{"id":991300,"date":"2026-08-06T12:02:49","date_gmt":"2026-08-06T16:02:49","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/"},"modified":"2026-08-06T12:02:49","modified_gmt":"2026-08-06T16:02:49","slug":"vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/","title":{"rendered":"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>Dosing of the first participant commenced ahead of schedule and was rapidly followed by initial dosing in all trial participants.<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>SLIM-1<\/em>\u2122<em> trial is a Phase 1, randomized, controlled clinical trial design to characterize the safety, tolerability, and pharmacokinetics of NPM-139 including a Wegovy\u00ae (semaglutide injection) group.<\/em><\/p>\n<p align=\"center\">\n        <em>Top-line data from the 20-participant trial is expected in November of 2026.<\/em>\n      <\/p>\n<p>ALAMEDA, Calif., Aug.  06, 2026  (GLOBE NEWSWIRE) &#8212; <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Y388AVYx5p80DtlLkCe8dX5CTJrtjMFbF8k_fsNFnzI4GpgNG1CQTcLFMYLtvodlnAfNyXT0Fvu4_grs4Qt3NuBvJtilcXl_bqQXssg3lf8=\" rel=\"nofollow\" target=\"_blank\"><u>Vivani Medical, Inc.<\/u><\/a> (Nasdaq: VANI) today announced full enrollment and successful initial dosing of all participants in its SLIM-1\u2122 Phase 1 trial for NPM-139, a miniature, subdermal semaglutide implant being designed to provide six- to twelve-months of continuous drug delivery utilizing our proprietary NanoPortal\u2122 technology. The trial of 20 GLP-1 na\u00efve participants in Australia includes low-doses of NPM-139 and Wegovy\u00ae to assess safety, tolerability, and pharmacokinetics. Changes in weight will be measured.<\/p>\n<p>\u201cDosing of the first 10 participants occurred on July 29, ahead of schedule. The remaining 10 participants were dosed one week later. All insertion procedures were completed successfully without any issues. Expeditious full enrollment of SLIM-1 trial participants highlights our commitment to rapidly advance the development of our innovative GLP-1 product candidates in chronic weight management and type 2 diabetes,\u201d said Adam Mendelsohn, Ph.D., CEO of Vivani Medical. \u201cWe look forward to sharing top-line SLIM-1 clinical data later this year which we anticipate will pave the way for initiation of a Phase 2 dose-ranging trial in 2027.\u201d<\/p>\n<p>This milestone follows NPM-139 preclinical studies demonstrating sustainable 20% weight reduction in animal models and a <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=LnUDXKQXG9UqZVStimL850a5DbTGq2X3H_8yQvKyS90txJ2qAJWL3MwJaITViLXCVKaj8cX96s8FH9CS-vpzBunpAV8U_b70F3Q_9c8YAuDz6GiiqtJoDVmPnDp1dAupvNLHFh1fmzIINATyX74w2kIVELFwsFSKEcg8lU9-a1D7zikfn6QvPsdsbUqKnPB7mEHkvju0TBRJF9GtcVELyJIovfX1jN_hp8Nte7fOYFxLBiYr1Hn4AesESSihYQuSK3icAYyTK-hcxh3kO1g_1g==\" rel=\"nofollow\" target=\"_blank\"><u>July 2026 agreement with Novo Nordisk<\/u><\/a> to evaluate NPM-139 and Vivani\u2019s proprietary NanoPortal implant technology.<\/p>\n<p>In addition to NPM-139\u2019s primary aim to improve convenience, medication adherence and tolerability, NanoPortal implants are uniquely designed to enable infrequent administration (six months or longer) and the ability to rapidly reverse GLP-1 drug exposure when cessation of therapy is needed or desired. Reversibility can be an important clinical consideration in certain situations, including when a woman becomes pregnant or when patients undergoing surgery have an increased aspiration risk.<\/p>\n<p>\n        <strong>About SLIM-1<\/strong><\/p>\n<p>SLIM-1 is an open-label, active-controlled trial evaluating a low-dose NPM-139 (semaglutide implant) given to 10 participants, and the starting dose of Wegovy (0.25mg\/week semaglutide injection) also given to 10 participants, over a four-week duration. The trial is designed to evaluate the safety, tolerability and pharmacokinetic profile in overweight or obese participants who are otherwise healthy. Top-line results from SLIM-1 are expected to be available in November.<\/p>\n<p>\n        <strong>About Vivani Medical, Inc.<\/strong>\n      <\/p>\n<p>Leveraging its proprietary NanoPortal\u2122 platform, Vivani develops miniature, biopharmaceutical implants designed to deliver drug molecules steadily over extended periods of time with the goal of guaranteeing adherence and improving patient tolerance to their medication. Vivani is developing a portfolio of GLP-1 based implants for metabolic diseases including obesity and type 2 diabetes. These NanoPortal implants are designed for once- or twice-yearly administration to provide patients with the opportunity to realize the full potential benefit of their medication by avoiding the numerous challenges associated with the daily or weekly administration of orals and injectables, including tolerability issues and loss of efficacy. Medication non-adherence occurs when patients do not take their medication as prescribed. This affects an alarming number of patients, approximately 50%, including those taking daily pills. For more information, please visit: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=fml-o-rYOWiMcVV350hsaZe6tYwSehL6HwmCTyOokBHE8JhBXSTjerT139zVNeD3aclKNp1aomA3UU1Vs8GUGg==\" rel=\"nofollow\" target=\"_blank\">www.vivani.com<\/a>.<\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong>\n      <\/p>\n<p>This press release contains certain \u201cforward-looking statements\u201d within the meaning of the \u201csafe harbor\u201d provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: \u201ctarget,\u201d \u201cbelieve,\u201d \u201cexpect,\u201d \u201cwill,\u201d \u201cmay,\u201d \u201canticipate,\u201d \u201cestimate,\u201d \u201cwould,\u201d \u201cpositioned,\u201d \u201cfuture,\u201d and other similar expressions that are used in this press release, including statements regarding Vivani\u2019s business, products in development, including the therapeutic potential thereof, the planned development thereof, and its technology, strategy, cash position and financial runway. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on Vivani\u2019s current beliefs, expectations, and assumptions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of Vivani\u2019s control. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements, including, without limitation, risks of unexpected costs or delays, and risks and uncertainties associated with the development and commercialization of products and product candidates that may impact or alter anticipated business plans, strategies and objectives. Actual results and outcomes may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. The foregoing sets forth many, but not all, of the factors that could cause actual results to differ from Vivani\u2019s expectations in any forward-looking statement. There may be additional risks that the Company considers immaterial, or which are unknown. A further list and description of risks and uncertainties are more fully described in periodic filings with the U.S. Securities and Exchange Commission (the \u201cSEC\u201d) including the factors described in Vivani\u2019s most recent Quarterly Report on Form 10-Q filed with the SEC on May 13, 2026, as updated by future filings with the SEC. Any forward-looking statement made by Vivani in this press release is based only on information currently available to the Company and speaks only as of the date on which it is made. The Company undertakes no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of added information, future developments or otherwise, except as required by law.<\/p>\n<p>\n        <strong>Company Contact:<\/strong><br \/>\n        <br \/>Donald Dwyer<br \/>Chief Business Officer<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=kfAddk0hNYTmAwc9bpLxq3Ixv6pkjfiMef5_BHdaFUvNoH9NMfyDGJq5Ud5bgf40Ff_8WH4InlSsCpTsoTflixTheZWPbtXkIXxzVFkoaC4=\" rel=\"nofollow\" target=\"_blank\">info@vivani.com<\/a><br \/>(415) 506-8462<\/p>\n<p>\n        <strong>Investor and Media Relations Contact:<\/strong><br \/>\n        <br \/>Jami Taylor<br \/>Investor and Media Relations Advisor<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ydniK3-iFuWni5BHekw0435JzCvJKSHeqow1bZXhIwNtvW7ql6tOGIhtUgKwYUZGShCyyjIwpcq3CQM3T0sYOjMNlvBQtFN68c-cbqZP-Pw=\" rel=\"nofollow\" target=\"_blank\">investors@vivani.com<\/a><br \/>(415) 506-8462<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/ZmM1YjA3NTMtNDJkOC00NGNmLThiZjMtMmU3NGRjN2M3NTFhLTEzMTA5NDAtMjAyNi0wOC0wNi1lbg==\/tiny\/Vivani-Medical-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dosing of the first participant commenced ahead of schedule and was rapidly followed by initial dosing in all trial participants. SLIM-1\u2122 trial is a Phase 1, randomized, controlled clinical trial design to characterize the safety, tolerability, and pharmacokinetics of NPM-139 including a Wegovy\u00ae (semaglutide injection) group. Top-line data from the 20-participant trial is expected in November of 2026. ALAMEDA, Calif., Aug. 06, 2026 (GLOBE NEWSWIRE) &#8212; Vivani Medical, Inc. (Nasdaq: VANI) today announced full enrollment and successful initial dosing of all participants in its SLIM-1\u2122 Phase 1 trial for NPM-139, a miniature, subdermal semaglutide implant being designed to provide six- to twelve-months of continuous drug delivery utilizing our proprietary NanoPortal\u2122 technology. The trial of 20 GLP-1 na\u00efve participants in Australia &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-991300","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Dosing of the first participant commenced ahead of schedule and was rapidly followed by initial dosing in all trial participants. SLIM-1\u2122 trial is a Phase 1, randomized, controlled clinical trial design to characterize the safety, tolerability, and pharmacokinetics of NPM-139 including a Wegovy\u00ae (semaglutide injection) group. Top-line data from the 20-participant trial is expected in November of 2026. ALAMEDA, Calif., Aug. 06, 2026 (GLOBE NEWSWIRE) &#8212; Vivani Medical, Inc. (Nasdaq: VANI) today announced full enrollment and successful initial dosing of all participants in its SLIM-1\u2122 Phase 1 trial for NPM-139, a miniature, subdermal semaglutide implant being designed to provide six- to twelve-months of continuous drug delivery utilizing our proprietary NanoPortal\u2122 technology. The trial of 20 GLP-1 na\u00efve participants in Australia &hellip; Continue reading &quot;Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-08-06T16:02:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management\",\"datePublished\":\"2026-08-06T16:02:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/\"},\"wordCount\":964,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/\",\"name\":\"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management - Market Newsdesk\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA=\",\"datePublished\":\"2026-08-06T16:02:49+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA=\",\"contentUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA=\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#website\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/\",\"name\":\"Market Newsdesk\",\"description\":\"Latest Business News in Real Time\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\",\"name\":\"Newsdesk\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g\",\"caption\":\"Newsdesk\"},\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/author\\\/newsdesk\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management - Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/","og_locale":"en_US","og_type":"article","og_title":"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management - Market Newsdesk","og_description":"Dosing of the first participant commenced ahead of schedule and was rapidly followed by initial dosing in all trial participants. SLIM-1\u2122 trial is a Phase 1, randomized, controlled clinical trial design to characterize the safety, tolerability, and pharmacokinetics of NPM-139 including a Wegovy\u00ae (semaglutide injection) group. Top-line data from the 20-participant trial is expected in November of 2026. ALAMEDA, Calif., Aug. 06, 2026 (GLOBE NEWSWIRE) &#8212; Vivani Medical, Inc. (Nasdaq: VANI) today announced full enrollment and successful initial dosing of all participants in its SLIM-1\u2122 Phase 1 trial for NPM-139, a miniature, subdermal semaglutide implant being designed to provide six- to twelve-months of continuous drug delivery utilizing our proprietary NanoPortal\u2122 technology. The trial of 20 GLP-1 na\u00efve participants in Australia &hellip; Continue reading \"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/","og_site_name":"Market Newsdesk","article_published_time":"2026-08-06T16:02:49+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management","datePublished":"2026-08-06T16:02:49+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/"},"wordCount":964,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/","name":"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management - Market Newsdesk","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/#primaryimage"},"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA=","datePublished":"2026-08-06T16:02:49+00:00","author":{"@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"breadcrumb":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/#primaryimage","url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA=","contentUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTgwNTAwMSM3NzYyNDMzIzIyOTkzOTA="},{"@type":"BreadcrumbList","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/vivani-medical-announces-successful-dosing-of-all-participants-in-slim-1-a-phase-1-trial-evaluating-npm-139-a-miniature-ultra-long-acting-semaglutide-implant-for-chronic-weight-management\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.marketnewsdesk.com\/"},{"@type":"ListItem","position":2,"name":"Vivani Medical Announces Successful Dosing of All Participants in SLIM-1, a Phase 1 Trial Evaluating NPM-139, a Miniature, Ultra Long-Acting Semaglutide Implant for Chronic Weight Management"}]},{"@type":"WebSite","@id":"https:\/\/www.marketnewsdesk.com\/#website","url":"https:\/\/www.marketnewsdesk.com\/","name":"Market Newsdesk","description":"Latest Business News in Real Time","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.marketnewsdesk.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979","name":"Newsdesk","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g","caption":"Newsdesk"},"url":"https:\/\/www.marketnewsdesk.com\/index.php\/author\/newsdesk\/"}]}},"_links":{"self":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/posts\/991300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/comments?post=991300"}],"version-history":[{"count":0,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/posts\/991300\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/media?parent=991300"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/categories?post=991300"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/tags?post=991300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}