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Chase Freedom® Announces Q3 2023 Quarterly Categories – Select Live Entertainment, Gas Stations and Electric Vehicle Charging

Freedom and Freedom Flex cardmembers can cashback on summer fun when they activate their Q3 2023 categories

WILMINGTON, Del.–(BUSINESS WIRE)–
Today, Chase Freedom announced the rotating quarterly categories for Freedom and Freedom Flex cardmembers: Select Live Entertainment, Gas Stations and Electric Vehicle (EV) Charging. Cardmembers can earn 5% cash back on up to $1,500 in combined purchases in these categories from July 1 through September 30, 2023.

“This quarter, cardmembers can take full advantage of the season by cashbacking on select live entertainment, gas and EV charging,” said Brent Reinhard, General Manager of Chase Freedom. “Whether it’s a road trip to the beach, attending a festival or cheering on their favorite team at a game, Chase Freedom has our cardmembers covered.”

Starting July 1 through September 30, 2023, Chase Freedom and Freedom Flex cardmembers can earn 5% cash back on up to $1,500 in combined purchases on the following:

• Select Live Entertainment: Back for a second year in a row, cardmembers can earn cash back while enjoying their favorite music artists or sporting events live this summer. *Excludes bowling alleys, movie theaters, gambling facilities or third-party vendor purchases.

• Gas Stations and EV Charging: Cardmembers can boost cash back earnings when fueling up at the pump or charging their EV. Excludes truck stops, marinas, and oil distribution.

For the first time, Chase is expanding its cashback offerings to include electric vehicle charging.

“With more than 1 million electric vehicles expected to be sold in the United States this year, there will be more people than ever looking for ways to charge up while on the road,” said Peter Muriungi, CEO, Chase Auto. “Chase is committed to environmental sustainability and supporting the growing EV movement, and this quarter’s cashback offers help make electric vehicles more accessible for our customers so they can get around and enjoy their summer.”

Chase provides access to tens of thousands of electric and hybrid vehicles available for sale through local dealers. Chase is currently the U.S. private label financer for EV manufacturers Rivian and Fisker, and last year announced a new EV Education Center and a pilot program for public fast-charging stations at 50 bank branches.

Along with 5% rotating categories, Freedom Flex cardmembers also earn 5% cash back on travel purchased through Chase’s Ultimate Rewards, 3% cash back on dining and drugstores and 1% cash back on all other purchases. Freedom Flex cardmembers also receive World Elite Mastercard Benefits, including cell phone protection and discounts with Lyft, Shoprunner and more, in addition to Priceless Experiences.

For more information on participating merchants and how to activate Freedom and Freedom Flex’s third quarter category offer, visit Chase.com/Freedom or Chase.com/FreedomFlex beginning June 15, 2023.

About Chase

Chase is the U.S. consumer and commercial banking business of JPMorgan Chase & Co. (NYSE: JPM), a leading financial services firm based in the United States with assets of $3.7 trillion and operations worldwide. Chase serves nearly 80 million consumers and 5.7 million small businesses, with a broad range of financial services, including personal banking, credit cards, mortgages, auto financing, investment advice, small business loans and payment processing. Customers can choose how and where they want to bank: More than 4,700 branches in 48 states and the District of Columbia, more than 15,000 ATMs, mobile, online and by phone. For more information, go to chase.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20230615120616/en/

Media:

Colton Moore

[email protected]

KEYWORDS: United States North America Delaware

INDUSTRY KEYWORDS: EV/Electric Vehicles Banking Automotive Personal Finance Technology Vacation Travel Professional Services Payments Other Travel Finance

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MEI Pharma and Infinity Pharmaceuticals Host Video Webcast Providing Overview and Update on Pending Merger to Advance Three Promising Clinical Oncology Candidates

Event Available at 8:00 a.m. Eastern Time on June 19, 2023

SAN DIEGO & CAMBRIDGE, Mass.–(BUSINESS WIRE)–
MEI Pharma, Inc. (Nasdaq: MEIP) (“MEI”), a clinical-stage pharmaceutical company focused on advancing new therapies for cancer, and Infinity Pharmaceuticals, Inc. (Nasdaq: INFI) (“Infinity”), a clinical-stage biotechnology company developing eganelisib, a first-in-class, oral, immuno-oncology macrophage reprogramming drug candidate, announced today that the companies will host a recorded joint video webcast that will be available at 8:00 am Eastern Time on June 19, 2023. On the webcast Mr. David Urso will provide an update on the pending merger and an overview of the combined company, which joins the expertise and resources of MEI and Infinity to advance a robust pipeline of three clinical-stage oncology drug candidates.

In addition to presentations from the executive management from MEI and Infinity on the three programs, the webcast includes commentary and discussion with Dr. Ezra Cohen, a recognized expert in the treatment of squamous cell carcinoma of the head & neck (SCCHN) and recently the Chief, Division of Hematology-Oncology, and Associate Director of Clinical Science at UC San Diego Moores Cancer Center. Following the prepared presentations, Dr. Nick Abbott, most recently the senior sell side biotech analyst at Wells Fargo Securities will ask questions of the presenters, Dr. Robert Ilaria, Dr. Ezra Cohen and Dr. Richard Ghalie.

The combined company’s development pipeline consists of three differentiated programs. All three clinical-stage development programs have the potential, in combination with current therapies, to overcome known resistance mechanisms and meaningfully improve patient outcomes:

• Eganelisib, an oral immuno-oncology macrophage reprogramming product candidate, which is planned to be evaluated in combination with the PD-1 targeted checkpoint inhibitor pembrolizumab (KEYTRUDA®) in patients with head and neck squamous cell carcinoma (HNSCC);

• Voruciclib, an oral CDK9 inhibitor, currently being studied in combination with venetoclax (VENCLEXTA®) in patients with hematologic malignancies; and

• ME-344, a novel tumor selective mitochondrial inhibitor targeting the OXPHOS pathway, to be evaluated in combination with bevacizumab (AVASTIN®) in patients with relapsed colorectal cancer.

Video Webcast Information

You can access the video webcast under the investor relations section of MEI’s website on the “Events and Presentation” page at www.meipharma.com, or under the investor relations page of Infinity’s website on its “Events and Presentation” page at www.infi.com. The pre-recorded video webcast will be archived for at least 30 days after the conclusion of the event.

About MEI Pharma

MEI Pharma, Inc. (Nasdaq: MEIP) is a pharmaceutical company focused on developing potential new therapies for cancer. MEI Pharma’s portfolio of drug candidates includes clinical stage candidates with differentiated mechanisms of action intended to address unmet medical needs and deliver improved benefits to patients, either as standalone treatments or in combination with other therapeutic options. For more information, please visit www.meipharma.com. Follow us on Twitter @MEI_Pharma and on LinkedIn.

About Infinity Pharmaceuticals

Infinity Pharmaceuticals, Inc. (Nasdaq: INFI) is a clinical-stage biotechnology company developing eganelisib (IPI-549), a potential first-in-class, oral, immuno-oncology macrophage reprogramming therapeutic which is designed to address a fundamental biologic mechanism of immune suppression in cancer in multiple clinical studies. For more information on Infinity, please refer to Infinity’s website at www.infi.com.

Important Information about the Merger and Where to Find It

This communication relates to a proposed transaction between Infinity) and MEI. In connection with the proposed merger, MEI filed with the SEC a registration statement on Form S-4 that includes a joint proxy statement of MEI and Infinity (the “Joint Proxy Statement/Prospectus) that also constitutes a prospectus of MEI. The registration statement on Form S-4 was declared effective by the SEC on June 6, 2023. MEI and Infinity have each filed and mailed the Joint Proxy Statement/Prospectus to their respective stockholders. INVESTORS AND MEI’S AND INFINITY’S RESPECTIVE STOCKHOLDERS ARE URGED TO READ THE JOINT PROXY STATEMENT/PROSPECTUS IN ITS ENTIRETY AND ANY OTHER DOCUMENTS FILED BY EACH OF MEI AND INFINITY WITH THE SEC IN CONNECTION WITH THE PROPOSED MERGER OR INCORPORATED BY REFERENCE THEREIN BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT THE PROPOSED MERGER AND THE PARTIES TO THE PROPOSED MERGER. Investors and stockholders may obtain a free copy of the Joint Proxy Statement/Prospectus and other documents containing important information about MEI and Infinity from the SEC’s website at www.sec.gov. MEI and Infinity make available free of charge at www.meipharma.com and www.infi.com, respectively (in the “Investors” and “Investors/Media” sections, respectively), copies of materials they file with, or furnish to, the SEC.

Participants in the Solicitation

MEI, Infinity and their respective directors, executive officers and certain employees and other persons may be deemed to be participants in the solicitation of proxies from the stockholders of MEI and Infinity in connection with the proposed merger. Securityholders may obtain information regarding the names, affiliations and interests of MEI’s and Infinity’s directors and executive officers in the Joint Proxy Statement/Prospectus which may be obtained free of charge from the SEC’s website at www.sec.gov, MEI’s investor website at https://www.meipharma.com/investors and Infinity’s investor website at https://investors.infi.com/.

No Offer or Solicitation

This communication shall not constitute an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No offering of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the U.S. Securities Act of 1933, as amended.

Cautionary Statement Regarding Forward-Looking Statements

Certain statements contained in this filing may be considered forward-looking statements within the meaning of the federal securities law. Such statements are based upon current plans, estimates and expectations of the management of MEI and Infinity that are subject to various risks and uncertainties that could cause actual results to differ materially from such statements. The inclusion of forward-looking statements should not be regarded as a representation that such plans, estimates and expectations will be achieved. Words such as “anticipate,” “expect,” “project,” “intend,” “believe,” “may,” “will,” “should,” “plan,” “could,” “continue,” “target,” “contemplate,” “estimate,” “forecast,” “guidance,” “predict,” “possible,” “potential,” “pursue,” “likely,” and words and terms of similar substance used in connection with any discussion of future plans, actions or events identify forward-looking statements. All statements, other than historical facts, including statements regarding: the expected timing of the closing of the proposed merger; the ability of the parties to complete the proposed merger considering the various closing conditions; the expected benefits of the proposed merger, including estimations of anticipated cost savings and cash runway; the competitive ability and position of the combined company; the potential, safety, efficacy, and regulatory and clinical progress of the combined company’s product candidates, including the anticipated timing for initiation of clinical trials and release of clinical trial data and the expectations surrounding potential regulatory submissions, approvals and timing thereof; the sufficiency of the combined company’s cash, cash equivalents and short-term investments to fund operations; and any assumptions underlying any of the foregoing, are forward-looking statements. Important factors that could cause actual results to differ materially from MEI’s and Infinity’s plans, estimates or expectations could include, but are not limited to: (i) the risk that the proposed merger may not be completed in a timely manner or at all, which may adversely affect MEI’s and Infinity’s businesses and the price of their respective securities; (ii) uncertainties as to the timing of the consummation of the proposed merger and the potential failure to satisfy the conditions to the consummation of the proposed merger, including obtaining stockholder and regulatory approvals; (iii) the proposed merger may involve unexpected costs, liabilities or delays; (iv) the effect of the announcement, pendency or completion of the proposed merger on the ability of MEI or Infinity to retain and hire key personnel and maintain relationships with customers, suppliers and others with whom MEI or Infinity does business, or on MEI’s or Infinity’s operating results and business generally; (v) MEI’s or Infinity’s respective businesses may suffer as a result of uncertainty surrounding the proposed merger and disruption of management’s attention due to the proposed merger; (vi) the outcome of any legal proceedings related to the proposed merger or otherwise, or the impact of the proposed merger thereupon; (vii) MEI or Infinity may be adversely affected by other economic, business, and/or competitive factors; (viii) the occurrence of any event, change or other circumstances that could give rise to the termination of the merger agreement and the proposed merger; (ix) restrictions during the pendency of the proposed merger that may impact MEI’s or Infinity’s ability to pursue certain business opportunities or strategic transactions; (x) the risk that MEI or Infinity may be unable to obtain governmental and regulatory approvals required for the proposed merger, or that required governmental and regulatory approvals may delay the consummation of the proposed merger or result in the imposition of conditions that could reduce the anticipated benefits from the proposed merger or cause the parties to abandon the proposed merger; (xi) risks that the anticipated benefits of the proposed merger or other commercial opportunities may otherwise not be fully realized or may take longer to realize than expected; (xii) the impact of legislative, regulatory, economic, competitive and technological changes; (xiii) risks relating to the value of MEI shares to be issued in the proposed merger; (xiv) the risk that integration of the proposed merger post-closing may not occur as anticipated or the combined company may not be able to achieve the benefits expected from the proposed merger, as well as the risk of potential delays, challenges and expenses associated with integrating the combined company’s existing businesses; (xv) exposure to inflation, currency rate and interest rate fluctuations, as well as fluctuations in the market price of MEI’s and Infinity’s traded securities; (xvi) the impact of the COVID-19 pandemic on MEI’s and Infinity’s industry and individual companies, including on counterparties, the supply chain, the execution of clinical development programs, access to financing and the allocation of government resources; (xvii) final data from pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; (xviii) costs and delays in the development and/or U.S. Food and Drug Administration (“FDA”) approval, or the failure to obtain such approval, of the combined company’s product candidates; (xix) regulatory authorities may not agree with the design or results of clinical studies and as a result future clinical studies may be subject to holds; (xx) uncertainties or differences in interpretation in clinical trial results; (xxi) the combined company’s inability to maintain or enter into, and the risks resulting from dependence upon, collaboration or contractual arrangements necessary for the development, manufacture, commercialization, marketing, sales and distribution of any product candidates; and (xxii) the ability of MEI or Infinity to protect and enforce intellectual property rights; and (xxiii) the unpredictability and severity of catastrophic events, including, but not limited to, acts of terrorism or outbreak of war or hostilities, as well as MEI’s and Infinity’s response to any of the aforementioned factors. Additional factors that may affect the future results of MEI and Infinity are set forth in their respective filings with the United States Securities and Exchange Commission (the “SEC”), including the section entitled “Risk Factors” in the Registration Statement on Form S-4 that was declared effective by the SEC on June 6, 2023 and each of MEI’s and Infinity’s most recently filed Annual Reports on Form 10-K, subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and other filings with the SEC, which are available on the SEC’s website at www.sec.gov. See in particular MEI’s Annual Report on Form 10-K for the fiscal year ended June 30, 2022 in Part I, Item 1A, “Risk Factors,” and Infinity’s Annual Report on Form 10-K for the fiscal year ended December 31, 2022, in Part I, Item 1A, “Risk Factors.” The risks and uncertainties described above and in the SEC filings cited above are not exclusive and further information concerning MEI and Infinity and their respective businesses, including factors that potentially could materially affect their respective businesses, financial conditions or operating results, may emerge from time to time. Readers are urged to consider these factors carefully in evaluating these forward-looking statements, and not to place undue reliance on any forward-looking statements. Any such forward-looking statements represent management’s reasonable estimates and beliefs as of the date of this press release. While MEI and Infinity may elect to update such forward-looking statements at some point in the future, they disclaim any obligation to do so, other than as may be required by law, even if subsequent events cause their views to change.

This press release contains hyperlinks to information that is not deemed to be incorporated by reference.

View source version on businesswire.com: https://www.businesswire.com/news/home/20230615541252/en/

Infinity Contact

Melissa Hackel

Tel: 617-453-1117

Morrow Sodali, LLC

Tel: (800) 662-5200

[email protected]

MEI Pharma Contacts

David A. Walsey

Tel: 858-369-7104

[email protected]

Joele Frank, Wilkinson Brimmer Katcher

Dan Katcher / Aaron Palash

Tel: 212-355-4449

[email protected]

KEYWORDS: United States North America California Massachusetts

INDUSTRY KEYWORDS: Oncology Health Communications General Health Pharmaceutical Biotechnology Public Relations/Investor Relations

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bioAffinity Technologies Presents Research Findings at UMass RNA Therapeutics Symposium

SAN ANTONIO, Texas–(BUSINESS WIRE)–bioAffinity Technologies, Inc. (Nasdaq: BIAF; BIAFW), a biotechnology company addressing the need for early-stage cancer detection and broad-spectrum cancer therapeutics, will present the poster “Vitamin B12 deprivation does not phenocopy selective cytotoxicity of CD320 and LRP2 silencing” at the University of Massachusetts (UMass) T.H. Chan Medical School’s fifth annual RNA Therapeutics Symposium June 21-23, 2023, in Worcester, MA.

The RNA Therapeutics Institute at UMass leverages RNA biology and clinical research to develop new therapeutics for multiple diseases based on the fundamental mechanisms of cellular RNAs.

David Elzi, Ph.D., Vice President of Research, and William Bauta, Ph.D., Senior Vice President of Therapeutics, will discuss the Company’s recent work that demonstrated that deprivation of vitamin B12 does not play a role in the selective cytotoxicity of cancer cells observed after silencing the expression of two specific genes, CD320 and LRP2. The vitamin B12 research follows the Company’s discovery that using small interfering RNA (siRNA) to knock down CD320 and LRP2 killed cancer cells in vitro without harming healthy cells.

One of the functions of CD320 and LRP2 is to bind to and transport vitamin B12 into cells. Since they have that in common, Drs. Elzi and Bauta tested the hypothesis that eliminating vitamin B12 could be the mechanism behind the death of cancer cells when CD320 and LRP2 are silenced. Experiments proved otherwise.

“Our research on targeted gene silencing began in order to better understand the mechanism behind our proprietary porphyrin TCPP’s ability to selectively stain cancer cells. In the process, we learned that treatment with siRNAs targeting specific cell surface receptors, CD320 and LRP2, both of which transport vitamin B12, adversely affects cancer cell survival but not normal cells,” Dr. Elzi said. “However, when the cell culture medium did not contain measurable amounts of vitamin B12, we found no difference in cell growth compared to the culture medium supplemented with vitamin B12.”

“We are continuing our investigation into how and why the simultaneous knockdown of CD320 and LRP2 inhibits cancer cell growth with no apparent effect on healthy cells. Our ultimate objective is to use this discovery to develop targeted therapeutics for multiple cancers,” Dr. Bauta added.

bioAffinity Technologies’ noninvasive test for early-stage lung cancer, CyPath^® Lung, incorporates TCPP to identify cell populations in sputum that indicate cancer is present in the lung. CyPath^® Lung uses flow cytometry and AI-driven automated analysis to detect signals indicative of lung cancer.

About bioAffinity Technologies, Inc.

bioAffinity Technologies, Inc. addresses the need for noninvasive diagnosis of early-stage cancer and diseases of the lung, and targeted cancer treatment. The Company’s first product, CyPath^® Lung, is a noninvasive test that has shown high sensitivity and specificity for the detection of early-stage lung cancer. CyPath^® Lung is marketed as a laboratory developed test (LDT) by Precision Pathology Services. OncoSelect^® Therapeutics, LLC, a subsidiary of bioAffinity Technologies, is advancing its discoveries shown in vitro to kill cancer cells without harm to normal cells. Research and optimization of the Company’s platform technologies are conducted in its laboratories at The University of Texas at San Antonio. For more information, visit www.bioaffinitytech.com.

Forward-Looking Statements

This press release contains forward-looking statements, including statements regarding the anticipated use of proceeds from the Company’s offering of common shares. Forward-looking statements can be identified by words such as “believes,” “expects,” “estimates,” “intends,” “may,” “plans,” “will” and similar expressions, or the negative of these words, including statements such as continuing the Company’s investigation into how and why the simultaneous knockdown of CD320 and LRP2 inhibits cancer cell growth with no apparent effect on healthy cells and obtaining the ultimate objective to use the discovery to develop targeted therapeutics for multiple cancers. Important factors that could cause actual results to differ materially from current expectations include, among others, the ability to meet the Company’s ultimate objective to use this discovery to develop targeted therapeutics for multiple cancers and the risk factors described in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022, the Company’s Quarterly Reports on Form 10-Q, the Company’s Current Reports on Form 8-K and subsequent filings with the SEC. Such forward-looking statements are based on facts and conditions as they exist at the time such statements are made and predictions as to future facts and conditions. Readers of this press release are cautioned not to place undue reliance on any forward-looking statements. The Company does not undertake any obligation to update any forward-looking statement relating to matters discussed in this press release, except as may be required by applicable securities laws.

View source version on businesswire.com: https://www.businesswire.com/news/home/20230615885384/en/

bioAffinity Technologies

Julie Anne Overton

Director of Communications

[email protected]

LHA Investor Relations

Tirth T. Patel

[email protected]

KEYWORDS: United States North America Texas Massachusetts

INDUSTRY KEYWORDS: Biotechnology FDA Other Health Health Pharmaceutical Oncology Vitamins/Supplements Other Science Research Science Clinical Trials

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Teva to Present Data at the 2023 American Headache Society Annual Scientific Meeting Demonstrating AJOVY^® (fremanezumab-vfrm) Injection Significantly Reduced Migraine and Depression Symptoms in Patients

• Six abstracts to be presented highlighting results of AJOVY preventive treatment in patients with migraine
• Oral presentation will feature data from the UNITE study showing that AJOVY significantly reduced migraine days and depression symptoms in patients with migraine and major depressive disorder
• Findings on AJOVY real-world benefits and potential cost savings will also be presented

TEL AVIV, Israel & PARSIPPANY, N.J.–(BUSINESS WIRE)–
Teva Pharmaceuticals, a U.S. affiliate of Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA), today announced that six abstracts revealing benefits of AJOVY (fremanezumab-vfrm) injection in patients with migraine will be presented at the 2023 American Headache Society (AHS) Annual Scientific Meeting, held June 15-18 in Austin, Texas.

Featured data will include an oral presentation of the Phase 4 UNITE randomized clinical study, investigating the efficacy and safety of AJOVY for preventive treatment in patients with migraine and comorbid major depressive disorder. Results showed that treatment with AJOVY was associated with statistically significant reductions in migraine days as well as reductions in symptoms of depression (HAMD-17 and PHQ-9 scores) over 12 weeks in patients with migraine and major depressive disorder.

“Patients who suffer from migraine and mental health disorders such as depression face a greater burden than those suffering from only one disease, and have higher risks for medication overuse, poorer quality of life and greater disability if untreated,” said Eric Hughes, MD, PhD, Executive Vice President of Global R&D and Chief Medical Officer at Teva. “The data we are presenting at AHS provide further insights into the potential efficacy, safety, and quality of life benefits of AJOVY for people with migraine and major depressive disorder.”

Additional presentations at AHS will include:

• Health economics and outcomes research (HEOR) analyses examining the health care resource use pattern during the individual AJOVY treatment cycle and modeling potential cost impact associated with early initiation of AJOVY in the treatment pathway; and

• Findings from the FINESSE study, a real-world, prospective, observational study to evaluate the effectiveness of AJOVY in patients with chronic and episodic migraine, including those for whom another calcitonin gene-related peptide (CGRP) pathway monoclonal antibody has failed.

The 2023 AHS Annual Scientific Meeting is being offered both in-person and virtually. Data presentations can be accessed by registering for the meeting.

The full set of Teva-sponsored AJOVY data to be presented includes:

UNITE

UNITE was a 12-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase 4 study followed by a 12-week open-label extension (OLE) period. The study aimed to evaluate the efficacy and safety of AJOVY in adults with migraine and major depressive disorder. Patients were randomized 1:1 to receive 225 mg subcutaneous monthly AJOVY or matched placebo for 12 weeks.

The primary endpoint was the mean change in average number of monthly migraine days from baseline to Week 12 after the first dose of the study drug. Secondary efficacy endpoints included the proportion of patients achieving ≥50% reduction in major depressive disorder from baseline to Week 12.

The UNITE presentations at AHS will include:

• P-231 Efficacy of fremanezumab treatment in reducing monthly migraine days in patients with migraine and major depressive disorder: results from the UNITE study
  
  Presentation type: Poster (de novo)
  
  Session: Friday Midday Exhibits and Posters
  
  Date/Time: June 16, 2023, 12:35-1:50 PM CT

• IO-05 Efficacy of fremanezumab in reducing depression in patients with migraine and major depressive disorder: results of the UNITE study
  
  Presentation type: Oral
  
  Session: Industry-Submitted Abstracts
  
  Date/Time: June 17, 2023, 8:10-8:20 AM CT

• P-232 Impact of fremanezumab treatment on disability outcomes in patients with migraine and major depressive disorder: results of the UNITE study
  
  Presentation type: Poster (de novo)
  
  Session: Saturday Midday Exhibits and Posters
  
  Date/Time: June 17, 2023, 12:45-2:00 PM CT

HEOR Analyses

Results from two analyses will be presented: an economic modeling analysis which estimated potential cost savings associated with use of AJOVY earlier in the treatment cycle; and a real-world database (administrative claims) analysis which examined health care resource use (HCRU) during individual AJOVY treatment cycles to determine if there was an indication of a wearing-off effect with AJOVY.

The two HEOR presentations at AHS will include:

• P-107 Initiation of fremanezumab earlier in the treatment cycle may result in cost savings to payors in the United States
  
  Presentation type: Poster (encore)
  
  Session: Friday Midday Exhibits and Posters
  
  Date/Time: June 16, 2023, 12:35-1:50 PM CT

• P-130 No ‘wearing-off effect’ seen with fremanezumab in the real‑world: a retrospective, claims-based analysis of migraine-related healthcare resource and acute medication use
  
  Presentation type: Poster (encore)
  
  Session: Saturday Midday Exhibits and Posters
  
  Date/Time: June 17, 2023, 12:45-2:00 PM CT

FINESSE

The FINESSE study is a 49-month (25-month recruitment and 24-month follow-up) multicenter, two-country (Germany/Austria) prospective observational study to evaluate the real-world effectiveness of AJOVY in patients with chronic and episodic migraine during routine clinical practice.

The primary endpoint is the proportion of patients reaching ≥ 50% reduction in the monthly average number of migraine days evaluated during the 6-month period after the first dose of AJOVY. Secondary endpoints of the study include changes from baseline in the monthly average number of migraine days, disability scores, and days of acute migraine medication use per month.

The FINESSE presentation at AHS will include:

• P-162 Real-world effectiveness of fremanezumab in patients with migraine who switched from another mAb targeting the CGRP pathway (subgroup analysis from FINESSE)
  
  Presentation type: Poster (encore)
  
  Session: Saturday Midday Exhibits and Posters
  
  Date/Time: June 17, 2023, 12:45-2:00 PM CT

About AJOVY (fremanezumab-vfrm) Injection

AJOVY is available as a 225 mg/1.5 mL single dose injection in a prefilled syringe or autoinjector with two dosing options – 225 mg administered monthly as one subcutaneous injection, or 675 mg every three months (quarterly), which is administered as three subcutaneous injections. AJOVY can be administered in office by a healthcare professional or at home by a patient or caregiver. No starting dose is required to begin treatment. AJOVY is now approved in 45 countries worldwide.

Indications and Usage

AJOVY is a calcitonin gene-related peptide antagonist indicated for the preventive treatment of migraine in adults.

U.S. Important Safety Information about AJOVY (fremanezumab-vfrm) injection

Contraindications: AJOVY is contraindicated in patients with serious hypersensitivity to fremanezumab-vfrm or to any of the excipients. Reactions have included anaphylaxis and angioedema.

Hypersensitivity Reactions: Hypersensitivity reactions, including rash, pruritus, drug hypersensitivity, and urticaria were reported with AJOVY in clinical trials. Most reactions were mild to moderate, but some led to discontinuation or required corticosteroid treatment. Most reactions were reported from within hours to one month after administration. Cases of anaphylaxis and angioedema have been reported in the postmarketing setting. If a hypersensitivity reaction occurs, consider discontinuing AJOVY and institute appropriate therapy.

Adverse Reactions: The most common adverse reactions in clinical trials (≥5% and greater than placebo) were injection site reactions.

Please click here for full U.S. Prescribing Information for AJOVY (fremanezumab-vfrm) injection.

About Teva

Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) has been developing and producing medicines to improve people’s lives for more than a century. We are a global leader in generic and innovative medicines with a portfolio consisting of over 3,500 products in nearly every therapeutic area. Around 200 million people around the world take a Teva medicine every day, and are served by one of the largest and most complex supply chains in the pharmaceutical industry. Along with our established presence in generics, we have significant innovative research and operations supporting our growing portfolio of innovative and biopharmaceutical products. Learn more at www.tevapharm.com.

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, which are based on management’s current beliefs and expectations and are subject to substantial risks and uncertainties, both known and unknown, that could cause our future results, performance or achievements to differ significantly from that expressed or implied by such forward-looking statements. You can identify these forward-looking statements by the use of words such as “should,” “expect,” “anticipate,” “estimate,” “target,” “may,” “project,” “guidance,” “intend,” “plan,” “believe” and other words and terms of similar meaning and expression in connection with any discussion of future operating or financial performance. Important factors that could cause or contribute to such differences include risks relating to the development and commercial success ofAJOVY; our ability to successfully compete in the marketplace, including our ability to develop and commercialize competition for our innovative medicines, including AUSTEDO^®, AJOVY and COPAXONE^®, our ability to achieve expected results from investments in our product pipeline, our ability to develop and commercialize additional pharmaceutical products, and the effectiveness of our patents and other measures to protect our intellectual property rights; our substantial indebtedness; our business and operations in general, including, the impact of global economic conditions and other macroeconomic developments and the governmental and societal responses thereto, and costs and delays resulting from the extensive pharmaceutical regulation to which we are subject; compliance, regulatory and litigation matters, including failure to comply with complex legal and regulatory environments; other financial and economic risks; and other factors discussed in our Quarterly Report on Form 10-Q for the first quarter of 2023 and in our Annual Report on Form 10-K for the year ended December 31, 2022, including in the section captioned “Risk Factors.” Forward-looking statements speak only as of the date on which they are made, and we assume no obligation to update or revise any forward-looking statements or other information contained herein, whether as a result of new information, future events or otherwise. You are cautioned not to put undue reliance on these forward-looking statements.

View source version on businesswire.com: https://www.businesswire.com/news/home/20230615055849/en/

IR

United States

Ran Meir

(267) 468-4072

Yael Ashman

972 (3) 914-8262

PR

United States

Doris Yiu

(973) 265-3752

Yonatan Beker

(973) 917-0851

KEYWORDS: United States North America Israel Middle East Texas New Jersey

INDUSTRY KEYWORDS: Mental Health Health Clinical Trials Research Science Pharmaceutical Biotechnology

MEDIA:

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