{"id":999924,"date":"2026-09-02T10:16:34","date_gmt":"2026-09-02T14:16:34","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/"},"modified":"2026-09-02T10:16:34","modified_gmt":"2026-09-02T14:16:34","slug":"hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/","title":{"rendered":"HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>HCW9302 is a best-in-class IL-2-based immunotherapeutic for treatment of autoimmune diseases through expanding and activating regulatory T cells<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>Patent allowance received for use of HCW9302 as treatment for alopecia areata<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>Phase 1 dose-escalating clinical study evaluating HCW9302 as monotherapy in patients with alopecia areata on track for completion in Q4 2026, continues to be well tolerated with no dose-limiting toxicities<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>Preliminary readout of first two dose cohorts is encouraging &#8212; patients diagnosed with alopecia areata show positive response after single dose of monotherapy at 3 micrograms\/kg dose level<\/em>\n      <\/p>\n<p align=\"justify\">MIRAMAR, Fla., Sept.  02, 2026  (GLOBE NEWSWIRE) &#8212; HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d) (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on developing novel fusion immunotherapeutics to treat autoimmune diseases, cancer, and senescence-associated dysplasia, announced receipt of a Notice of Allowance from the U.S. Patent and Trademark Office (\u201cUSPTO\u201d) for claims directed to use of HCW9302 to treat alopecia areata (U.S. Patent Application Publication No. US2026\/0139043).<\/p>\n<p align=\"justify\">Together with four other recently issued patents (U.S. Patent No. 11,401,326, U.S. Patent No. 11,987,619, U.S. Patent No.12,018,071, U.S. Patent No. 12,516,112) with claims for broad compositions, nucleic acids encoding for HCW9302 and the vectors comprising these, and method of treating other autoimmune diseases, the underlying U.S. patent estate has been further strengthened for the protection of the Company\u2019s intellectual property related to further development and potential commercialization of HCW9302, a best-in-class IL-2-based immunotherapeutic for the treatment of autoimmune diseases. The Company continues to extend protection of its broad rights for treatments for all indications with respect to HCW9302 built on the foundation of its worldwide, perpetual, fully paid-up, royalty-free, exclusive license rights for this compound. \u00a0\u00a0\u00a0<\/p>\n<p align=\"justify\">Dr. Hing C. Wong, the Company\u2019s Founder and Chief Executive Officer, stated, \u201cOur lead clinical product candidate HCW9302 exhibits a strong IL-2R\u03b1 bias, a unique and novel mechanism of action, while preferentially expanding and stimulating T<sub>reg<\/sub>\u00a0cells to reduce pro-inflammatory and autoimmune responses in relevant animal models, including alopecia areata, atherosclerosis, and atopic dermatitis. This strong IL-2R\u03b1 bias differentiates HCW9302 from native recombinant IL-2 and other IL-2-based muteins and PEG conjugates, which typically exhibit reduced binding activity to IL-2R\u03b1 components. In addition, HCW9302 is comprised of all human-derived components and can be produced with a cost-effective, streamlined process similar to therapeutic monoclonal antibodies. Ongoing clinical activity for alopecia areata patients continues to be encouraging. With exceptionally strong intellectual property protection in place, we are vigorously pursuing alopecia areata as our lead indication of HCW9302. We are on track to provide the full Phase 1 readout of the current trial in Q4 2026 (<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=l95eBaMDU8tqDwgHajPReFWK-TucgyQ23Hic4srLgkwU4PqAQUJJIqsntgu1mWRMTxmJTR2TlUe6qLcHUkCBQD4FXgxzdqitd1C7B9U4WgmxlAwmoUPRg88ERZpohwUVA3r1z0fswspKc63fIJa4Sg==\" rel=\"nofollow\" target=\"_blank\">ClinicalTrials.gov ID: NCT07049328<\/a>).\u201d\u00a0\u00a0\u00a0\u00a0<\/p>\n<p align=\"justify\">\n        <strong>About HCW Biologics:<\/strong>\n      <\/p>\n<p align=\"justify\">HCW Biologics Inc. (the \u201cCompany\u201d) (NASDAQ: HCWB) is a clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to treat diseases promoted by chronic inflammation, including autoimmune diseases, cancer, and senescence-associated dysplasia. HCW Biologics is the leader in creation of multi-valent immunotherapeutics with a unique protein-based scaffold, without the antibody Fc domain. The Company\u2019s immunotherapeutics represent a new class of drugs that it believes have the potential to fundamentally change the treatment of proinflammatory and senescence-associated diseases and conditions that are promoted by chronic inflammation \u2014and in doing so, improve patients\u2019 quality of life and possibly extend longevity. A key aspect of the Company\u2019s clinical development and financing strategy is to focus on its business development programs, including its commercial-ready reagents to be used in the production of immunotherapeutics for cancer and infectious diseases. To date, the Company has entered into two licensing agreements in which it has licensed exclusive, worldwide rights for some of its proprietary molecules. See the Company Pipeline at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=IsSc0AiGb0yEKgfbWqQ6ITlt4hlpKphX5ySGi1312cSTl1q44xpWLZwZlQ2Bme3uaP3gGjjNlJyXeRX0Ss9K19bkJsEVHwwnjz-EBFfVjesTt1YRi-5dnymeVCyRA-rC\" rel=\"nofollow\" target=\"_blank\">https:\/\/hcwbiologics.com\/pipeline\/<\/a><\/p>\n<p align=\"justify\">\n        <strong>Forward Looking Statements:<\/strong>\n      <\/p>\n<p align=\"justify\">Statements in this press release contain \u201cforward-looking statements\u201d that are subject to substantial risks and uncertainties. These statements are made under the \u201csafe harbor\u201d provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements contained in this press release may be identified by the use of words such as \u201canticipate,\u201d \u201cexpect,\u201d \u201cbelieve,\u201d \u201cwill,\u201d \u201cmay,\u201d \u201cshould,\u201d \u201cestimate,\u201d \u201cproject,\u201d \u201coutlook,\u201d \u201cforecast\u201d or other similar words and include, that a patent and\/or specific alopecia treatment allowed claims will issue from U.S. Patent Application Publication No. US2026\/0139043; the safety, ability and efficacy of HCW9302 to treat autoimmune diseases and other inflammatory diseases, including the efficacy of HCW9302 in the treatment of alopecia areata from preliminary clinical safety data; the ability of HCW9302 to advance to Phase 2 clinical trials; the ability of HCW9302 to treat other autoimmune or neurodegenerative conditions; the ability of HCW9302 to expand and stimulate T<sub>reg<\/sub>\u00a0cells to reduce pro-inflammatory and autoimmune responses in relevant animal models; the completion of the full Phase 1 readout of the trial in Q4 2026. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Factors that could cause actual results to differ include, but are not limited to, the risks and uncertainties that are described in the section titled \u201cRisk Factors\u201d in the annual report on Form 10-K filed with the United States Securities and Exchange Commission (the \u201cSEC\u201d) on March 31, 2026, the quarterly report on Form 10-Q filed with the SEC on August 14, 2026, and in other filings filed from time to time with the SEC.<\/p>\n<p align=\"justify\">\n        <strong>Company Contact:<\/strong><br \/>\n        <br \/>\n        <strong>Dr. Peter Rhode<\/strong><br \/>\n        <br \/>Chief Scientific Officer and Vice President of Clinical Operations<br \/>HCW Biologics Inc.<br \/>PeterRhode@HCWBiologics.com<\/p>\n<p>This press release was published by a CLEAR\u00ae Verified individual.<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgxOTcxMyM3ODExNjIxIzIyMTAxOTg=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/NWVjYmFmMDUtMDYwZS00MzVkLTg0NzEtNTU3Yzg2ZmQ2Mzg0LTEyMjE3NTEtMjAyNi0wOS0wMi1lbg==\/tiny\/HCW-Biologics-Inc.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>HCW9302 is a best-in-class IL-2-based immunotherapeutic for treatment of autoimmune diseases through expanding and activating regulatory T cells Patent allowance received for use of HCW9302 as treatment for alopecia areata Phase 1 dose-escalating clinical study evaluating HCW9302 as monotherapy in patients with alopecia areata on track for completion in Q4 2026, continues to be well tolerated with no dose-limiting toxicities Preliminary readout of first two dose cohorts is encouraging &#8212; patients diagnosed with alopecia areata show positive response after single dose of monotherapy at 3 micrograms\/kg dose level MIRAMAR, Fla., Sept. 02, 2026 (GLOBE NEWSWIRE) &#8212; HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d) (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on developing novel fusion immunotherapeutics to treat autoimmune &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-999924","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"HCW9302 is a best-in-class IL-2-based immunotherapeutic for treatment of autoimmune diseases through expanding and activating regulatory T cells Patent allowance received for use of HCW9302 as treatment for alopecia areata Phase 1 dose-escalating clinical study evaluating HCW9302 as monotherapy in patients with alopecia areata on track for completion in Q4 2026, continues to be well tolerated with no dose-limiting toxicities Preliminary readout of first two dose cohorts is encouraging &#8212; patients diagnosed with alopecia areata show positive response after single dose of monotherapy at 3 micrograms\/kg dose level MIRAMAR, Fla., Sept. 02, 2026 (GLOBE NEWSWIRE) &#8212; HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d) (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on developing novel fusion immunotherapeutics to treat autoimmune &hellip; Continue reading &quot;HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-09-02T14:16:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgxOTcxMyM3ODExNjIxIzIyMTAxOTg=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment\",\"datePublished\":\"2026-09-02T14:16:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\\\/\"},\"wordCount\":918,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTgxOTcxMyM3ODExNjIxIzIyMTAxOTg=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\\\/\",\"name\":\"HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/","og_locale":"en_US","og_type":"article","og_title":"HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment - Market Newsdesk","og_description":"HCW9302 is a best-in-class IL-2-based immunotherapeutic for treatment of autoimmune diseases through expanding and activating regulatory T cells Patent allowance received for use of HCW9302 as treatment for alopecia areata Phase 1 dose-escalating clinical study evaluating HCW9302 as monotherapy in patients with alopecia areata on track for completion in Q4 2026, continues to be well tolerated with no dose-limiting toxicities Preliminary readout of first two dose cohorts is encouraging &#8212; patients diagnosed with alopecia areata show positive response after single dose of monotherapy at 3 micrograms\/kg dose level MIRAMAR, Fla., Sept. 02, 2026 (GLOBE NEWSWIRE) &#8212; HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d) (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on developing novel fusion immunotherapeutics to treat autoimmune &hellip; Continue reading \"HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/","og_site_name":"Market Newsdesk","article_published_time":"2026-09-02T14:16:34+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgxOTcxMyM3ODExNjIxIzIyMTAxOTg=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment","datePublished":"2026-09-02T14:16:34+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/"},"wordCount":918,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgxOTcxMyM3ODExNjIxIzIyMTAxOTg=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-strengthens-u-s-patent-estate-for-its-lead-clinical-stage-immunotherapeutic-hcw9302-as-alopecia-areata-treatment\/","name":"HCW Biologics Strengthens U.S. Patent Estate for Its Lead Clinical-Stage Immunotherapeutic HCW9302 as Alopecia Areata Treatment - 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