Everbridge Announces Successful Deployment of National Public Warning System for The United Kingdom (UK) to Protect Over 100 Million Residents and Visitors

Everbridge Announces Successful Deployment of National Public Warning System for The United Kingdom (UK) to Protect Over 100 Million Residents and Visitors

  • Everbridge now powers the national public warning systems for six European countries – more than any other provider
  • Mobile network operators EE, O2, and Three deploy Everbridge Public Warning as part of successful testing of UK government’s nationwide emergency system, planned for national roll-out later this year

COLCHESTER, United Kingdom–(BUSINESS WIRE)–Everbridge, Inc. (NASDAQ: EVBG), the global leader in critical event management (CEM), today announced that the company successfully deployed its Public Warning Cell Broadcast technology within three of the largest Mobile Network Operators in the United Kingdom, as a key technology component of the UK Government’s first-ever, nationwide emergency alerting system, planned for rollout later this year.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210712005429/en/

Everbridge Announces Successful Deployment of National Public Warning System for The United Kingdom (UK) to Protect Over 100 Million Residents and Visitors

Everbridge Announces Successful Deployment of National Public Warning System for The United Kingdom (UK) to Protect Over 100 Million Residents and Visitors

The system allows the government to reach people quickly during national emergencies such as public health crises, terror attacks, industrial incidents, earthquakes, and flooding. Powered by Everbridge’s industry-leading Public Warning technology, the UK Emergency Alert system will target mobile phones of residents and visitors present in the area impacted by an emergency. Everbridge contracts with mobile network operators EE – part of the British Telecommunications (BT Group), O2, and Three, represent the majority of UK mobile subscribers, and a population of over 65 million residents and 35 million annual visitors.

As UK Paymaster General Penny Mordaunt explained in an official statement, “The Emergency Alerts service will be a vital tool in helping us to better respond to emergencies, both nationally and locally. The concept was used to good effect during the pandemic when we asked people, via text message, to stay at home to protect the NHS and save lives. This new system builds on that capability and will allow us to more quickly and effectively get life-saving messages to people across the UK.”

Everbridge Public Warning, in partnership with three of the country’s largest mobile network operators, was used to complete two recent successful UK trials, the first in East Suffolk, the second in Reading. In the midst of the COVID-19 pandemic, Everbridge rapidly deployed the emergency alert system in under 100 days.

“The UK Government presented a challenge to deploy Cell Broadcast technology in a short timeframe in response to the coronavirus outbreak,” said Nazirali Rajvani, Director of Architecture, Solutions & Analysis at British Telecommunications. “We partnered with Everbridge to provide a trusted and proven world-class solution which was already in use in several other countries.”

The nationwide UK emergency alerting system implementation expands on Everbridge’s position as the global leader in population-wide Public Warning solutions used by over 1,500 municipalities, counties, cities, states and countries in every major region of the world including Europe, Asia, Oceania, the Middle East, Africa, and the Americas. Everbridge serves more countrywide deployments than any other provider, enabling the Public Warning system for many of the most technically-advanced countries including Sweden, Norway, Iceland, Greece, the Netherlands, Singapore, New Zealand, Australia, Peru, and multiple countries across the Middle East and Africa; entire states including California, New York, Andhra Pradesh, Kerala, Florida, Odisha, Connecticut, Vermont, Massachusetts, Washington, D.C. and the United States Virgin Islands; counties within 49 of the 50 U.S. states and within all of Canada’s provinces, many of the largest cities in the world, and in support of the most populous Native American and First Nations tribes and indigenous populations across the globe. Everbridge also powers the front-end of the Integrated Public Alert & Warning System (IPAWS) gateway for the U.S. Federal Government to supplement their own communication channels for issuing live emergency and Presidential Alerts in the United States.

“We are pleased to be part of this important milestone and support the United Kingdom on the evolution of its national warning system,” said Valerie Risk, Vice President of Public Warning Solutions at Everbridge. “Every nation can benefit from a modern platform that reaches all citizens in times of crisis. Our Public Warning solution enables government organizations to immediately connect with every person in an affected area during a critical event regardless of nationality, residency or mobile handset type.”

Everbridge Public Warning leverages existing telecom infrastructure, with no opt-in required, to reach everyone within a geographic area to reduce disaster risk, support first responder communications, and analyze disaster communication effectiveness for subsequent mitigation activities. The platform is fully compliant with data privacy regulations including GDPR and allows public safety agencies to send an alert to any device within a few seconds without sharing any personal details, such as names or phone numbers.

Everbridge recently launched its enhanced Public Warning Center, the first-of-its-kind modular and multi-channel front-end interface featuring the ability to create and transmit a combination of cell broadcast and address-, group-, and location-based SMS alerts for countrywide alerting from a single console. The new Public Warning Center meets and exceeds the needs of any public authority looking for an advanced warning solution to protect its citizens and visitors – from EU-directive approved systems to more sophisticated hybrid and multi-channel alert and warning platforms. The company also recently announced a new patent for its revolutionary work in enabling end-to-end multimedia population alerting capabilities. The patent – one of more than 160 overall across Everbridge’s market-leading population alerting suite of solutions – highlights the need for delivering alerts through a combination of 5G, cell broadcast, and multimedia. Everbridge remains the leader in 5G integrations for public warning systems.

Everbridge featured some of the leading experts in the world on public alerting technologies at its recent global Road to Recovery leadership symposiums. The topic of population-wide alerting best practices was addressed heavily during the sessions which featured keynote addresses by Presidents Bill Clinton and George W. Bush, former U.S. Secretary of State Dr. Madeleine K. Albright, Virgin Group Founder Sir Richard Branson, representatives from EENA (the European Emergency Number Association), and government officials, city mayors, and emergency management professionals from Australia, Canada, and the U.S., to name a few.

About Everbridge

Everbridge, Inc. (NASDAQ: EVBG) is a global software company that provides enterprise software applications that automate and accelerate organizations’ operational response to critical events in order to Keep People Safe and Organizations Running™. During public safety threats such as active shooter situations, terrorist attacks or severe weather conditions, as well as critical business events including IT outages, cyber-attacks or other incidents such as product recalls or supply-chain interruptions, over 5,700 global customers rely on the Company’s Critical Event Management Platform to quickly and reliably aggregate and assess threat data, locate people at risk and responders able to assist, automate the execution of pre-defined communications processes through the secure delivery to over 100 different communication modalities, and track progress on executing response plans. Everbridge serves 8 of the 10 largest U.S. cities, 9 of the 10 largest U.S.-based investment banks, 47 of the 50 busiest North American airports, 9 of the 10 largest global consulting firms, 8 of the 10 largest global automakers, 9 of the 10 largest U.S.-based health care providers, and 7 of the 10 largest technology companies in the world. Everbridge is based in Boston with additional offices in 20 cities around the globe. For more information visit www.everbridge.com.

Cautionary Language Concerning Forward-Looking Statements

This press release contains “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995, including but not limited to, statements regarding the anticipated opportunity and trends for growth in our critical communications and enterprise safety applications and our overall business, our market opportunity, our expectations regarding sales of our products, our goal to maintain market leadership and extend the markets in which we compete for customers, and anticipated impact on financial results. These forward-looking statements are made as of the date of this press release and were based on current expectations, estimates, forecasts and projections as well as the beliefs and assumptions of management. Words such as “expect,” “anticipate,” “should,” “believe,” “target,” “project,” “goals,” “estimate,” “potential,” “predict,” “may,” “will,” “could,” “intend,” variations of these terms or the negative of these terms and similar expressions are intended to identify these forward-looking statements. Forward-looking statements are subject to a number of risks and uncertainties, many of which involve factors or circumstances that are beyond our control. Our actual results could differ materially from those stated or implied in forward-looking statements due to a number of factors, including but not limited to: the ability of our products and services to perform as intended and meet our customers’ expectations; our ability to successfully integrate businesses and assets that we may acquire; our ability to attract new customers and retain and increase sales to existing customers; our ability to increase sales of our Mass Notification application and/or ability to increase sales of our other applications; developments in the market for targeted and contextually relevant critical communications or the associated regulatory environment; our estimates of market opportunity and forecasts of market growth may prove to be inaccurate; we have not been profitable on a consistent basis historically and may not achieve or maintain profitability in the future; the lengthy and unpredictable sales cycles for new customers; nature of our business exposes us to inherent liability risks; our ability to attract, integrate and retain qualified personnel; our ability to maintain successful relationships with our channel partners and technology partners; our ability to manage our growth effectively; our ability to respond to competitive pressures; potential liability related to privacy and security of personally identifiable information; our ability to protect our intellectual property rights, and the other risks detailed in our risk factors discussed in filings with the U.S. Securities and Exchange Commission (“SEC”), including but not limited to our Annual Report on Form 10-K for the year ended December 31, 2020 filed with the SEC on February 26, 2021. The forward-looking statements included in this press release represent our views as of the date of this press release. We undertake no intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.

All Everbridge products are trademarks of Everbridge, Inc. in the USA and other countries. All other product or company names mentioned are the property of their respective owners.

Everbridge:

Jim Gatta

Media Relations

[email protected]

215-290-3799

Joshua Young

Investor Relations

[email protected]

781-236-3695

KEYWORDS: United Kingdom Europe

INDUSTRY KEYWORDS: Mobile/Wireless Technology Homeland Security Security Telecommunications Public Policy/Government Software Networks White House/Federal Government State/Local

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Everbridge Announces Successful Deployment of National Public Warning System for The United Kingdom (UK) to Protect Over 100 Million Residents and Visitors
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Aptinyx to Participate in William Blair Biotech Focus Conference 2021

Aptinyx to Participate in William Blair Biotech Focus Conference 2021

EVANSTON, Ill.–(BUSINESS WIRE)–
Aptinyx Inc. (Nasdaq: APTX), a clinical-stage biopharmaceutical company developing transformative therapies for the treatment of nervous system disorders, today announced that Norbert Riedel, Ph.D., chief executive officer, will participate in the Updates in Neuropysch panel discussion at the William Blair Biotech Focus Conference on Thursday, July 15 at 12:00 p.m. ET.

A live webcast of the presentation will be available to view on the “Events and Presentations” page in the “Investors & Media” section of Aptinyx’s website at https://ir.aptinyx.com and will be archived on Aptinyx’s website for 30 days following the event.

About Aptinyx

Aptinyx Inc. is a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of proprietary synthetic small molecules for the treatment of brain and nervous system disorders. Aptinyx has a platform for discovery of novel compounds that work through a unique mechanism to modulate—rather than block or over-activate—NMDA receptors and enhance synaptic plasticity, the foundation of neural cell communication. The company has three product candidates in clinical development in central nervous system indications, including chronic pain, post-traumatic stress disorder, and cognitive impairment. Aptinyx is also advancing additional compounds from its proprietary discovery platform, which continues to generate a rich and diverse pipeline of small-molecule NMDA receptor modulators with the potential to treat an array of neurologic disorders. For more information, visit www.aptinyx.com.

Source: Aptinyx Inc.

Investor and Media Contact:

Nick Smith

Aptinyx Inc.

[email protected] or [email protected]

847-871-0377

KEYWORDS: United States North America Illinois

INDUSTRY KEYWORDS: Biotechnology Pharmaceutical Health

MEDIA:

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Nebula Caravel Acquisition Corp. Announces Effectiveness of Registration Statement and Special Meeting Date of July 28, 2021 to Approve the Proposed Business Combination with A Place for Rover, Inc.

– Special Meeting Scheduled on July 28, 2021 at 1:00 p.m. Eastern Time

– Stockholders as of the close of business on July 8, 2021 should vote their shares, no matter how many shares they own

– For assistance voting your shares, please contact Morrow Sodali LLC, Nebula Caravel Acquisition Corp.’s proxy solicitor, toll-free at 1 (800) 662 5200, or send a message to [email protected]

PR Newswire

SAN FRANCISCO, July 12, 2021 /PRNewswire/ — Nebula Caravel Acquisition Corp (Nasdaq: NEBC) (“Caravel”), a special purpose acquisition company sponsored by True Wind Capital, L.P. (“True Wind Capital”), announced today its registration statement on Form S-4 (File No. 333-253110), relating to the business combination with A Place for Rover, Inc. (“Rover”), the world’s largest online marketplace for pet care, has been declared effective by the U.S. Securities and Exchange Commission (“SEC”). Caravel has set a record date of July 8, 2021 (the “Record Date”) and a meeting date of July 28, 2021 for its special meeting for Caravel stockholders to approve the previously announced business combination (the “Special Meeting”).            

The Special Meeting will be held virtually via live webcast on July 28, 2021 at https://web.lumiagm.com/228541062. If the proposals at the Special Meeting are approved, the business combination is expected to close promptly thereafter, subject to the satisfaction of customary closing conditions.    

Every stockholder’s vote is important, regardless of the number of shares held. As such, all stockholders as of the Record Date are encouraged to vote “FOR” ALL PROPOSALS described in the proxy statement/prospectus in advance of the Special Meeting by telephone, via the Internet or by signing, dating and returning the proxy card upon receipt by following the instructions on the proxy card. 

Your voting control number is found on your Voting Instruction Form. If you did hold shares as of the July 8, 2021 Record Date and did not receive or misplaced your Voting Instruction Form, contact your bank, broker or other nominee for a replacement or to obtain your control number in order to vote. A bank, broker or other nominee is a person or firm that acts as an intermediary between an investor and the stock exchange, who can help you vote your shares. 

If you need assistance with voting your shares, please contact Morrow Sodali LLC (“Morrow”), Caravel’s proxy solicitor, for help, by calling toll-free at +1 (800) 662-5200 (banks and brokers can call collect at +1 (203) 658-9400), or by email at [email protected].    

Holders of Rover stock may elect to receive cash for some or all of their shares of Rover stock beginning on July 12, 2021 and ending at 11:59 p.m. PT on July 26, 2021, with instructions to be provided via an email from Shareworks on July 12, 2021. Under the terms of the business combination agreement, holders of Rover stock are not guaranteed to receive merger consideration in cash even if a valid cash election is made.

About Rover

Founded in 2011 and based in Seattle, Rover is the world’s largest online marketplace for pet care. Rover connects pet parents with pet providers who offer overnight services, including boarding and in-home pet sitting, as well as daytime services, including doggy daycare, dog walking, drop-in visits, and grooming.

About True Wind Capital

True Wind Capital is a San Francisco-based private equity firm focused on investing in leading technology companies. True Wind Capital has a broad investing mandate, with deep industry expertise across software, data analytics, tech-enabled services, internet, financial technology, and hardware. Rover will be True Wind Capital’s 8th platform investment.

About Nebula Caravel Acquisition Corp.

Nebula Caravel Acquisition Corp. is a blank check company sponsored by True Wind Capital and led by Adam H. Clammer and James H. Greene, Jr., who serve as Chief Executive Officer and Chairman, respectively, formed for the purpose of partnering with one high-quality technology business. Caravel was formed following Nebula Acquisition Corporation’s successful merger with Open Lending (NASDAQ: LPRO) in June 2020.

Important Information and Where to Find It

This press release relates to the proposed business combination involving Caravel and Rover. Caravel has filed a registration statement on Form S-4 with the SEC, which includes a proxy statement and prospectus of Caravel, and Caravel will file other documents with the SEC regarding the proposed transaction. The registration statement on Form S-4 was declared effective on July 9, 2021. The definitive proxy statement/prospectus is also being sent to the stockholders of Caravel, seeking any required stockholder approvals. Before making any voting or investment decision, investors and securityholders of Caravel are urged to carefully read the entire registration statement and proxy statement/prospectus and any other relevant documents filed with the SEC, as well as any amendments or supplements to these documents, because they will contain important information about the proposed transaction. The documents filed by Caravel with the SEC may be obtained free of charge at the SEC’s website at http://www.sec.gov. Alternatively, these documents can be obtained free of charge from Caravel upon written request to: Nebula Caravel Acquisition Corp., Four Embarcadero Center, Suite 2100, San Francisco, California 94111.

Participants in the Solicitation

Caravel, Rover and certain of their respective directors and executive officers may be deemed to be participants in the solicitation of proxies from the stockholders of Caravel, in favor of the approval of the business combination. Information regarding Caravel’s directors and executive officers is contained in the section of Caravel’s registration statement on Form S-4 titled “Information About Carvel”. Additional information regarding the interests of those participants and other persons who may be deemed participants in the transaction may be obtained by reading the registration statement and the proxy statement/prospectus and other relevant documents filed with the SEC when they become available. Free copies of these documents may be obtained as described in the preceding paragraph.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995 including, but not limited to, Caravel’s and Rover’s expectations or predictions of future financial or business performance or conditions. Forward-looking statements are inherently subject to risks, uncertainties and assumptions. Generally, statements that are not historical facts, including statements concerning possible or assumed future actions, business strategies, events or results of operations, including financial projections, are forward-looking statements. These statements may be preceded by, followed by or include the words “believes,” “estimates,” “expects,” “projects,” “forecasts,” “may,” “will,” “should,” “seeks,” “plans,” “scheduled,” “anticipates” or “intends” or similar expressions. Such forward-looking statements involve risks and uncertainties that may cause actual events, results or performance to differ materially from those indicated by such statements. Certain of these risks are identified and discussed in the section of Caravel’s registration statement on Form S-4 titled “Risk Factors”, which will be important to consider in determining future results and should be reviewed in their entirety. These forward-looking statements include, without limitation, expectations with respect to approval by Caravel’s stockholders of the business combination and satisfaction of other closing conditions. Forward-looking statements are based on Caravel’s or Rover’s management’s current expectations and beliefs, as well as a number of assumptions concerning future events. However, there can be no assurance that the events, results or trends identified in these forward-looking statements will occur or be achieved. Forward-looking statements speak only as of the date they are made, and neither Caravel nor Rover is under any obligation, and expressly disclaim any obligation, to update, alter or otherwise revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.  Readers should carefully review the statements set forth in the reports, which Caravel has filed or will file from time to time with the SEC.

In addition to factors previously disclosed in Caravel’s reports filed with the SEC and those identified elsewhere in this press release, the following factors, among others, could cause actual results to differ materially from forward-looking statements or historical performance: risks and uncertainties related to the inability of the parties to successfully or timely consummate the business combination, including the risk that any required regulatory approvals or stockholder approvals of Caravel or Rover are not obtained, are delayed or are subject to unanticipated conditions that could adversely affect the combined company or the expected benefits of the business combination is not obtained; failure to realize the anticipated benefits of the business combination; risks related to Rover’s ability to execute on its business strategy, attract and retain users, develop new offerings, enhance existing offerings, compete effectively, and manage growth and costs; the duration and global impact of COVID-19; the number of redemption requests made by Caravel’s public stockholders; the ability of the combined company to meet Nasdaq’s listing standards (or the standards of any other securities exchange on which securities of the public entity are listed) following the business combination; the inability to complete the private placement of common stock of Caravel to certain institutional accredited investors; the risk that the announcement and consummation of the transactions disrupts Rover’s current plans and operations; costs related to the transactions; the outcome of any legal proceedings that may be instituted against Caravel, Rover, or any of their respective directors or officers, regarding the proposed transaction; the ability of Caravel or the combined company to issue equity or equity-linked securities in connection with the proposed business combination or in the future; the failure to realize anticipated pro forma results and underlying assumptions, including with respect to estimated stockholder redemptions and purchase price and other adjustments; and those factors discussed in documents of Caravel filed, or to be filed, with SEC.

Additional factors that could cause actual results to differ materially from those expressed or implied in forward-looking statements can be found in Caravel’s most recent filings with the SEC, which are available, free of charge, at the SEC’s website at http://www.sec.gov, and in the registration statement on Form S-4 and Caravel’s proxy statement/prospectus.

This press release is not intended to be all-inclusive or to contain all the information that a person may desire in considering an investment in Caravel and is not intended to form the basis of an investment decision in Caravel. All subsequent written and oral forward-looking statements concerning Caravel and Rover, the proposed transaction or other matters and attributable to Caravel and Rover or any person acting on their behalf are expressly qualified in their entirety by the cautionary statements above.

No Offer or Solicitation

This press release is for informational purposes only and shall not constitute an offer to sell or the solicitation of an offer to buy any securities pursuant to the transaction or otherwise, nor shall there be any sale of securities in any jurisdiction in which the offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.  No offer of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended.

 

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SOURCE Nebula Caravel Acquisition Corp.

Imperial to hold 2021 Second Quarter Earnings Call

Imperial to hold 2021 Second Quarter Earnings Call

CALGARY, Alberta–(BUSINESS WIRE)–
(TSE:IMO, NYSE American: IMO) Brad Corson, chairman, president and chief executive officer, and Dave Hughes, vice-president investor relations, Imperial Oil Limited, will host a 2021 Second Quarter Earnings Call on Friday, July 30, following the company’s second quarter earnings release that morning. The event begins at 9 a.m. MT and will be accessible by webcast.

During the call, Mr. Corson will offer brief remarks prior to taking questions from Imperial’s covering analysts.

Please click here [https://edge.media-server.com/mmc/p/k22sqghu] to register for the live webcast. The webcast will be available for one year on the company’s website at www.imperialoil.ca/en-ca/company/investors.

Source: Imperial

After more than a century, Imperial continues to be an industry leader in applying technology and innovation to responsibly develop Canada’s energy resources. As Canada’s largest petroleum refiner, a major producer of crude oil, a key petrochemical producer and a leading fuels marketer from coast to coast, our company remains committed to high standards across all areas of our business.

Investor relations

(587) 476-4743

Media relations

(587) 476-7010

KEYWORDS: North America Canada

INDUSTRY KEYWORDS: Technology Energy Other Technology Oil/Gas

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GOL announces Investor Update

PR Newswire

SÃO PAULO, July 12, 2021 /PRNewswire/ — GOL Linhas Aéreas Inteligentes S.A. (NYSE: GOL and B3: GOLL4), (“GOL” or “Company”), Brazil’s largest airline, today provides an Investor Update on its expectations for the second quarter of 2021. The information below is preliminary and unaudited. The Company will discuss its 2Q21 results in a conference call on July 29, 2021.


2Q21 Commentary

  • GOL expects a Loss Per Share (EPS) and a Loss Per American Depositary Share (EPADS) for 2Q21 of approximately R$3.251 and US$1.231, respectively.
  • EBITDA2 margin for the second quarter, excluding non-operating and non-recurring expenses, is expected to be 16% to 18%, a decrease in relation to the margin for the quarter ended in June 2020 (28%2).
  • Passenger unit revenue (PRASK) for the 2Q21 is expected to be approximately 17% lower year-over-year. GOL anticipates unit revenue (RASK) to be 33% lower when compared to 2Q20. Daily sales ended the quarter at around R$21 million, representing a 200% increase over the end of 1Q21. At 85%, GOL’s load factor continues to effectively match supply with demand.
  • Non-fuel unit costs (CASK ex-fuel) for 2Q21, excluding non-operating and non-recurring expenses, are expected to decrease approximately 55%2 compared to 2Q20 reported CASK ex-fuel, primarily due to four times higher ASKs and the 1% appreciation of the Brazilian Real versus the US dollar. Fuel unit costs (CASK fuel) are expected to increase by approximately 54% year-over-year, mainly due to an 82% increase in the average fuel price, partially offset by the higher fuel efficiency consumption of MAX aircraft and by the BRL appreciation versus USD.
  • GOL’s financial leverage, as measured by the Net Debt3/LTM EBITDA ratio, was approximately 11x at the end of June 2021. The Company amortized around R$800 million of total debt in the quarter, including R$420 million of financial debt and R$310 million of aircraft lease debt. The Company also settled the R$744 million payment to the minority shareholders of Smiles Fidelidade S.A.
  • Total liquidity at the end of the June 2021 was R$1.7 billion, comprised of R$1.0 billion in cash and investments and R$0.7 billion in receivables. Including the financeable amounts of deposits, GOL’s liquidity sources total approximately R$3.7 billion. This is consistent with the Company’s liquidity levels throughout the pandemic.
  • GOL plans to increase its 3Q21 capacity by approximately 80% over 2Q21, in anticipation of stronger seasonal demand. 
  • In 2Q21, Gross Global Scope 1 emissions were approximately 281.6 thousand metric tons of CO2, a 42% reduction versus 1Q21, while Total Fuel Consumed was 32.3 thousand liters per RPK, 6% lower compared to 1Q21. The Greenhouse Gas Emissions per Flight Hour were around 8.5 tons of CO2, stable versus the 1Q21.

 


Preliminary and Unaudited Projections 2Q21

 

Domestic Routes Served (average) / % of 2019

Average Operating Fleet / % of 2019

Net Operating Revenues (R$ BN) / % of 2019

Load Factor

EBITDA Margin2

EBIT Margin2

Capex (R$ MM)

Net Cash Burn (R$MM/day)4

Other Revenue (cargo, loyalty, other)

Average fuel price per liter

Avg. exchange rate / End of 2Q21 exchange rate

Gross Global Scope 1 emissions (000 m t CO2)

Total Fuel Consumed (1,000 liters per RPK)

Greenhouse Gas Emissions/Flight Hour (t CO2)

 

 

Passenger unit revenue (PRASK)

Operating CASK Ex-fuel2

Domestic Demand – RPK

Domestic Capacity – ASK

Domestic Capacity – Seats

Total Demand – RPK

Total Capacity – ASK

Total Capacity – Seats



2Q21

~126 / 87%

~55 / 50%

~1.0 / 31%

85.1%

16% – 18%

8% – 10%

~54

Neutral

15% of revenues

R$3.38 – R$3.44

R$5.32 / R$5.00

~281.6

~32.3

~8.5

 



2Q21 vs. 2Q20

Down ~17%

Down ~55%

Up ~345%

Up ~310%

 Up ~328%

 Up ~344%

 Up ~307%

 Up ~327%


1. 

Excluding gains and losses on currency and Exchangeable Senior Notes. 


2. 

Excluding non-operating expenses and depreciation related to fleet idleness and personnel-related costs of approximately R$914 million in 2Q21 and R$918 million in 2Q20.


3. 

Excluding Perpetual Notes and Exchangeable Senior Notes.


4. 

Excluding payment of interest on financial debts.

Investor Relations

[email protected]

www.voegol.com.br/ir

+55(11) 2128-4700

Media Relations

Becky Nye, Montieth & Company
[email protected]

About GOL Linhas Aéreas Inteligentes S.A.

GOL is Brazil’s largest airline, leader in the corporate and leisure segments. Since its founding in 2001, it has been the airline with the lowest unit cost in Latin America, which has enabled the democratization of air transportation. The Company has a strategic alliance with Air France-KLM, in addition to making available to Customers many codeshare and interline agreements, bringing more convenience and ease of connections to any place served by these partnerships. With the purpose of “Being First for Everyone”, GOL offers the best travel experience to its passengers, including: the largest inventory of seats and the most legroom; the most complete platform with internet, movies and live TV; and the best loyalty program SMILES. In cargo transportation, GOLLOG delivers parcels to various regions in Brazil and abroad. The Company has a team of 15,000 highly qualified airline professionals focused on Safety, GOL’s number one value, and operates a standardized fleet of 127 Boeing 737 aircraft. GOL’s shares are traded on the NYSE (GOL) and the B3 (GOLL4). For further information, visit www.voegol.com.br/ir.

Disclaimer

The information contained in this press release has not been subject to any independent audit or review and contains “forward-looking” statements, estimates and projections that relate to future events, which are, by their nature, subject to significant risks and uncertainties. All statements other than statements of historical fact contained in this press release including, without limitation, those regarding GOL’s future financial position and results of operations, strategy, plans, objectives, goals and targets, future developments in the markets in which GOL operates or is seeking to operate, and any statements preceded by, followed by or that include the words “believe”, “expect”, “aim”, “intend”, “will”, “may”, “project”, “estimate”, “anticipate”, “predict”, “seek”, “should” or similar words or expressions, are forward-looking statements. The future events referred to in these forward-looking statements involve known and unknown risks, uncertainties, contingencies and other factors, many of which are beyond GOL’s control, that may cause actual results, performance or events to differ materially from those expressed or implied in these statements. These forward-looking statements are based on numerous assumptions regarding GOL’s present and future business strategies and the environment in which GOL will operate in the future and are not a guarantee of future performance. Such forward-looking statements speak only as at the date on which they are made. None of GOL or any of its affiliates, officers, directors, employees and agents undertakes any duty or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except to the extent required by law. None of GOL or any of its affiliates, officers, directors, employees, professional advisors and agents make any representation, warranty or prediction that the results anticipated by such forward-looking statements will be achieved, and such forward-looking statements represent, in each case, only one of many possible scenarios and should not be viewed as the most likely or standard scenario. Although GOL believes that the estimates and projections in these forward-looking statements are reasonable, they may prove materially incorrect and actual results may materially differ. As a result, you should not rely on these forward-looking statements.

Non-GAAP Measures

To be consistent with industry practice, GOL discloses so-called non-GAAP financial measures which are not recognized under IFRS or U.S. GAAP, including “Net Debt”, “Adjusted Net Debt”, “total liquidity” and “EBITDA”. The Company’s management believes that disclosure of non-GAAP measures provides useful information to investors, financial analysts and the public in their review of its operating performance and their comparison of its operating performance to the operating performance of other companies in the same industry and other industries. However, these non-GAAP items do not have standardized meanings and may not be directly comparable to similarly-titled items adopted by other companies. Potential investors should not rely on information not recognized under IFRS as a substitute for the GAAP measures of earnings or liquidity in making an investment decision.

 

Cision View original content:https://www.prnewswire.com/news-releases/gol-announces-investor-update-301331415.html

SOURCE GOL Linhas Aéreas Inteligentes S.A.

Independent Bank Corporation Announces Date for its Second Quarter 2021 Earnings Release

GRAND RAPIDS, Mich., July 12, 2021 (GLOBE NEWSWIRE) — Independent Bank Corporation (NASDAQ: IBCP), the holding company of Independent Bank, a Michigan-based community bank, announced that it expects to issue its 2021 second quarter results on Thursday, July 29, 2021, at approximately 8:00 am ET. The release will be available on the Internet at IndependentBank.com within the “News” section of the “Investor Relations” area of the Company’s website.

Brad Kessel, President and CEO and Gavin Mohr, CFO will review the quarterly results in a conference call for investors and analysts beginning at 12:00 pm ET on Thursday, July 29, 2021.

To participate in the live conference call, please dial 1-866-200-8394. Also the conference call will be accessible through an audio webcast with user-controlled slides via the following event site/URL: https://services.choruscall.com/links/ibcp210729.html.

A playback of the call can be accessed by dialing 1-877-344-7529 (Conference ID # 10158604). The replay will be available through August 5, 2021.


About Independent Bank Corporation

Independent Bank Corporation (NASDAQ: IBCP) is a Michigan-based bank holding company with total assets of approximately $4.4 billion. Founded as First National Bank of Ionia in 1864, Independent Bank Corporation operates a branch network across Michigan’s Lower Peninsula through one state-chartered bank subsidiary. This subsidiary (Independent Bank) provides a full range of financial services, including commercial banking, mortgage lending, investments, insurance and title services. Independent Bank Corporation is committed to providing exceptional personal service and value to its customers, stockholders and the communities it serves.

For more information, please visit our Web site at: IndependentBank.com.



ZoomInfo to Report Financial Results for Second Quarter 2021 on August 2, 2021

ZoomInfo to Report Financial Results for Second Quarter 2021 on August 2, 2021

VANCOUVER, Wash.–(BUSINESS WIRE)–ZoomInfo (NASDAQ: ZI), a global leader in go-to-market intelligence solutions, today announced that it will publish financial results for the second quarter 2021 following the close of U.S. financial markets on Monday, August 2, 2021. The news release and any accompanying materials will be posted to the Investor Relations portion of ZoomInfo’s website at https://ir.zoominfo.com/.

On that day, ZoomInfo management will host a conference call and webcast at 4:30 p.m. ET (1:30 p.m. PT) to review financial results.

What:

ZoomInfo Second Quarter 2021 Financial Results Conference Call

When:

Monday, August 2, 2021

Time:

4:30 p.m. ET / 1:30 p.m. PT

Live webcast:

https://ir.zoominfo.com/

Live Call:

+1-833-519-1261 (U.S.)

+ 1-914-800-3834 (International)

Conference ID:

4023098

Following the conference call, an archived webcast of the call will be available for one year on ZoomInfo’s Investor Relations website at https://ir.zoominfo.com/.

About ZoomInfo

ZoomInfo (NASDAQ: ZI) is a Go-To-Market Intelligence Solution for more than 20,000 companies worldwide. The ZoomInfo platform empowers business-to-business sales, marketing, and recruiting professionals to hit their number by pairing best-in-class technology with unrivaled data coverage, accuracy, and depth of company and contact information. With integrations embedded into workflows and technology stacks, including the leading CRM, Sales Engagement, Marketing Automation, and Talent Management applications, ZoomInfo drives more predictable, accelerated, and sustainable growth for its customers. ZoomInfo emphasizes GDPR and CCPA compliance. In addition to creating the industry’s first proactive notice program, the company is a registered data broker with the states of California and Vermont. Read about ZoomInfo’s commitment to compliance, privacy, and security. For more information about our leading Go-To-Market Intelligence Solution, and how it helps sales, marketing, and recruiting professionals, please visit www.zoominfo.com.

Investor Contact:

Jeremiah Sisitsky

VP of Investor Relations

617-826-2068

[email protected]

Media Contact:

Steve Vittorioso

Director, Communications

978-875-1297

[email protected]

KEYWORDS: United States North America Washington

INDUSTRY KEYWORDS: Software Professional Services Search Engine Marketing Data Management Technology Small Business Other Communications Other Professional Services Marketing Advertising Communications Other Technology

MEDIA:

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HUYA Inc. Announces Termination of Merger Agreement with DouYu

PR Newswire

GUANGZHOU, China, July 12, 2021 /PRNewswire/ — HUYA Inc. (NYSE: HUYA) (“Huya” or the “Company”), a leading game live streaming platform in China, today announced that according to the announcement posted by the State Administration for Market Regulation of the People’s Republic of China (the “SAMR”) on July 10, 2021, the SAMR decided to prohibit the proposed merger (the “Merger”) between Huya and DouYu International Holdings Limited (“DouYu”) following SAMR’s antitrust review (the “SAMR Decision”). Huya fully respects and will abide by the SAMR Decision, and will comply with all regulatory requirements, and conduct its businesses in accordance with the applicable laws and regulations.

In light of the SAMR Decision, on July 12, 2021, Huya, Tiger Company Ltd., a wholly owned subsidiary of Huya, DouYu, and Nectarine Investment Limited, a wholly owned subsidiary of Tencent Holdings Limited, entered into a termination agreement, pursuant to which the Agreement and Plan of Merger, dated October 12, 2020, by and among the same parties (the “Merger Agreement”), including all schedules and exhibits thereto, and all ancillary agreements contemplated thereby or entered pursuant thereto, were terminated with immediate effect.

Huya previously announced that, in accordance with the terms of the Merger Agreement, its board of directors approved a cash dividend in an aggregate amount of US$200,000,000 (the “Cash Dividend”) to be paid on or around the date of the closing of the Merger and in no event later than 20 days after the closing of the Merger to the holders of ordinary shares of Huya whose names appear on Huya’s register of members as of the close of business on certain record date after the date when the required DouYu shareholder approval is obtained and prior to the closing of the Merger.  In consideration of the termination of the Merger, Huya’s board of directors approved the cancellation of the Cash Dividend.

Concurrently, Linen Investment Limited, a wholly-owned subsidiary of Tencent Holdings Limited (“Linen”), and affiliates of Mr. Rongjie Dong entered into a termination agreement on July 12, 2021, pursuant to which the Share Transfer Agreement, dated October 12, 2020, by and among the same parties with respect to the purchase by Linen of 1,970,804 Class B ordinary shares of Huya from affiliates of Mr. Rongjie Dong, including all schedules and exhibits thereto, and all ancillary agreements contemplated thereby or entered pursuant thereto, were terminated with immediate effect.

About HUYA Inc.

HUYA Inc. is a leading game live streaming platform in China with a large and active game live streaming community. The Company cooperates with e-sports event organizers, as well as major game developers and publishers, and has developed e-sports live streaming as one of the most popular content genres on its platform. The Company has created an engaged, interactive and immersive community for game enthusiasts of China’s young generation. Building on its success in game live streaming, Huya has also extended its content to other entertainment content genres. Huya’s open platform also functions as a marketplace for broadcasters and talent agencies to congregate and closely collaborate with the Company.

For investor and media inquiries, please contact:

In China:

HUYA Inc.
Investor Relations
Tel: +86-20-2290-7829
E-mail: [email protected]

The Piacente Group, Inc.
Jenny Cai
Tel: +86-10-6508-0677
E-mail: [email protected]

In the United States:

The Piacente Group, Inc. 
Brandi Piacente
Tel: +1-212-481-2050
E-mail: [email protected]

Cision View original content:https://www.prnewswire.com/news-releases/huya-inc-announces-termination-of-merger-agreement-with-douyu-301331407.html

SOURCE HUYA Inc.

Hyzon Motors deepens strategic hydrogen mobility partnership with TotalEnergies SE

– Partnership accelerates Hyzon, TotalEnergies’ deployment of hydrogen-powered trucks, refueling infrastructure for long-haul transport across Europe

– TotalEnergies is a broad energy company, with the ambition to be a world-class player in the energy transition. It operates a wide refueling and retail infrastructure business worldwide

– TotalEnergies previously made direct investment in Hyzon through its venture arm, TotalEnergies Ventures

– Hyzon expects to supply by 2023 up to 80 hydrogen fuel cell-powered trucks to TotalEnergies’ customers in France to support development of hydrogen infrastructure

PR Newswire

ROCHESTER, N.Y., July 12, 2021 /PRNewswire/ — Hyzon Motors Inc. announced today it has signed a memorandum of understanding (MoU) with TotalEnergies (NYSE: TTE) through its Marketing & Services division. The MoU reinforces the two companies’ shared commitment to evaluate and develop hydrogen refueling and vehicle supply solutions for long-haul transport to customers across Europe.

Hyzon and TotalEnergies aim to make it easier for fleet owners to transition to renewable hydrogen fuel by combining their existing infrastructure and technology. TotalEnergies, which operates over 15,500 service stations globally, and Hyzon, a leading supplier of hydrogen fuel cell-powered trucks, already have hydrogen refueling stations and hydrogen-powered vehicles in operation, respectively.

This MoU strengthens the existing commercial relationship between one of the world’s largest energy companies and a leading supplier of hydrogen commercial vehicles. TotalEnergies previously made a direct investment in Hyzon through its venture arm, TotalEnergies Ventures in 2020, to help fund the buildout of Hyzon’s manufacturing and engineering centers in the United States, Europe and China.

TotalEnergies is also a member of the Hyzon Zero Carbon Alliance, a consortium dedicated to accelerating the global development of the hydrogen ecosystem.

A first concrete operational step is the announcement of the signature of an additional MoU between Hyzon and TotalEnergies, this time through its French affiliate TotalEnergies Marketing France, which oversees its service-stations network and new mobilities solutions in France. Under this second MoU, the companies will collaborate on developing ecosystems and will secure by 2023 the production of 80 hydrogen fuel cell-powered trucks for TotalEnergies’ French customers.

Starting from trials, Hyzon aims to eventually be able to supply customers with a hydrogen fuel cell truck at total cost of ownership (TCO) parity with diesel-powered commercial vehicles in Europe.

“At TotalEnergies, we are convinced that hydrogen is a mobility solution of the future. That is why TotalEnergies Ventures previously invested in Hyzon Motors,” said John Wilson, vice president, Gas Mobility at the Marketing & Services division of TotalEnergies. “The anouncement today takes that relationship further, giving the company leverage to expand the reach of hydrogen in the commercial vehicle market in Europe. To achieve our climate ambition of net zero emissions by 2050, together with society, hydrogen fuel cell-powered trucks must come to market. We are therefore excited about this partnership with Hyzon.”

TotalEnergies is a broad energy company active in more than 130 countries with more than 105,000 employees. The company produces and markets energies on a global scale: oil and biofuels, natural gas and green gases, renewables and electricity.

“It’s rare to find a company as committed to the energy transition as Hyzon – but we’ve found that in TotalEnergies. While this is another important development in our relationship, we don’t expect it to be the last,” Craig Knight, CEO of Hyzon said. “Hydrogen will play a significant role in decarbonizing transport and we look forward to working with one of the world’s leading energy companies to deploy hydrogen solutions at scale across Europe. Their relationships, customer base and current infrastructure are a huge asset as we aim to make it as easy as possible for fleet owners to make the switch to hydrogen.”

About Hyzon Motors Inc.
 
Headquartered in Rochester, N.Y., with U.S. operations also in Chicago and Detroit, and international operations in the Netherlands, Singapore, Australia and China, Hyzon is a leader in hydrogen mobility. Hyzon is a pure-play hydrogen mobility company with an exclusive focus on hydrogen in the commercial vehicle market. Utilizing its proven and proprietary hydrogen fuel cell technology, Hyzon aims to supply zero-emission heavy duty trucks and buses to customers in North America, Europe and around the world. The company is contributing to the escalating adoption of hydrogen vehicles through its demonstrated technology advantage, leading fuel cell performance and history of rapid innovation. Visit www.hyzonmotors.com. 

About TotalEnergies SE
TotalEnergies is a broad energy company that produces and markets energies on a global scale: oil and biofuels, natural gas and green gases, renewables and electricity. Our 105,000 employees are committed to energy that is ever more affordable, clean, reliable and accessible to as many people as possible. Active in more than 130 countries, TotalEnergies puts sustainable development in all its dimensions at the heart of its projects and operations to contribute to the well-being of people.

Forward-Looking Statements
This press release includes “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements, other than statements of present or historical fact included in this press release, including those regarding Decarbonization Plus Acquisition Corporation’s (“DCRB”) proposed acquisition of Hyzon and DCRB’s ability to consummate the transaction, are forward-looking statements. When used in this press release, the words “could,” “should,” “will,” “may,” “believe,” “anticipate,” “intend,” “estimate,” “expect,” “project,” the negative of such terms and other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain such identifying words. These forward-looking statements are based on management’s current expectations and assumptions about future events and are based on currently available information as to the outcome and timing of future events. Except as otherwise required by applicable law, DCRB and Hyzon disclaim any duty to update any forward looking statements, all of which are expressly qualified by the statements in this section, to reflect events or circumstances after the date of this press release. DCRB and Hyzon caution you that these forward-looking statements are subject to numerous risks and uncertainties, most of which are difficult to predict and many of which are beyond the control of either DCRB or Hyzon, including risks and uncertainties described in the “Risk Factors” section of Exhibit 99.3 of DCRB’s Current Report on Form 8-K filed with the U.S. Securities and Exchange Commission (the “SEC”) on Feb. 9, 2021, the “Risk Factors” section of DCRB’s definitive proxy statement on Schedule 14A filed with the SEC on June 21, 2021, and other documents filed by DCRB from time to time with the SEC. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements, such as risks related to the ability to convert non-binding memoranda of understanding into binding orders or sales (including because of the current or prospective financial resources of the counterparties to Hyzon’s non-binding memoranda of understanding and letters of intent), or the ability to identify additional potential customers and convert them to paying customers. Hyzon gives no assurance that Hyzon will achieve its expectations.

Important Information for Investors and Stockholders
In connection with the proposed business combination, DCRB filed a proxy statement and other relevant documents with the SEC. Stockholders and other interested persons are urged to read the proxy statement and any other relevant documents filed with the SEC because they contain important information about DCRB, Hyzon and the proposed business combination. Stockholders may obtain a free copy of the proxy statement, as well as other filings containing information about DCRB, Hyzon and the proposed business combination, without charge, at the SEC’s website at www.sec.gov.

Participants in the Solicitation
DCRB, Hyzon and their directors and executive officers and other persons may be deemed to be participants in the solicitations of proxies from DCRB’s stockholders in respect of the proposed business combination and the other matters set forth in the proxy statement. Information regarding DCRB’s directors and executive officers is available in DCRB’s Annual Report on Form 10-K for the annual period ended Dec. 31, 2020, and under the heading “Information About DCRB” in DCRB’s definitive proxy statement related to the proposed business combination filed with the SEC on June 21, 2021. Additional information regarding the participants in the proxy solicitation and a description of their direct and indirect interests, by security holdings or otherwise, is set forth in the proxy statement relating to the proposed business combination.  

Hyzon Motors contacts 
For U.S., Europe and Asia media: 
Caroline Curran
Hill+Knowlton Strategies
+1 256-653-5811
[email protected] 

For Australasian media:
Fraser Beattie
Cannings Purple
+61 421 505 557
[email protected] 

For investors:
Caldwell Bailey
ICR, Inc.
[email protected] 

TotalEnergies Media Relations:
[email protected]

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SOURCE HYZON Motors

KalVista Pharmaceuticals Presents Data Showing Single On-Demand Treatment with Orally Administered KVD900 Significantly Slows Progression and Accelerates Resolution of Attacks in Patients with HAE

KalVista Pharmaceuticals Presents Data Showing Single On-Demand Treatment with Orally Administered KVD900 Significantly Slows Progression and Accelerates Resolution of Attacks in Patients with HAE

– Phase 2 data for KVD900 in late-breaking session at European Academy of Allergy and Clinical Immunology (EAACI) Congress –

CAMBRIDGE, Mass. & SALISBURY, England–(BUSINESS WIRE)–
KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors, today announced data presented for its oral drug candidates at the European Academy of Allergy and Clinical Immunology (EAACI) Congress. Data presentations include a late-breaking poster for the Phase 2 data for KVD900, KalVista’s lead drug program for oral on-demand treatment of hereditary angioedema (HAE) attacks, two posters on the prevalence and clinical management of normal C1-INH HAE in the US, and two posters on the Company’s earlier stage research assets.

“HAE patients continue to seek an oral option for on-demand treatment of their disease, to fully manage their disease or for breakthrough attacks for those on prophylaxis,” said Dr. Emel Aygören-Pürsün, Principal Investigator for the KVD900 Phase 2 Clinical Trial and Head of the HAE Center at the University Hospital Frankfurt. “As KVD900 halted attack progression and resolved attacks more quickly in patients with HAE, while demonstrating a good safety and tolerability profile, it could be a valued choice for physicians and patients in managing HAE.”

The late-breaking poster, titledA single on-demand treatment with orally administered KVD900 significantly slows progression and accelerates resolution of attacks in patients with hereditary angioedema (HAE): results of a phase 2, placebo-controlled, double-blind cross-over trial, contains the comprehensive data set from the company’s Phase 2 clinical trial of KVD900 in HAE patients. The presented data supports the topline results reported in February 2021.

  • Early use of KVD900 halted attack progression.
  • Use of KVD900 significantly shortened the time to improvement of attack symptoms.
  • KVD900 accelerated attack resolution.
  • KVD900 was generally safe and well tolerated in the study.

KalVista presented four other posters at EAACI related to the HAE clinical landscape and unmet needs, as well as preclinical data from other oral molecules.

Poster Title:Prevalence of hereditary angioedema with normal C1-inhibitor (nC1-HAE) in the United States: results from a nationwide survey of HAE-treating physicians

  • While patients with nC1-HAE require similar care to those with C1INH-HAE (type I and II), the population prevalence of this condition is unknown.
  • This study aimed to estimate the prevalence of nC1-HAE in the U.S. based on physician-level prescription data and responses to an internet-based survey which yielded 113 survey responses.
  • Respondents were required to have seen at least 5 HAE patients in the prior 12 months and treated at least 1 nC1-HAE patient in that timeframe.
  • The estimated prevalence for nC1-HAE was 0.44 per 100,000, accounting for up to 16.4%-22.7% of the total HAE population.
  • Patients with nC1-HAE may represent a more sizeable population of patients with HAE in the U.S. than previously suspected.

Poster Title:Current management of hereditary angioedema with normal C1-inhibitor (nC1-HAE) in the United States: results from a nationwide survey of HAE-treating physicians

  • Robust study data are lacking on the management of patients with nC1-HAE.
  • The study included a 10-minute online survey of specialist practices managing HAE who commonly evaluate and treat patients with HAE and nC1-HAE.
  • Patients are currently managed and treated with medications studied in patients with HAE types I and II, with icatibant being the most commonly used treatment for acute attacks and lanadelumab most preferred for prophylaxis.
  • The highest-ranked unmet need in acute treatment and preventative care was for an oral, FDA-approved, nC1-HAE-specific treatment.

Poster Title: Oral plasma kallikrein inhibitor KV998052 improves arterial blood oxygenation in a murine model of acute respiratory distress syndrome (ARDS)

  • Recent data from published sources support the association of kallikrein-kinin activation and bradykinin generationwith SARS-CoV-2 induced acute respiratory distress syndrome (ARDS).
  • Pretreatment of mice with orally administered KV998052 was associated with significantly improved blood oxygenation in mice with HCI induced ARDS compared with mice receiving vehicle.
  • Pharmacological inhibition of plasma kallikrein (PKa) provides a therapeutic opportunity to improve arterial blood oxygenation in ARDS.

Poster Title:Selective oral Factor XIIa inhibitor KV998083 protects mice against captopril induced vascular leakage and cleavage of high molecular weight kininogen

  • In the study, FactorXII knockout mice were fully protected against captopril-induced leakage.
  • KV998083 achieved protection of kininogen (HK) in plasma.
  • These preclinical results suggest that Factor XIIa inhibition may prevent bradykinin-induced angioedema.

About KalVista Pharmaceuticals, Inc.

KalVista Pharmaceuticals, Inc. is a pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors for diseases with significant unmet need. KalVista has developed a proprietary portfolio of novel, small molecule plasma kallikrein inhibitors initially targeting hereditary angioedema (HAE) and diabetic macular edema (DME). KalVista is developing KVD900 as an oral on-demand therapy for acute HAE attacks, which completed a Phase 2 efficacy trial in February 2021, demonstrating statistical and clinical significance across all endpoints. KVD824 is in development for prophylactic treatment of HAE. In addition, KalVista’s oral Factor XIIa inhibitor program represents a new generation of therapies that may further improve the treatment of HAE for patients. In DME, an intravitreally administered plasma kallikrein inhibitor, called KVD001, has completed a Phase 2 clinical trial.

For more information, please visit www.kalvista.com.

Forward-Looking Statements

This press release contains “forward-looking” statements within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: “anticipate,” “intend,” “plan,” “goal,” “seek,” “believe,” “project,” “estimate,” “expect,” “strategy,” “future,” “likely,” “may,” “should,” “will” and similar references to future periods. These statements are subject to numerous risks and uncertainties, including the potential impact of COVID-19, that could cause actual results to differ materially from what we expect. Examples of forward-looking statements include, among others, our expectations about safety and efficacy of our product candidates and timing of clinical trials and its results, our ability to commence or complete clinical studies and to obtain regulatory approvals for KVD900, KVD824 and other candidates in development, our ability to resolve a clinical hold with regards to KVD824, the ability of KVD900, KVD824 and other candidates in development to treat HAE or DME, the size of the potential market or incidence rates of KVD900, the future progress and potential success of our oral Factor XIIa program, and the sufficiency of our cash, cash equivalents and investments to fund our operations. Further information on potential risk factors that could affect our business and financial results are detailed in our annual report on Form 10-K when it is filed, our quarterly reports on Form 10-Q, and other filings we may make from time to time with the Securities and Exchange Commission. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

KalVista Pharmaceuticals, Inc.

Leah Monteiro

Senior Director, Corporate Communications & Investor Relations

857-999-0808

[email protected]

KEYWORDS: Europe United States United Kingdom North America Massachusetts

INDUSTRY KEYWORDS: Biotechnology Pharmaceutical Health Clinical Trials

MEDIA:

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