutions with our company-owned assets and professional drivers, we will be an unstoppable force in the intermodal marketplace,” said Schneider Senior Vice President and Chief Commercial Officer Jim Filter.

Moving freight by rail is one of the most environmentally responsible options, reducing greenhouse gas emissions by up to 75% and helping Union Pacific customers cut their own environmental footprint. At Union Pacific, a ton of freight can move 454 miles on a single gallon of diesel gas, and the company is committed to investing in technology that helps it identify further fuel-saving opportunities.

ABOUT UNION PACIFIC
Union Pacific (NYSE: UNP) delivers the goods families and businesses use every day with safe, reliable and efficient service. Operating in 23 western states, the company connects its customers and communities to the global economy. Trains are the most environmentally responsible way to move freight, helping Union Pacific protect future generations. More information about Union Pacific is available at www.up.com.

www.up.com 

www.facebook.com/unionpacific 

www.twitter.com/unionpacific 

ABOUT SCHNEIDER

Schneider is a premier provider of transportation and logistics services. Offering one of the broadest portfolios in the industry, Schneider’s solutions include Regional and Long-HaulTruckload, Expedited, Dedicated, Bulk, Intermodal, Brokerage, Warehousing, Supply Chain Management, Port Logistics and Logistics Consulting.

With nearly $4.6 billion in annual revenue, Schneider has been safely delivering superior customer experiences and investing in innovation for over 85 years. The company’s digital marketplace, Schneider FreightPower®, is revolutionizing the industry giving shippers access to an expanded, highly flexible capacity network and provides carriers with unmatched access to quality drop-and-hook freight – Always Delivering, Always Ahead.

For more information about Schneider, visit Schneider.com or follow the company socially on Facebook, LinkedIn and Twitter: @WeAreSchneider.

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SOURCE Union Pacific Railroad

LifeMD Provides Initial FY2022 Guidance and Announces Preliminary FY2021 Revenues

Total FY2022 revenue anticipated to be in the range of $142 to $148 million

Remains on track to achieve Adjusted EBITDA profitability by Q4 2022

Reports preliminary fourth quarter revenue of $27.4 million and FY2021 consolidated revenue of $92.9 million, +149% vs. year-ago period

NEW YORK, Jan. 19, 2022 (GLOBE NEWSWIRE) — LifeMD, Inc. (“the Company”) (NASDAQ: LFMD) today announced initial FY2022 revenue guidance of $142 to $148 million and reaffirmed previous guidance of achieving Adjusted EBITDA profitability by the fourth quarter of 2022. The Company also announced fourth quarter unaudited revenues of $27.4 million and FY2021 unaudited revenues of $92.9 million, representing year-over-year growth of 149% with continued sequential improvement in fourth quarter Adjusted EBITDA.

“We are very pleased about our strong finish to 2021 and the continued growing demand for our telehealth products and services,” said Justin Schreiber, CEO of LifeMD. “2022 should prove to be an even stronger year as our momentum and strength accelerates from the launch of our LifeMD Virtual Primary Care Platform and our recent acquisition of Cleared. We continue to explore new areas of clinical opportunity and currently anticipate FY 2022 revenues to be in the range of $142 to $148 million.”

LifeMD CFO Marc Benathen added, “In addition to aggressively growing our revenues, we’re achieving excellent progress in continuing to drive sequential improvements in Adjusted EBITDA and meaningfully reducing cash burn. We’re also pleased to see the continued strength of our subscription revenue. Thanks to our strong focus on unit economics, we remain on track to achieve Adjusted EBITDA profitability by the fourth quarter of 2022 and believe we have more than ample liquidity to do so while achieving aggressive top-line growth goals.”


FY2022 Guidance
 
Total Revenue: $142-148 Million
Adjusted EBITDA: ($14M)-($20M)
   

Q1 2022 Guidance
 
Total Revenue: $30-32 Million
Adjusted EBITDA: ($6.5M)-($7.5M)

About LifeMD

LifeMD is a 50-state direct-to-patient telehealth company with a portfolio of brands that offer virtual primary care, diagnostics, and specialized treatment for men’s and women’s health, allergy & asthma, and dermatological issues. By leveraging its proprietary technology platform, 50-state medical group, and nationwide mail-order pharmacy network, LifeMD is increasing access to amazing healthcare that is affordable to everyone. To learn more, go to LifeMD.com.

Cautionary Note Regarding Forward Looking Statements

This news release includes forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended; Section 21E of the Securities Exchange Act of 1934, as amended; and the safe harbor provision of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements contained in this news release may be identified by the use of words such as: “believe,” “expect,” “anticipate,” “project,” “should,” “plan,” “will,” “may,” “intend,” “estimate,” predict,” “continue,” and “potential,” or, in each case, their negative or other variations or comparable terminology referencing future periods. Examples of forward-looking statements include, but are not limited to, statements regarding our financial outlook and guidance, short and long-term business performance and operations, future revenues and earnings, regulatory developments, legal events or outcomes, ability to comply with complex and evolving regulations, market conditions and trends, new or expanded products and offerings, growth strategies, underlying assumptions, and the effects of any of the foregoing on our future results of operations or financial condition.

Forward-looking statements are not historical facts and are not assurances of future performance. Rather, these statements are based on our current expectations, beliefs, and assumptions regarding future plans and strategies, projections, anticipated and unanticipated events and trends, the economy, and other future conditions, including the impact of any of the aforementioned on our future business. As forward-looking statements relate to the future, they are subject to inherent risk, uncertainties, and changes in circumstances and assumptions that are difficult to predict, including some of which are out of our control. Consequently, our actual results, performance, and financial condition may differ materially from those indicated in the forward-looking statements. These risks and uncertainties include, but are not limited to, “Risk Factors” identified in our filings with the Securities and Exchange Commission, including, but not limited to, our most recently filed Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and any amendments thereto. Even if our actual results, performance, or financial condition are consistent with forward-looking statements contained in such filings, they may not be indicative of our actual results, performance, or financial condition in subsequent periods.

Any forward-looking statement made in the news release is based on information currently available to us as of the date on which this release is made. We undertake no obligation to update or revise any forward-looking statement, whether as a result of new information, future events, or otherwise, except as may be required under applicable law or regulation.

Company Contact

LifeMD, Inc.
Marc Benathen, CFO
[email protected]

Investor Relations Contact

Ashley Robinson
LifeSci Advisors, LLC
[email protected]



PepGen Appoints Laurie Keating as Chair of Board of Directors

Keating brings strong experience as a life science executive and Board member

BOSTON, Jan. 19, 2022 (GLOBE NEWSWIRE) — PepGen, Inc., a company advancing next-generation oligonucleotide therapies for neuromuscular and neurologic diseases, today announced that it has appointed Laurie Keating as Chair of the company’s Board of Directors.

“We are very pleased that Laurie has agreed to join as Chair of our Board of Directors – she is a seasoned executive and Board member who has been a key member of the executive teams of two Boston biotechs that have transitioned from preclinical to successful commercial companies. We look forward to her strategic contributions and guidance as we continue to grow and build PepGen into a leading oligonucleotide therapies company focused on serious genetic disorders,” said James McArthur, Ph.D., President and Chief Executive Officer of PepGen.

Dr. McArthur continued, “Laurie replaces Ramin Farzaneh-Far, M.D., who served as PepGen’s Board Chair from November 2020 and will continue in his current role as acting Chief Medical Officer. We are very grateful to Ramin for his critical service in advancing the company, and for his support during our Series A and B fundraising rounds.”

In addition to her role on the PepGen Board of Directors, Laurie also serves as a Director of Immuneering Corp (Nasdaq:IMRX) and Imago Biosciences (Nasdaq:IMGO), and has served for more than ten years on the Board of MassBio. Laurie previously served as the Executive Vice President, General Counsel and Corporate Secretary of Alnylam Pharmaceuticals. In this role she led global government affairs, legal, IP, litigation and compliance, and advised the Board on financing and strategic collaborations, governance, and corporate strategy. Prior to Alnylam, she served as SVP, General Counsel and Corporate Secretary of Millennium Pharmaceuticals, a commercial stage company that was later acquired by Takeda. At Millennium, Laurie led the global Legal, Intellectual Property, Corporate Quality and Compliance groups. Prior to Millennium, Laurie was founding CEO and a director of Hydra Biosciences. Her contributions and executive leadership at public high technology companies earlier in her career led to her being named one of the 45 most influential in-house lawyers in the U.S. under the age of 45. Laurie earned her bachelor’s degree in Economics from the University of California at Berkeley, and her JD from the University of California, Hastings College of the Law.

“I am thrilled to be joining PepGen as the new Chair of the Board of Directors. I look forward to guiding the company’s development and supporting the leadership team as they seek to transform the lives of patients with innovative new treatment options for severe neuromuscular and neurologic diseases,” Keating said.

About PepGen 

PepGen, Inc. is a biotechnology company advancing next-generation oligonucleotide therapies for neuromuscular and neurologic diseases. PepGen’s proprietary Enhanced Delivery Oligonucleotides (EDOs) are designed to target the underlying causes of rare diseases safely and effectively such as Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1). In preclinical studies, PepGen’s enhanced delivery peptides demonstrated success in cell penetration and delivery of therapeutic candidates to multiple tissue types, including cardiac tissue. PepGen was founded by leading neurology researchers in Oxford, UK and is backed by a strong syndicate of investors including RA Capital Management, Oxford Science Enterprises, and others. The company is headquartered in Boston, Mass. For more information, visit www.pepgen.com or follow PepGen on Twitter and LinkedIn.

Media Contact 
Gwendolyn Schanker 
LifeSci Communications 
[email protected]



WISeKey Signs Agreement with Universa Blockchain to join the La Linea, Gibraltar 4th Industrial Revolution Center of Excellence

WISeKey Signs Agreement with Universa Blockchain to join the La Linea, Gibraltar 4th Industrial Revolution Center of Excellence

Geneva, Moscow, Gibraltar, La Linea – January 19, 2022 – WISeKey International Holding Ltd (“WISeKey “) (SIX: WIHN, NASDAQ: WKEY), a leading global cybersecurity, AI, Blockchain and IoT company, announces the signing of a strategic partnership with Universa Blockchain.

The agreement includes deep cooperation at the La Linea Gibraltar 4th Industrial Revolution Center of Excellence (LLG 4IR).

It was created following the signing of two Memoranda of Understanding (MoUs) with Mr. Fabian Picardo, Chief Minister of Gibraltar and the Mayor of La Línea de la Concepción, Mr. Juan Franco, to spearhead innovation in the region.

The parties will unite joint efforts in the breakthrough directions of Advanced Air Mobility (AAM), Energy sector, Central Bank Digital Currency (CBDC), Non-fungible tokens (NFT) and Metaverses that Morgan Stanley predicts an $8 trillion opportunity.

The partnership also thrives the ecosystem of cities of the Future: National Blockchain, Digital Passports, Smart City Management, Digital coupons and instant verification of documents based on QR codes, Tokenization and Digital Commodity.

According to research from Markets and Markets, the global Internet of Things (IoT) in smart cities market size is projected to hit $350 billion by 2026.

Alexander Borodich, CEO of Universa Blockchain stated: “There should be a digital hub of expertise for the whole world. It is a great honor for us to stand next to partners who look to the future. We plan to implement the best blockchain solutions focused on air mobility and digital assets that will set the basis for the flourishing of the LLG 4IR center.”

The fourth industrial revolution is a way of breaking down the boundaries between the physical and digital worlds.

It is a fusion of advances in artificial intelligence (AI), blockchain, robotics, the Internet of Things (IoT), genetic engineering, quantum computing and other technologies.

The Industrial Revolution Center of Excellence started its operations with the successful launch of WISeSAT Fossa Systems satellites ​​aboard SpaceX transporter rideshare 3 mission last week.

It will be managed from the ground by the recently installed control station based in La Linea de la Concepcion, Spain.

The business model of the joint 4IR Center of Excellence is to assist innovative start-ups in areas such as AI, Blockchain, IoT, Satellite, IoT, Drones, Cybersecurity and Quantum to perform collective R&D activities, promote their technologies internationally, facilitate the rapid adaptation and on-boarding of 4IR-based solutions, foster stronger collaboration between the public, private and academic sectors and cooperate to ensure that the latest technological standards are made available in a safe and trusted manner.

About Universa Blockchain

Universa Blockchain is a decentralized infrastructure offering an extremely fast and secure blockchain network, smart-contracts, tokenization and data storage services for enterprises and governments.

The company was founded in 2017 by Alexander Borodich, a blockchain investor, serial entrepreneur, and digital media strategist.

He is the current Chairman of the Scientific Research & Innovative Technologies Commission at the International Aerospace Committee.

For more information, visit https://universablockchain.com/

About WISeKey

WISeKey (SIX Swiss Exchange: WIHN) is a leading global cybersecurity company currently deploying large scale digital identity ecosystems for people and objects using Blockchain, AI and IoT respecting the Human as the Fulcrum of the Internet. WISeKey Microprocessors Secures the pervasive computing shaping today’s Internet of Everything. WISeKey IoT has an install base of over 1.6 billion microchips in virtually all IoT sectors (connected cars, smart cities, drones, agricultural sensors, anti-counterfeiting, smart lighting, servers, computers, mobile phones, crypto tokens etc.). WISeKey is uniquely positioned to be at the edge of IoT as our semiconductors produce a huge amount of Big Data that, when analyzed with Artificial Intelligence (AI), can help industrial applications to predict the failure of their equipment before it happens.

Our technology is Trusted by the OISTE. WISeKey’s Swiss based cryptographic Root of Trust (“RoT”) provides secure authentication and identification, in both physical and virtual environments, for the Internet of Things, Blockchain and Artificial Intelligence. The WISeKey RoT serves as a common trust anchor to ensure the integrity of online transactions among objects and between objects and people. For more information, visit www.wisekey.com.

Press and investor contacts

WISeKey

Company Contact:
Carlos Moreira
Chairman & CEO
Tel: +41 22 594 3000
[email protected]
WISeKey Investor Relations (US)

Contact:
Lena Cati
The Equity Group Inc.
Tel: +1 212 836-9611
[email protected]

Disclaimer:

This communication expressly or implicitly contains certain forward-looking statements concerning WISeKey International Holding Ltd and its business. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of WISeKey International Holding Ltd to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. WISeKey International Holding Ltd is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise.

This press release does not constitute an offer to sell, or a solicitation of an offer to buy, any securities, and it does not constitute an offering prospectus within the meaning of article 652a or article 1156 of the Swiss Code of Obligations or a listing prospectus within the meaning of the listing rules of the SIX Swiss Exchange. Investors must rely on their own evaluation of WISeKey and its securities, including the merits and risks involved. Nothing contained herein is or shall be relied on as, a promise or representation as to the future performance of WISeKey.



ImmixBio Announces Positive IMX-110 Phase 1b/2a Interim Clinical Trial Safety Data Demonstrating 100% Completion of Planned Treatment Cycles

  • 100% of patients treated with IMX-110 completed planned treatment cycles without drug-related interruptions in its ongoing Phase 1b/2a clinical trial
  • IMX-110 is in clinical development as a monotherapy for soft tissue sarcoma (STS), a $3 billion market expected to grow to $6.5 billion by 2030

A chart accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/b83a7ede-262b-4777-a2f9-beb13ee761bc

LOS ANGELES, Jan. 19, 2022 (GLOBE NEWSWIRE) — Immix Biopharma, Inc. (Nasdaq: IMMX) (“ImmixBio”, “Company”, “We” or “Us”), a biopharmaceutical company pioneering Tissue-Specific Therapeutics (TSTx)™ targeting oncology and immuno-dysregulated diseases, today announced positive interim clinical trial safety data demonstrating 100% completion of IMX-110 planned treatment cycles in its ongoing Phase 1b/2a clinical trial. Historically, 43-67% of patients have completed planned treatment cycles with approved drugs used to treat soft tissue sarcoma (STS) according to Demetri et al., 2016, and Schöffski et al., 2016. Completion of planned treatment cycles refers to lack of drug-related interruptions (cycle delays, dose reductions, or dose interruptions due to drug toxicity).

“With standard treatments widely used today, cancer patients face a long list of drug-related debilitating side-effects that cause treatment delays, dose reductions, or dose interruptions due to toxicity, interfering with the ability to treat them effectively,” said Ilya Rachman, MD PhD, CEO of ImmixBio. “In this interim clinical trial update, we are thrilled to report that IMX-110 has been well tolerated. We believe that IMX-110 could become a potentially attractive option to improve the patient experience in oncology in the future.”

The U.S. Food and Drug Administration (“FDA”) has approved orphan drug designation (“ODD”) for IMX-110 for the treatment of soft tissue sarcoma. The FDA has already approved rare pediatric disease (“RPD”) designation to IMX-110 for the treatment of a life-threatening pediatric cancer in children, rhabdomyosarcoma.

About Immix Biopharma, Inc.

Immix Biopharma, Inc. (ImmixBio™) (Nasdaq: IMMX) is a clinical-stage biopharmaceutical company pioneering a novel class of Tissue-Specific Therapeutics (TSTx)™ targeting oncology and immuno-dysregulated diseases. Our lead asset IMX-110, currently in Phase 1b/2a clinical trials, holds orphan drug designation (ODD) by the FDA for soft tissue sarcoma, and has received Rare Pediatric Disease Designation (RPDD) for the treatment of rhabdomyosarcoma, a life-threatening form of cancer in children. RPPD qualifies ImmixBio to receive fast track review and a priority review voucher (PRV) at the time of marketing approval of IMX-110. Our proprietary SMARxT Tissue-Specific™ Platform produces drug candidates that circulate in the bloodstream, exit through tumor blood vessels and simultaneously attack all 3 components of the tumor micro-environment (TME). We believe ImmixBio’s TME Normalization™ technology severs the lifelines between the tumor and its metabolic and structural support. Learn more at www.immixbio.com.

Forward Looking Statements

This press release contains “forward-looking statements” Forward-looking statements reflect our current view about future events. When used in this press release, the words “anticipate,” “believe,” “estimate,” “expect,” “future,” “intend,” “plan,” or the negative of these terms and similar expressions, as they relate to us or our management, identify forward-looking statements. Such statements, include, but are not limited to, statements contained in this press release relating to our business strategy, our future operating results and liquidity and capital resources outlook. Forward-looking statements are based on our current expectations and assumptions regarding our business, the economy and other future conditions. Because forward–looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict. Our actual results may differ materially from those contemplated by the forward-looking statements. They are neither statements of historical fact nor guarantees of assurance of future performance. We caution you therefore against relying on any of these forward-looking statements. Important factors that could cause actual results to differ materially from those in the forward-looking statements include, without limitation, our ability to raise capital to fund continuing operations; our ability to protect our intellectual property rights; the impact of any infringement actions or other litigation brought against us; competition from other providers and products; our ability to develop and commercialize products and services; changes in government regulation; our ability to complete capital raising transactions; and other factors relating to our industry, our operations and results of operations. Actual results may differ significantly from those anticipated, believed, estimated, expected, intended or planned.

Factors or events that could cause our actual results to differ may emerge from time to time, and it is not possible for us to predict all of them. We cannot guarantee future results, levels of activity, performance or achievements. The Company assumes no obligation to update any forward-looking statements in order to reflect any event or circumstance that may arise after the date of this release

Contacts

Immix Biopharma, Inc.
Gabriel Morris
Chief Financial Officer
[email protected]
+1 (888) 958-1084



HCW Biologics’ Founder and CEO Dr. Hing C. Wong Participating in Cambridge Healthtech Institute’s Annual PepTalk Conference 2022

A Novel Platform to Create Multi-Functional Immunotherapeutics for Cancer Will Feature TOBI™ Discovery Platform and Lead Product Candidate, HCW9218

MIRAMAR, Fla., Jan. 19, 2022 (GLOBE NEWSWIRE) — HCW Biologics Inc. (“HCW Biologics” or the “Company”) (NASDAQ: HCWB), a biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between chronic, low-grade inflammation and age-related diseases, today announced that Hing C. Wong, Ph.D., Founder and CEO of HCW Biologics, will speak at the Cambridge Healthtech Institute’s 24th Annual PepTalk Conference to be held on January 17-19, 2022 (https://www.chi-peptalk.com/protein-expression-production). The conference is taking place virtually and in person at the Hilton San Diego Bayfront in San Diego, California.

Dr. Wong’s presentation entitled, “A Novel Platform to Create Multi-Functional Immunotherapeutics for Cancer,” is part of the session for Recombinant Protein Expression and Production: Effective Expression and Production of Unique Bioproducts and takes place on January 19 at 11:15 a.m. PST. His presentation will feature a discussion of the Company’s internally developed platform for drug discovery called the TOBI™ (Tissue factOr-Based fusIon) platform. The TOBI™ platform is a scaffold for the creation of novel multi-functional immunotherapeutics that have the potential to rejuvenate the immune system by reducing the accumulation of senescent cells and suppressing the activity of inflammasomes. Using the TOBI™ platform, the Company has developed over 30 molecules that are capable of activating and targeting desired immune responses and blocking unwanted immunosuppressive activities.

Dr. Wong stated, “The TOBI™ platform is a novel approach to construct multi-functional fusion proteins and fusion protein complexes, all components are human-derived, using a novel tissue factor (TF) scaffold. The extracellular domain of human TF was selected as it has a rigid elongated structure comprised mainly of ß-sheets with its N- and C-termini located at distal ends of the polypeptide, permitting genetic fusions of other protein domains without anticipated steric interference. This TF domain does not interact with the cell membrane phospholipid bilayer and, as a result, does not exhibit procoagulant activity. It is expressed at high levels by most cell types and is not expected to be immunogenic in humans.”

Dr. Wong added, “Consistent with these properties, we found that genetic fusion to the TF domain promoted increased production of difficult-to-express proteins, such as IL-15. Additionally, the TF fusion proteins could be readily purified by affinity chromatography using an anti-TF antibodies and low pH elution conditions, like those used in Protein A-based affinity purification of therapeutic antibodies.”

Dr. Wong’s presentation will include a discussion of data and conclusions contained in recent papers authored by the Company’s scientists that have been published in peer-reviewed journals. The presentation will highlight information contained in a pivotal paper published in Molecular Therapy related to preclinical data from in vivo studies demonstrating the potential of the Company’s lead investigational candidate, HCW9218, in eliminating therapy-induced senescence and the unwanted side effects of chemotherapy. This ground-breaking finding revealed the underlying mechanism that HCW9218 enhanced the anti-tumor activities and lessened the side effects of chemotherapies. In addition, Dr. Wong’s presentation will include a discussion of another paper published in Molecular Therapy related to preclinical data from in vivo studies demonstrating that HCW9218 exhibited favorable pharmacokinetics and pharmacodynamics as a novel immunostimulant with the ability to simultaneously lessen immunosuppression. Finally, the presentation will discuss some of the information in a paper published in Cancer Immunology Research that looked at HCW Biologics’ TOBI™ discovery platform.

About TOBI™
HCW Biologics has combined deep understanding of disease-related immunology with its expertise in advanced protein engineering to develop the TOBI™ discovery platform. TOBI™ is a proprietary immunotherapeutic drug design and discovery platform. HCW has utilized this modular, tunable technology to generate a novel pipeline of immunotherapeutic candidates capable of activating and targeting desired immune responses while blocking unwanted immunosuppressive activities. The balancing of these two activities is believed to be the key to developing immunotherapeutic agents that will be safe, well tolerated and efficacious.

About HCW Biologics:
HCW Biologics is a transformative immunotherapy company that focuses on inflammaging, a state of unresolved inflammatory responses and chronic inflammation. The Company is developing novel immunotherapies designed to improve health span by disrupting the link between chronic, low-grade inflammation and age-related diseases such as cancer, cardiovascular diseases, diabetes, neurodegenerative diseases and autoimmune diseases. The Company uses its TOBI™ discovery platform to generate designer, novel multi-functional fusion molecules with immunotherapeutic properties for the treatment of inflammaging. The invention of HCW Biologics’ two lead molecules, HCW9218 and HCW9302, was made via the TOBI™ discovery platform. The FDA has cleared HCW Biologics to initiate a first-in-human Phase 1b clinical trial for HCW9218 in patients with advanced pancreatic cancer. The Company is also advancing IND-enabling studies for HCW9302 for an autoimmune indication.

Forward Looking Statements:
Statements in this press release contain “forward-looking statements” that are subject to substantial risks and uncertainties. These statements are made under the “safe harbor” provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements contained in this press release may be identified by the use of words such as “anticipate,” “expect,” “believe,” “will,” “may,” “should,” “estimate,” “project,” “outlook,” “forecast” or other similar words and include, without limitation, statements regarding immunotherapeutic candidates capable of activating and targeting desired immune responses while blocking unwanted immunosuppressive activities; the balancing of certain activities believed to be the key to developing immunotherapeutic agents that are expected to be safe, well tolerated and efficacious; the Company’s intention to use TOBI™ technology to develop the next generation of cancer immunotherapeutics; development of molecules that are capable of activating and targeting desired immune responses and blocking unwanted immunosuppressive activities; development of immunotherapeutics that have the potential to rejuvenate the immune system by reducing the accumulation of senescent cells and suppressing the activity of inflammasomes; the TF domain of the TOBI platform is expressed at high levels by most cell types and is not expected to be immunogenic in humans; claims regarding TF fusion protein production and purification; potential of HCW9218 in eliminating therapy-induced senescence and the unwanted off-target and side effects of chemotherapy; potential of HCW9218 as a novel immunostimulant with the ability to simultaneously lessen immunosuppression in patients with cancer; and development of immunotherapies designed to improve health by disrupting the link between chronic, low-grade inflammation and age-related diseases such as cancer, cardiovascular diseases, diabetes, neurodegenerative diseases and autoimmune diseases. Forward-looking statements are based on the Company’s current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Factors that could cause actual results to differ include, but are not limited to, the risks and uncertainties that are described in the section titled “Risk Factors” in the final prospectus related to the Company’s initial public offering filed with the Securities and Exchange Commission on July 21, 2021. Forward-looking statements contained in this press release are made as of this date, and the Company undertakes no duty to update such information except as required under applicable law.

Company Contact:

Rebecca Byam
CFO
HCW Biologics Inc.
[email protected] 

Investor Relations Contact:

Lisa Sher
Senior Vice President
Tiberend Strategic Advisors, Inc.
[email protected] 

Media Relations Contact:

Dave Schemelia
Senior Vice President
Tiberend Strategic Advisors, Inc.
[email protected] 



Splash Beverage Group’s Pulpoloco Brand Receives Authorization for 187 Ralph’s Grocery Stores

Fort Lauderdale, Florida, Jan. 19, 2022 (GLOBE NEWSWIRE) — Splash Beverage Group, Inc. (NYSE American: SBEV) (“Splash” or the “Company”), a portfolio company of leading beverage brands, today announced it has received authorization to sell its Pulpoloco Sangria line in 187 of Ralph’s Grocery stores.   Ralph’s Grocery, a division of The Kroger Company, is a market share leader with 187 stores across Southern California.

“This is another significant milestone for Splash and a meaningful step in our strategy to expand into major supermarket chains,” said Robert Nistico, Splash Beverage Group’s Chairman and CEO.  “After a successful test run, Ralph’s authorized all three SKU’s of Pulpoloco white, rosé and classic red.  Ralph’s already carries Splash’s Copa di Vino varietals, which were added in early summer of 2021, and now all 3 Pulpoloco varietals. We believe this is a strong affirmation that consumers are catching on to the unique product lines that Splash distributes and bodes well for future expansion.”

Ralph’s Grocery is owned by The Kroger Company, one of the world’s largest food retailers with 2750 grocery retail stores under a variety of banner names.

“AB One’s coverage includes Southern California, and Ralph’s confidence in them as an elite service provider in beverage distribution was a key element in our obtaining this authorization,” Nistico said. 

Follow Splash Beverage Group on Twitter: www.twitter.com/SplashBev

About Splash Beverage Group, Inc.

Splash Beverage Group, an innovator in the beverage industry, owns a growing portfolio of alcoholic and non-alcoholic beverage brands including Copa di Vino wine by the glass, SALT flavored tequilas, Pulpoloco sangria, and TapouT performance hydration and recovery drink. Splash’s strategy is to rapidly develop early stage brands already in its portfolio as well as acquire and then accelerate brands that have high visibility or are innovators in their categories. Led by a management team that has built and managed some of the top brands in the beverage industry and led sales from product launch into the billions, Splash is rapidly expanding its brand portfolio and global distribution. 

For more information, visit:
www.SplashBeverageGroup.com
www.copadivino.com
www.drinksalttequila.com
www.pulpo-loco.com
www.tapoutdrinks.com

Forward-Looking Statement

This press release includes “forward-looking statements” within the meaning of U.S. federal securities laws. Words such as “expect,” “estimate,” “project,” “budget,” “forecast,” “anticipate,” “intend,” “plan,” “may,” “will,” “could,” “should,” “believes,” “predicts,” “potential,” “continue” and similar expressions are intended to identify such forward-looking statements. These forward-looking statements involve significant risks and uncertainties that could cause the actual results to differ materially from the expected results and, consequently, you should not rely on these forward-looking statements as predictions of future events. These forward-looking statements and factors that may cause such differences include, without limitation, the risks disclosed in the Company’s Annual Report on Form 10-K filed with the SEC on March 8, 2021, and in the Company’s other filings with the SEC. Readers are cautioned not to place undue reliance upon any forward-looking statements, which speak only as of the date made. Except as required by law, the Company disclaims any obligation to update or publicly announce any revisions to any of the forward-looking statements contained in this press release.

Contact Information:

Splash Beverage Group
[email protected]
954-745-5815

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