Burning Rock Reports Third Quarter 2025 Financial Results

GUANGZHOU, China, Nov. 20, 2025 (GLOBE NEWSWIRE) — Burning Rock Biotech Limited (NASDAQ: BNR, the “Company” or “Burning Rock”), a company focused on the application of next generation sequencing (NGS) technology in the field of precision oncology, today reported financial results for the three months ended September 30, 2025.

Recent Business Updates

  • Therapy Selection

    • Presented study results at the Cell Reports Medicine on esophageal squamous cell carcinoma in September 2025. “Integrating ctDNA with clinical response evaluation improves residual disease detection post-neoadjuvant chemoradiotherapy to support organsparing strategies and that postoperative ctDNA stratifies recurrence risk beyond pathological response to inform adjuvant immunotherapy decisions”.
  • Early Detection

    • PROMISE study test results presented at The Innovation in September 2025. “The PROMISE study was conducted to investigate the feasibility of a multi-omics integration strategy in multi-cancer detection blood tests across nine types of cancers in head and neck (excluding nasopharynx), esophagus, lung, stomach, liver, biliary tract, pancreas, colorectum, and ovary……Compared to the methylation-based classifier, the multimodal classifier combining methylation and protein features, exhibited an improved sensitivity of 75.1% (95% 75 confidence interval [CI], 69.3%–80.3%) at the same specificity of 98.8% with the accuracy of top predicted origin (TPO1) of 73.1% (95% CI, 66.2%–79.2%)”.
  • Pharma Services

    • The OncoGuide™ OncoScreen™ Plus CDx System based on OncoScreen™ Plus to be used as a companion diagnostic for AstraZeneca’s capivasertib has received Manufacturing and Marketing Approval from Japan’s Ministry of Health, Labour and Welfare (MHLW) in September, 2025.

Third Quarter 2025 Financial Results

Total revenues were RMB131.6 million (US$18.5 million) for the three months ended September 30, 2025, representing a 2.3% increase from RMB128.6 million for the same period in 2024.

  • Revenue generated from in-hospital business was RMB52.8 million (US$7.4 million) for the three months ended September 30, 2025, representing a 17.1% decrease from RMB63.8 million for the same period in 2024, driven by a decrease in sales volume.
  • Revenue generated from central laboratory business was RMB36.8 million (US$5.2 million) for the three months ended September 30, 2025, representing a 7.9% decrease from RMB40.0 million for the same period in 2024, primarily attributable to a decrease in the number of tests, as we continued our transition towards in-hospital testing.
  • Revenue generated from pharma research and development services was RMB42.0 million (US$5.9 million) for the three months ended September 30, 2025, representing a 68.6% increase from RMB24.9 million for the same period in 2024, primarily attributable to an increased development and testing services performed for our pharma customers.

Cost of revenues was RMB32.8 million (US$4.6 million) for the three months ended September 30, 2025, representing an 10.9% decrease from RMB36.8 million for the same period in 2024.

Gross profit was RMB98.8 million (US$13.9 million) for the three months ended September 30, 2025, representing a 7.6% increase from RMB91.8 million for the same period in 2024. Gross margin was 75.1% for the three months ended September 30, 2025, compared to 71.4% for the same period in 2024. By channel, gross margin of central laboratory business and in-hospital business were 81.8% and 71.8% for the three months ended September 30, 2025, compared to 83.2% and 73.0% during the same period in 2024, primarily due to the cost reduction caused by the rent subsidy for the headquarter building in the third quarter of 2024; gross margin of pharma research and development services was 73.4% for the three months ended September 30, 2025, compared to 48.2% during the same period of 2024, primarily due to the significant increase in revenue from high-margin companion diagnostic (CDx) projects.

Non-GAAP gross profit, which excludes depreciation and amortization expenses, was RMB100.9 million (US$14.2million) for the three months ended September 30, 2025, representing a 3.2% increase from RMB97.8 million for the same period in 2024. Non-GAAP gross margin was 76.7% for the three months ended September 30, 2025, compared to 76.0% for the same period in 2024.

Operating expenses were RMB115.0 million (US$16.2 million) for the three months ended September 30, 2025, representing a 11.9% decrease from RMB130.4 million for the same period in 2024. The decrease was primarily driven by decreases in amortized expense on share-based compensation, budget control measures and headcount reduction to improve the Company’s operating efficiency.

  • Research and development expenses were RMB41.5 million (US$5.8 million) for the three months ended September 30, 2025, representing a 15.6% decrease from RMB49.2 million for the same period in 2024, primarily due to (i) a decrease in the expenditure for research projects; (iii) a decrease in amortized expense on share-based compensation; and (iv) a decrease in amortized expenses for office building decoration.
  • Selling and marketing expenses were RMB41.8 million (US$5.9 million) for the three months ended September 30, 2025, representing a 13.6% decrease from RMB48.4 million for the same period in 2024, primarily due to (i) a decrease in staff cost resulted from the reorganization of the sales department and improvement in operating efficiency; (ii) a decrease in amortized expense on share-based compensation; and (iii) a decrease in amortized expenses for office building decoration.
  • General and administrative expenses were RMB31.7 million (US$4.5 million) for the three months ended September 30, 2025, representing a 3.6% decrease from RMB32.9 million for the same period in 2024, primarily due to (i) a decrease in the general and administrative personnel’s staff cost; (ii) a decrease in amortized expense on share-based compensation; and partially offset by (i) an increase in impairment expenses for accounts receivables and contract assets; (iii) an increase in operating lease.

Net loss was RMB16.8 million (US$2.4 million) for the three months ended September 30, 2025, compared to RMB35.7 million for the same period in 2024.

Cash, cash equivalents and restricted cash were RMB467.0 million (US$65.6 million) as of September 30, 2025.

About Burning Rock

Burning Rock Biotech Limited (NASDAQ: BNR), whose mission is to guard life via science, focuses on the application of next generation sequencing (NGS) technology in the field of precision oncology. Its business consists of i) NGS-based therapy selection testing for late-stage cancer patients, and ii) cancer early detection, which has moved beyond proof-of-concept R&D into the clinical validation stage.

For more information about Burning Rock, please visit: ir.brbiotech.com.

Safe Harbor Statement

This press release contains forward-looking statements. These statements constitute “forward-looking” statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and as defined in the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as “will,” “expects,” “anticipates,” “future,” “intends,” “plans,” “believes,” “estimates,” “target,” “confident” and similar statements. Burning Rock may also make written or oral forward-looking statements in its periodic reports to the SEC, in its annual report to shareholders, in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Statements that are not historical facts, including statements about Burning Rock’s beliefs and expectations, are forward-looking statements. Such statements are based upon management’s current expectations and current market and operating conditions, and relate to events that involve known or unknown risks, uncertainties and other factors, all of which are difficult to predict and many of which are beyond Burning Rock’s control. Forward-looking statements involve risks, uncertainties and other factors that could cause actual results to differ materially from those contained in any such statements. All information provided in this press release is as of the date of this press release, and Burning Rock does not undertake any obligation to update any forward-looking statement as a result of new information, future events or otherwise, except as required under applicable law.

Non-GAAP Measures

In evaluating the business, the Company considers and uses non-GAAP measures, such as non-GAAP gross profit and non-GAAP gross margin, as supplemental measures to review and assess operating performance. The presentation of these non-GAAP financial measures is not intended to be considered in isolation or as a substitute for the financial information prepared and presented in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”). The company defines non-GAAP gross profit as gross profit excluding depreciation and amortization. The company defines non-GAAP gross margin as gross margin excluding depreciation and amortization.

The company presents these non-GAAP financial measures because they are used by management to evaluate operating performance and formulate business plans. The company believe non-GAAP gross profit and non-GAAP gross margin excluding non-cash impact of depreciation and amortization reflect the company’s ongoing business operations in a manner that allows more meaningful period-to-period comparisons.

Contact: [email protected]

 
Selected Operating Data
   
  As of
  September 30,
2024
December 31,
2024
March 31,
2025
June 30,

2025
September 30,
2025
In-hospital Channel:          
Pipeline partner hospitals(1) 30 29 30 30 31
Contracted partner hospitals(2) 61 63 63 63 63
Total number of partner
hospitals
69 92 93 93 94

(1) Refers to hospitals that are in the process of establishing in-hospital laboratories, laboratory equipment procurement or installation, staff training or pilot testing using the Company’s products.
(2) Refers to hospitals that have entered into contracts to purchase the Company’s products for use on a recurring basis in their respective in-hospital laboratories the Company helped them establish. Kit revenue is generated from contracted hospitals.
   

Selected Financial Data
                 
    For the three months ended
  For the nine months ended
Revenues   September 30,
2024
  September 30,
2025
  September 30,
2024
  September 30,
2025
    (RMB in thousands)
  (RMB in thousands)
Central laboratory channel   39,984   36,811   136,371   115,968
In-hospital channel   63,769   52,847   181,028   173,030
Pharma research and development channel   24,891   41,959   72,401   124,255
Total revenues   128,644   131,617   389,800   413,253
                 

    For the three months ended
  For the nine months ended
Revenues by location of customer   September 30,
2024
  September 30,
2025
  September 30,
2024
  September 30,
2025
    (RMB in thousands)
  (RMB in thousands)
Overseas   25,840   17,214   59,553   79,079
Mainland China   102,804   114,403   330,247   334,174
Total Revenues   128,644   131,617   389,800   413,253
                 

    For the three months ended
  For the nine months ended
Gross profit   September 30,
2024
  September 30, 2025   September 30,
2024
  September 30, 2025
    (RMB in thousands)
  (RMB in thousands)
Central laboratory channel   33,262   30,126   108,688   98,254
In-hospital channel   46,580   37,925   129,830   128,310
Pharma research and development channel   12,004   30,793   34,460   77,784
Total gross profit   91,846   98,844   272,978   304,348
                 

    For the three months ended
  For the nine months ended
Share-based compensation expenses   September 30,
2024
  September 30,
2025
  September 30,
2024
  September 30,
2025
    (RMB in thousands)
  (RMB in thousands)
Cost of revenues   289   301   1,349   889
Research and development expenses   3,180   73   27,475   1,603
Selling and marketing expenses   1,917   624   3,657   2,013
General and administrative expenses   4,732   2,831   115,129   6,249
Total share-based compensation expenses   10,118   3,829   147,610   10,754
                 

Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

(in thousands, except for number of shares and per share data)
   
  For the three months ended
  September 30,
2024
  December 31,
2024
  March 31,
2025
  June 30,

2025
  September 30,
2025
  September 30,
2025
 
  RMB   RMB   RMB   RMB   RMB   US$  
Revenues 128,644   126,022   133,082   148,554   131,617   18,488  
Cost of revenues (36,798 ) (36,600 ) (35,681 ) (40,451 ) (32,773 ) (4,604 )
Gross profit 91,846   89,422   97,401   108,103   98,844   13,884  
Operating expenses:            
Research and development expenses (49,150 ) (52,203 ) (40,389 ) (49,770 ) (41,469 ) (5,825 )
Selling and marketing expenses (48,411 ) (46,730 ) (40,888 ) (38,413 ) (41,808 ) (5,873 )
General and administrative expenses (32,874 ) (37,289 ) (31,303 ) (31,417 ) (31,698 ) (4,453 )
Impairment loss on long-lived assets   (35,127 )        
Total operating expenses (130,435 ) (171,349 ) (112,580 ) (119,600 ) (114,975 ) (16,151 )
Loss from operations (38,589 ) (81,927 ) (15,179 ) (11,497 ) (16,131 ) (2,267 )
Interest income 3,173   1,814   2,581   2,226   1,744   245  
Interest expense         (15 ) (2 )
Other income (expense), net 1   4,353   (652 ) 387   7   1  
Foreign exchange loss, net (129 ) (220 ) (26 ) (574 ) (2,151 ) (302 )
Loss before income tax (35,544 ) (75,980 ) (13,276 ) (9,458 ) (16,546 ) (2,325 )
Income tax expenses (201 ) (5,314 ) (224 ) (244 ) (212 ) (30 )
Net loss (35,745 ) (81,294 ) (13,500 ) (9,702 ) (16,758 ) (2,355 )
Net loss attributable to Burning Rock Biotech Limited’s shareholders (35,745 ) (81,294 ) (13,500 ) (9,702 ) (16,758 ) (2,355 )
Net loss attributable to ordinary shareholders (35,745 ) (81,294 ) (13,500 ) (9,702 ) (16,758 ) (2,355 )
Loss per share for class A and class B ordinary shares:            
Class A ordinary shares – basic and diluted (0.35 ) (0.79 ) (0.13 ) (0.09 ) (0.16 ) (0.02 )
Class B ordinary shares – basic and diluted (0.35 ) (0.79 ) (0.13 ) (0.09 ) (0.16 ) (0.02 )
Weighted average shares outstanding used in loss per share computation:            
Class A ordinary shares – basic and diluted 85,902,670   86,036,286   90,291,658   90,357,970   90,416,619   90,416,619  
Class B ordinary shares – basic and diluted 17,324,848   17,324,848   17,324,848   17,324,848   17,324,848   17,324,848  
Other comprehensive (loss) income, net of tax of nil:            
Foreign currency translation adjustments (4,054 ) 6,009   (72 ) (243 ) (1,724 ) (242 )
Total comprehensive loss (39,799 ) (75,285 ) (13,572 ) (9,945 ) (18,482 ) (2,597 )
Total comprehensive loss attributable to Burning Rock Biotech Limited’s shareholders (39,799 ) (75,285 ) (13,572 ) (9,945 ) (18,482 ) (2,597 )
Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

(in thousands, except for number of shares and per share data)
   
  For the nine months ended
  September 30,
2024
  September 30,
2025
  September 30,
2025
 
  RMB RMB US$
Revenues 389,800   413,253   58,049  
Cost of revenues (116,822 ) (108,905 ) (15,299 )
Gross profit 272,978   304,348   42,750  
Operating expenses:      
Research and development expenses (180,087 ) (131,628 ) (18,490 )
Selling and marketing expenses (144,174 ) (121,109 ) (17,012 )
General and administrative expenses (224,349 ) (94,418 ) (13,263 )
Total operating expenses (548,610 ) (347,155 ) (48,765 )
Loss from operations (275,632 ) (42,807 ) (6,015 )
Interest income 10,398   6,551   920  
Interest expense   (15 ) (2 )
Other income, net 353   (258 ) (36 )
Foreign exchange gain (loss), net 120   (2,751 ) (386 )
Loss before income tax (264,761 ) (39,280 ) (5,519 )
Income tax expenses (571 ) (680 ) (96 )
Net loss (265,332 ) (39,960 ) (5,615 )
Net loss attributable to Burning Rock Biotech Limited’s shareholders (265,332 ) (39,960 ) (5,615 )
Net loss attributable to ordinary shareholders (265,332 ) (39,960 ) (5,615 )
Loss per share for class A and class B ordinary shares:      
Class A ordinary shares – basic and diluted (2.58 ) (0.37 ) (0.05 )
Class B ordinary shares – basic and diluted (2.58 ) (0.37 ) (0.05 )
Weighted average shares outstanding used in loss per share computation:      
Class A ordinary shares – basic and diluted 85,467,131   90,332,672   90,332,672  
Class B ordinary shares – basic and diluted 17,324,848   17,324,848   17,324,848  
Other comprehensive loss, net of tax of nil:      
Foreign currency translation adjustments (2,524 ) (2,039 ) (286 )
Total comprehensive loss (267,856 ) (41,999 ) (5,901 )
Total comprehensive loss attributable to Burning Rock Biotech Limited’s shareholders (267,856 ) (41,999 ) (5,901 )
Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets

(In thousands)

   
  As of
  December 31,
2024
  September 30,
2025
  September 30,
2025
  RMB   RMB   US$
ASSETS          
Current assets:          
Cash and cash equivalents 519,849   463,994   65,177
Restricted cash 2,313   2,985   419
Accounts receivable, net 152,013   183,841   25,824
Contract assets, net 13,855   13,049   1,833
Inventories, net 62,625   54,469   7,651
Prepayments and other current assets, net 25,963   20,985   2,950
Total current assets 776,618   739,323   103,854

Non-current assets:
         
Property and equipment, net 47,152   33,755   4,742
Operating right-of-use assets 53,188   32,281   4,534
Intangible assets, net 421   316   44
Other non-current assets 7,926   6,493   912
Total non-current assets 108,687   72,845   10,232
TOTAL ASSETS 885,305   812,168   114,086
Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets (Continued)

(in thousands)

   
  As of
  December 31,
2024
  September 30,
2025
  September 30,
2025
 
  RMB RMB US$
LIABILITIES AND SHAREHOLDERS’ EQUITY      
Current liabilities:      
Accounts payable 33,747   34,277   4,815  
Deferred revenue 117,895   106,448   14,953  
Accrued liabilities and other current liabilities 89,498   76,992   10,816  
Customer deposits 592   592   83  
Short-term borrowings   200   28  
Current portion of operating lease liabilities 24,567   16,603   2,332  
Total current liabilities 266,299   235,112   33,027  
Non-current liabilities:      
Long-term borrowings   1,800   253  
Non-current portion of operating lease liabilities 27,754   14,577   2,048  
Other non-current liabilities 10,425   11,102   1,559  
Total non-current liabilities 38,179   27,479   3,860  
TOTAL LIABILITIES 304,478   262,591   36,887  

Shareholders’ equity:
     
Class A ordinary shares 124   120   17  
Class B ordinary shares 21   21   3  
Additional paid-in capital 5,002,255   5,006,937   703,320  
Treasury stock (63,264 ) (57,193 ) (8,034 )
Accumulated deficits (4,200,261 ) (4,240,221 ) (595,620 )
Accumulated other comprehensive loss (158,048 ) (160,087 ) (22,487 )
Total shareholders’ equity 580,827   549,577   77,199  
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY 885,305   812,168   114,086  
Burning Rock Biotech Limited

Unaudited Condensed Statements of Cash Flows

(in thousands)

   
  For the three months ended
  September

30,
2024
  September

30,
2025
  September 30,

2025
 
  RMB RMB US$
Net cash used in operating activities (30,278 ) 16,394   2,303  
Net cash used in investing activities (987 ) (2,747 ) (386 )
Net cash generated from financing activities 2      
Effect of exchange rate on cash, cash equivalents and restricted cash (3,537 ) (1,692 ) (237 )
Net decrease in cash, cash equivalents and restricted cash (34,800 ) 11,955   1,680  
Cash, cash equivalents and restricted cash at the beginning of period 533,047   455,024   63,916  
Cash, cash equivalents and restricted cash at the end of period 498,247   466,979   65,596  
       

  For the nine months ended
  September

30,
2024
  September

30,
2025
  September

30,
2025
 
  RMB RMB US$
Net cash used in operating activities (111,323 ) (51,482 ) (7,232 )
Net cash used in investing activities (3,600 ) (4,071 ) (572 )
Net cash generated from financing activities 2   2,000   281  
Effect of exchange rate on cash, cash equivalents and restricted cash (2,048 ) (1,630 ) (229 )
Net decrease in cash, cash equivalents and restricted cash (116,969 ) (55,183 ) (7,752 )
Cash, cash equivalents and restricted cash at the beginning of period 615,216   522,162   73,348  
Cash, cash equivalents and restricted cash at the end of period 498,247   466,979   65,596  
     

Burning Rock Biotech Limited

Reconciliations of GAAP and Non-GAAP Results

     
  For the three months ended
  September 30,
2024
  December 31,
2024
  March 31,

2025
  June 30,

2025
  September 30,
2025
 
  (RMB in thousands)
Gross profit:
   
Central laboratory channel 33,262   33,153   32,191   35,937   30,126  
In-hospital channel 46,580   29,563   43,895   46,490   37,925  
Pharma research and development channel 12,004   26,706   21,315   25,676   30,793  
Total gross profit
91,846   89,422   97,401   108,103   98,844  
Add: depreciation and amortization:          
Central laboratory channel 1,277   1,010   562   456   231  
In-hospital channel 798   623   290   389   372  
Pharma research and development channel 3,846   2,534   2,412   1,528   1,491  
Total depreciation and amortization included in cost of revenues
5,921   4,167   3,264   2,373   2,094  
Non-GAAP gross profit:          
Central laboratory channel 34,539   34,163   32,753   36,393   30,357  
In-hospital channel 47,378   30,186   44,185   46,879   38,297  
Pharma research and development channel 15,850   29,240   23,727   27,204   32,284  
Total non-GAAP gross profit 97,767   93,589   100,665   110,476   100,938  
Non-GAAP gross margin:          
Central laboratory channel 86.4%   87.0%   85.5%   89.1%   82.5%  
In-hospital channel 74.3%   69.5%   76.6%   75.0%   72.5%  
Pharma research and development channel 63.7%   67.6%   64.0%   60.2%   76.9%  
Total non-GAAP gross margin 76.0
%
  74.3
%
  75.6
%
  74.4
%
  76.7
%