{"id":996646,"date":"2026-08-19T08:35:23","date_gmt":"2026-08-19T12:35:23","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/biodexa-announces-major-milestone-for-its-serenta-registrational-phase-3-trial-in-fap\/"},"modified":"2026-08-19T08:35:23","modified_gmt":"2026-08-19T12:35:23","slug":"biodexa-announces-major-milestone-for-its-serenta-registrational-phase-3-trial-in-fap","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/biodexa-announces-major-milestone-for-its-serenta-registrational-phase-3-trial-in-fap\/","title":{"rendered":"Biodexa announces major milestone for its Serenta registrational Phase 3 trial in FAP"},"content":{"rendered":"
\n

August 19, 2026<\/p>\n

\n Biodexa announces major milestone for its Serenta registrational Phase 3 trial in FAP<\/b>\n <\/p>\n

\n 87 subjects, over 50% of target, recruited<\/b>\n <\/p>\n

Biodexa Pharmaceuticals PLC (Nasdaq: BDRX) (\u201cBiodexa\u201d or \u201cthe Company\u201d), a clinical stage biopharmaceutical company developing innovative products focused on the treatment or prevention of gastrointestinal cancers is pleased to announce that it has exceeded the half-way point in the recruitment of subjects in its registrational Phase 3 trial of eRapa in Familial Adenomatous Polyposis (FAP), NCT06950385. As of today, 87 of a planned 168 subjects have been recruited into the Serenta trial. The trial is recruiting at 29 clinical sites across the US and five countries in Europe with a further three sites in Canada expected to be initiated shortly.<\/p>\n

The Company is planning a futility analysis after 25 Progression Free Survival (PFS) events and database lock after 75 PFS events in the Serenta trial. The Serenta protocol includes a composite endpoint which defines the nature of the PFS events.<\/p>\n

Commenting, Stephen Stamp, Chief Executive Officer of Biodexa said \u201cI should like to thank our collaborators at the leading FAP treatment centers who have helped drive recruitment in Serenta and put us ahead of any competition.\u201d<\/i><\/p>\n

\n About Familial Adenomatous Polyposis<\/b>\n <\/p>\n

FAP is characterized by the proliferation of polyps in the colon and\/or rectum, usually occurring in mid-teens. There is no approved therapeutic option for treating FAP patients, for whom active surveillance and surgical resection of the colon and\/or rectum remain the standard of care. If untreated, FAP typically leads to cancer of the colon and\/or rectum. There is a significant hereditary component to FAP with a reported incidence of one in 5,000 to 10,000 in the US and one in 11,300 to 37,600 in Europe. eRapa has received Orphan Drug Designation in the US and in Europe. Importantly, mTOR has been shown to be over-expressed in FAP polyps \u2013 thereby underscoring the rationale for using a potent and safe mTOR inhibitor like eRapa to treat FAP.<\/p>\n

\n About eRapa<\/b>
\n
eRapa is a proprietary oral capsule formulation of rapamycin, also known as sirolimus. Rapamycin is an mTOR (mammalian Target Of Rapamycin) inhibitor. mTOR has been shown to have a significant role in the signalling pathway that regulates cellular metabolism, growth and proliferation and is activated during tumorigenesis. Importantly, mTOR has been shown to be over-expressed in FAP polyps \u2013 thereby underscoring the rationale for using a potent and safe mTOR inhibitor like eRapa to treat FAP. Data from an open label Phase 2 trial were presented at Digestive Disease Week and InSIGHT 2024 in May and June 2024, respectively. Based on those data, Biodexa initiated a double-blind, placebo-controlled Phase 3 registrational trial which is planned to initiate 30 clinical sites across the US and Europe and to enrol 168 subjects randomized 2:1, drug: placebo. The Phase 3 program is supported by a $20 million grant from the Cancer Prevention and Research Institute of Texas.<\/p>\n

\n The Cancer Prevention and Research Institute of Texas<\/b>
\n
To date, CPRIT has awarded\u00a0$2.9 billion\u00a0in grants to\u00a0Texas\u00a0research institutions and organizations through its academic research, prevention and product development research programs. CPRIT has recruited 237 distinguished researchers, supported the establishment, expansion or relocation of 43 companies to\u00a0Texas\u00a0and generated over\u00a0$5.7 billion\u00a0in additional public and private investment. CPRIT funding has advanced scientific and clinical knowledge and provided 7.4 million life-saving cancer prevention and early detection services reaching Texans from all 254 counties. On\u00a0November 5, 2019,\u00a0Texas\u00a0voters overwhelmingly approved a constitutional amendment to provide an additional\u00a0$3 billion\u00a0to CPRIT for a total\u00a0$6 billion\u00a0investment in cancer research and prevention. Learn more at\u00a0https:\/\/cprit.texas.gov\/<\/a>.<\/p>\n

\n About Biodexa Pharmaceuticals PLC<\/b>\n <\/p>\n

The Company\u2019s lead development programs include eRapa, under development for Familial Adenomatous Polyposis and Non-Muscle Invasive Bladder Cancer, MTX240 under development for Gastrointestinal Stromal Tumors (GIST) and tolimidone, under development for the treatment of type 1 diabetes.<\/p>\n

eRapa is a proprietary oral capsule formulation of rapamycin, also known as sirolimus. Rapamycin is an mTOR (m<\/u>ammalian T<\/u>arget O<\/u>f R<\/u>apamycin) inhibitor. mTOR has been shown to have a significant role in the signalling pathway that regulates cellular metabolism, growth and proliferation and is activated during tumorigenesis.<\/p>\n

MTX240 is a molecular glue, bringing two intracellular proteins, PDE3a and SLFN12, specifically co-expressed by GIST cancer cells, into close proximity to form a stable complex. This interaction stabilizes SLFN12, enabling it to drive RNase-mediated apoptosis in GIST cells through a mechanism independent of KIT or PDGFR signalling.<\/p>\n

Tolimidone is an orally delivered, potent and selective inhibitor of Lyn kinase. Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues, liver, and adipose tissue. Tolimidone has demonstrated glycaemic control via insulin sensitization in animal models of diabetes and has the potential to become a first-in-class blood glucose modulating agent.<\/p>\n

Biodexa\u2019s headquarters and R&D facility is in Cardiff, UK. For more information visit www.biodexapharma.com<\/a>.<\/p>\n

\n For more company information, please contact:<\/b>\n <\/p>\n

Stephen Stamp, CEO
Tel: +44 (0)29 20480 180
www.biodexapharma.com<\/p>\n

For information on the Company\u2019s Early Access Program for eRapa, please contact <\/b>erapa@tannerpharma.com<\/b><\/a><\/p>\n

\n Forward-Looking Statements<\/b>
\n
Certain statements in this announcement may constitute \u201cforward-looking statements\u201d within the meaning of legislation in the United Kingdom and\/or United States. Such statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 and are based on management\u2019s belief or interpretation. All statements contained in this announcement that do not relate to matters of historical fact should be considered forward-looking statements, including, without limitation, statements regarding the pace, timing and completion of recruitment and enrolment in the Serenta trial; the planned number of subjects and clinical sites and the expected initiation of additional sites, including in Canada; the planned futility analysis and database lock and the timing and number of PFS events; the potential therapeutic benefits, safety and efficacy of eRapa, MTX240 and tolimidone and the potential for tolimidone to be first-in-class; the Company\u2019s plans to seek orphan drug designation in Europe; the availability of funding under the CPRIT grant; and the Company\u2019s development and regulatory plans generally. In certain cases, forward-looking statements can be identified by the use of words such as \u201cplans\u201d, \u201cexpects\u201d or \u201cdoes not anticipate\u201d, or \u201cbelieves\u201d, \u201canticipates\u201d, \u201cintends\u201d, \u201cestimates\u201d, \u201ctargets\u201d, \u201cpotential\u201d, \u201cplanned\u201d, \u201cshould\u201d or \u201ccontinue\u201d, or variations of such words and phrases or statements that certain actions, events or results \u201cmay\u201d, \u201ccould\u201d, \u201cwould\u201d, \u201cmight\u201d or \u201cwill be taken\u201d, \u201coccur\u201d or \u201cbe achieved.\u201d Forward-looking statements and information are subject to various known and unknown risks and uncertainties, many of which are beyond the ability of the Company to control or predict, that may cause the Company\u2019s actual results, performance or achievements to be materially different from those expressed or implied thereby, and are developed based on assumptions about such risks, uncertainties and other factors set out herein, including, without limitation: the rate of subject recruitment, enrolment and retention and the risk that recruitment is not completed on the anticipated timetable; delays in initiating or the failure to initiate additional clinical sites; the rate at which PFS events accrue and the resulting timing of the futility analysis and database lock; the outcome of the futility analysis and the risk that earlier or interim data are not predictive of final results; risks relating to the safety, efficacy and regulatory approval of eRapa, MTX240 and tolimidone; the Company\u2019s ability to obtain and maintain regulatory designations; the availability of funding under the CPRIT grant and the Company\u2019s ability to satisfy its conditions; and the Company\u2019s need for additional capital.<\/p>\n

Reference should be made to those documents that Biodexa shall file from time to time or announcements that may be made by Biodexa in accordance with the rules and regulations promulgated by the SEC, which contain and identify other important factors that could cause actual results to differ materially from those contained in any projections or forward-looking statements. These forward-looking statements speak only as of the date of this announcement. All subsequent written and oral forward-looking statements by or concerning Biodexa are expressly qualified in their entirety by the cautionary statements above. Except as may be required under relevant laws in the United States, Biodexa does not undertake any obligation to publicly update or revise any forward-looking statements because of new information, future events or events otherwise arising.<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

August 19, 2026 Biodexa announces major milestone for its Serenta registrational Phase 3 trial in FAP 87 subjects, over 50% of target, recruited Biodexa Pharmaceuticals PLC (Nasdaq: BDRX) (\u201cBiodexa\u201d or \u201cthe Company\u201d), a clinical stage biopharmaceutical company developing innovative products focused on the treatment or prevention of gastrointestinal cancers is pleased to announce that it has exceeded the half-way point in the recruitment of subjects in its registrational Phase 3 trial of eRapa in Familial Adenomatous Polyposis (FAP), NCT06950385. As of today, 87 of a planned 168 subjects have been recruited into the Serenta trial. The trial is recruiting at 29 clinical sites across the US and five countries in Europe with a further three sites in Canada expected to … <\/p>\n

Continue reading “Biodexa announces major milestone for its Serenta registrational Phase 3 trial in FAP”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-996646","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nBiodexa announces major milestone for its Serenta registrational Phase 3 trial in FAP - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/biodexa-announces-major-milestone-for-its-serenta-registrational-phase-3-trial-in-fap\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biodexa announces major milestone for its Serenta registrational Phase 3 trial in FAP - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"August 19, 2026 Biodexa announces major milestone for its Serenta registrational Phase 3 trial in FAP 87 subjects, over 50% of target, recruited Biodexa Pharmaceuticals PLC (Nasdaq: BDRX) (\u201cBiodexa\u201d or \u201cthe Company\u201d), a clinical stage biopharmaceutical company developing innovative products focused on the treatment or prevention of gastrointestinal cancers is pleased to announce that it has exceeded the half-way point in the recruitment of subjects in its registrational Phase 3 trial of eRapa in Familial Adenomatous Polyposis (FAP), NCT06950385. 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As of today, 87 of a planned 168 subjects have been recruited into the Serenta trial. 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