Market Newsdesk

VANCOUVER, British Columbia, Dec. 09, 2020 (GLOBE NEWSWIRE) — P2 Gold Inc. (“P2” or the “Company”) (TSX-V:PGLD) reports on the results of the surface sampling program and airborne geophysical survey at its Silver Reef Property located in northwest British Columbia. Surface sampling has returned numerous high-grade samples, which range in value up to 3.21 g/t gold and 3,885 g/t silver. The airborne geophysical survey shows that the zones are located along the margins of pronounced magnetic lineaments which extend beyond the current limits of the zones by up to 10 kilometers.

Surface Sampling Results

Mapping and prospecting at Silver Reef as part of the 2020 exploration program has expanded the footprint of mineralization. At the time the Silver Reef property was optioned in June of this year, the Main Zone and Northwest Zone were originally thought to be extensions of the same zone, which was defined over 1.5 kilometers. The Main Zone and Northwest Zone have now been determined to be separate trends and part of a stacked system of multiple mineral horizons, which have now been defined over five kilometers. All zones encountered to date are hosted within moderately metamorphosed sediments located along the margins of felsic dykes. The Northwest Zone has been surface sampled for over 800 meters of strike length and is open for expansion. The felsic dyke associated with this zone has been mapped for over 2.5 kilometers and remains open. Likewise, the Main Zone has been extended almost two kilometers to the south where it remains open.

Surface grab sampling has shown that the Northwest Zone and southern extension of the Main Zone, known as Main Zone South, appear to be higher grade than the Main Zone, with grab sample values ranging in value up to 3.21 g/t gold and 3,885 g/t silver.   Both zones remain open for expansion. The Northwest Zone was targeted as part of the 2020 exploration program Phase 1 and Phase 2 drill programs, while the Main Zone South has yet to be drilled.  

Airborne Geophysical Survey

The airborne geophysical survey completed as part of the 2020 exploration program identified numerous magnetic features, which are interpreted to be magnetite skarn developed within the sediments along the margins of dykes and intrusions. At the southern end of the property, two circular intrusions which host historical copper and molybdenum showings are clearly defined. These intrusions are thought to be part of the heat source for the epithermal mineralization seen elsewhere on the property.

The Main Zone follows the edge of a moderate magnetic lineament. This lineament projects to the south through Main Zone South, terminating against an east-west feature some two kilometers to the south. The Northwest Zone is located along the margin of a very strong magnetic lineament that extends over 10 kilometers to the south and at least two kilometers to the north. The association of mineralization with these linear geophysical features suggests the Silver Reef Project has extremely good exploration potential for extending the existing zones and finding new ones. Prospecting and mapping followed by drilling is being planned as part of the 2021 field season.

Plan maps showing the results of the 2020 exploration program surface sampling and airborne geophysical survey are available at www.p2gold.com.

The Phase Two exploration drill program at Silver Reef was completed in September and consisted of four holes totaling 374 meters. Two of the drill holes targeted the Main Zone, with the other two holes targeting the Northwest Zone. Assays will be reported on receipt.  

Quality Assurance

Amanda Tuck, P.Geo is the qualified person responsible for the Silver Reef Property and has reviewed, verified and approved the scientific and technical information in this news release relating thereto.

About
P2 Gold Inc
.

P2 is a mineral exploration and development company focused on advancing precious metals discoveries and acquisitions in the Pacific Northwest.

For further information, please contact:

P2 Gold Inc. www.p2gold.com Joseph Ovsenek President, CEO and Chairman [email protected] Tel: +1 (604) 558-5167

Forward Looking Information

This press release contains “forward-looking information” within the meaning of applicable securities laws that is intended to be covered by the safe harbours created by those laws. “Forward-looking information” includes statements that use forward-looking terminology such as “may”, “will”, “expect”, “anticipate”, “believe”, “continue”, “potential” or the negative thereof or other variations thereof or comparable terminology. Such forward-looking information includes, without limitation, the Company’s expectations, strategies and plans for the Silver Reef Property, including the Company’s planned expenditures and exploration activities.

Forward-looking information is not a guarantee of future performance and is based upon a number of estimates and assumptions of management at the date the statements are made. Furthermore, such forward-looking information involves a variety of known and unknown risks, uncertainties and other factors which may cause the actual plans, intentions, activities, results, performance or achievements of the Company to be materially different from any future plans, intentions, activities, results, performance or achievements expressed or implied by such forward-looking information. See “Risk Factors” in the Company’s annual information form dated October 21, 2020 filed on SEDAR at www.sedar.com for a discussion of these risks.

The Company cautions that there can be no assurance that forward-looking information will prove to be accurate, as actual results and future events could differ materially from those anticipated in such information. Accordingly, investors should not place undue reliance on forward-looking information.

Except as required by law, the Company does not assume any obligation to release publicly any revisions to forward-looking information contained in this press release to reflect events or circumstances after the date hereof.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

CALGARY, Alberta, Dec. 09, 2020 (GLOBE NEWSWIRE) — Canadian Natural’s President, Tim McKay, commented “Canadian Natural is a unique, sustainable and robust company, proven by its ability to generate sustainable free cash flow through the commodity price cycle, setting us apart from our peers. Our balanced, diverse and high quality assets, of which the majority are long life no decline Synthetic Crude Oil reserves with low reservoir risk and low capital requirements, provide us the opportunity to sustain or grow production. Our effective and efficient operations, culture of continuous improvement, disciplined capital allocation and strong balance sheet position the Company for success, allowing us to continue to innovate through technology to lower costs and reduce our environmental footprint.

The Company has been nimble in the past to changing market conditions and can quickly adjust our targeted capital expenditure levels or reallocate capital to our highest returning assets. Our 2021 plan will be no different, targeting capital of approximately $3.2 billion, delivering targeted production of approximately 1,225,000 BOE/d, with disciplined growth of approximately 62,000 BOE/d from forecasted 2020 levels. Safe, reliable, low cost operations continue to be a focus for the Company as we target to capture synergies, increase margins and maximize value for our shareholders in 2021 and beyond.”

Canadian Natural’s Chief Financial Officer, Mark Stainthorpe, continued “In 2021, our capital program will be prudent and disciplined. Our commitment to maintain our robust financial position is supported by effective and efficient operations, significant adjusted funds flow generation and ample liquidity. Free cash flow, at US$45 WTI is targeted to be strong in 2021, between $2.0 billion – $2.5 billion after dividend requirements, with continued priority towards further strengthening the Company’s balance sheet. We continue to deliver value to our shareholders and have proven throughout 2020 that our dividend is sustainable, with a 20 year track record of dividend growth. Our sustainable and growing returns are underpinned by our low cost structure, industry leading break-even of WTI US$30-31 per barrel and our financial strength, affording us the ability to deliver on our plan and continue to drive long-term shareholder value.”

Tim McKay continued “Canadian Natural is delivering leading environmental performance. Our long life, low decline assets are advantaged as we can leverage technology, innovation and continuous improvement to deliver ever improving environmental performance. Some of the highlights achieved to date include corporate GHG emissions intensity decreasing by 16% from 2015 to 2019 and the Company reduced its GHG emissions intensity in its Oil Sands Mining and Upgrading and thermal in situ segments by 36% from 2016 to 2019. In our North American E&P segment we reduced methane emissions by 15% from 2016 to 2019.

Canadian Natural is also committed to progressively reclaim land and return sites to their natural state. Canadian Natural’s reclamation team at the Athabasca Oil Sands Project placed the one millionth reclamation tree in the ground in Q3/20. This milestone follows the one millionth tree being planted at Horizon Oil Sands in Q3/18. To date, the Oil Sands Mining and Upgrading segment has planted over 2.3 million trees and reclaimed over 1,600 hectares of land. In the Company’s North America E&P segment, Canadian Natural has reclaimed more than 7,600 hectares of land since 2015, planted over 2 million trees and abandoned over 5,000 wells, reducing our environmental footprint.”

HIGHLIGHTS OF THE 2021 BUDGET

• The Company’s large, balanced and diverse asset base is complemented by an extensive network of owned and operated infrastructure and is supported by a deep inventory of long life low decline assets as well as conventional and unconventional assets. The Company’s focus on effective and efficient operations and cost control provides high return on capital projects that deliver industry leading free cash flow.
• Canadian Natural’s 2021 capital budget is disciplined, targeted at approximately $3.205 billion, of which $1.345 billion is allocated to conventional and unconventional assets and $1.860 billion is allocated to long life low decline assets.
• Production in 2021 is targeted between 1,190,000 BOE/d and 1,260,000 BOE/d, an increase of approximately 5% from 2020 forecasted levels.
  • Product mix is approximately 48% high value Synthetic Crude Oil (“SCO”) and light crude oil and NGLs, approximately 30% heavy crude oil and approximately 22% natural gas.
• Liquids production, including crude oil, SCO and NGLs, is targeted to grow approximately 4% from targeted 2020 levels, ranging from 920,000 bbl/d to 980,000 bbl/d. Long life low decline production is targeted to be approximately 81% of total liquids production.

• Natural gas production is targeted between 1,620 MMcf/d to 1,680 MMcf/d, representing growth of approximately 11% from targeted 2020 levels, as capital investment within the Company’s natural gas portfolio is targeted to increase in 2021. Canadian Natural targets to capture additional value from improving natural gas strip pricing as a result of the Company’s ability to be nimble and flexible with capital allocation decisions within the Company’s large, balanced and diversified asset base.

PRODUCTION AND CAPI
TAL EXPENDITURES

Canadian Natural’s strategy of maintaining a large, diverse portfolio of assets enables the Company to maximize shareholder value through flexible capital allocation and optimized product mix. Annual budgets are developed and scrutinized throughout the year and can be changed, if necessary, in the context of price volatility, project returns and the balancing of project risks and time horizons. Canadian Natural maintains a high ownership level and operatorship in its properties and can therefore control the nature, timing and extent of expenditures in each of its project areas.

Daily Production Volumes (before royalties)	2020 Forecast	2021 Budget
Natural gas (MMcf/d)	1,481	1,620 – 1,680
Crude oil, SCO and NGLs (Mbbl/d)	916	920 – 980
Total MBOE/d	1,163	1,190 – 1,260

Capital Expenditures (C$ millions)	2020 Forecast (1)		2021 Budget
Total Capital Expenditures	$ 2,700		$ 3,205

^{(1) 2020 forecast excludes net acquisition costs.}

Details of the Canadian Natural’s leading ESG performance can be found in the Company’s 2019 Stewardship Report to Stakeholders on the Company’s website at www.cnrl.com.

ADVISORY

Special Note Regarding Forward-Looking Statements

Certain statements relating to Canadian Natural Resources Limited (the “Company”) in this document or documents incorporated herein by reference constitute forward-looking statements or information (collectively referred to herein as “forward-looking statements”) within the meaning of applicable securities legislation. Forward-looking statements can be identified by the words “believe”, “anticipate”, “expect”, “plan”, “estimate”, “target”, “continue”, “could”, “intend”, “may”, “potential”, “predict”, “should”, “will”, “objective”, “project”, “forecast”, “goal”, “guidance”, “outlook”, “effort”, “seeks”, “schedule”, “proposed” or expressions of a similar nature suggesting future outcome or statements regarding an outlook. Disclosure related to expected future commodity pricing, forecast or anticipated production volumes, royalties, production expenses, capital expenditures, income tax expenses and other guidance provided throughout this Management’s Discussion and Analysis (“MD&A”) of the financial condition and results of operations of the Company, constitute forward-looking statements. Disclosure of plans relating to and expected results of existing and future developments, including but not limited to the Horizon Oil Sands (“Horizon”), the Athabasca Oil Sands Project (“AOSP”), Primrose thermal projects, the Pelican Lake water and polymer flood project, the Kirby Thermal Oil Sands Project, the Jackfish Thermal Oil Sands Project, the timing and future operations of the North West Redwater bitumen upgrader and refinery, construction by third parties of new, or expansion of existing, pipeline capacity or other means of transportation of bitumen, crude oil, natural gas, natural gas liquids (“NGLs”) or synthetic crude oil (“SCO”) that the Company may be reliant upon to transport its products to market, and the development and deployment of technology and technological innovations also constitute forward-looking statements. These forward-looking statements are based on annual budgets and multi-year forecasts, and are reviewed and revised throughout the year as necessary in the context of targeted financial ratios, project returns, product pricing expectations and balance in project risk and time horizons. These statements are not guarantees of future performance and are subject to certain risks. The reader should not place undue reliance on these forward-looking statements as there can be no assurances that the plans, initiatives or expectations upon which they are based will occur.

In addition, statements relating to “reserves” are deemed to be forward-looking statements as they involve the implied assessment based on certain estimates and assumptions that the reserves described can be profitably produced in the future. There are numerous uncertainties inherent in estimating quantities of proved and proved plus probable crude oil, natural gas and NGLs reserves and in projecting future rates of production and the timing of development expenditures. The total amount or timing of actual future production may vary significantly from reserves and production estimates.

The forward-looking statements are based on current expectations, estimates and projections about the Company and the industry in which the Company operates, which speak only as of the date such statements were made or as of the date of the report or document in which they are contained, and are subject to known and unknown risks and uncertainties that could cause the actual results, performance or achievements of the Company to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Such risks and uncertainties include, among others: general economic and business conditions which will, among other things, impact demand for and market prices of the Company’s products; volatility of and assumptions regarding crude oil and natural gas prices; fluctuations in currency and interest rates; assumptions on which the Company’s current guidance is based; economic conditions in the countries and regions in which the Company conducts business; political uncertainty, including actions of or against terrorists, insurgent groups or other conflict including conflict between states; industry capacity; ability of the Company to implement its business strategy, including exploration and development activities; impact of competition; the Company’s defense of lawsuits; availability and cost of seismic, drilling and other equipment; ability of the Company and its subsidiaries to complete capital programs; the Company’s and its subsidiaries’ ability to secure adequate transportation for its products; unexpected disruptions or delays in the resumption of the mining, extracting or upgrading of the Company’s bitumen products; potential delays or changes in plans with respect to exploration or development projects or capital expenditures; ability of the Company to attract the necessary labour required to build its thermal and oil sands mining projects; operating hazards and other difficulties inherent in the exploration for and production and sale of crude oil and natural gas and in mining, extracting or upgrading the Company’s bitumen products; availability and cost of financing; the Company’s and its subsidiaries’ success of exploration and development activities and its ability to replace and expand crude oil and natural gas reserves; timing and success of integrating the business and operations of acquired companies and assets; production levels; imprecision of reserves estimates and estimates of recoverable quantities of crude oil, natural gas and NGLs not currently classified as proved; actions by governmental authorities (including production curtailments mandated by the Government of Alberta); government regulations and the expenditures required to comply with them (especially safety and environmental laws and regulations and the impact of climate change initiatives on capital expenditures and production expenses); asset retirement obligations; the adequacy of the Company’s provision for taxes; and other circumstances affecting revenues and expenses.

The Company’s operations have been, and in the future may be, affected by political developments and by national, federal, provincial and local laws and regulations such as restrictions on production, changes in taxes, royalties and other amounts payable to governments or governmental agencies, price or gathering rate controls and environmental protection regulations. Should one or more of these risks or uncertainties materialize, or should any of the Company’s assumptions prove incorrect, actual results may vary in material respects from those projected in the forward-looking statements. The impact of any one factor on a particular forward-looking statement is not determinable with certainty as such factors are dependent upon other factors, and the Company’s course of action would depend upon its assessment of the future considering all information then available.

Readers are cautioned that the foregoing list of factors is not exhaustive. Unpredictable or unknown factors not discussed in the Company’s MD&A could also have adverse effects on forward-looking statements. Although the Company believes that the expectations conveyed by the forward-looking statements are reasonable based on information available to it on the date such forward-looking statements are made, no assurances can be given as to future results, levels of activity and achievements. All subsequent forward-looking statements, whether written or oral, attributable to the Company or persons acting on its behalf are expressly qualified in their entirety by these cautionary statements. Except as required by applicable law, the Company assumes no obligation to update forward-looking statements in the Company’s MD&A, whether as a result of new information, future events or other factors, or the foregoing factors affecting this information, should circumstances or the Company’s estimates or opinions change.

Special Note Regarding non-GAAP Financial Measures

This press release includes references to financial measures commonly used in the crude oil and natural gas industry, such as: adjusted net earnings from operations; adjusted funds flow (previously referred to as funds flow from operations) and net capital expenditures. These financial measures are not defined by International Financial Reporting Standards (“IFRS”) and therefore are referred to as non-GAAP measures. The non-GAAP measures used by the Company may not be comparable to similar measures presented by other companies. The Company uses these non-GAAP measures to evaluate its performance. The non-GAAP measures should not be considered an alternative to or more meaningful than net earnings, cash flows from operating activities, and cash flows used in investing activities, as determined in accordance with IFRS, as an indication of the Company’s performance.

Adjusted net earnings (loss) from operations is a non-GAAP measure that represents net earnings (loss) as presented in the Company’s consolidated Statements of Earnings (Loss), adjusted for the after-tax effects of certain items of a non- operational nature. The Company considers adjusted net earnings (loss) from operations a key measure in evaluating its performance, as it demonstrates the Company’s ability to generate after-tax operating earnings from its core business areas. The reconciliation “Adjusted Net Earnings (Loss) from Operations, as Reconciled to Net Earnings (Loss)” is presented in the Company’s MD&A.

Adjusted funds flow (previously referred to as funds flow from operations) is a non-GAAP measure that represents cash flows from operating activities as presented in the Company’s consolidated Statements of Cash Flows, adjusted for the net change in non-cash working capital, abandonment expenditures and movements in other long-term assets, including the unamortized cost of the share bonus program and prepaid cost of service tolls. The Company considers adjusted funds flow a key measure as it demonstrates the Company’s ability to generate the cash flow necessary to fund future growth through capital investment and to repay debt. The reconciliation “Adjusted Funds Flow, as Reconciled to Cash Flows from Operating Activities” is presented in the Company’s MD&A.

Net capital expenditures is a non-GAAP measure that represents cash flows used in investing activities as presented in the Company’s consolidated Statements of Cash Flows, adjusted for the net change in non-cash working capital, investment in other long-term assets, share consideration in business acquisitions and abandonment expenditures. The Company considers net capital expenditures a key measure as it provides an understanding of the Company’s capital spending activities in comparison to the Company’s annual capital budget. The reconciliation “Net Capital Expenditures, as Reconciled to Cash Flows used in Investing Activities” is presented in the Net Capital Expenditures section of the Company’s MD&A.

Free cash flow is a non-GAAP measure that represents cash flows from operating activities as presented in the Company’s consolidated Statements of Cash Flows, adjusted for the net change in non-cash working capital from operating activities, abandonment, certain movements in other long-term assets, less net capital expenditures and dividends on common shares. The Company considers free cash flow a key measure in demonstrating the Company’s ability to generate cash flow to fund future growth through capital investment, pay returns to shareholders, and to repay debt.

Special Note Regarding Currency, Financial Information and Production

This press release should be read in conjunction with the Company’s MD&A and the unaudited interim consolidated financial statements for the three and nine months ended September 30, 2019 and the MD&A and the audited consolidated financial statements of the Company for the year ended December 31, 2018. All dollar amounts are referenced in millions of Canadian dollars, except where noted otherwise. The Company’s unaudited interim consolidated financial statements for the three and nine months ended September 30, 2019 and the Company’s MD&A have been prepared in accordance with IFRS as issued by the International Accounting Standards Board (“IASB”). Changes in the Company’s accounting policies in accordance with IFRS, including the adoption of IFRS 16 “Leases” on January 1, 2019, are discussed in the “Changes in Accounting Policies” section of the Company’s MD&A. In accordance with the new “Leases” standard, comparative period balances in 2018 reported in the Company’s MD&A have not been restated.

Production volumes and per unit statistics are presented throughout the Company’s MD&A on a “before royalties” or “company gross” basis, and realized prices are net of blending and feedstock costs and exclude the effect of risk management activities. In addition, reference is made to crude oil and natural gas in common units called barrel of oil equivalent (“BOE”). A BOE is derived by converting six thousand cubic feet (“Mcf”) of natural gas to one barrel (“bbl”) of crude oil (6 Mcf:1 bbl). This conversion may be misleading, particularly if used in isolation, since the 6 Mcf:1 bbl ratio is based on an energy equivalency conversion method primarily applicable at the burner tip and does not represent a value equivalency at the wellhead. In comparing the value ratio using current crude oil prices relative to natural gas prices, the 6 Mcf:1 bbl conversion ratio may be misleading as an indication of value. In addition, for the purposes of the Company’s MD&A, crude oil is defined to include the following commodities: light and medium crude oil, primary heavy crude oil, Pelican Lake heavy crude oil, bitumen (thermal oil), and SCO. Production on an “after royalties” or “company net” basis is also presented in the Company’s MD&A for information purposes only.

Additional information relating to the Company, including its Annual Information Form for the year ended December 31, 2018, is available on SEDAR at www.sedar.com, and on EDGAR at www.sec.gov. Detailed guidance on production levels, capital expenditures and production expenses can be found on the Company’s website at www.cnrl.com, provided that such guidance does not form part of and is not incorporated by reference in the Company’s MD&A.

CONFERENCE CALL

A conference call and webcast will include a presentation to be held at 9:00 a.m. Mountain Time, 11:00 a.m. Eastern Time on Wednesday, December 9, 2020. The North American conference call number is 1-866-521-4909 and the international conference call number is 001-647-427-2311.

Note: The presentation will be available for download on the home page of our webs
ite 30 minutes prior to the call.

The conference call and presentation will be broadcast live and may be accessed on the home page our website at www.cnrl.com.

An archive of the broadcast will be available until 6:00 p.m. Mountain Time, Wednesday, December 23, 2020. To access the rebroadcast in North America, dial 1-800-585-8367. Those outside of North America, dial 001-416-621-4642. The conference archive ID number is 5899757.

Canadian Natural is a senior oil and natural gas production company, with continuing operations in its core areas located in Western Canada, the U.K. portion of the North Sea and Offshore Africa.

	CANADIAN NATURAL RESOURCES LIMITED
	2100, 855 – 2nd Street S.W. Calgary, Alberta, T2P4J8 Phone: 403-514-7777 Email: [email protected] www.cnrl.com
	TIM S. MCKAY President MARK A. STAINTHORPE Chief Financial Officer and Senior Vice-President, Finance JASON M. POPKO Manager, Investor Relations Trading Symbol – CNQ Toronto Stock Exchange New York Stock Exchange

 

COPENHAGEN, Denmark, Dec. 09, 2020 (GLOBE NEWSWIRE) — Evaxion Biotech A/S, a clinical-stage AI-immunology company developing immunotherapies to improve the lives of patients with cancer and infectious diseases, today announced the publication of an article in Nature Communications showing how deep data on immune complex stability could optimize immunotherapy in cancer.

Evaxion has generated data on the thermostability of peptide-MHC complexes (pMHC), the biological context for antigen processing. The new data have already proved valuable in enabling Evaxion’s artificial neural networks to more readily predict the immunological behavior of the peptide epitopes.

By surveying the thermostability of thousands of pMHC interactions simultaneously by mass spectrometry, the Nature Communications paper provides an additional layer of previously unobtainable data on interactions within the pMHC. That data enabled Evaxion to train its unique AI platform to select epitopes for optimal immunogenicity, which may lead to better patient-specific cancer immunotherapies. Evaxion’s work has been conducted in close collaboration with the leading academic research group of Professor Anthony Purcell at Monash University, Australia.

“My group has worked closely with Evaxion since 2016, to build on innovations in the identification of peptide ligands of MHC molecules using mass spectrometry, generate large databases of such peptides and to harness this information to improve prediction of peptide binding and immunogenicity using AI-based approaches. The thermostability assay is a great example of innovation in data generation and its application to the prediction of better targets for cancer immunotherapy,” said Professor Anthony Purcell, Principal Research Fellow and Deputy Head (Research) of the Department of Biochemistry at Monash University, Melbourne, Australia.

Evaxion’s immuno-oncology platform PIONEER™ uses sophisticated algorithms to identify and select tumor-specific mutations that the Company believes are most likely to generate a de novo T-cell activation and anti-tumor immune response. These tumor-specific mutations, termed neoepitopes, are incorporated into patient-specific immunotherapies.

Evaxion is continuously improving the performance of its PIONEER platform in selecting putative neoepitopes by modifying aspects of the underlying algorithms and through the development of novel methods for data generation. The research published in Nature Communications represents an important step in the journey towards improving the methodologies used to generate data that can be incorporated into the platform to further improve the identification and selection of neoepitopes.

“We now know that scanning peptide-MHC complexes for thermostability yields new data that we believe further improves our AI-based development of immunotherapies,” said Lars Wegner, CEO of Evaxion. “These data add to our understanding of MHC-neoepitope interactions in cancer, one of the most intensively studied biological systems within the pharmaceutical arena, and we believe that such data are likely to be valuable in other areas, like infectious disease and autoimmunity.”

Evaxion believes that this novel mass spectrometry-based approach can be applied to any cells bearing MHC or MHC-like molecules, thereby providing insights not only into normal immune balance but also into the stimulation and memory underlying new patient-specific immunotherapies for cancer treatments. Beyond cancer, similar data gathered from pathogen-derived sequences could also improve future responses to infectious epidemic threats.

About Evaxion

Evaxion Biotech A/S is an AI-immunology™ platform company decoding the human immune system to discover and develop novel, targeted immunotherapies to treat cancer and infectious diseases. Based on its proprietary and scalable AI-immunology core technology, Evaxion Biotech is developing a broad pipeline of novel assets which comprises three patient-specific cancer immunotherapies, two of which are in Phase 1/2 clinical development. In addition, the Company is advancing a portfolio of vaccines to treat bacterial and viral infections with one program currently in preclinical development against S. aureus and skin and soft tissue infections (SSTI).

For more information
Evaxion				LifeSci Advisors LLC
Glenn S. Vraniak				Mary-Ann Chang
Chief Financial Officer				Managing Director
[email protected]				[email protected]
t: +1 (513) 476-2669				+44 7483 284 853

SAN FRANCISCO, Dec. 09, 2020 (GLOBE NEWSWIRE) — Reason, San Francisco’s premier high tech team building company, launches the Community Hero Awards. The program recognizes local heroes and rewards them with an epic sci-fi adventure that can be enjoyed remotely with their family and friends. Nominations are open to the public with no geographical restrictions. The program aims to celebrate human kindness and inspire others to follow in their footsteps.

Critical time for communities to thrive
What we need more than anything at this moment in time is empathy. Empathy brings people together, it allows teams and communities to thrive in difficult times. One can be empathetic by engaging meaningfully with others, being aware of others’ needs, and being kind. In the midst of something unpredictable and chaotic, helping others not only improves the wellbeing of the community but can also be a source of empowerment for oneself. “In our escape games, we try to inspire empathy in every participant to make their team stronger and more capable,” said Emily Katz, experience manager at Reason. “The Community Hero Awards give us a chance to energize and catalyze the empathy that is all around us.”

Strengthening a 5-Year Legacy

Since 2016, Reason has been accelerating leadership development in company teams and professional organizations; as well as supporting schools, charities, and community organizations through donations and partnerships. The Community Hero Awards expand these efforts to the grassroots level by engaging directly with stakeholders and individuals making an impact in their communities.

Awarding community heroes
Nominations are received through online submissions with no cost involved. Everyone can nominate someone that made an impact in their community. Winners will be selected based on their awesomeness and featured on the awards page starting in January. The winners will also receive a complimentary Lola in Space° session where family from different locations can participate remotely. Lola in Space° is an uplifting remote escape room experience where players video conference into the International Space Station to help the human astronaut host, Lola, escape the supply module.

What is a remote escape game

On March 17, 2020, Reason launched the world’s first remote escape room experience, Lola in Space°. The game was a direct response to the need for human interaction during the spring pandemic lockdown, giving people a way to engage and have fun with one another even when physically apart. The game led the digital transformation of the industry and inspired a whole new generation of remote escape rooms.

Remote escape rooms bring a whole new perspective to the game. They bypass physical restraints by enabling players to join from anywhere in the world via video conference. They bring characters to life with elements of immersive theatre while experimenting with a new media format that merges the digital and the real world. Lastly, they foster creative problem solving and team bonding for distributed teams.

About Reason


Reason is the world’s first future technology escape room & remote team escape. It is a small business in San Francisco founded by a husband and wife team Mike and Crina. Reason’s mission is to humanize our relationship with technology and each other.

Contact: Mike Chen – [email protected]  – (415) 800-2062

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/92fdc04d-ecc5-48c7-a31d-f4c1e4c1ae2c

­­Orphazyme A/S
Company announcement                                                                                       

No. 71/2020                                                                                                          
Company Registration No. 32266355

Copenhagen, December 9, 2020 – Orphazyme A/S (ORPHA.CO; ORPH), a late-stage biopharmaceutical company pioneering the Heat-Shock Protein response for the treatment of neurodegenerative orphan diseases, today announces that the company expects to publish financial reports according to the following schedule:

Deadline for submission of shareholder proposals to Annual General Meeting

February 11, 2021

Annual Report 2020

March 2, 2021

Annual General Meeting 2021

March 25, 2021

Interim Report First Half 2021

August 24, 2021

The financial reports will upon their release be available at the Company’s website, www.orphazyme.com, where information relating to Orphazyme’s Annual General Meeting 2020 will also be available in due course prior to the meeting.

For additional information, please contact

Orphazyme A/S

Anders Vadsholt, CFO                                  +45 28 98 90 55

About Orphazyme A/S 
Orphazyme is a late-stage biopharmaceutical company pioneering the Heat-Shock Protein response for the treatment of neurodegenerative orphan diseases. The company is harnessing amplification of Heat-Shock Proteins (or HSPs) in order to develop and commercialize novel therapeutics for diseases caused by protein misfolding, protein aggregation, and lysosomal dysfunction, including lysosomal storage diseases and neuromuscular degenerative diseases. Arimoclomol, the company’s lead candidate, is in clinical development for four orphan diseases: Niemann-Pick disease Type C (NPC), Amyotrophic Lateral Sclerosis (ALS), sporadic Inclusion Body Myositis (sIBM) and Gaucher disease. Orphazyme is headquartered in Denmark and has operations in the U.S. and Switzerland. Orphazyme’s shares are listed on Nasdaq U.S. (ORPH) and Nasdaq Copenhagen (ORPHA). 

About arimoclomol 

Arimoclomol is an investigational drug candidate that amplifies the production of Heat-Shock Proteins (HSPs). HSPs can rescue defective misfolded proteins, clear protein aggregates, and improve the function of lysosomes. Arimoclomol is administered orally, crosses the blood-brain barrier, and has now been studied in seven phase 1, four phase 2 and one pivotal phase 2/3 trial. Arimoclomol is in clinical development for NPC, Gaucher Disease, sIBM, and ALS. Arimoclomol has received orphan drug designation (ODD) for NPC, sIBM, and ALS in the US and EU. Arimoclomol has received fast-track designation (FTD) from the U.S. Food and Drug Administration (FDA) for NPC, sIBM and ALS. In addition, arimoclomol has received breakthrough therapy designation (BTD) and rare-pediatric disease designation (RPDD) from the FDA for NPC.

Forward-looking statement 
This company announcement may contain certain forward-looking statements, including relating to the terms of the proposed offering, the Extraordinary General Meeting and the completion of the proposed offering. Although the Company believes its expectations are based on reasonable assumptions, all statements other than statements of historical fact included in this company announcement about future events are subject to (i) change without notice and (ii) factors beyond the Company’s control. These statements may include, without limitation, any statements preceded by, followed by, or including words such as “target,” “believe,” “expect,” “aim,” “intend,” “may,” “anticipate,” “estimate,” “plan,” “project,” “will,” “can have,” “likely,” “should,” “would,” “could”, and other words and terms of similar meaning or the negative thereof. Forward-looking statements are subject to inherent risks and uncertainties beyond the Company’s control that could cause the Company’s actual results, performance, or achievements to be materially different from the expected results, performance, or achievements expressed or implied by such forward-looking statements. Except as required by law, the Company assumes no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially from those anticipated in the forward-looking statements, even if new information becomes available in the future. 

Attachment

• 71-2020 Financial Calendar 2021

MACAU, Dec. 09, 2020 (GLOBE NEWSWIRE) — Melco Resorts & Entertainment, a global leader in premium integrated resorts, announces that it will be rolling out Winnow Vision, an Artificial Intelligence (A.I.)-powered product to tackle food waste across its properties. Driven by Melco’s strong focus around environmental sustainability, an initial six-month trial has shown excellent results in the Company’s flagship property, City of Dreams Macau, with:

• Food waste in the employee dining area reduced by 67%
• 3,915kg food waste saved, equivalent to almost 17 tonnes CO2e¹

Melco now plans to roll out Winnow Vision into its own-operated buffet restaurants, adopting the A.I. system as part of the Company’s broader sustainability strategy ‘Above & Beyond’. Using a camera, a set of smart scales and the same type of machine learning technology found in autonomous vehicles, Winnow Vision learns to recognize various foods being discarded and calculates the financial and environmental impact of such food waste for commercial kitchens. Chefs can then adjust their food purchasing decisions accordingly, reducing spending and tackling a fundamental problem of overproduction.

Denise Chen, Senior Vice President and Chief Sustainability Officer of Melco Resorts & Entertainment, said, “Melco is dedicated to tackling one of the industry’s biggest challenges, food waste, while inspiring others to follow suit. We are excited about continuing our collaboration with Winnow across our resorts to lead the charge against food waste in Macau. The A.I. system initiative allows us to maximize operational efficiency and data accuracy across both front- and heart of-house food outlets, with the ability to significantly reduce food waste as we work towards our goal of achieving zero waste and contributing to circular economic leadership in Asia by the year 2030.”

The F&B team at City of Dreams identified dishes such as noodles, potatoes and rice served to employees as key opportunities to reduce waste. Waste levels steadily reduced over the six-month period as the team adjusted production volumes using Winnow’s analytics. Melco is set to roll out the program to customer facing dining areas, as well as its operations in City of Dreams Manila in the Philippines.

Melco is also planning to work with Winnow to measure plate waste in its employee dining areas. The project aims to increase internal awareness on food and plate waste, which will contribute to the Company’s existing Clean Plate Challenge efforts since 2019.

Marc
Zornes
, Winnow CEO and
C
o-founder says, “We’re delighted with the results the team at City of Dreams have seen using Winnow Vision, with food waste cut by over 65% in just six months. This is testament to Melco’s commitment to sustainability and innovation, and we look forward to replicating these early successes across the group.”

About Melco Resorts & Entertainment Limited

The Company, with its American depositary shares listed on the NASDAQ Global Select Market (NASDAQ: MLCO), is a developer, owner and operator of integrated resort facilities in Asia and Europe. The Company currently operates Altira Macau (www.altiramacau.com), an integrated resort hotel located at Taipa, Macau and City of Dreams (www.cityofdreamsmacau.com), an integrated urban resort located in Cotai, Macau. Its business also includes the Mocha Clubs (www.mochaclubs.com), which comprise the largest non-casino based operations of electronic gaming machines in Macau. The Company also majority owns and operates Studio City (www.studiocity-macau.com), a cinematically-themed integrated resort in Cotai, Macau. In the Philippines, a Philippine subsidiary of the Company currently operates and manages City of Dreams Manila (www.cityofdreamsmanila.com), an integrated resort in the Entertainment City complex in Manila. In Europe, the Company is currently developing City of Dreams Mediterranean (www.cityofdreamsmed.com.cy) in the Republic of Cyprus, which is expected to be the largest and premier integrated destination resort in Europe. The Company is currently operating a temporary casino, the first authorized casino in the Republic of Cyprus, and is licensed to operate four satellite casinos (“Cyprus Casinos”). Upon the opening of City of Dreams Mediterranean, the Company will continue to operate the satellite casinos while operation of the temporary casino will cease. For more information about the Company, please visit www.melco-resorts.com.

The Company is strongly supported by its single largest shareholder, Melco International Development Limited, a company listed on the Main Board of The Stock Exchange of Hong Kong Limited and is substantially owned and led by Mr. Lawrence Ho, who is the Chairman, Executive Director and Chief Executive Officer of the Company.

About Winnow

Winnow develops cutting-edge digital tools to help chefs run more profitable, sustainable kitchens. Launched in a single staff restaurant in 2013, Winnow is trusted today by thousands of chefs in over 40 countries, where kitchens’ food waste is consistently cut in half. Together Winnow and its partners are saving over 36 million meals a year from the bin: the equivalent of $40 million in food cost savings for its clients. For more info: www.winnowsolutions.com

For media enquiries, please contact:

Chimmy Leung
Executive Director, Corporate Communications
Tel: +852 3151 3765
Email: [email protected]

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1</sup> CO2e calculated as 4.3kg CO2e to 1kg food waste saved (source blend of FAO and WRAP data)

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/b49a07c6-aef2-4afb-9fbd-6e139763aa9b