ZipRecruiter to Report First Quarter 2023 Financial Results on May 9, 2023

ZipRecruiter to Report First Quarter 2023 Financial Results on May 9, 2023

SANTA MONICA, Calif.–(BUSINESS WIRE)–
ZipRecruiter®, a leading online employment marketplace, today announced that the company will report first quarter 2023 financial results for the quarter ended March 31, 2023, on Tuesday, May 9, 2023. On that day, management will host a conference call and webcast at 2:00pm PT (5:00pm ET) to discuss the company’s business and financial results.

Event: ZipRecruiter First Quarter 2023 Earnings Conference Call

Date: Tuesday, May 9, 2023

Time: 2:00pm PT (5:00pm ET)

Live Call: (888) 440-4199 or (646) 960-0818, Conference ID: 9351892

Live Webcast: investors.ziprecruiter.com

ZipRecruiter’s shareholder letter and a live webcast of the call will be available from the Investor Relations section of the company’s website at investors.ziprecruiter.com. A telephonic replay of the conference call will be available until Tuesday, May 16, 2023, and can be accessed by dialing (800) 770-2030 or (647) 362-9199 and using the Conference ID 9351892.

ABOUT ZIPRECRUITER

ZipRecruiter® (www.ziprecruiter.com) is a leading online employment marketplace that actively connects people to their next great opportunity. ZipRecruiter’s powerful matching technology improves the job search experience for job seekers and helps businesses of all sizes find and hire the right candidates quickly. ZipRecruiter has been the #1 rated job search app on iOS & Android for the past six years1 and is rated the #1 employment job site by G2.2

Visit us at ZipRecruiter.com and ZipRecruiter.com/blog.

1Based on job seeker app ratings, during the period of January 2017 to January 2023 from AppFollow for ZipRecruiter, CareerBuilder, Glassdoor, Indeed, LinkedIn, and Monster.

2Based on G2 satisfaction ratings as of December 13, 2022.

Investors:

Drew Haroldson

The Blueshirt Group, for ZipRecruiter

[email protected]

Corporate Communications:

Claire Walsh

Press Relations

[email protected]

KEYWORDS: California United States North America

INDUSTRY KEYWORDS: Professional Services Apps/Applications Technology Human Resources Mobile/Wireless Software Internet

MEDIA:

Logo
Logo

Usio to Host First Quarter Fiscal 2023 Conference Call to Discuss Results and Provide Company Update on May 3, 2023

Usio to Host First Quarter Fiscal 2023 Conference Call to Discuss Results and Provide Company Update on May 3, 2023

SAN ANTONIO–(BUSINESS WIRE)–
Usio, Inc. (Nasdaq:USIO), a leading FinTech that operates a full stack of integrated, cloud-based electronic payment and embedded financial solutions, today announced it will release first quarter fiscal 2023 financial results for the period ended March 31, 2023, after the market closes on Wednesday, May 3, 2023.

Usio’s management will host a conference call the same day, May 3, 2023, beginning at 4:30 p.m. eastern time to review financial results and provide a business update. Following management’s formal remarks, there will be a question-and-answer session.

To listen to the conference call, interested parties within the U.S. should call 1-844-883-3890. International callers should call 1-412-317-9246. All callers should ask for the Usio conference call. The conference call will also be available through a live webcast, which can be accessed via the company’s website at www.usio.com/investors.

A replay of the call will be available approximately one hour after the end of the call through June 3, 2023. The replay can be accessed via the Company’s website or by dialing 1-877-344-7529 (U.S.) or 1-412-317-0088 (international). The replay conference playback code is:4947465.

About Usio, Inc.

Usio, Inc. (Nasdaq: USIO), is a leading Fintech that operates a full stack of proprietary, cloud-based integrated payment and embedded financial solutions in a single ecosystem to a wide range of merchants, billers, banks, service bureaus and card issuers. The Company operates credit/debit and ACH payment processing platforms, as well as a turn-key card issuing platform to deliver convenient, world-class payment solutions and services to their clients. The company, through its Usio Output Solutions division offers services relating to electronic bill presentment, document composition, document decomposition and printing and mailing services. The strength of the Company lies in its ability to provide tailored solutions for card issuance, payment acceptance, and bill payments as well as its unique technology in the prepaid sector. Usio is headquartered in San Antonio, Texas, and has a development office in Austin, Texas.

Websites: www.usio.com, www.payfacinabox.com, www.akimbocard.com and www.usiooutput.com. Find us on Facebook® and Twitter.

FORWARD-LOOKING STATEMENTS DISCLAIMER

Except for the historical information contained herein, the matters discussed in this release include forward-looking statements which are covered by safe harbors. Those statements include, but may not be limited to, all statements regarding management’s intent, belief, and expectations, such as statements concerning our future and our operating and growth strategy. These forward-looking statements are identified by the use of words such as “believe,” “intend,” “look forward,” “anticipate,” “schedule,” and “expect” among others. Forward-looking statements in this press release are subject to certain risks and uncertainties inherent in the Company’s business that could cause actual results to vary, including such risks related to an economic downturn as a result of the COVID-19 pandemic, the realization of opportunities from the IMS acquisition, the management of the Company’s growth, the loss of key resellers, the relationships with the Automated Clearinghouse network, bank sponsors, third-party card processing providers and merchants, the security of our software, hardware and information, the volatility of the stock price, the need to obtain additional financing, risks associated with new tax legislation, and compliance with complex federal, state and local laws and regulations, and other risks detailed from time to time in the Company’s filings with the Securities and Exchange Commission including its annual report on Form 10-K for the fiscal year ended December 31, 2022. One or more of these factors have affected, and in the future, could affect the Company’s businesses and financial results in the future and could cause actual results to differ materially from plans and projections. The Company believes that the assumptions underlying the forward-looking statements included in this release will prove to be accurate. In light of the significant uncertainties inherent in the forward-looking statements included herein, the inclusion of such information should not be regarded as a representation by us or any other person that the objectives and plans will be achieved. All forward-looking statements made in this release are based on information presently available to management. The Company assumes no obligation to update any forward-looking statements, except as required by law.

Paul Manley

Senior Vice President, Investor Relations

[email protected]

612.834.1804

KEYWORDS: Texas United States North America

INDUSTRY KEYWORDS: Professional Services Payments Technology Finance Software Fintech

MEDIA:

Logo
Logo

Forrester Announces Full Conference Agenda For CX North America 2023

Forrester Announces Full Conference Agenda For CX North America 2023

The event will share actionable insights to help organizations align their customer-facing functions to increase customer retention and drive revenue growth

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Forrester (Nasdaq: FORR) today announced the full conference agenda for its CX North America event being held in Nashville, Tennessee, and digitally, June 13–15, 2023. Digital consumers are dictating the pace of business. To accelerate digital innovation to better meet customers’ evolving expectations, B2C organizations must align key functions — including customer experience (CX), marketing, and digital — around customer value. According to Forrester, firms with high levels of alignment across these customer-facing functions report 2.4x higher revenue growth and 2x higher growth in profitability than those with some or no alignment.

A must-attend event for CX, marketing, and digital leaders, CX North America will showcase role-based sessions, new research, proven frameworks, and tailored guidance to help leaders build their strategies around customer value to drive revenue growth. This year’s event will also honor the winners of Forrester’s 2023 North American Customer Obsession Awards, which recognize an organization and senior executive that put customers at the center of everything they do.

Noteworthy sessions include:

  • Supercharge Your Customer-Obsessed Growth Engine. The business world is finally moving at the speed that digital consumers demand. This session will explore how and why aligned marketing, CX, and digital functions can pivot organizations toward greater growth.
  • Customer Obsession For When The Going Gets Tough. This session explores how investing in customer obsession helps businesses thrive in uncertain times and how defaulting to comfortable old ways of doing business opens companies to acute new risks.
  • Manage Brand Growth In An Economic Downturn. While seemingly counterintuitive, now is the right time to craft a marketing strategy to drive short-term and long-term profitable growth. This session will highlight tactics that CMOs are utilizing today, in a time of economic uncertainty, to spur profitable growth.
  • The Right Leader For Turbulent Times. Even leaders who have successfully stepped up their organizations over the past two years are asking if they have what it takes to continue doing so in 2023. This session will help leaders see clearly through the cloud of economic and social uncertainty in order for them to guide their teams.
  • What To Do About The Coming Collapse Of The Customer Lifecycle. As interactions between consumers and companies become faster and more automated, customer experiences will become immediate ─ causing the old reliable distinctions among customer lifecycle phases to evaporate. This session dives into what customer experiences will be like after the collapse.
  • Creativity And Dynamism Must Power Your Digital Strategy. Learn how companies that drive profitable growth over multiple business cycles achieve this goal by pushing themselves to be more dynamic and creative — especially in their digital strategies.

“In this unsteady economy, it’s imperative that organizations zero in on their customers. Success in this environment will require customer obsession — putting the customer at the center of an organization’s leadership, strategy, and operations,” said Rick Parrish, event host and VP and research director at Forrester. “At CX North America, CX, B2C marketing, and digital leaders will learn the skills needed to align their ecosystems around shared goals to achieve growth during this tough time.”

In-person attendees will experience facilitated discussions, consulting workshops, and special sessions. They will also have access to several special programs, including Forrester’s CX Certification course and the Executive Leadership Exchange, an exclusive program targeted at C-level leaders.

Resources:

About Forrester

Forrester (Nasdaq: FORR) is one of the most influential research and advisory firms in the world. We help leaders across technology, customer experience, digital, marketing, sales, and product functions use customer obsession to accelerate growth. Through Forrester’s proprietary research, consulting, and events, leaders from around the globe are empowered to be bold at work — to navigate change and put their customers at the center of their leadership, strategy, and operations. Our unique insights are grounded in annual surveys of more than 700,000 consumers, business leaders, and technology leaders worldwide; rigorous and objective research methodologies, including Forrester Wave™ evaluations; 100 million real-time feedback votes; and the shared wisdom of our clients. To learn more, visit Forrester.com.

Shweta Agarwal

[email protected]

KEYWORDS: Massachusetts United States North America

INDUSTRY KEYWORDS: Digital Marketing Marketing Advertising Communications

MEDIA:

Logo
Logo

The University of Maryland Medical Center Chooses SOPHiA GENETICS Technology

The University of Maryland Medical Center Chooses SOPHiA GENETICS Technology

SOPHiA GENETICS supports The University of Maryland Medical Center to advance their rare disease research

BOSTON & LAUSANNE, Switzerland–(BUSINESS WIRE)–
SOPHiA GENETICS (Nasdaq: SOPH), a cloud-native software company in the healthcare space and a leader in data-driven medicine, today announced that the University of Maryland Medical Center (UMMC) is using SOPHiA GENETICS technology to enhance their capabilities around rare disease detection and treatment. UMMC has chosen SOPHiA Whole Exome Solution™ v2, a next-generation sequencing (NGS)-based application that provides a streamlined end-to-end workflow, to accelerate its rare and inherited disease research.

Rare diseases are estimated to affect over 30 million people in the United States, with more than 10,000 genetic and rare diseases currently known.1 NGS of the human exome analyzes exons, the protein-coding regions of the human genome, and has the potential to help detect and identify rare diseases. While whole-exome sequencing is reliable and cost-effective, it produces vast and complex genomic data sets. The SOPHiA Whole Exome Solution™ v2 is designed to aid users in sorting and analyzing these complex data sets.

The implementation of SOPHiA Whole Exome Solution ™ v2 will support UMMC’s work in furthering research of the rare diseases that are affecting millions of people each year. In addition, the technology will allow UMMC to deepen its in-house knowledge, making it faster for researchers to identify and categorize rare diseases.

The SOPHiA Whole Exome Solution™ v2 targets nuclear genes and the full mitochondrial genome. Coupled with the SOPHiA DDM™ Platform, the solution uses artificial intelligence and machine learning to analyze and interpret the data, increasing efficiency for researchers.

“UMMC’s implementation of SOPHiA Whole Exome Solution™ v2 will help to further our work at SOPHiA GENETICS to make data-driven medicine more accessible for patients worldwide,” said Ken Freedman, Chief Revenue Officer, SOPHiA GENETICS. “The identification of rare diseases is complex, timely and costly. Our technology is designed to ease the burden for researchers and allow them to more thoroughly and quickly analyze complex datasets, benefitting the rare disease community as a whole.”

As part of their research, UMMC will work to characterize the genetic basis of inherited rare disorders, including mitochondrial variants. Mutations in mitochondrial DNA (mtDNA) cause a diverse range of diseases affecting a substantial portion of the rare disease community.2 NGS of the mitochondrial genome, alongside the exome, is therefore valuable in rare disease research. SOPHiA DDM™ Platform’s sophisticated algorithms will help to address the unique challenges associated with the mitochondrial genome and further expedite the work of researchers at UMMC.

For more information on SOPHiA GENETICS, visit SOPHiAGENETICS.COM, or connect on Twitter, LinkedIn, Facebook, and Instagram.

About SOPHiA GENETICS

SOPHiA GENETICS (Nasdaq: SOPH) is a cloud-native software company in the healthcare space dedicated to establishing the practice of data-driven medicine as the standard of care and for life sciences research. It is the creator of the SOPHiA DDM™ Platform, a cloud-native platform capable of analyzing data and generating insights from complex multimodal data sets and different diagnostic modalities. The SOPHiA DDM™ Platform and related solutions, products and services are currently used by a broad global network of hospitals, academic centers, laboratories and biopharma institutions. For more information, visit SOPHiAGENETICS.COM, or connect on Twitter, LinkedIn, Facebook, and Instagram. Where others see data, we see answers.

SOPHiA GENETICS products are for Research Use Only and not for use in diagnostic procedures, unless specified otherwise. The information in this press release is about products that may or may not be available in different countries and, if applicable, may or may not have received approval or market clearance by a governmental regulatory body for different indications for use. Please contact [email protected] to obtain the appropriate product information for your country of residence.

SOPHiA GENETICS Forward-Looking Statements:

This press release contains statements that constitute forward-looking statements. All statements other than statements of historical facts contained in this press release, including statements regarding our future results of operations and financial position, business strategy, products, and technology, as well as plans and objectives of management for future operations, are forward-looking statements. Forward-looking statements are based on our management’s beliefs and assumptions and on information currently available to our management. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including those described in our filings with the U.S. Securities and Exchange Commission. No assurance can be given that such future results will be achieved. Such forward-looking statements contained in this press release speak only as of the date hereof. We expressly disclaim any obligation or undertaking to update these forward-looking statements contained in this press release to reflect any change in our expectations or any change in events, conditions, or circumstances on which such statements are based, unless required to do so by applicable law. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.

1https://rarediseases.info.nih.gov/

2https://www.sophiagenetics.com/clinical/rare-and-inherited-diseases/rare-diseases/

Media:

Nick Puleo

[email protected]

KEYWORDS: Massachusetts Europe Switzerland United States North America

INDUSTRY KEYWORDS: Technology Genetics Health Technology Software Networks Health University Data Management Education

MEDIA:

Logo
Logo

MAIA Biotechnology Announces Excellent Efficacy of THIO in Liver Cancer Models

MAIA Biotechnology Announces Excellent Efficacy of THIO in Liver Cancer Models

  • Study showed THIO with complete and durable responses in Hepatocellular Carcinoma (HCC), or the dominate histology in primary liver cancer (90%), in vivo models

  • When combined with immunotherapy checkpoint inhibitor (CPI), duration of response was further potentiated

  • Administration of THIO alone and in combination with CPI generated anti-cancer immune memory Upon rechallenge with two times more cancer cells and no additional treatment, tumor growth was completely prevented

CHICAGO–(BUSINESS WIRE)–
MAIA Biotechnology, Inc. (NYSE American: MAIA) today announced the peer-reviewed publication of original research article in this month’s issue of Molecular Cancer Therapeutics (volume 22, issue 4), a renowned American Association of Cancer Research (AACR) journal that publishes translational research studies focused on the discovery and preclinical development of therapeutic agents for oncology. The preclinical study, entitled “Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma,” showed highly potent anticancer activity of THIO in multiple HCC preclinical models.

The study revealed the anti-tumor immune response role of THIO as a telomerase-dependent telomere targeting therapeutic in HCC models. THIO induces telomere damage and activates the cGAS-STING pathway, which is a major intracellular signaling pathway that plays a role in innate immune responses. THIO enhances the cross-priming capacity of dendritic cells (DCs), which are antigen presenting cells of the adaptive immune system and activates tumor specific T cells. Observed potent anticancer activity is taking place in CD8-positive T cell dependent manner. Moreover, the study showed a potential role of immunogenic protein molecule HMGB1 (high-mobility group box 1, which are released during cancer cell death), in THIO induced T cell activation. In addition, the study demonstrated enhanced efficacy and durability of complete tumor regression when THIO is followed by administration of immunotherapies (an anti-PD-1 or anti-PD-L1) and anti-VEGF (anti-vascular endothelial growth factor, one of the major anti-angiogenic drug target) in advanced, resistant HCC tumors providing a strong scientific rationale for a clinical trial in HCC.

“The knowledge gained from this study will help support our understanding of the compound’s mechanism of action and its broad therapeutic utility. Moreover, this publication strengthens our scientific rationale already included in our current clinical development plan for THIO-102, a Phase 2 clinical study in multiple solid tumor indications, including HCC,” said MAIA’s Chief Scientific Officer Sergei Gryaznov, Ph.D.

“The findings from our study provides solid rationale for THIO to be evaluated as a treatment of liver cancer, as our Company already holds the US FDA Orphan Drug Designation for this clinical indication. This published evidence supports our strong belief that THIO, especially in combination with immune checkpoint inhibitors and other standard of care agents, may be clinically studied for treatment of various forms of cancer,” added Vlad Vitoc, M.D., MAIA’s Chief Executive Officer.

The full results are available in Molecular Cancer Therapeutics and online here.

About MAIA Biotechnology, Inc.

MAIA is a targeted therapy, immuno-oncology company focused on the development and commercialization of potential first-in-class drugs with novel mechanisms of action that are intended to meaningfully improve and extend the lives of people with cancer. Its lead program is THIO, a potential first-in-class cancer telomere targeting agent in clinical development for the treatment of NSCLC patients with telomerase-positive cancer cells. For more information, please visit www.maiabiotech.com.

Forward Looking Statements

MAIA cautions that all statements, other than statements of historical facts, contained in this press release, are forward-looking statements. Forward-looking statements are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry’s actual results, levels or activity, performance or achievements to be materially different from those anticipated by such statements. The use of words such as “may,” “might,” “will,” “should,” “could,” “expect,” “plan,” “anticipate,” “believe,” “estimate,” “project,” “intend,” “future,” “potential,” or “continue,” and other similar expressions are intended to identify forward looking statements. However, the absence of these words does not mean that statements are not forward-looking. For example, all statements we make regarding (i) the initiation, timing, cost, progress and results of our preclinical and clinical studies and our research and development programs, (ii) our ability to advance product candidates into, and successfully complete, clinical studies, (iii) the timing or likelihood of regulatory filings and approvals, (iv) our ability to develop, manufacture and commercialize our product candidates and to improve the manufacturing process, (v) the rate and degree of market acceptance of our product candidates, (vi) the size and growth potential of the markets for our product candidates and our ability to serve those markets, and (vii) our expectations regarding our ability to obtain and maintain intellectual property protection for our product candidates, are forward looking. All forward-looking statements are based on current estimates, assumptions and expectations by our management that, although we believe to be reasonable, are inherently uncertain. Any forward-looking statement expressing an expectation or belief as to future events is expressed in good faith and believed to be reasonable at the time such forward-looking statement is made. However, these statements are not guarantees of future events and are subject to risks and uncertainties and other factors beyond our control that may cause actual results to differ materially from those expressed in any forward-looking statement. Any forward-looking statement speaks only as of the date on which it was made. We undertake no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law. In this release, unless the context requires otherwise, “MAIA,” “Company,” “we,” “our,” and “us” refers to MAIA Biotechnology, Inc. and its subsidiaries.

 

Investor Inquiries

MAIA Biotechnology

Joseph McGuire

Chief Financial Officer

[email protected]

904-228-2603

ICR Westwicke

Stephanie Carrington

[email protected]

646-277-1282

KEYWORDS: Illinois United States North America

INDUSTRY KEYWORDS: Oncology FDA Health Clinical Trials Pharmaceutical Biotechnology

MEDIA:

Logo
Logo

Lincoln Educational Services Corporation Selects Cushman & Wakefield as Exclusive Real Estate Services Provider

Parsippany, NJ, April 18, 2023 (GLOBE NEWSWIRE) — Lincoln Educational Services Corporation (NASDAQ: LINC), a national leader in specialized technical training for more than 75 years, announced today that it has retained Cushman & Wakefield as its exclusive real estate services provider across the United States.

“Cushman & Wakefield’s national coverage and platform of resources will be instrumental in helping us achieve our real estate goals as well as our overall growth initiatives,” said Brian Meyers, Lincoln Tech’s Chief Financial Officer. “We look forward to having them as our trusted advisors, especially as we continue to evaluate additional opportunities for expansion.”

Cushman & Wakefield’s Edward Duenas and Ryan DePaul will serve as the exclusive real estate advisors for the company.

“We are thrilled to partner with Lincoln Educational Services to build upon the company’s success and help them achieve their strategic growth objectives,” said Duenas. “We look forward to expanding Lincoln’s footprint across multiple markets and delivering customized real estate solutions.”

Lincoln Educational Services, headquartered in Parsippany, New Jersey, is a highly successful publicly traded private educational institution currently operating 22 campuses in 14 states. Lincoln is looking to expand into new markets to help fill the skills gap that companies across the country are experiencing in a variety of essential industries. Lincoln provides superior education and training for in-demand careers to its students in the automotive, skilled trades, health sciences, culinary, spa & cosmetology, and information technology fields.

###

 

About Lincoln Educational Services Corporation

Lincoln Educational Services Corporation is a leading provider of diversified career-oriented post-secondary education. Lincoln offers recent high school graduates and working adults career-oriented programs in five principal areas of study: automotive technology, health sciences, skilled trades, business and information technology, and hospitality services. Lincoln has provided the workforce with skilled technicians since its inception in 1946. Lincoln currently operates 22 campuses in 14 states under four brands: Lincoln College of Technology, Lincoln Technical Institute, Lincoln Culinary Institute and Euphoria Institute of Beauty Arts and Sciences. For more information, please go to www.lincolntech.edu.

 

About Cushman & Wakefield
 

Cushman & Wakefield (NYSE: CWK) is a leading global real estate services firm that delivers exceptional value for real estate occupiers and owners. Cushman & Wakefield is among the largest real estate services firms with approximately 52,000 employees in over 400 offices and approximately 60 countries. In 2022, the firm had revenue of $10.1 billion across core services of property, facilities and project management, leasing, capital markets, and valuation and other services. To learn more, visit www.cushmanwakefield.com or follow @CushWake on Twitter. 



Peter Tahinos
Lincoln Educational Services
973-766-9656
[email protected]

Monaghan Medical and Premier Inc. Sign AscenDrive Contract

Partnership makes Monaghan respiratory devices part of AscenDrive supply chain to improve patient outcomes

PLATTSBURGH, N.Y., April 18, 2023 (GLOBE NEWSWIRE) — Monaghan Medical Corporation (Monaghan) and Premier, Inc., today announced their agreement to a three-year contract, effective May 1, 2023, creating a partnership between two healthcare industry leaders. Through this partnership, Monaghan will provide Premier AscenDrive Program members with respiratory devices in two categories: Respiratory Therapy Medication Delivery devices and Oscillatory Positive Expiratory Pressure/Positive Airway Pressure devices.

The agreement, specific to Premier’s committed AscenDrive performance group, recognizes the value of Monaghan’s medical devices in treating COPD, asthma, and respiratory illness. The signed agreement acknowledges Monaghan’s reputation for both industry-leading technology and proven clinical outcomes. Monaghan’s devices consistently show evidence of better patient outcomes and are gold-standard medical devices. Monaghan’s respiratory devices also align with Premier’s desire to drive process efficiencies and value-driven healthcare spending.

AscenDrive is Premier’s unique new national program designed to drive the highest-level commitment and savings for members through aggregated purchasing of high-quality products and services. The collaborative agreement will also leverage Premier’s robust tools and services to measure and improve the cost and quality of care. Standardizing the care delivery process is a central pillar within the total cost management approach in achieving highly reliable care

Monaghan is a U.S.-based manufacturer based in Plattsburgh, New York. Monaghan and its affiliates are leaders in the development and manufacture of medical devices that improve the quality of life for patients with respiratory diseases like asthma, Cystic Fibrosis, and COPD. Monaghan’s strength lies in product development and mechanical design supported by a world-class Aerosol and Research Laboratory.

During the COVID-19 pandemic, Monaghan was able to respond quickly to fluctuating market demands, primarily because their suppliers are within driving distance from their production facility, which meant a quick response to the changing healthcare needs.

To learn more about Monaghan Medical products, visit www.monaghanmed.com

About Monaghan Medical Corporation (MMC)

Monaghan Medical Corporation focuses on developing cost-efficient, outcome-based solutions for its customers and continues to introduce new products and new product enhancements to support its mission to ensure device quality for patients. MMC’s strength lies in product development around core capabilities in mechanical design complimented by collaboration with a state-of-the-art Global Aerosol and Research Laboratory.

About Premier

Premier Inc. (NASDAQ: PINC) is a healthcare improvement company uniting an alliance of approximately 4,400 U.S. hospitals and health systems and more than 250,000 other providers and organizations. Our goal is to improve our members’ quality outcomes, while safely reducing costs. By engaging members and revealing new opportunities, we empower the alliance to improve the performance of healthcare organizations, helping them do what they do best, Heal First™.


For information contact:


Bill Seitz, MBA
Vice President, Sales & Marketing
Monaghan Medical Corporation
1-800-833-9653



Qualigen Therapeutics Announces Four Posters on QN-302 Presented at the American Association of Cancer Research (AACR) 2023 Annual Meeting in Orlando, FL

CARLSBAD, Calif., April 18, 2023 (GLOBE NEWSWIRE) — Qualigen Therapeutics, Inc. (“Qualigen” or “the Company,” Nasdaq: QLGN), a diversified life sciences company focused on developing treatments for adult and pediatric cancers with potential for Orphan Drug Designation, while also commercializing diagnostics, today announces data from the Company’s four posters regarding its’ lead program, QN-302, was presented at the American Association for Cancer Research (AACR) Annual Meeting 2023 held April 14-19 in Orlando, FL.

“These data corroborate our approach in utilizing QN-302 as a potential treatment for pancreatic cancer, as they provide significant and encouraging understanding of how the compound interacts with in vitro and in vivo PDAC models,” commented Dr. Tariq Arshad, Qualigen’s Chief Medical Officer. “We continue to be on track to complete our preparations for submitting an Investigational New Drug (IND) package to the FDA with the goal to proceed to Phase 1 trials with QN-302, and we believe these data will play an integral role in that regard toward becoming a clinical stage company.”

The Annual AACR Conference is a focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine.

Highlights from
QN-302
Posters

Abstract #390 – A comparison of the activity of the quadruplex-targeting experimental drugs QN-302 and CX-5461 (Pidnarulex) in wild-type and gemcitabine-resistant pancreatic cancer cell linesAhmed Ahmed, Tariq Arshad, and Stephen Neidle – Results demonstrated that QN-302 (10-fold more potent than CM03), retains potency in the two gemcitabine resistant cell lines. Up-regulated G4 genes in the resistant line are down-regulated by QN-302. The retention of QN-302 activity in chemo-resistant PDAC cell lines suggests that it may potentially offer significant advantage in the clinic over gemcitabine-based therapies. Gemcitabine either alone or in combination is still among the standard of care for current PDAC treatment. Resistance to gemcitabine is common and is a major contributor to the poor outcomes for most PDAC patients.

Compound MIA-PaCa2
Parental (S)
MIA-PaCa2

GemResist
PANC-1

Parental
PANC-1

GemResist
 
Gemcitabine 6.5 ± 0.7 11055.7 ± 540.0 23.3 ± 8.4 28750.9 ± 6121.3  
CM03 13.0 ± 8.4 14.9 ± 8.3 10.4 ± 1.2 15.5 ± 1.8  
CX-5461 90.3 ± 30.7 88.7 ± 22.0 32.9 ± 7.6 58.8 ± 13.8  
QN-302 2.6 ± 1.0 3.8 ± 1.2 2.3 ± 0.4 3.3 ± 0.7  


Abstract #4981 – “The potent quadruplex-binding compound QN-302 down-regulates the S100P gene in vitro and in vivo models of pancreatic cancer: a potential therapeutic target and biomarker for PDACNicole Williams, Jenny Worthington, Ahmed Ahmed, Tariq Arshad andStephen NeidleThe poster highlighted that QN-302 showed lower expression of the S100P gene on xenograft models following dosing either twice or four times weekly with QN-302 (P < 0.05, P < 0.01). S100P is elevated in human PDAC. Investigators posit that S100P may be a potential biomarker for QN-302 therapy as it contains a G4 in its promoter region and binds QN-302.

Abstract #6240 – “The potent quadruplex-binding compound QN-302 shows anti-tumor activity as a monotherapy in an orthotopic in vivo model of pancreatic cancer”Nicole Williams, Danielle Santos, Jenny Worthington, Ahmed Ahmed, Tariq Arshad and Stephen NeidleStudy authors identify orthotopic study as the fourth in vivo pancreatic cancer model showing anticancer activity for QN-302, further confirming its potential for human cancer treatment.

Abstract #3098 – “Structure-based design rules for potent quadruplex-binding compounds based on the naphthalene diimide core” Stephen NeidleThe study author concluded that the available data indicates that G4 affinity is necessary but insufficient for cellular activity. The ND core contributes little to G4 affinity. Charged side chains are important for strong G4 binding and cellular activity; >2 cationic side chains are required for both G4 binding and activity. Four highly cationic side chains reduce cellular activity but enhance G4 affinity – less basic morpholine groups enhance it. Molecular modeling suggests that enhancing the ND core with a planar hydrophobic group could increase G4 affinity and enhance cellular uptake. Four basic side chains, two of which are morpholino, are used to optimize the series without excess basicity. Docking QN-302 into the G4-duplex structure (using MOLSOFT) indicates that the phenyl substituent is well stacked on a G of the quartet, as predicted.

About
QN-302

QN-302 is a small molecule G-Quadruplex (G4)-selective transcription inhibitor in development for the treatment of G4-expressing tumors, such as pancreatic cancer (PDAC), prostate cancer, sarcomas, Gastrointestinal Stromal Tumors (GIST), and others. Orphan Drug Designation (ODD) was granted by the FDA in January of this year for pancreatic cancer. QN-302 is currently in IND enabling studies toward submission of an Investigational New Drug (IND) application.

About
Qualigen
Therapeutics,
Inc.

Qualigen Therapeutics, Inc. is a diversified life sciences company focused on developing treatments for adult and pediatric cancer, while also commercializing diagnostics. Our investigational QN-302 compound is a small molecule selective transcription inhibitor with strong binding affinity to G4s prevalent in cancer cells; such binding could, by stabilizing the G4s against “unwinding,” help inhibit cancer cell proliferation. The investigational compounds within Qualigen’s family of RAS oncogene protein-protein interaction inhibitor small molecules are believed to inhibit or block the binding of mutated RAS genes’ proteins to their effector proteins, thereby leaving the proteins from the mutated RAS unable to cause further harm. In theory, such mechanism of action may be effective in the treatment of about one quarter of all cancers, including certain forms of pancreatic, colorectal, and lung cancers. Our investigational QN-247 compound inhibits nucleolin, a key multi-functional regulatory protein that is overexpressed in cancer cells; QN-247 may thereby be able to inhibit the cells’ proliferation. QN-247 has shown promise in preclinical studies for the treatment of acute myeloid leukemia (AML). In addition to its oncology drug pipeline, Qualigen has an established diagnostics business which manufactures and distributes proprietary and highly accurate rapid blood testing systems to physician offices and small hospitals for the management of prostate cancer and other diseases and health conditions.

For more information about Qualigen Therapeutics, Inc., please visit www.qualigeninc.com.

Contact:

Jules Abraham
JQA Partners, Inc.
917-885-7378
[email protected]

Source: Qualigen Therapeutics, Inc.

Attachments



Oncocyte Presents New Data at AACR

IRVINE, Calif., April 18, 2023 (GLOBE NEWSWIRE) — Oncocyte Corporation (Nasdaq: OCX), a precision diagnostics company, today announced that five posters of original research are being presented at the Annual Meeting of the American Association for Cancer Research. Four abstracts explore the tumor microenvironment and its potential implications for therapeutic response, leveraging expertise and technology behind DetermaIO. A fifth poster highlights exciting study results applying DetermaCNI, Oncocyte’s proprietary therapeutic monitoring blood test, to metastatic pancreatic cancer.


  1. Cronister, et al. “Methylation as a surrogate for mutations to identify therapeutic targets”

  2. Seitz, et al. “Using tumor immune microenvironment physiologic profiling to tailor immune checkpoint inhibitor diagnostic classification”

  3. Cronister, et al. “The role of microRNAs in the tumor immune microenvironment”

  4. Ring, et al. “In Silico dissection of immune infiltrate signatures that are detected by DetermaIO, a predictor of response to immune therapy”

  5. Cannas, et al. “Liquid biopsy signature combining copy number instability and mutant KRAS detection is associated with survival for patients with metastatic pancreatic cancer”

“DetermaIO continues to build its case as the best-in-class measure of the tumor microenvironment. We are making rapid progress on feasibility for a Research Use Only version of this test to support researchers who need a better tool to identify patients poised to respond to immunotherapies,” said Joshua Riggs, Oncocyte CEO. “And DetermaCNI is a blood-only solution for efficacy monitoring, which we believe will make it an attractive alternative for researchers that need to conserve precious tissue, since no upfront tumor typing is required.”

About Oncocyte

Oncocyte is a precision diagnostics company. The Company’s tests are designed to help provide clarity and confidence to physicians and their patients. DetermaIO™ is a gene expression test that assesses the tumor microenvironment to predict response to immunotherapies. VitaGraft™ is a blood-based solid organ transplantation monitoring test, and pipeline test DetermaCNI™ is blood-based monitoring tool for assessing therapeutic efficacy in cancer. 

DetermaIO™, DetermaCNI™, and VitaGraft™ are trademarks of Oncocyte Corporation.

Forward-Looking Statements

Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,” “may,” and similar expressions) are forward-looking statements. These statements include those pertaining to, among other things, the expectation that there will be a Research Use Only version of DetermaIO to support researchers who need a better tool to identify patients poised to respond to immunotherapies, the expectation that DetermaCNI will be an attractive alternative for researchers that need to conserve precious tissue, and other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management. Forward-looking statements involve risks and uncertainties, including, without limitation, the potential impact of COVID-19 on Oncocyte or its subsidiaries’ financial and operational results, risks inherent in the development and/or commercialization of diagnostic tests or products, uncertainty in the results of clinical trials or regulatory approvals, the capacity of Oncocyte’s third-party supplied blood sample analytic system to provide consistent and precise analytic results on a commercial scale, potential interruptions to supply chains, the need and ability to obtain future capital, maintenance of intellectual property rights in all applicable jurisdictions, obligations to third parties with respect to licensed or acquired technology and products, the need to obtain third party reimbursement for patients’ use of any diagnostic tests Oncocyte or its subsidiaries commercialize in applicable jurisdictions, and risks inherent in strategic transactions such as the potential failure to realize anticipated benefits, legal, regulatory or political changes in the applicable jurisdictions, accounting and quality controls, potential greater than estimated allocations of resources to develop and commercialize technologies, or potential failure to maintain any laboratory accreditation or certification. Actual results may differ materially from the results anticipated in these forward-looking statements and accordingly such statements should be evaluated together with the many uncertainties that affect the business of Oncocyte, particularly those mentioned in the “Risk Factors” and other cautionary statements found in Oncocyte’s Securities and Exchange Commission (SEC) filings, which are available from the SEC’s website. You are cautioned not to place undue reliance on forward-looking statements, which speak only as of the date on which they were made. Oncocyte undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.

Investor Contact

Jesse Arno
(949) 409-6770
[email protected]  



LuxUrban Hotels Secures Multi-Year Extension and Conversion of Debt Expected to Significantly Improve Cash Position, Enhance Growth Prospects, and Accelerate Free Cash Flow

LuxUrban Hotels Secures Multi-Year Extension and Conversion of Debt Expected to Significantly Improve Cash Position, Enhance Growth Prospects, and Accelerate Free Cash Flow

MIAMI–(BUSINESS WIRE)–LuxUrban Hotels Inc. (Nasdaq: LUXH) (or “the Company”), which utilizes an asset-light business model to lease entire hotels on a long-term basis and rent out hotel rooms in these properties in key major metropolitan cities, announced today that on April 16, 2023 it entered into an agreement with the holder of its’ senior secured convertible notes (“Convertible Notes”) totaling approximately $5 million. The terms of this agreement are designed to allow the Company, subject to the satisfaction of certain conditions, to eliminate all debt associated with the Convertible Notes and gain access to new equity capital through a mandatory conversion feature.

Terms of the amended agreement include:

  • a two-year extension on the maturity of the Convertible Notes to April 15, 2025;

  • an agreement by the holder of the Convertible Notes to a modification of the terms of the Convertible Notes and existing warrants that it holds (separate and apart from the new warrants described below), which are registered for resale, that has the effect of increasing the equity capital and cash position of the Company through a mandatory conversion feature; and

  • the issuance by the Company to the holder of the Convertible Notes a new warrant to purchase 1,000,000 shares of common stock at an exercise price of $3 per share and a new warrant to purchase 250,000 shares of common stock at an exercise price of $4 per share. The closing price of Company’s common stock on the date of the agreement was $2.995.

“Should the mandatory conversion feature be exercised in full on both the Convertible Notes and existing warrants, we would eliminate all senior secured debt associated with the Convertible Notes and generate new funding of approximately $8.3 million through the exercise of the existing warrants,” said Brian Ferdinand, Chairman and Chief Executive Officer. “We appreciate the continued willingness of our debt holders to amend the terms of our pre-IPO financing agreements. We believe that their continued support in this regard reflects their recognition of the evolution of our business model, an acknowledgment of the opportunities inherent in our industry, and faith in our ability to deliver long-term value for all shareholders.”

“As our business continues to grow and mature, we remain focused on strengthening our financial position with emphasis on debt reduction and free cash flow generation, without compromising our projected growth targets,” said Shanoop Kothari, President and Chief Financial Officer. “This agreement reflects our success in advancing these initiatives.”

Terms and Conditions

Subject to the satisfaction of certain conditions, the Convertible Debt and the existing warrants are subject to a mandatory conversion into common stock if the VWAP of common shares for each of the three trading days prior to the forced conversion is at least equal to the Trigger Price. For the Convertible Debt and the existing warrants issued at $2 per share (1,856,251 shares) the Trigger Price is $3/share; for Convertible Debt and existing warrants issued at $3 per share (1,000,000 shares), the Trigger Price is $4 per share; and for Convertible Debt and existing warrants issued at $4 per share (250,000 shares), the Trigger Price is $5.50/share.

Among the conditions that must be met prior to a mandatory conversion, in addition to the Trigger Price condition: (i) the shares underlying the Convertible Note or existing warrants must be registered with the Securities and Exchange Commission for resale; (ii) the aggregate dollar volume of the common stock sold on the principal trading market over the 10 consecutive days prior to conversion is at least $3.75 million; and (iii) no mandatory conversion would cause the holder of the Convertible Notes to beneficially own more than 9.9 percent of the common stock.

Additional terms and details regarding the amended Agreement shall be available in a Form 8-K to be filed by the Company with the Securities and Exchange Commission on or about April 18, 2023.

LuxUrban Hotels Inc.

LuxUrban Hotels Inc. utilizes an asset light business model to lease entire hotels on a long-term basis and rent out hotel rooms in the properties it leases to business and vacation travelers through the company’s online portal and third-party sales and distribution channels. The company currently manages a portfolio of hotel rooms in New York, Washington D.C., Miami Beach, New Orleans and Los Angeles. As of the date of this release, the company has approximately 1,200 hotel rooms available for rent, and seeks to rapidly build its portfolio on favorable economics through the acquisition of additional accommodations that were dislocated or are underutilized as a result of the pandemic and current economic conditions. In late 2021, the company commenced the process of winding down its legacy business of leasing and re-leasing multifamily residential units, as it pivoted toward its new strategy of leasing hotels. This transition has been substantially completed.

Forward Looking Statements

This press release contains forward-looking statements, including with respect to the anticipated success of the transactions contemplated by this press release, the ability of the Company to eliminate all debt associated with the Convertible Notes and gain access to new equity capital through a mandatory conversion feature and the Company’s ability to commercialize efficiently and profitably the properties it leases and will lease in the future. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including those set forth under the caption “Risk Factors” in our public filings with the SEC, including in Item 1A of our 10-K for the year ended December 31, 2022. Generally, such forward-looking information or forward-looking statements can be identified by the use of forward-looking terminology such as “plans”, “expects” or “does not expect”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates” or “does not anticipate”, or “believes”, or variations of such words and phrases or may contain statements that certain actions, events or results “may”, “could”, “would”, “might” or “will be taken”, “will continue”, “will occur” or “will be achieved”. Forward-looking information may relate to anticipated events or results including, but not limited to business strategy, leasing terms, high-level occupancy rates, and sales and growth plans. The financial projections provided herein are based on certain assumptions and existing and anticipated market, travel and public health conditions, all of which may change. The forward-looking information and forward-looking statements contained in this press release are made as of the date of this press release, and the Company does not undertake to update any forward-looking information and/or forward-looking statements that are contained or referenced herein, except in accordance with applicable securities laws.

LuxUrban Hotels Inc.

Shanoop Kothari

President & Chief Financial Officer

[email protected]

The Equity Group Inc.

Devin Sullivan, Managing Director

[email protected]

KEYWORDS: Florida United States North America

INDUSTRY KEYWORDS: Commercial Building & Real Estate Construction & Property Professional Services Other Travel Lodging Vacation Destinations Residential Building & Real Estate Travel Other Professional Services

MEDIA:

Logo
Logo