Trevi Therapeutics to Participate in Upcoming September Conferences

PR Newswire


NEW HAVEN, Conn.
, Aug. 28, 2025 /PRNewswire/ — Trevi Therapeutics, Inc. (Nasdaq: TRVI), a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine ER)  for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF), non-IPF interstitial lung disease (non-IPF ILD), and refractory chronic cough (RCC), today announced that senior management will be participating in the following conferences in September.


2025 Wells Fargo Healthcare Conference


September 3 – 5, 2025, Everett, Massachusetts
Trevi Representatives: Jennifer Good, President and CEO, and Farrell Simon, Pharm.D. CCO


Cantor Global Healthcare Conference 2025


September 3 – 5, 2025, New York, New York
Trevi Representatives: Jennifer Good, President and CEO, and James Cassella, Ph.D., CDO


Morgan Stanley 23rd Annual Global Healthcare Conference


September 8 – 10, 2025, New York, New York
Fireside Chat:September 9, 4:05 p.m. ET
Trevi Representatives: Jennifer Good, President and CEO, and James Cassella, Ph.D., CDO
Register here to watch the live presentation.


H.C. Wainwright & Co. 27th Annual Global Investment Conference


September 8 – 10, 2025, New York, New York
Trevi Representatives: Jennifer Good, President and CEO, and Farrell Simon, Pharm.D. CCO


2025 Leerink Partners Biopharma Summit


September 17 – 19, 2025, Healdsburg, California
Trevi Representative: Jennifer Good, President and CEO


European Respiratory Society (ERS) Congress


September 27 – October 1, 2025, Amsterdam, Netherlands
Trevi Representatives: Jennifer Good, President and CEO, and James Cassella, Ph.D., CDO, Danine Summers, Vice President of Medical Affairs, and Abbey Nakano, Pharm.D., Associate Director of Medical Affairs

About Trevi Therapeutics, Inc.    
Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing the investigational therapy Haduvio™ (oral nalbuphine extended-release) for the treatment of chronic cough in patients with idiopathic pulmonary fibrosis (IPF), non-IPF interstitial lung disease (non-IPF ILD), and refractory chronic cough (RCC). Haduvio is the first and only investigational therapy to show a statistically-significant reduction in cough frequency in clinical trials of patients with IPF chronic cough and in patients with RCC. Haduvio acts on the cough reflex arc both centrally and peripherally as a kappa agonist and a mu antagonist (KAMA), targeting opioid receptors that play a key role in controlling chronic cough. Nalbuphine is not currently scheduled by the U.S. Drug Enforcement Agency.

Chronic cough is a highly prevalent condition, impacting up to 85% of patients with IPF. There are ~150,000 patients in the U.S. with IPF. The impact of chronic cough is significant with patients coughing up to 1,500 times per day. This consistent cough and any associated damage may lead to worsening disease, a higher risk of progression, death, or need for lung transplant. Chronic cough also often leads to a decline in patients’ social, physical, and psychological quality of life. There are no approved therapies for the treatment of chronic cough in patients with IPF and current off-label treatment options provide minimal benefit to patients.

Refractory chronic cough has no approved therapies in the U.S. and is defined as a persistent cough lasting >8 weeks despite treatment for an underlying condition (i.e., asthma, gastroesophageal reflux disease, non-asthmatic eosinophilic bronchitis, and upper airway cough syndrome or post-nasal drip) and includes unexplained chronic cough. RCC affects ~2-3 million patients in the U.S. and is caused by cough reflex hypersensitivity in both the central and peripheral nerves. It is a highly debilitating disease and accompanied by a wide range of complications, ranging from urinary incontinence in females to sleep disruption and social embarrassment that causes significant social and economic burdens for patients and those around them.

Trevi intends to propose Haduvio as the trade name for oral nalbuphine ER. Its safety and efficacy have not been evaluated by any regulatory authority. 

For more information, visit www.TreviTherapeutics.com and follow Trevi on X (formerly Twitter) and LinkedIn. 

Investor Contact 
Jonathan Carlson 
Trevi Therapeutics, Inc. 
(203) 654 3286 
[email protected]

Media Contact 
Rosalia Scampoli 
914-815-1465 
[email protected] 

Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/trevi-therapeutics-to-participate-in-upcoming-september-conferences-302540243.html

SOURCE Trevi Therapeutics, Inc.

Zimmer Biomet Announces New Chief Medical Advisors to Help Improve Standard of Musculoskeletal Care

PR Newswire

Dr. Jonathan M. Vigdorchik Named Chief Medical Technology Advisor, Adult Reconstruction and Hip Implants

Dr. Anand M. Murthi Appointed Chief Medical Advisor, Shoulder, Sports, Extremities, and Trauma (S.E.T.)


WARSAW, Ind.
, Aug. 28, 2025 /PRNewswire/ — Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a global medical technology leader, today announced the appointments of Jonathan M. Vigdorchik, MD, as Chief Medical Technology Advisor focused on Adult Reconstruction and Hip Implants, and Anand M. Murthi, MD, FAAOS, as Chief Medical Advisor, Shoulder, Sports, Extremities, and Trauma (S.E.T.). As strategic advisors, Drs. Vigdorchik and Murthi will leverage their extensive clinical experience to help guide the Company’s new product pipeline and portfolio strategy across their respective areas of focus, and enhance Zimmer Biomet’s medical education initiatives.

Dr. Vigdorchik is a board-certified, fellowship-trained orthopaedic surgeon at Hospital for Special Surgery (HSS) in New York City, specializing in hip and knee replacement surgery. Dr. Murthi is a board-certified, fellowship-trained orthopaedic surgeon who serves as Chief of Shoulder and Elbow Surgery and Director of the Shoulder and Elbow Fellowship Program at MedStar Union Memorial Hospital in Baltimore, Md.

“These appointments reflect Zimmer Biomet’s commitment to deepening clinical collaboration and accelerating advancements across our portfolio – from implants and robotic technology to sports medicine and extremities,” said Ivan Tornos, Chairman, President and Chief Executive Officer, Zimmer Biomet. “We’re proud to welcome them both as strategic partners in helping to redefine the future of musculoskeletal care.”

In these roles, Drs. Vigdorchik and Murthi will assist with our medical education and surgeon engagement; advise on the Company’s technology and implant strategy and development roadmap; and serve as strategic liaisons between Zimmer Biomet and the broader surgical community.

About Dr. Jonathan M. Vigdorchik 
Dr. Vigdorchik holds several prominent academic and clinical leadership positions, including serving as Division Chief of Adult Reconstruction and Joint Replacement at HSS and Director of Bone Implant Longevity Research at HSS’s Griffin Research Accelerator. In addition, he is currently an Associate Professor of Orthopaedic Surgery at Weill Cornell Medical College. He is active in professional societies including The Hip Society, The Knee Society, the American Academy of Orthopaedic Surgeons (AAOS) and the American Association of Hip and Knee Surgeons (AAHKS), where he currently serves as the Education and Communications Council Chair and earlier served as Program Chair for the 2024 AAHKS Annual Meeting.

Dr. Vigdorchik earned his medical degree from the University of Missouri – Columbia School of Medicine, completed his orthopaedic surgery residency at the Detroit Medical Center / Providence Hospital, and received fellowship training in Adult Reconstruction and Joint Replacement at HSS. He also completed an international traveling fellowship in hip preservation surgery with training at centers in Switzerland, Boston Children’s Hospital, and Washington University in St. Louis.

Tornos said, “Dr. Vigdorchik is one of the most well-known, well-respected and well-published voices in orthopedics today. As a leading surgeon, clinical educator and true innovator, he brings an invaluable combination of experience and insight to this role. We are excited to partner with him as we continue to accelerate advancements in AI, smart implants, robotics and digital technologies that are redefining joint replacement care.”

“I’m honored to take on this role with Zimmer Biomet at such an exciting time in the evolution of orthopedic care,” said Dr. Vigdorchik. “We’re at the intersection of AI, powerful digital technologies and advanced implants that together have the potential to dramatically improve outcomes and personalize care for each patient. I look forward to partnering with the Zimmer Biomet team to help shape the future of joint replacement.”

About Dr. Anand M. Murthi
In addition to his role at MedStar, Dr. Murthi is also a Professor of Orthopaedic Surgery at Georgetown University School of Medicine. He is globally recognized for his expertise as an active surgeon, innovator, and pioneer in surgical techniques and device design. He is a founding member of prestigious societies including the Association of Clinical Elbow and Shoulder Surgeons (ACESS), Indian American Shoulder & Elbow Surgeons (IASES), and an active member of American Shoulder and Elbow Surgeons (ASES), where he established the Mentorship Program, chaired the Educational Committee, and was recently elected to the Neer Circle. He also serves as Co-Chairman of the Mid-Atlantic Shoulder and Elbow Society and the Orthopaedic Summit and Emerging Technologies Conference, while remaining a highly sought-after speaker and faculty member at major U.S. and international meetings. He is the Editor-in-Chief of Current Orthopaedic Practice Journal. He is also the co-designer of Shoulder JAM by OBERD, the first international shoulder data registry.

Dr. Murthi received his medical degree from Case Western Reserve University School of Medicine and completed his general surgery internship and orthopaedic surgery residency at George Washington University Medical Center. He completed a fellowship in shoulder and elbow reconstruction at the New York Orthopaedic Hospital – Columbia Presbyterian Medical Center. 

Tornos said, “Dr. Murthi brings deep clinical expertise, a proven track record of innovation, and visionary leadership in surgical techniques and device design. His partnership will be instrumental as we continue to accelerate growth across our S.E.T. business. With his influence and insight, Zimmer Biomet will further solidify our position as a trusted partner in delivering customer-centric solutions.”

“Throughout my career, I’ve been driven by a passion for advancing surgical techniques and designing intelligent technologies that raise the standard of care in shoulder and elbow surgery,” said Dr. Murthi. “I’m thrilled to join the Zimmer Biomet team—a team equally dedicated to innovation. Together, we have a remarkable opportunity to redefine what’s possible in musculoskeletal care and deliver transformative solutions to surgeons and patients worldwide.”

About Zimmer Biomet
Zimmer Biomet is a global medical technology leader with a comprehensive portfolio designed to maximize mobility and improve health. We seamlessly transform the patient experience through our innovative products and suite of integrated digital and robotic technologies that leverage data, data analytics and artificial intelligence.

With 90+ years of trusted leadership and proven expertise, Zimmer Biomet is positioned to deliver the highest quality solutions to patients and providers. Our legacy continues to come to life today through our progressive culture of evolution and innovation. 

For more information about our product portfolio, our operations in 25+ countries and sales in 100+ countries or about joining our team, visit www.zimmerbiomet.com or follow on LinkedIn at www.linkedin.com/company/zimmerbiomet or X / Twitter at www.x.com/zimmerbiomet.


Zimmer Biomet:


Media



Investors

Kristen Cardillo

David DeMartino

925-786-4913

646-531-6115



[email protected]



[email protected]

Kirsten Fallon

Zach Weiner

781-779-5561

908-591-6955



[email protected]



[email protected]

Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/zimmer-biomet-announces-new-chief-medical-advisors-to-help-improve-standard-of-musculoskeletal-care-302539376.html

SOURCE Zimmer Biomet Holdings, Inc.

SpartanNash Declares Quarterly Cash Dividend

PR Newswire


GRAND RAPIDS, Mich.
, Aug. 28, 2025 /PRNewswire/ — Food solutions company SpartanNash® (the “Company”) (Nasdaq: SPTN) today announced that on Aug. 27, 2025, its Board of Directors approved a quarterly cash dividend of $0.22 per common share. The dividend will be paid on Sept. 30, 2025, to shareholders of record as of the close of business on Sept. 15, 2025. As of Aug. 26, 2025, there were 33,862,518 common shares outstanding.

About SpartanNash

SpartanNash (Nasdaq: SPTN) is a food solutions company that delivers the ingredients for a better life. Committed to fostering a People First culture, the SpartanNash family of Associates is 20,000 strong. SpartanNash operates two complementary business segments – food wholesale and grocery retail. Its global supply chain network serves wholesale customers that include independent and chain grocers, national retail brands, e-commerce platforms, and U.S. military commissaries and exchanges. The Company distributes products for every aisle in the grocery store, from fresh produce to household goods to its OwnBrands, which include the Our Family® portfolio of products. On the retail side, SpartanNash operates nearly 200 brick-and-mortar grocery stores, primarily under the banners of Family Fare®, Martin’s Super Markets and D&W® Fresh Market, in addition to dozens of pharmacies and fuel centers with convenience stores. Leveraging insights and solutions across its segments, SpartanNash offers a full suite of support services for independent grocers. For more information, visit spartannash.com.

INVESTOR CONTACT:

Kayleigh Campbell

Head of Investor Relations
[email protected] 

MEDIA CONTACT:

Adrienne Chance 
SVP and Chief Communications Officer
[email protected] 

Cision View original content to download multimedia:https://www.prnewswire.com/news-releases/spartannash-declares-quarterly-cash-dividend-302540427.html

SOURCE SpartanNash

Stock Yards Bancorp to Participate in the Raymond James 2025 U.S. Bank and Banking on Tech Conferences

LOUISVILLE, Ky., Aug. 28, 2025 (GLOBE NEWSWIRE) — Stock Yards Bancorp, Inc. (NASDAQ: SYBT), parent company of Stock Yards Bank & Trust Company, with offices in Louisville, central, eastern and northern Kentucky, as well as the Indianapolis, Indiana and Cincinnati, Ohio metropolitan markets, today announced that Ja Hillebrand, Chairman and CEO and T. Clay Stinnett, EVP and CFO will participate in the Raymond James 2025 U.S. Bank and Banking on Tech Conferences to be held September 3rd through September 4th, and will participate in a series of one-on-one meetings with institutional investors.

Management’s discussion materials to be used at this conference will be posted to the investor section of the Company’s website, www.syb.com, on or before September 3, 2025.

Louisville, Kentucky-based Stock Yards Bancorp, Inc., with $9.21 billion in assets, was incorporated in 1988 as a bank holding company. It is the parent company of Stock Yards Bank & Trust Company, which was established in 1904. The Company’s common shares trade on The Nasdaq Stock Market under the symbol “SYBT.”

Contact: T. Clay Stinnett
  Executive Vice President,
  Treasurer and Chief Financial Officer
  (502) 625-0890



Palvella Therapeutics to Present at Upcoming Healthcare Investor Conferences

WAYNE, Pa., Aug. 28, 2025 (GLOBE NEWSWIRE) — (Nasdaq: PVLA) Palvella Therapeutics, Inc. (Palvella), a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapies to treat patients suffering from serious, rare genetic skin diseases for which there are no Food and Drug Administration-approved therapies, today announced that Wes Kaupinen, Founder and Chief Executive Officer of Palvella, will present at two upcoming healthcare investor conferences. The details are as follows:

Cantor Global Healthcare Conference

Thursday, September 4, 2025, at 2:45pm ET

H.C. Wainwright 27th Annual Global Investment Conference

Monday, September 8, 2025, at 10:30am ET

A live webcast of both presentations will be available on the Events and Presentations section of Palvella’s website at www.palvellatx.com. An archived replay of the webcast will be available for approximately 90 days following the presentation.

About Palvella Therapeutics

Founded and led by rare disease drug development veterans, Palvella Therapeutics, Inc. (Nasdaq: PVLA) is a clinical-stage biopharmaceutical company focused on developing and commercializing novel therapies to treat patients suffering from serious, rare genetic skin diseases for which there are no Food and Drug Administration-approved therapies. Palvella is developing a broad pipeline of product candidates based on its patented QTORIN™ platform, with an initial focus on serious, rare genetic skin diseases, many of which are lifelong in nature. Palvella’s lead product candidate, QTORIN™ 3.9% rapamycin anhydrous gel (QTORIN™ rapamycin), is currently being evaluated in the Phase 3 SELVA clinical trial in microcystic lymphatic malformations and the Phase 2 TOIVA clinical trial in cutaneous venous malformations. For more information, please visit www.palvellatx.com or follow Palvella on LinkedIn or X (formerly known as Twitter). QTORIN™ rapamycin is for investigational use only and has not been approved or cleared by the FDA or by any other regulatory agency for any indication.

Contact Information

Investors

Wesley H. Kaupinen
Founder and CEO, Palvella Therapeutics
[email protected]

Media

Marcy Nanus
Managing Partner, Trilon Advisors, LLC
[email protected]



Crescent Biopharma to Present at September Investor Conferences

WALTHAM, Mass., Aug. 28, 2025 (GLOBE NEWSWIRE) — Crescent Biopharma, Inc. (“Crescent” or the “Company”) (Nasdaq: CBIO), a biotechnology company dedicated to rapidly advancing the next wave of therapies for cancer patients, today announced that management is scheduled to present at the following investor conferences in September:

  • Cantor Global Healthcare Conference 2025, fireside chat on Thursday, September 4, 2025, at 1:00 p.m. ET in New York.
  • Morgan Stanley 23

    rd

    Annual Global Healthcare Conference, fireside chat on Monday, September 8, 2025, at 5:35 p.m. ET in New York.

A live webcast of each presentation will be available in the Investors section of the Company’s website at https://investors.crescentbiopharma.com/news-events/events, and a replay will be accessible for 90 days.

About Crescent Biopharma

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit www.crescentbiopharma.com and follow the Company on LinkedIn and X.

Contact

Amy Reilly
Chief Communications Officer
[email protected]
617-465-0586



Zevra Therapeutics Announces Multiple Datasets on MIPLYFFA® (arimoclomol) to be Presented at the International Congress of Inborn Errors of Metabolism (ICIEM)

CELEBRATION, Fla., Aug. 28, 2025 (GLOBE NEWSWIRE) — Zevra Therapeutics, Inc. (NasdaqGS: ZVRA) (Zevra, or the Company), a commercial-stage company focused on providing therapies for people living with rare disease, today announced four posters on MIPLYFFA® (MY-PLY-FAH) (arimoclomol) will be presented at the International Congress of Inborn Errors of Metabolism (ICIEM), taking place September 2-6, 2025, in Kyoto, Japan.

MIPLYFFA is approved in the U.S. for the treatment of Niemann-Pick disease type C (NPC). A poster (# BP-19) detailing that MIPLYFFA’s mechanism of action uniquely targets the underlying pathophysiology of NPC was selected for a Best Poster award. Additionally, positive, new data from a multi-center pediatric substudy in patients younger than two years old, as well as a new prespecified efficacy analysis of patients on routine clinical care with miglustat who switched from placebo to MIPLYFFA in their treatment regimen, will be presented.

Poster Details

Title:  Safety and efficacy of arimoclomol in a pediatric substudy of Niemann-Pick disease type C patients aged 6 to <24 months at study enrollment
Presentation No: P-261
Date/Time:  Wednesday, September 3, 2025; 6:00pm JST 
Presenter:  Laila Arash-Kaps, M.D.; SpinCS, Clinical Science for LSD

Title:  Arimoclomol upregulates expression of genes belonging to the coordinated lysosomal expression and regulation (CLEAR) network


Best Poster Award

Presentation No: BP-19
Date/Time:  Thursday, September 4, 2025; 5:30pm JST 
Presenter:  Hadeel Shammas, Ph.D.; Zevra Therapeutics

Title:  Arimoclomol for the treatment of Niemann-Pick disease type C in a real-world setting: long-term outcomes from an expanded access program in the United States
Presentation No: P-76
Date/Time:  Thursday, September 4, 2025; 5:30pm JST 
Presenter:  Caroline Hastings, M.D.; UCSF Benioff Children’s Hospitals

Title:  Efficacy results across a 12-month double-blind randomized trial and an open-label extension phase of arimoclomol for treatment of Niemann-Pick disease type C in patients treated with miglustat
Presentation No: P-264
Date/Time:  Thursday, September 4, 2025; 5:30pm JST 
Presenter:  Laila Arash-Kaps, M.D.; SpinCS, Clinical Science for LSD



About MIPLYFFA® (arimoclomol)

MIPLYFFA (arimoclomol) is Zevra’s approved therapy for the treatment of Niemann-Pick disease type C (NPC). Approved by the U.S. Food and Drug Administration on Sep. 20, 2024, MIPLYFFA (arimoclomol) increases the activation of the transcription factors EB (TFEB) and E3 (TFE3) resulting in the upregulation of coordinated lysosomal expression and regulation (CLEAR) genes. MIPLYFFA has also been shown to reduce unesterified cholesterol in the lysosomes of human NPC fibroblasts. The clinical significance of these findings is not fully understood. In the pivotal phase 3 trial, MIPLYFFA halted disease progression compared to placebo over the one-year duration of the trial when measured by the only validated disease progression measurement tool, the NPC Clinical Severity Scale. MIPLYFFA has also received Orphan Medicinal Product designation by the European Medicines Agency (EMA) for the treatment of NPC. The extensive data generated for MIPLYFFA has shown long-term, meaningful clinical outcomes with 5 and in some patients 7 years of patient experience across more than 270 NPC patients worldwide through a Phase 2/3 clinical trial, Open-Label Extension (OLE) study, Expanded Access Programs (EAP), and a pediatric sub-study, which is the most expansive clinical development program in NPC to date. A Marketing Authorization Application for the evaluation of arimoclomol for the treatment of Niemann-Pick disease type C has been validated and is under review by the European Medicines Agency. 

INDICATIONS AND USAGE

MIPLYFFA is indicated for use in combination with miglustat for the treatment of neurological manifestations of Niemann-Pick disease type C (NPC) in adult and pediatric patients 2 years of age and older. 

IMPORTANT SAFETY INFORMATION 

Hypersensitivity Reactions:

Hypersensitivity reactions such as urticaria and angioedema have been reported in patients treated with MIPLYFFA during Trial 1: two patients reported both urticaria and angioedema (6%) and one patient (3%) experienced urticaria alone within the first two months of treatment. Discontinue MIPLYFFA in patients who develop severe hypersensitivity reactions. If a mild or moderate hypersensitivity reaction occurs, stop MIPLYFFA and treat promptly. Monitor the patient until signs and symptoms resolve.

Embryofetal Toxicity:

MIPLYFFA may cause embryofetal harm when administered during pregnancy based on findings from animal reproduction studies. Advise pregnant females of the potential risk to the fetus and consider pregnancy planning and prevention for females of reproductive potential. 

Increased Creatinine without Affecting Glomerular Function:

Across clinical trials of MIPLYFFA, mean increases in serum creatinine of 10% to 20% compared to baseline were reported. These increases occurred mostly in the first month of MIPLYFFA treatment and were not associated with changes in glomerular function.

During MIPLYFFA treatment, use alternative measures that are not based on creatinine to assess renal function. Increases in creatinine reversed upon MIPLYFFA discontinuation. 

The most common adverse reactions in Trial 1 (≥15%) in MIPLYFFA-treated patients who also received miglustat were upper respiratory tract infection, diarrhea, and decreased weight.
Three (6%) of the MIPLYFFA-treated patients had the following adverse reactions that led to withdrawal from Trial 1: increased serum creatinine (one patient), and progressive urticaria and angioedema (two patients). Serious adverse reactions reported in MIPLYFFA-treated patients were hypersensitivity reactions including urticaria and angioedema. 

To report SUSPECTED ADVERSE REACTIONS, contact Zevra Therapeutics, Inc. at toll-free phone 1-844-600-2237 or FDA at 1 800-FDA-1088 or www.fda.gov/medwatch.

Drug Interaction(s):

Arimoclomol is an inhibitor of the organic cationic transporter 2 (OCT2) transporter and may increase the exposure of drugs that are OCT2 substrates. When MIPLYFFA is used concomitantly with OCT2 substrates, monitor for adverse reactions and reduce the dosage of the OCT2 substrate.

Use in Females and Males of Reproductive Potential:

Based on animal findings, MIPLYFFA may impair fertility and may increase post-implantation loss and reduce maternal, placental, and fetal weights.

Renal Impairment:

The recommended dosage of MIPLYFFA, in combination with miglustat, in patients with an eGFR ≥15 mL/minute to <50 mL/minute is lower than the recommended dosage (less frequent dosing) in patients with normal renal function.

MIPLYFFA capsules for oral use are available in the following strengths: 47 mg, 62 mg, 93 mg, and 124 mg.

About Zevra Therapeutics, Inc.

Zevra Therapeutics, Inc. is a commercial-stage company combining science, data and patient need to create transformational therapies for rare diseases with limited or no treatment options. Our mission is to bring life-changing therapeutics to people living with rare diseases. With unique, data-driven development and commercialization strategies, the Company is overcoming complex drug development challenges to make new therapies available to the rare disease community.

For more information, please visit www.zevra.com or follow us on X and LinkedIn.

Caution Concerning Forward-Looking Statements

This press release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include all statements that do not relate solely to historical or current facts, including without limitation statements regarding the promise and potential impact of our preclinical or clinical trial data; or the potential benefits of any of our products or product candidates for any specific disease or at any dosage. Forward-looking statements are based on information currently available to Zevra and its current plans or expectations. They are subject to several known and unknown uncertainties, risks, and other important factors that may cause our actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. These and other important factors are described in detail in the “Risk Factors” section of Zevra’s Annual Report on Form 10-K for the year ended December 31, 2024, filed on March 12, 2025, and Zevra’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2025, filed on August 12, 2025, and Zevra’s other filings with the SEC. While we may elect to update such forward-looking statements at some point in the future, except as required by law, we disclaim any obligation to do so, even if subsequent events cause our views to change. Although we believe the expectations reflected in such forward-looking statements are reasonable, we cannot assure that such expectations will prove correct. These forward-looking statements should not be relied upon as representing our views as of any date after the date of this press release.  

Zevra Contact

Nichol Ochsner 
+1 (732) 754-2545 
[email protected]  



Ollie’s Bargain Outlet Holdings, Inc. Announces Second Quarter Fiscal 2025 Results


Store Openings, Sales, and Earnings Ahead of Expectations


Net Sales Increased 17.5% and Earnings Per Share Increased 25.0%


Raising Fiscal 2025 Sales and Earnings Outlook

HARRISBURG, Pa., Aug. 28, 2025 (GLOBE NEWSWIRE) —  Ollie’s Bargain Outlet Holdings, Inc. (NASDAQ: OLLI) (the “Company”) today announced financial results for the second quarter fiscal 2025 ended August 2, 2025.

“We had a very strong second quarter and are operating with the wind in our sails,” said Eric van der Valk, President and Chief Executive Officer. “We are driving the business to new heights through improved planning, coordination, and execution across the organization. New store openings, total sales, comparable store sales, and earnings were all ahead of our expectations in the quarter and we are raising our full-year outlook across the board.”

Mr. van der Valk continued, “Consumers responded to our compelling assortment of bargains, especially in our consumer staples and seasonal categories. Ollie’s Army growth was another bright spot in the quarter, headlined by an outstanding response to our reimagined Ollie’s Days event.”

    Thirteen weeks ended
    August 2,   August 3,
      2025       2024  

(Dollars in thousands, except per share data)
       
Net sales   $ 679,556     $ 578,375  
Yr/yr change     17.5%       12.4%  
Comparable store sales change(1)     5.0%       5.8%  
Net income   $ 61,310     $ 48,982  
Net income per diluted share   $ 0.99     $ 0.79  
Adjusted net income per diluted share   $ 0.99     $ 0.78  
Yr/yr change     26.9%       16.4%  
Adjusted EBITDA   $ 93,786     $ 74,450  
% of net sales     13.8%       12.9%  
Store openings     29       9  
Store growth, yr/yr change     16.8%       8.9%  
         
(1)Calculated based on the comparable number of weeks from the prior year.    
     

Second Quarter Fiscal 2025 Highlights and Year-Over-Year Comparisons     

  • Opened 29 stores, ending the quarter with a total of 613 stores in 34 states, an increase of 16.8% year-over-year.
  • Ollie’s Army loyalty members increased 10.6% to 16.1 million members.
  • Net sales increased 17.5% to $679.6 million, driven by new store unit growth and an increase in comparable store sales.
  • Comparable store sales increased 5.0%, driven by an increase in transactions.
  • Gross margin increased 200 basis points to 39.9%. The increase was primarily driven by lower supply chain costs and higher merchandise margin.
  • Selling, general, and administrative (“SG&A”) expenses as a percentage of net sales increased 60 basis points to 25.8%. The increase was primarily driven by higher medical and casualty claims, as well as slightly higher store labor expenses.
  • Pre-opening expenses increased $4.4 million to $9.0 million, driven by new store growth and $2.3 million of dark rent expense associated with the former Big Lots locations that were acquired through the bankruptcy auction process.
  • Operating margin increased 80 basis points to 11.3%.
  • Adjusted net income per diluted share increased 26.9% to $0.99.
  • Adjusted EBITDA increased 26.0% to $93.8 million and adjusted EBITDA margin increased 90 basis points to 13.8%.
  • Total cash and investments increased 30.3%, or $107.1 million, to $460.3 million. This included cash and cash equivalents of $231.2 million, short-term investments of $85.9 million, and long-term investments of $143.2 million.  

Fiscal 2025 Outlook   

The Company is raising its previously provided sales and earnings outlook for fiscal 2025. A comparison of the current and previous outlook figures is contained in the table below.

       
  Current   Previous
Store Openings 85    75 
Net sales $2.631 to $2.644 billion   $2.579 to $2.599 billion
Comparable store sales increase 3.0% to 3.5%   1.4% to 2.2%
Gross margin 40.3%   40.0%
Operating income(1) $292 to $298 million   $283 to $292 million
Adjusted net income (1)(2)(3) $233 to $237 million   $225 to $232 million
Adjusted net income per diluted share(1)(2)(3) $3.76 to $3.84   $3.65 to $3.75
Annual effective tax rate(3) ~ 25%   ~ 25%
Diluted weighted average shares outstanding ~ 62 million   ~ 62 million
Capital expenditures $83 to $88 million   $83 to $88 million
       
(1) Includes dark rent expenses of approximately $5 million, or $0.06 in adjusted net income per diluted share, related to the opening of stores where the leases were acquired through the bankruptcy process.
(2) Includes interest income of approximately $18 million. This assumes the potential for lower interest rates in fiscal 2025.
(3) Excludes the excess tax benefits related to stock-based compensation, as the Company cannot predict such estimates without unreasonable effort.
       

Conference Call Information

A conference call to discuss second quarter fiscal 2025 financial results is scheduled for today, August 28, 2025, at 8:30 a.m. Eastern Time. To access the live conference call, please preregister here. Registrants will receive a confirmation with dial-in instructions. Interested parties can also listen to a live webcast or replay of the conference call by logging on to the Investor Relations section on the Company’s website at https://investors.ollies.com/. A replay of the conference call webcast will be available on the investor relations website for one year.

About Ollie’s        
Ollie’s is a leading off-price retailer of brand name household products. Since our founding in 1982, our mission has been to sell Good Stuff Cheap®. We do this through a flexible buying model that focuses on closeout merchandise and excess inventory from suppliers and manufacturers around the world. Our stores offer Real Brands! Real Bargains! ® in a treasure hunt environment at prices up to 70% below traditional retailers. As of August 2, 2025, we operated 613 stores in 34 states and growing! For more information, visit www.ollies.com.

Non-GAAP Reconciliation

The Company’s results are reported in this press release on a GAAP and as adjusted, non-GAAP basis. Adjusted net income (loss), adjusted net income (loss) per diluted share, and adjusted operating income (loss) are non-GAAP measures, and are not intended to replace GAAP financial information, and may be different from non-GAAP measures reported by other companies. The Company believes the income and expense items excluded as non-GAAP adjustments are not reflective of the performance of its core business, and that providing this supplemental disclosure to investors will facilitate comparisons of the past and present performance of its core business.

Please refer to the “Reconciliation of GAAP to Non-GAAP Financial Measures” table included in this press release, which sets forth the non-GAAP operating adjustments for the 13-week and 26-week periods ended August 2, 2025 and August 3, 2024.

Forward-Looking Statements

This press release contains certain forward-looking statements, which includes but is not limited to statements regarding industry trends, value creation, customer trends, new stores, distribution centers, and various financial outlook figures, including new store openings, net sales, comparable store sales, gross margin, SG&A, operating income, net income, adjusted net income, adjusted net income per diluted share, effective tax rate, diluted weighted average shares outstanding and capital expenditures. All forward-looking statements are subject to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, are subject to the finalization of the Company’s quarterly financial and accounting procedures, and may be affected by certain risks and uncertainties, any one, or a combination, of which could materially affect the results of the Company’s operations. Forward-looking statements are usually identified by or are associated with such words as “could”, “may”, “might”, “will,” “likely”, “anticipates”, “intends”, “plans”, “believes”, “estimates”, “expects”, “continues”, “projects”, “forecasts”, and similar terminology. Actual results could vary materially from the expectations reflected in these statements. As with any business, all phases of our operations are subject to factors outside of our control. These factors include, without limitation, the impact of the recent tariff announcements and the corresponding macroeconomic pressures and those factors discussed in the “Risk Factors” section of the Company’s Annual Reports or Form 10-K and other filings with the Securities and Exchange Commission. Forward-looking statements made by or on behalf of the Company are based on knowledge of its business and the environment in which it operates, but because of the factors listed above, actual results could differ materially from those reflected by any forward-looking statements. Consequently, all of the forward-looking statements made are qualified by these cautionary statements and those contained in the Company’s Annual Report on Form 10-K, quarterly reports on Form 10-Q, and other filings with the Securities and Exchange Commission. There can be no assurance that the results or developments anticipated by the Company will be realized or, even if substantially realized, that they will have the expected consequences to or effects on the Company or its business and operations. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. The Company does not undertake any obligation to release publicly any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events, except as required by law.

Investor Contact

John Rouleau
Managing Director of Corporate Communication & Business Development
[email protected]

Media Contact

Tom Kuypers
Senior Vice President – Marketing & Advertising
717-657-2300
[email protected]

Ollie’s Bargain Outlet Holdings, Inc.

Condensed Consolidated Statements of Income (unaudited)

(In thousands except for per share amounts)

    Thirteen weeks ended   Twenty-six weeks ended
    August 2,   August 3,   August 2,   August 3,
      2025       2024       2025       2024  
Net sales   $ 679,556     $ 578,375     $ 1,256,323     $ 1,087,193  
Cost of sales     408,218       359,344       747,954       658,804  
Gross profit     271,338       219,031       508,369       428,389  
Selling, general and administrative expenses     175,476       145,673       340,308       288,092  
Depreciation and amortization expenses     9,916       8,004       19,273       15,720  
Pre-opening expenses     8,972       4,595       15,628       7,321  
Operating income     76,974       60,759       133,160       117,256  
Interest income, net     (4,534 )     (3,928 )     (9,322 )     (8,229 )
Income before income taxes     81,508       64,687       142,482       125,485  
Income tax expense     20,198       15,705       33,612       30,161  
Net income   $ 61,310     $ 48,982     $ 108,870     $ 95,324  
Earnings per common share:                
Basic   $ 1.00     $ 0.80     $ 1.77     $ 1.55  
Diluted   $ 0.99     $ 0.79     $ 1.76     $ 1.54  
Weighted average common shares outstanding:                
Basic     61,340       61,313       61,342       61,347  
Diluted     61,796       61,721       61,806       61,731  
                 
Percentage of net sales:                
Net sales     100.0 %     100.0 %     100.0 %     100.0 %
Cost of sales     60.1       62.1       59.5       60.6  
Gross profit     39.9       37.9       40.5       39.4  
Selling, general and administrative expenses     25.8       25.2       27.1       26.5  
Depreciation and amortization expenses     1.5       1.4       1.5       1.4  
Pre-opening expenses     1.3       0.8       1.2       0.7  
Operating income     11.3       10.5       10.6       10.8  
Interest income, net     (0.7 )     (0.7 )     (0.7 )     (0.8 )
Income before income taxes     12.0       11.2       11.3       11.6  
Income tax expense     3.0       2.7       2.7       2.8  
Net income     9.0 %     8.5 %     8.7 %     8.8 %
                 
Components may not add to totals due to rounding.                
                 

Ollie’s Bargain Outlet Holdings, Inc.

Condensed Consolidated Balance Sheets (unaudited)

(In thousands)

    August 2,   August 3,
Assets     2025       2024  
Current assets:        
Cash and cash equivalents   $ 231,163     $ 170,600  
Short-term investments     85,893       182,544  
Inventories     637,236       531,286  
Accounts receivable     1,810       1,187  
Prepaid expenses and other current assets     11,716       9,813  
Total current assets     967,818       895,430  
Property and equipment, net     360,836       307,163  
Operating lease right-of-use assets     652,341       494,169  
Goodwill     444,850       444,850  
Trade name     230,559       230,559  
Long-term investments     143,206       –  
Other assets     2,242       2,122  
Total assets   $ 2,801,852     $ 2,374,293  
Liabilities and Stockholders’ Equity        
Current liabilities:        
Current portion of long-term debt   $ 518     $ 589  
Accounts payable     165,629       129,824  
Income taxes payable     129       –  
Current portion of operating lease liabilities     103,122       87,476  
Accrued expenses and other current liabilities     98,968       79,952  
Total current liabilities     368,366       297,841  
Long-term debt     912       984  
Deferred income taxes     85,640       72,803  
Long-term portion of operating lease liabilities     561,024       411,994  
Total liabilities     1,015,942       783,622  
Stockholders’ equity:        
Common stock     68       67  
Additional paid-in capital     745,636       713,509  
Retained earnings     1,476,583       1,263,275  
Treasury – common stock     (436,377 )     (386,180 )
Total stockholders’ equity     1,785,910       1,590,671  
Total liabilities and stockholders’ equity   $ 2,801,852     $ 2,374,293  
         

Ollie’s Bargain Outlet Holdings, Inc.

Condensed Consolidated Statements of Cash Flows (unaudited)

(In thousands)

    Thirteen weeks ended   Twenty-six weeks ended
    August 2,   August 3,   August 2,   August 3,
      2025       2024       2025       2024  
Net cash provided by operating activities   $ 80,712     $ 43,875     $ 109,414     $ 84,059  
Net cash used in investing activities     (39,744 )     (90,883 )     (58,010 )     (159,398 )
Net cash (used in) provided by financing activities     (8,823 )     5,358       (25,364 )     (20,323 )
Net increase (decrease) in cash and cash equivalents     32,145       (41,650 )     26,040       (95,662 )
Cash and cash equivalents, beginning of the period     199,018       212,250       205,123       266,262  
Cash and cash equivalents, end of the period   $ 231,163     $ 170,600     $ 231,163     $ 170,600  
                 

Ollie’s Bargain Outlet Holdings, Inc.

Reconciliation of GAAP to Non-GAAP Financial Measures (unaudited)

(In thousands except for per share amounts)

    Thirteen weeks Ended   Twenty-six weeks ended
    August 2,   August 3,   August 2,   August 3,
      2025       2024       2025       2024  
Net income   $ 61,310     $ 48,982     $ 108,870     $ 95,324  
Excess tax benefits related to stock-based compensation(1)   (425 )     (756 )     (1,912 )     (1,888 )
Adjusted net income   $ 60,885     $ 48,226     $ 106,958     $ 93,436  
                 
Net income per diluted share   $ 0.99     $ 0.79     $ 1.76     $ 1.54  
Adjustments as noted above, per dilutive share:                
Excess tax benefits related to stock-based compensation(1)     (0.01 )     (0.01 )     (0.03 )     (0.03 )
Adjusted net income per diluted share   $ 0.99     $ 0.78     $ 1.73     $ 1.51  
                 
Diluted weighted-average common shares outstanding     61,796       61,721       61,806       61,731  
                 
Net income   $ 61,310     $ 48,982     $ 108,870     $ 95,324  
Interest income, net     (4,534 )     (3,928 )     (9,322 )     (8,229 )
Depreciation and amortization expenses     13,452       10,039       26,261       19,824  
Income tax expense     20,198       15,705       33,612       30,161  
EBITDA     90,426       70,798       159,421       137,080  
Non-cash stock-based compensation expense     3,360       3,652       6,524       6,801  
Adjusted EBITDA   $ 93,786     $ 74,450     $ 165,945     $ 143,881  
                 
                 
Components may not add to totals due to rounding.                
(1)Amount represents the impact from the recognition of excess tax benefits pursuant to Accounting Standards Update 2016-09, Stock Compensation
                 

Ollie’s Bargain Outlet Holdings, Inc.

Key Statistics (unaudited)

(Dollars in thousands)

    Thirteen weeks ended
    August 2,   August 3,
      2025       2024  
Number of stores – beginning of period     584       516  
Store openings     29       9  
Store closings     –       –  
Number of stores – end of period     613       525  
Yr/yr store growth     16.8 %     8.9 %
Comparable stores sales change     5.0 %     5.8 %
Comparable store count – end of period     510       475  
Total cash and investments(1)   $ 460,262     $ 353,144  
Capital expenditures   $ 26,416     $ 38,289  
Share repurchases   $ 11,516     $ 6,428  
         
(1) Includes cash and cash equivalents, short-term investments, and long-term investments.



Kura Oncology to Participate in Three Upcoming Investor Conferences

SAN DIEGO, Aug. 28, 2025 (GLOBE NEWSWIRE) — Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, today announced that management is scheduled to participate in three investor conferences in September.

Cantor Global Health Conference
Thursday, September 4, 2025
8:35 a.m. ET / 5:35 a.m. PT

H.C. Wainwright 27th Annual Global Investment Conference
Monday, September 8, 2025
1:00 p.m. ET / 10:00 a.m. PT

Morgan Stanley 23rd Annual Global Healthcare Conference
Wednesday, September 10, 2025
1:50 p.m. ET / 10:50 a.m. PT

Live audio webcasts will be available in the Investors section of Kura’s website at https://kuraoncology.com/, with archived replays available following all three events.

About Kura Oncology

Kura Oncology is a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer. The Company’s pipeline of small molecule drug candidates is designed to target cancer signaling pathways and address high-need hematologic malignancies and solid tumors. Kura is developing ziftomenib, a menin inhibitor targeting certain genetic drivers of acute myeloid leukemias and continues to pioneer advancements in both menin inhibition and farnesyl transferase inhibition to address mechanisms of adaptive and innate resistance in the treatment of solid tumors. For additional information, please visit the Kura website at https://kuraoncology.com/ and follow us on X and LinkedIn.

Contacts

Investors and media:
Greg Mann
858-987-4046
[email protected]



Zai Lab Announces Participation in Investor Conferences in September 2025

Zai Lab Announces Participation in Investor Conferences in September 2025

SHANGHAI & CAMBRIDGE, Mass.–(BUSINESS WIRE)–
Zai Lab Limited (NASDAQ: ZLAB; HKEX: 9688) today announced that members of the Company’s senior management team will participate in the following investor conferences in September 2025:

Cantor Global Healthcare Conference

Presentation: Thursday, September 4, 2025, 10:20 a.m. ET

Location: New York, NY

Morgan Stanley 23rd Annual Global Healthcare Conference

Fireside Chat: Tuesday, September 9, 2025, 2:35 p.m. ET

Location: New York, NY

Live webcasts will be available on the Investor Relations page of Zai Lab’s website at ir.zailaboratory.com/webcasts-presentations and archived replays will be available for up to 90 days following the completion of the events.

About Zai Lab

Zai Lab (NASDAQ: ZLAB; HKEX: 9688) is an innovative, research-based, commercial-stage biopharmaceutical company based in China and the United States. We are focused on discovering, developing, and commercializing innovative products that address medical conditions with significant unmet needs in the areas of oncology, immunology, neuroscience, and infectious disease. Our goal is to leverage our competencies and resources to positively impact human health.

For additional information about Zai Lab, please visit www.zailaboratory.com or follow us at www.X.com/ZaiLab_Global.

For more information, please contact:


Investor Relations:

Christine Chiou

+1 (917) 886-6929

[email protected]

Lina Zhang

+86 136 8257 6943

[email protected]

Media:

Shaun Maccoun

+1 (857) 270-8854

[email protected]

Xiaoyu Chen

+86 185 0015 5011

[email protected]

KEYWORDS: China United States North America Asia Pacific Massachusetts

INDUSTRY KEYWORDS: Science Neurology Biotechnology Research Pharmaceutical Oncology Health Infectious Diseases

MEDIA:

Logo
Logo