{"id":990190,"date":"2026-08-05T08:33:51","date_gmt":"2026-08-05T12:33:51","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/"},"modified":"2026-08-05T08:33:51","modified_gmt":"2026-08-05T12:33:51","slug":"volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/","title":{"rendered":"Volition Reports Publication of First Peer Reviewed Paper on New Capture-Seq\u2122 Liquid Biopsy Technology"},"content":{"rendered":"<div class=\"xn-newslines\">\n<p class=\"xn-distributor\">PR Newswire<\/p>\n<\/p><\/div>\n<div class=\"xn-content\">\n<ul type=\"disc\">\n<li>\n          <i>Targets $36 Billion TAM in Early Cancer Detection and MRD. <\/i>\n        <\/li>\n<li>\n          <i>Company in active discussions with global diagnostic leaders to accelerate commercialization<\/i><br \/>\n          <b><br \/>\n            <i>.<\/i><br \/>\n          <\/b>\n        <\/li>\n<\/ul>\n<p>\n        <span class=\"legendSpanClass\">HENDERSON, Nev.<\/span>, <span class=\"legendSpanClass\">Aug. 5, 2026<\/span> \/PRNewswire\/ &#8212; VolitionRx Limited (NYSE AMERICAN: VNRX) (&#8220;Volition&#8221;), a multi-national epigenetics company, was the first to demonstrate the isolation and analysis of &gt;99% pure circulating tumor-derived DNA (ctDNA). Volition today announces the publication of the first peer-reviewed paper describing the technology in detail &#8211; entitled <a href=\"https:\/\/doi.org\/10.1186\/s13148-026-02205-x\" target=\"_blank\" rel=\"nofollow\">&#8220;<b>Direct analysis of transcription factor protected cfDNA in plasma by ChIP-seq: Measurement of altered CTCF binding in cancer is a novel biomarker for liquid biopsy<\/b><b><sup>1<\/sup><\/b><\/a>&#8220;.<\/p>\n<p>Most current liquid biopsy methods involve deep sequencing of plasma DNA and bioinformatic analysis of the data produced to identify the presence of cancer in a patient. The biggest problem facing all liquid biopsy methods worldwide is that the vast majority of circulating DNA in blood plasma samples comes from healthy cells, not cancer cells. Volition&#8217;s new technology employs an entirely novel approach to liquid biopsy that has overcome this hurdle and produced &gt;99% pure cancer associated plasma DNA sequence sets for liquid biopsy.<\/p>\n<p>\n        <b>Mr. Gael Forterre<\/b>, Chief Licensing Officer, Volition added:<\/p>\n<p>&#8220;We are delighted that the <a href=\"https:\/\/doi.org\/10.1186\/s13148-026-02205-x\" target=\"_blank\" rel=\"nofollow\">paper<\/a>\u00a0detailing this breakthrough technology has been peer reviewed and published.<\/p>\n<p>&#8220;We are in active discussions with several large liquid biopsy and diagnostic companies to accelerate the development of this technology, &#8220;Capture-Seq\u2122&#8221;,\u00a0 and indeed are in the process of undertaking technical evaluations with potential licensors. \u00a0<\/p>\n<p>&#8220;We believe the potential use cases for Capture-Seq\u2122\u00a0represent a significant commercial opportunity with a Total Addressable Market on an annualized basis of approximately $23 billion<sup>2<\/sup>\u00a0for the human Multi-Cancer Early Detection (MCED) use, and over $13 Billion<sup>2 <\/sup>for Minimum Residual Disease (MRD).&#8221;<\/p>\n<p>\n        <b>Dr Jake Micallef<\/b>, Chief Scientific Officer, Volition commented:<\/p>\n<p>&#8220;Distinguishing cancer derived plasma DNA from healthy DNA when the two are mixed is problematic as they are chemically similar. As the cancer DNA may make up 1% or less of the total DNA, it is extremely problematic.\u00a0<\/p>\n<p>&#8220;Our manuscript describes a new liquid biopsy chemistry for isolating CTCF-DNA from plasma. Our work on CTCF-bound DNA has revealed what we believe to be an unprecedented new discovery; that there is almost no CTCF-bound DNA in healthy plasma and almost all CTCF-bound DNA in the blood of a cancer patient is derived from cancer cells \u2013 i.e.<b> it is virtually pure circulating tumor-derived DNA.<\/b><\/p>\n<p>&#8220;Removal of background normal cell free DNA from the blood to reveal this level of tumor derived DNA has been a long term goal of liquid biopsy. I believe this is a world-first and could, in my opinion, represent the biggest scientific breakthrough in cancer testing and monitoring in recent years.<\/p>\n<p>&#8220;In this <a href=\"https:\/\/doi.org\/10.1186\/s13148-026-02205-x\" target=\"_blank\" rel=\"nofollow\">published paper<\/a>\u00a0we report a new, two-step method for preparing pure circulating tumor DNA data sets for cancer patients:<\/p>\n<ol type=\"i\">\n<li>physical enrichment of the sample; and<\/li>\n<li>bioinformatic removal of virtually all remaining non-tumor cfDNA sequences from the DNA sequence data set.<\/li>\n<\/ol>\n<p>&#8220;This new method produced &gt;99% pure ctDNA sequencing data sets for blood samples from cancer patients and, whilst we capture a subset of the ctDNA (i.e. not all the ctDNA in a sample), it is virtually <b>pure cancer DNA. <\/b><\/p>\n<p>&#8220;These methodological and technological breakthroughs represent a novel liquid biopsy method for a novel class of potentially thousands of liquid biopsy sequence biomarkers. Capture-Seq\u2122 shows potential for both a multi-cancer early detection (MCED) approach, either alone or in combination with other tests, and the detection of Minimal Residual Disease (MRD).<\/p>\n<p>&#8220;We are fast-tracking the development of Capture-Seq\u2122\u00a0conducting further studies, including competing conditions and larger sample sets and working with oncology Key Opinion Leaders.<\/p>\n<p>&#8220;Volition is, I believe, the first liquid biopsy company to focus on circulating cell free nucleoproteins and we have filed a number of new patents to protect this technology.&#8221;<\/p>\n<p>\n        <b>Dr Andrew Retter<\/b>, Medical Consultant, Volition commented:<\/p>\n<p>&#8220;From a clinical perspective, the proof of concept and early blinded validation results reported in this paper are extremely encouraging. In two independent cohorts we reported no false positives and detected 49\/49 cancers in the first cohort (including 23 early stage I\/II and 21 controls) and validated it in a second blinded cohort with 13\/14 later stage cancers detected with 10 additional controls. \u00a0<\/p>\n<p>&#8220;We have also subsequently <a href=\"https:\/\/ir.volition.com\/news-events\/press-releases\/detail\/877\/volition-announces-detection-of-over-95-of-early-stage-cancers\" target=\"_blank\" rel=\"nofollow\">reported<\/a>\u00a0data from a blinded validation cohort of 81 subjects (colorectal and lung cancer patients = 59, healthy controls = 22) and are extremely encouraged by the results; the early-stage cancer detection of 95% of stage I and II cancers is particularly noteworthy.<\/p>\n<p>&#8220;For patients, the potential significance is huge. If validated in larger cohorts, CTCF Capture-Seq\u2122 could contribute to Multi-Cancer Early Detection (MCED) fulfilling a significant unmet clinical need.<\/p>\n<p>&#8220;We also believe that Capture-Seq\u2122 has the potential to play a role in cancer management, including but not limited to, Minimal Residual Disease detection and treatment monitoring, either alone or potentially in combination with other technologies too.&#8221;<\/p>\n<ol type=\"1\">\n<li>Pamart, D.,\u00a0<i>et al.<\/i>\u00a0Direct analysis of transcription factor protected cfDNA in plasma by ChIP-seq: measurement of altered CTCF binding in cancer is a novel biomarker for liquid biopsy.\u00a0<i>Clin Epigenet<\/i>\u00a0(2026). <a href=\"https:\/\/doi.org\/10.1186\/s13148-026-02205-x\" target=\"_blank\" rel=\"nofollow\">https:\/\/doi.org\/10.1186\/s13148-026-02205-x<\/a><\/li>\n<li>Data on File\u00a0: Volition TAM Model<\/li>\n<\/ol>\n<p>\n        <b>About Volition <\/b>\n      <\/p>\n<p>\n        <a href=\"https:\/\/volition.com\/\" target=\"_blank\" rel=\"nofollow\">Volition<\/a>\u00a0is a multi-national company focused on advancing the science of epigenetics. Volition is dedicated to saving lives and improving outcomes for people and animals with life-altering diseases through earlier detection, as well as disease and treatment monitoring.<\/p>\n<p>Through its subsidiaries, Volition is developing and commercializing simple, easy to use, cost-effective blood tests to help detect and monitor a range of diseases, including some cancers and diseases associated with NETosis, such as sepsis. Early detection and monitoring have the potential not only to prolong the life of patients, but also to improve their quality of life.<\/p>\n<p>Volition&#8217;s research and development activities are centered in Belgium, with an innovation laboratory and office in the U.S. and an office in London.<\/p>\n<p>The contents found at Volition&#8217;s website address are not incorporated by reference into this document and should not be considered part of this document. Such website address is included in this document as an inactive textual reference only.<\/p>\n<p>\n        <b>Media Enquiries:<\/b>\u00a0Louise Batchelor, Volition, <a href=\"mailto:mediarelations@volition.com\" target=\"_blank\" rel=\"nofollow\">mediarelations@volition.com<\/a>,+44 (0)7557 774620<\/p>\n<p>\n        <b>Safe Harbor Statement<\/b>\n      <\/p>\n<p>Statements contained or referenced herein, including in any associated video or link, may be &#8220;forward-looking statements&#8221; within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements are those that are not statements of historical fact and instead address predictions, expectations, beliefs, plans, projections, objectives, goals, assumptions or future events or performance. Words such as &#8220;expects,&#8221; &#8220;anticipates,&#8221; &#8220;intends,&#8221; &#8220;plans,&#8221; &#8220;aims,&#8221; &#8220;targets,&#8221; &#8220;believes,&#8221; &#8220;seeks,&#8221; &#8220;estimates,&#8221; &#8220;optimizing,&#8221; &#8220;potential,&#8221; &#8220;goal,&#8221; &#8220;suggests,&#8221; &#8220;could,&#8221; &#8220;would,&#8221; &#8220;should,&#8221; &#8220;may,&#8221; &#8220;will&#8221; and similar expressions identify such statements.<\/p>\n<p>These forward-looking statements relate to, among other topics, Volition&#8217;s expectations regarding revenue opportunities and growth; the effectiveness and availability of its blood-based diagnostic, prognostic and disease monitoring tests; its ability to develop and successfully commercialize such test platforms for the early detection and monitoring of cancer and other diseases; its expectations regarding future publications; and its success in securing, and the terms of, licensing and\/or distribution agreements with third parties.<\/p>\n<p>Forward-looking statements are based on current expectations, estimates and projections about Volition&#8217;s business, in part on assumptions made by management. They are not guarantees of future performance and involve risks and uncertainties that are difficult to predict and that could cause actual results to differ materially from those anticipated. These risks and uncertainties include, without limitation: the results of studies testing the efficacy of Volition&#8217;s tests; failure to develop and commercialize its products, which may prevent it from executing its plan of operations; failure to obtain necessary regulatory clearances or approvals; failure to achieve healthcare system or insurance reimbursement; failure of the marketplace to accept its products; failure to secure adequate intellectual property protection; the highly competitive and rapidly evolving nature of the diagnostics and disease monitoring market, which may render its products obsolete; downturns in domestic and foreign economies; and other risks identified in Volition&#8217;s most recent Annual Report on Form 10-K, its Quarterly Reports on Form 10-Q, and other documents filed with the Securities and Exchange Commission.<\/p>\n<p>Forward-looking statements are made as of the date hereof and, except as required by law, Volition undertakes no obligation to update them to reflect future events or circumstances.<\/p>\n<p>Nu.Q<sup>\u00ae<\/sup>, Nucleosomics\u2122, Capture-PCR\u2122, Capture-Seq\u2122 and rNuQ\u2122 and their respective logos are trademarks and\/or service marks of VolitionRx Limited and its subsidiaries. All other trademarks, service marks and trade names referred to in this press release or associated video or link are the property of their respective owners. Additionally, unless otherwise specified, all references to &#8220;$&#8221; refer to the legal currency of the United States of America.<\/p>\n<p id=\"PURL\">\n        <img loading=\"lazy\" decoding=\"async\" title=\"Cision\" width=\"12\" height=\"12\" alt=\"Cision\" src=\"https:\/\/edge.prnewswire.com\/c\/img\/favicon.png?sn=LN19731&amp;sd=2026-08-05\" \/> View original content:<a id=\"PRNURL\" rel=\"nofollow\" href=\"https:\/\/www.prnewswire.com\/news-releases\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology-302843578.html\" target=\"_blank\">https:\/\/www.prnewswire.com\/news-releases\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology-302843578.html<\/a><\/p>\n<p>SOURCE VolitionRx Limited<\/p>\n<\/p><\/div>\n<p>    <img decoding=\"async\" alt=\"\" src=\"https:\/\/rt.prnewswire.com\/rt.gif?NewsItemId=LN19731&amp;Transmission_Id=202608050817PR_NEWS_USPR_____LN19731&amp;DateId=20260805\" style=\"border:0px;width:1px;height:1px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PR Newswire Targets $36 Billion TAM in Early Cancer Detection and MRD. Company in active discussions with global diagnostic leaders to accelerate commercialization . HENDERSON, Nev., Aug. 5, 2026 \/PRNewswire\/ &#8212; VolitionRx Limited (NYSE AMERICAN: VNRX) (&#8220;Volition&#8221;), a multi-national epigenetics company, was the first to demonstrate the isolation and analysis of &gt;99% pure circulating tumor-derived DNA (ctDNA). Volition today announces the publication of the first peer-reviewed paper describing the technology in detail &#8211; entitled &#8220;Direct analysis of transcription factor protected cfDNA in plasma by ChIP-seq: Measurement of altered CTCF binding in cancer is a novel biomarker for liquid biopsy1&#8220;. Most current liquid biopsy methods involve deep sequencing of plasma DNA and bioinformatic analysis of the data produced to identify the &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Volition Reports Publication of First Peer Reviewed Paper on New Capture-Seq\u2122 Liquid Biopsy Technology&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-990190","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Volition Reports Publication of First Peer Reviewed Paper on New Capture-Seq\u2122 Liquid Biopsy Technology - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Volition Reports Publication of First Peer Reviewed Paper on New Capture-Seq\u2122 Liquid Biopsy Technology - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"PR Newswire Targets $36 Billion TAM in Early Cancer Detection and MRD. Company in active discussions with global diagnostic leaders to accelerate commercialization . HENDERSON, Nev., Aug. 5, 2026 \/PRNewswire\/ &#8212; VolitionRx Limited (NYSE AMERICAN: VNRX) (&#8220;Volition&#8221;), a multi-national epigenetics company, was the first to demonstrate the isolation and analysis of &gt;99% pure circulating tumor-derived DNA (ctDNA). Volition today announces the publication of the first peer-reviewed paper describing the technology in detail &#8211; entitled &#8220;Direct analysis of transcription factor protected cfDNA in plasma by ChIP-seq: Measurement of altered CTCF binding in cancer is a novel biomarker for liquid biopsy1&#8220;. 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Company in active discussions with global diagnostic leaders to accelerate commercialization . HENDERSON, Nev., Aug. 5, 2026 \/PRNewswire\/ &#8212; VolitionRx Limited (NYSE AMERICAN: VNRX) (&#8220;Volition&#8221;), a multi-national epigenetics company, was the first to demonstrate the isolation and analysis of &gt;99% pure circulating tumor-derived DNA (ctDNA). Volition today announces the publication of the first peer-reviewed paper describing the technology in detail &#8211; entitled &#8220;Direct analysis of transcription factor protected cfDNA in plasma by ChIP-seq: Measurement of altered CTCF binding in cancer is a novel biomarker for liquid biopsy1&#8220;. Most current liquid biopsy methods involve deep sequencing of plasma DNA and bioinformatic analysis of the data produced to identify the &hellip; Continue reading \"Volition Reports Publication of First Peer Reviewed Paper on New Capture-Seq\u2122 Liquid Biopsy Technology\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/","og_site_name":"Market Newsdesk","article_published_time":"2026-08-05T12:33:51+00:00","og_image":[{"url":"https:\/\/edge.prnewswire.com\/c\/img\/favicon.png?sn=LN19731&amp;sd=2026-08-05","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Volition Reports Publication of First Peer Reviewed Paper on New Capture-Seq\u2122 Liquid Biopsy Technology","datePublished":"2026-08-05T12:33:51+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/"},"wordCount":1466,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/#primaryimage"},"thumbnailUrl":"https:\/\/edge.prnewswire.com\/c\/img\/favicon.png?sn=LN19731&amp;sd=2026-08-05","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/volition-reports-publication-of-first-peer-reviewed-paper-on-new-capture-seq-liquid-biopsy-technology\/","name":"Volition Reports Publication of First Peer Reviewed Paper on New Capture-Seq\u2122 Liquid Biopsy Technology - 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