Janux Therapeutics Reports Third Quarter 2025 Financial Results and Business Highlights
- Enrollment ongoing for JANX007 and JANX008
- Updates on JANX007 and JANX008 expected in the fourth quarter of 2025
- $989.0 million in cash, cash equivalents, and short-term investments at end of third quarter 2025
SAN DIEGO–(BUSINESS WIRE)–
Janux Therapeutics, Inc. (Nasdaq: JANX) (Janux), a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technologies to its Tumor Activated T Cell Engager (TRACTr), Tumor Activated Immunomodulator (TRACIr), and Adaptive Immune Response Modulator (ARM) platforms, today reported financial results for the third quarter ended September 30, 2025, and provided a business update.
“With enrollment ongoing in the JANX007 and JANX008 clinical trials and multiple new drug candidates expected to enter the clinic next year, we remain confident in our ability to advance these programs, supported by a strong balance sheet that enables continued execution,” said David Campbell, Ph.D., President and CEO of Janux.
RECENT BUSINESS HIGHLIGHTS AND FUTURE MILESTONES:
- JANX007 continues to enroll in the first-in-human Phase 1 clinical trial in mCRPC (NCT05519449).
- JANX008 continues to enroll in the first-in-human Phase 1 clinical trial in advanced or metastatic solid tumors (NCT05783622).
Additional data from JANX007 and JANX008 will be presented at future Janux events in the fourth quarter of 2025.
THIRD QUARTER 2025 FINANCIAL RESULTS:
- Cash and cash equivalents and short-term investments: As of September 30, 2025, Janux reported cash and cash equivalents and short-term investments of $989.0 million, compared to $1.03 billion at December 31, 2024.
- Research and development expenses: Research and development expenses for the quarter ended September 30, 2025 were $34.6 million, compared to $18.6 million for the comparable period in 2024.
- General and administrative expenses: General and administrative expenses for the quarter ended September 30, 2025 were $10.6 million, compared to $17.7 million for the comparable period in 2024. With respect to the quarter ended September 30, 2024, $9.5 million of the general and administrative expense incurred was due to stock-based compensation expense associated with equity modifications.
- Net loss: For the quarter ended September 30, 2025, Janux reported a net loss of $24.3 million, compared to a net loss of $28.1 million for the comparable period in 2024.
Janux’s TRACTr, TRACIr and ARM Pipeline
Janux’s first clinical candidate, JANX007, is a TRACTr that targets prostate-specific membrane antigen (PSMA) and is being investigated in a Phase 1 clinical trial in adult patients with mCRPC. Janux’s second clinical candidate, JANX008, is a TRACTr that targets epidermal growth factor receptor (EGFR) and is being studied in a Phase 1 clinical trial for the treatment of multiple solid cancers including colorectal carcinoma, squamous cell carcinoma of the head and neck, non-small cell lung cancer, renal cell carcinoma, small cell lung cancer, pancreatic ductal adenocarcinoma and triple-negative breast cancer. Janux is also advancing additional CD3-based TRACTr and CD28-based TRACIr programs for future clinical development, including a PSMA-TRACIr for use in combination with our PSMA-TRACTr JANX007, and a TROP2-TRACTr for the treatment of TROP2+ solid tumors. Janux is advancing its first ARM platform program candidate, a CD19-ARM for the potential treatment of autoimmune diseases toward clinical trials. Janux is also generating a number of additional TRACTr, TRACIr and ARM programs for potential future development.
About Janux Therapeutics
Janux is a clinical-stage biopharmaceutical company developing a broad pipeline of novel immunotherapies by applying its proprietary technology to its Tumor Activated T Cell Engager (TRACTr), Tumor Activated Immunomodulator (TRACIr), and Adaptive Immune Response Modulator (ARM) platforms. Janux has two TRACTr therapeutic candidates in clinical trials, the first targeting PSMA is in development for prostate cancer, and the second targeting EGFR is being developed for colorectal carcinoma, squamous cell carcinoma of the head and neck, non-small cell lung cancer, renal cell carcinoma, small cell lung cancer, pancreatic ductal adenocarcinoma and triple-negative breast cancer. For more information, please visit www.januxrx.com and follow us on LinkedIn.
Forward-Looking Statements
This news release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. Such forward-looking statements include statements regarding, among other things, Janux’s ability to bring new treatments to cancer patients in need, expectations regarding the timing, scope and results of Janux’s development activities, including its ongoing and planned preclinical studies and clinical trials, and the potential benefits of Janux’s product candidates and platform technologies, expectations regarding the use of Janux’s platform technologies to generate novel product candidates and the strength of Janux’s balance sheet and the adequacy of cash on hand. Factors that may cause actual results to differ materially include the risk that interim results of a clinical trial are not necessarily indicative of final results and one or more of the clinical outcomes may materially change as patient enrollment continues, following more comprehensive reviews of the data and as more patient data becomes available, including the risk that unconfirmed responses may not ultimately result in confirmed responses to treatment after follow-up evaluations, the risk that compounds that appear promising in early research do not demonstrate safety and/or efficacy in later preclinical studies or clinical trials, the risk that Janux may not obtain approval to market its product candidates, uncertainties associated with performing clinical trials, regulatory filings and applications, risks associated with reliance on third parties to successfully conduct clinical trials, the risks associated with reliance on outside financing to meet capital requirements, and other risks associated with the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. You are urged to consider statements that include the words “may,” “will,” “would,” “could,” “should,” “believes,” “estimates,” “projects,” “promise,” “potential,” “expects,” “plans,” “anticipates,” “intends,” “continues,” “designed,” “goal,” or the negative of those words or other comparable words to be uncertain and forward-looking. For a further list and description of the risks and uncertainties Janux faces, please refer to Janux’s periodic and other filings with the Securities and Exchange Commission, which are available at www.sec.gov. Such forward-looking statements are current only as of the date they are made, and Janux assumes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. All forward-looking statements are qualified in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.
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Janux Therapeutics, Inc. |
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Condensed Balance Sheets |
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(in thousands) |
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|
|
September 30, |
December 31, |
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|
Assets |
(unaudited) |
|
|||
|
Current assets: |
|
|
|||
|
Cash and cash equivalents |
$ |
48,389 |
$ |
430,605 |
|
|
Short-term investments |
|
940,604 |
|
594,568 |
|
|
Prepaid expenses and other current assets |
|
9,093 |
|
8,493 |
|
|
Total current assets |
|
998,086 |
|
1,033,666 |
|
|
Restricted cash |
|
816 |
|
816 |
|
|
Property and equipment, net |
|
4,314 |
|
4,864 |
|
|
Operating lease right-of-use assets |
|
18,923 |
|
19,286 |
|
|
Other long-term assets |
|
2,627 |
|
2,884 |
|
|
Total assets |
$ |
1,024,766 |
$ |
1,061,516 |
|
|
|
|
|
|||
|
Liabilities and Stockholders’ Equity |
|
|
|||
|
Current liabilities: |
|
|
|||
|
Accounts payable |
$ |
3,395 |
$ |
4,026 |
|
|
Accrued expenses |
|
22,156 |
|
11,684 |
|
|
Current portion of operating lease liabilities |
|
2,280 |
|
1,749 |
|
|
Total current liabilities |
|
27,831 |
|
17,459 |
|
|
Operating lease liabilities, net of current portion |
|
20,380 |
|
21,276 |
|
|
Total liabilities |
|
48,211 |
|
38,735 |
|
|
Total stockholders’ equity |
|
976,555 |
|
1,022,781 |
|
|
Total liabilities and stockholders’ equity |
$ |
1,024,766 |
$ |
1,061,516 |
|
|
Janux Therapeutics, Inc. |
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Unaudited Condensed Statements of Operations and Comprehensive Loss |
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(in thousands, except share and per share data) |
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Three Months Ended |
Nine Months Ended |
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|
2025 |
2024 |
2025 |
2024 |
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Collaboration revenue |
$ |
10,000 |
|
$ |
439 |
|
$ |
10,000 |
|
$ |
10,588 |
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Operating expenses: |
|
|
|
|
|||||||||||
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Research and development |
|
34,629 |
|
|
18,614 |
|
|
94,348 |
|
|
47,582 |
|
|||
|
General and administrative |
|
10,622 |
|
|
17,667 |
|
|
30,918 |
|
|
32,831 |
|
|||
|
Total operating expenses |
|
45,251 |
|
|
36,281 |
|
|
125,266 |
|
|
80,413 |
|
|||
|
Loss from operations |
|
(35,251 |
) |
|
(35,842 |
) |
|
(115,266 |
) |
|
(69,825 |
) |
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Total other income |
|
10,938 |
|
|
7,783 |
|
|
33,587 |
|
|
21,047 |
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Net loss |
$ |
(24,313 |
) |
$ |
(28,059 |
) |
$ |
(81,679 |
) |
$ |
(48,778 |
) |
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Other comprehensive gain (loss): |
|
|
|
|
|||||||||||
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Unrealized gain on available-for-sale securities, net |
|
815 |
|
|
9,447 |
|
|
2,399 |
|
|
7,166 |
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Comprehensive loss |
$ |
(23,498 |
) |
$ |
(18,612 |
) |
$ |
(79,280 |
) |
$ |
(41,612 |
) |
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Net loss per common share, basic and diluted |
$ |
(0.39 |
) |
$ |
(0.51 |
) |
$ |
(1.32 |
) |
$ |
(0.93 |
) |
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|
Weighted-average shares of common stock outstanding, basic and diluted |
|
62,023,685 |
|
|
54,628,670 |
|
|
61,906,789 |
|
|
52,717,020 |
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View source version on businesswire.com: https://www.businesswire.com/news/home/20251106163122/en/
Investors:
Andy Meyer
Janux Therapeutics
[email protected]
(202) 215-2579
Media:
Jessica Yingling, Ph.D.
Little Dog Communications Inc.
[email protected]
(858) 344-8091
KEYWORDS: California United States North America
INDUSTRY KEYWORDS: Oncology Health Clinical Trials Research Science Pharmaceutical Biotechnology
MEDIA:
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