{"id":985615,"date":"2026-07-28T08:40:51","date_gmt":"2026-07-28T12:40:51","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/niagen-bioscience-announces-a-newly-published-analysis-of-past-clinical-studies-demonstrating-niagen-patented-nicotinamide-riboside-nr-supplementation-improved-a-muscle-specific-marker-of-bio\/"},"modified":"2026-07-28T08:40:51","modified_gmt":"2026-07-28T12:40:51","slug":"niagen-bioscience-announces-a-newly-published-analysis-of-past-clinical-studies-demonstrating-niagen-patented-nicotinamide-riboside-nr-supplementation-improved-a-muscle-specific-marker-of-bio","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/niagen-bioscience-announces-a-newly-published-analysis-of-past-clinical-studies-demonstrating-niagen-patented-nicotinamide-riboside-nr-supplementation-improved-a-muscle-specific-marker-of-bio\/","title":{"rendered":"Niagen Bioscience Announces a Newly Published Analysis of Past Clinical Studies Demonstrating Niagen\u00ae (Patented Nicotinamide Riboside, NR) Supplementation Improved a Muscle-Specific Marker of Biological Aging"},"content":{"rendered":"

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Niagen Bioscience Announces a Newly Published Analysis of Past Clinical Studies Demonstrating Niagen\u00ae <\/sup>(Patented Nicotinamide Riboside, NR) Supplementation Improved a Muscle-Specific Marker of Biological Aging<\/b><\/p>\n

New epigenetic findings show Niagen NR reduces muscle biological aging and supports healthy muscle function<\/i><\/p>\n

LOS ANGELES–(BUSINESS WIRE<\/a>)–Niagen Bioscience, Inc.<\/a> (NASDAQ: NAGE), the global authority on NAD+ (nicotinamide adenine dinucleotide) with a focus on the science of healthy aging, today announced the publication of a new peer-reviewed analysis of past clinical studies in Aging Cell<\/i><\/a> examining the effects of Niagen\u00ae<\/sup> (patented nicotinamide riboside, NR) supplementation was associated with reduced muscle epigenetic age acceleration measured by the Muscle Epigenetic Age Test (MEAT) clock. In addition, changes in muscle mitochondrial DNA content correlated with changes in MEAT-derived epigenetic age acceleration, suggesting a potential relationship between mitochondrial adaptations and epigenetic clock measures.<\/p>\n

\n\u201cThis is among the first human studies suggesting that Niagen NR supplementation may alter epigenetic aging in skeletal muscle, rather than simply increasing NAD+ or improving mitochondrial function,\u201d said Rob Fried, CEO of Niagen Bioscience. \u201cIt strengthens the idea that NAD+ restoration can influence biological aging pathways at the tissue level.\u201d<\/p>\n

\nThe study was led by first author Aino Heikkinen, doctoral researcher, and principal investigator Miina Ollikainen, PhD, Docent in Epigenetics, both of the Minerva Foundation Institute for Medical Research in Helsinki, Finland, in collaboration with Eija Pirinen, PhD, Associate Professor, University of Oulu, and University Researcher, University of Helsinki, and a multi-institution research team spanning Finland, Denmark, and Australia. With a portion of the data generated through Niagen Bioscience’s external Niagen Research Program<\/a>, the study analyzed skeletal muscle and blood samples from three previously published, independent clinical studies, alongside new laboratory experiments in human muscle cells using seven distinct epigenetic clocks to assess epigenetic age acceleration (EAA), a molecular measure of biological aging.<\/p>\n

\n\u201cOur earlier work showed that Niagen NR can enhance muscle mitochondrial health, and this study shows that these benefits may extend to the epigenetic level,\u201d said Dr. Eija Pirinen, University of Helsinki and University of Oulu, and a senior author on the study. \u201cIt is a meaningful step toward understanding how NAD+ restoration may influence molecular markers of aging in human skeletal muscle; however, additional research must be conducted.\u201d<\/p>\n

The Connection Between NAD+ and Skeletal Muscle<\/b><\/p>\n

\nSkeletal muscle is central to mobility, metabolic function, and quality of life, which changes significantly with age. Aging muscles tend to lose mitochondrial content and function, contributing to sarcopenia and frailty. NAD+ is a coenzyme essential to mitochondrial energy production and also serves as a required co-substrate for enzymes that regulate the epigenome, inflammation, and cellular repair. NAD+ levels decline with age (up to 65% between ages 30-70) in both muscle and skin, a decline linked to many of the functional changes associated with aging.<\/p>\n

\nBoth Niagen NR supplementation and exercise, including HIIT, have been shown in prior research to alter the NAD+ metabolome in skeletal muscle. Because NAD+ sits at the intersection of mitochondrial function and epigenetic regulation, researchers have long hypothesized that boosting NAD+ through supplementation, exercise, or both may influence not only cellular energy metabolism, but also biological or epigenetic aging.<\/p>\n

Study Highlights<\/b><\/p>\n

\nThe analysis integrated skeletal muscle and blood samples from three previously conducted, independent clinical trials: a five-month, 1,000 mg\/day Niagen NR supplementation twin study (Lapatto et al., 2023<\/a>), and two independent 4\u20136 week supervised HIIT training studies (S\u00f8gaard et al., 2017<\/a>; Jacques et al., 2020<\/a>), along with in vitro experiments in primary human myotubes. To measure changes in epigenetic age acceleration, skeletal muscle and blood samples were assessed using seven established epigenetic clocks, including DunedinPACE, PCHorvath, PCHannum, PCPhenoAge, PCGrimAge, GrimAge2, and MEAT, a muscle-specific clock.<\/p>\n

Key Findings<\/b><\/p>\n