{"id":997422,"date":"2026-08-24T07:33:47","date_gmt":"2026-08-24T11:33:47","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/"},"modified":"2026-08-24T07:33:47","modified_gmt":"2026-08-24T11:33:47","slug":"briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/","title":{"rendered":"BriaCell Advances Personalized Melanoma Immunotherapy Vaccine Candidate, Bria-MEL+\u2122"},"content":{"rendered":"<div class=\"mw_release\">\n<ul type=\"disc\">\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Cell-based immunotherapy program is designed to harness patients\u2019 own immune systems <\/em><br \/>\n          <\/strong>\n        <\/li>\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Bria-MEL+ is a personalized, off-the-shelf immunotherapy vaccine candidate intended to enable patient specific treatment without individualized manufacturing<\/em><br \/>\n          <\/strong>\n        <\/li>\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Program builds on BriaCell\u2019s experience in metastatic breast cancer and prostate cancer, further expanding its therapeutic vaccine platform <\/em><br \/>\n          <\/strong>\n        <\/li>\n<li style=\"text-align:justify\">\n          <strong><br \/>\n            <em>Melanoma remains a significant unmet medical need, with approximately 112,000 new cases and 8,510 deaths expected in the US in 2026<\/em><br \/>\n          <\/strong>\n        <\/li>\n<\/ul>\n<p align=\"justify\">PHILADELPHIA and VANCOUVER, British Columbia, Aug.  24, 2026  (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, today announced that Bria-MEL+, its personalized whole cell melanoma immunotherapy vaccine candidate, has achieved a key genetic engineering milestone, advancing the program toward clinical development.<\/p>\n<p align=\"justify\">Bria-MEL+ is a cell-based therapeutic cancer vaccine designed to harness a patient\u2019s own immune system to combat melanoma. The program is <em>personalized<\/em> yet \u2018<em>off-the-shelf<\/em>\u2019: a simple patient saliva test will determine which of the several premanufactured treatment cell lines will be selected for personalized treatment, avoiding the need to manufacture a unique product for each individual patient.<\/p>\n<p align=\"justify\">\u201cBria-MEL+\u00a0is designed to combine the advantages of personalized immunotherapy with the accessibility of an off-the-shelf vaccine,\u201d said William V. Williams, MD, President and Chief Executive Officer of BriaCell. \u201cBy eliminating individualized manufacturing, we believe this approach has the potential to broaden access, shorten treatment timelines, and reduce treatment costs while preserving patient-specific matching.\u201d<\/p>\n<p align=\"justify\">\u201cBuilding on the encouraging efficacy and tolerability results from BriaCell\u2019s metastatic breast cancer immunotherapy program, we continue to expand our pipeline with additional personalized, cell-based immunotherapy vaccine candidates, including Bria-MEL+\u00a0for melanoma,\u201d stated Miguel A. Lopez-Lago, PhD, BriaCell\u2019s Chief Scientific Officer.<\/p>\n<p align=\"justify\">\n        <strong>About Bria-MEL+\u2122<\/strong>\n      <\/p>\n<p align=\"justify\">Bria-MEL+ is a personalized, off-the-shelf, genetically modified whole-cell cancer vaccine designed to activate multiple components of the immune system, including innate and adaptive immune responses, to target and destroy melanoma cells. The program is derived from BriaCell\u2019s Bria-OTS+\u2122 (<strong><u>o<\/u><\/strong>ff-<strong><u>t<\/u><\/strong>he-<strong><u>s<\/u><\/strong>helf) cellular immunotherapy platform and is being developed using premanufactured cell lines selected through patient HLA matching.<\/p>\n<p align=\"justify\">BriaCell\u2019s Bria-MEL+ expands the Company\u2019s personalized immunotherapy platform which is led by Bria-IMT\u2122, currently in a pivotal Phase 3 trial for metastatic breast cancer. BriaCell is also advancing Bria-OTS\u2122 in breast cancer, in which the first patient dosed experienced <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Mgf_PmjX4haTv_7lq4s_-V1W_u7zkPtHBSFUoLCBzbAdeGcLOgwpE4MPTOyWq5cbHK7qlvHuviax8muYG0U4vwgXogOvCbL-yeL_yUikTrzlVR7NAc0zuSfMpAYWtoTHwFEGeAyDCCgyeUOIYv3xCxlwlj5CivmxIi3R-J8SSRlIhZbN3jv4b9uL4kIa0iZ058FiQGVW-DhySD5rLIjO693QPYVsmeF7nLQFoFnn_lQ=\" rel=\"nofollow\" target=\"_blank\">sustained complete resolution of a lung metastasis<\/a>, and Bria-PROS+\u2122 in prostate cancer which has recently received FDA clearance to initiate clinical evaluation. The Bria-MEL+, Bria-PROS+ and Bria-OTS programs are based on matching patient HLA type with the corresponding immunotherapy cell line.<\/p>\n<p align=\"justify\">Earlier In 2026, BriaCell reported preclinical data from the Bria-OTS+ platform at the <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=0TCqW_aLlm24iBdwBg4I7fUnf8IgoTzUMxE-PqAQiIefQpUPS9NW_G1cMxJMgcHEW-fFLEPVkgOlQkncsC7X4lKgOt0OhpORe6BX8IdhtKXOMVmjX3iCGNCtzq6nEQX44IFB-GPdhEuNhegsPHL0EKtIc07rqJMYWSz6nmcz3V7AKjumCs2EmJNVAg8HOVau\" rel=\"nofollow\" target=\"_blank\">AACR Annual Meeting<\/a>, Bria-OTS+ demonstrated activation of both adaptive and innate immunity, including na\u00efve\/resting T cells, dendritic cells, and natural killer (NK) cells, inducing immune memory and eliciting \u201cserial killer\u201d activity against cancer cells. BriaCell believes this multipronged immune activation supports the potential of the Bria-OTS+ platform to generate anti-tumor immune responses and informs the development of Bria-MEL+ for melanoma.<\/p>\n<p align=\"justify\">BriaCell has commenced development activities to support production of Bria-MEL+ for potential clinical use. Bria-MEL+ recently passed a key milestone in the genetic engineering process, streamlining the path to the clinic.<\/p>\n<p align=\"justify\">\n        <strong>Melanoma Facts<\/strong>\n      <\/p>\n<p align=\"justify\">The American Cancer Society estimates that approximately 112,000 new cases of melanomas will be diagnosed in the United States in 2026, including about 65,400 in men and 46,600 in women. Based on 2021\u20132023 Surveillance, Epidemiology, and End Results (SEER)\u00a0data, approximately 2.2% of men and women will be diagnosed with skin melanoma during their lifetime.<\/p>\n<p align=\"justify\">Despite major advances in treatment, melanoma remains a significant unmet medical need. Approximately 8510 people are expected to die from melanoma in the United States in 2026, including about 5500 men and 3010 women. Melanoma accounts for only about 1% of skin cancers but causes a large majority of skin cancer deaths.<\/p>\n<p align=\"justify\">\n        <strong>About BriaCell Therapeutics Corp.<\/strong>\n      <\/p>\n<p align=\"justify\">BriaCell is an immuno-oncology-focused biotechnology company developing targeted and effective approaches for the management of cancer. More information is available at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=7idsnuiM77Mc4J_E2FuCJrKxFgLZNCag0Er3EdEmGItoyYQZNlvEiTJvHPsf_WLS1pR_63rksxSJZOS0zAp-lV_4xpskhUrymQxQhAyRFFQ=\" rel=\"nofollow\" target=\"_blank\">https:\/\/briacell.com\/<\/a>.<\/p>\n<p align=\"justify\">\n        <strong>Safe Harbor<\/strong>\n      <\/p>\n<p align=\"justify\">This press release contains \u201cforward-looking statements\u201d that are subject to substantial risks and uncertainties. All statements, other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements contained in this press release may be identified by the use of words such as \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccontemplate,\u201d \u201ccould,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cseek,\u201d \u201cmay,\u201d \u201cmight,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201ctarget,\u201d \u201caim,\u201d \u201cshould,\u201d \u201cwill,\u201d \u201cwould,\u201d or the negative of these words or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements, including those regarding the development of Bria-MEL+, its potential clinical use in melanoma, its personalized off-the-shelf design and potential immune\u2011stimulating and anti\u2011tumor activity, the advancement of Bria-MEL+ toward clinical development, pipeline expansion leveraging BriaCell\u2019s oncology immunotherapy platform, and expectations regarding the potential clinical benefits of the Bria\u2011OTS+ platform, are based on BriaCell\u2019s current expectations and are subject to inherent uncertainties, risks, and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. These and other risks and uncertainties are described more fully under the heading \u201cRisks and Uncertainties\u201d in the Company\u2019s most recent Management\u2019s Discussion and Analysis, under the heading \u201cRisk Factors\u201d in the Company\u2019s most recent Annual Information Form, and under \u201cRisks and Uncertainties\u201d in the Company\u2019s other filings with the Canadian securities regulatory authorities and the U.S. Securities and Exchange Commission, all of which are available under the Company\u2019s profiles on SEDAR+ at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=SiRqLUUAiJKRwZ8f6elbUWk88km5tID1N0fq4KAVIuUjl9xqD2VdJbx8bu2Cxo4l61pU6NZiCyZBOmB8K6MDOBlm5XvDcKM_Bsx3P8SGfIE=\" rel=\"nofollow\" target=\"_blank\"><strong>www.sedarplus.ca<\/strong><\/a> and on EDGAR at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=SiRqLUUAiJKRwZ8f6elbUW2ArFCfVDLNQm2tAk6dAlHnw1vgubz5IX2NLxSZCTpKawzV8Na1DZAtsYSxqcQa1w==\" rel=\"nofollow\" target=\"_blank\"><strong>www.sec.gov<\/strong><\/a>. Forward-looking statements contained in this announcement are made as of this date, and BriaCell Therapeutics Corp. undertakes no duty to update such information except as required under applicable law.<\/p>\n<p align=\"justify\">Neither the Toronto Stock Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Toronto Stock Exchange) accepts responsibility for the adequacy or accuracy of this release.<\/p>\n<p align=\"left\">\n        <strong>Contact Information<\/strong>\n      <\/p>\n<p align=\"left\">\n        <strong>Company Contact:<\/strong><br \/>\n        <br \/>William V. Williams, MD<br \/>President &amp; CEO<br \/>1-888-485-6340<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=C_lykjY6EIzrLiespBoSiTGOmM5efgVbHeZMyuYXTMFffBnx5OSLlJ1tazgGtEC8IUyOK0Tnu5ysqp44nOEUXZvPkGEemlbCFqDAMB47HkE=\" rel=\"nofollow\" target=\"_blank\">info@briacell.com<\/a>\u00a0<\/p>\n<p align=\"left\">\n        <strong>Investor Relations Contact:<\/strong><br \/>\n        <br \/>\n        <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=4TeqGD93m7ZOIv2LLJ5r9qinKOrsyu5oZJXV7ID0Kia6c1TTS7LA-8uZyenp8SHptUL9CaYEDw7tmfAoqSVvfSZMrLX10AyzHkLEQx9JAJk=\" rel=\"nofollow\" target=\"_blank\">investors@briacell.com<\/a>\n      <\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgxNDc0MSM3Nzg4MzU2IzIwOTA2NTg=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/NmIzMmM0NjYtNzRlZC00Zjk2LTg2YmYtNjQ1YzI1YjMxMjk1LTExMDIyMjktMjAyNi0wOC0yNC1lbg==\/tiny\/BriaCell-Therapeutics-Corp-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cell-based immunotherapy program is designed to harness patients\u2019 own immune systems Bria-MEL+ is a personalized, off-the-shelf immunotherapy vaccine candidate intended to enable patient specific treatment without individualized manufacturing Program builds on BriaCell\u2019s experience in metastatic breast cancer and prostate cancer, further expanding its therapeutic vaccine platform Melanoma remains a significant unmet medical need, with approximately 112,000 new cases and 8,510 deaths expected in the US in 2026 PHILADELPHIA and VANCOUVER, British Columbia, Aug. 24, 2026 (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, today announced that Bria-MEL+, its personalized whole cell melanoma immunotherapy vaccine candidate, has achieved a key genetic engineering milestone, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;BriaCell Advances Personalized Melanoma Immunotherapy Vaccine Candidate, Bria-MEL+\u2122&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-997422","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BriaCell Advances Personalized Melanoma Immunotherapy Vaccine Candidate, Bria-MEL+\u2122 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BriaCell Advances Personalized Melanoma Immunotherapy Vaccine Candidate, Bria-MEL+\u2122 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Cell-based immunotherapy program is designed to harness patients\u2019 own immune systems Bria-MEL+ is a personalized, off-the-shelf immunotherapy vaccine candidate intended to enable patient specific treatment without individualized manufacturing Program builds on BriaCell\u2019s experience in metastatic breast cancer and prostate cancer, further expanding its therapeutic vaccine platform Melanoma remains a significant unmet medical need, with approximately 112,000 new cases and 8,510 deaths expected in the US in 2026 PHILADELPHIA and VANCOUVER, British Columbia, Aug. 24, 2026 (GLOBE NEWSWIRE) &#8212; BriaCell Therapeutics Corp. (Nasdaq: BCTX, BCTXL) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, today announced that Bria-MEL+, its personalized whole cell melanoma immunotherapy vaccine candidate, has achieved a key genetic engineering milestone, &hellip; Continue reading &quot;BriaCell Advances Personalized Melanoma Immunotherapy Vaccine Candidate, Bria-MEL+\u2122&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-08-24T11:33:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgxNDc0MSM3Nzg4MzU2IzIwOTA2NTg=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"BriaCell Advances Personalized Melanoma Immunotherapy Vaccine Candidate, Bria-MEL+\u2122\",\"datePublished\":\"2026-08-24T11:33:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\\\/\"},\"wordCount\":1013,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTgxNDc0MSM3Nzg4MzU2IzIwOTA2NTg=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\\\/\",\"name\":\"BriaCell Advances Personalized Melanoma Immunotherapy Vaccine Candidate, Bria-MEL+\u2122 - 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(Nasdaq: BCTX, BCTXL) (TSX: BCT) (\u201cBriaCell\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company developing novel immunotherapies to transform cancer care, today announced that Bria-MEL+, its personalized whole cell melanoma immunotherapy vaccine candidate, has achieved a key genetic engineering milestone, &hellip; Continue reading \"BriaCell Advances Personalized Melanoma Immunotherapy Vaccine Candidate, Bria-MEL+\u2122\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/","og_site_name":"Market Newsdesk","article_published_time":"2026-08-24T11:33:47+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgxNDc0MSM3Nzg4MzU2IzIwOTA2NTg=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"BriaCell Advances Personalized Melanoma Immunotherapy Vaccine Candidate, Bria-MEL+\u2122","datePublished":"2026-08-24T11:33:47+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/"},"wordCount":1013,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgxNDc0MSM3Nzg4MzU2IzIwOTA2NTg=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/briacell-advances-personalized-melanoma-immunotherapy-vaccine-candidate-bria-mel\/","name":"BriaCell Advances Personalized Melanoma Immunotherapy Vaccine Candidate, Bria-MEL+\u2122 - 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