{"id":985543,"date":"2026-07-28T08:14:03","date_gmt":"2026-07-28T12:14:03","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\/"},"modified":"2026-07-28T08:14:03","modified_gmt":"2026-07-28T12:14:03","slug":"corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\/","title":{"rendered":"Corbus Pharmaceuticals Announces FDA Clearance to Initiate TEMPO-1 Registrational Study of CRB-701 in Patients with 2L Oropharyngeal Cancer"},"content":{"rendered":"<div class=\"mw_release\">\n<ul type=\"disc\">\n<li>\n          <em>Company expects to initiate enrollment in TEMPO-1 in September 2026<\/em><br \/>\n          \n        <\/li>\n<li style=\"margin-bottom:1pt\">\n          <em>OPSCC is estimated to represent 1 in 2 head and neck cancer patients in the 2L setting in the U.S. with approximately 14,000 patients eligible annually for treatment <\/em><\/p>\n<\/li>\n<\/ul>\n<p align=\"justify\">NORWOOD, Mass., July  28, 2026  (GLOBE NEWSWIRE) &#8212; Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) (\u201cCorbus\u201d or the \u201cCompany\u201d) a clinical-stage company focusing on developing new therapies in oncology and obesity, today announced that the U.S. Food and Drug Administration (FDA) has cleared the start of the Company\u2019s registrational study (\u201cTEMPO-1\u201d) of CRB-701, a next-generation Nectin-4 targeted antibody drug conjugate (ADC), in second-line (2L) oropharyngeal squamous cell carcinoma (OPSCC).<\/p>\n<p align=\"justify\">TEMPO-1 is a randomized controlled study (n=250) designed to evaluate the efficacy and safety of CRB-701 compared with investigator\u2019s choice of capecitabine, cetuximab or docetaxel. The study&#8217;s primary endpoint is objective response rate (ORR), which is intended to support a potential accelerated approval; overall survival (OS) is intended to support potential conversion to full approval.<\/p>\n<p align=\"justify\">The incidence and prevalence of OPSCC continue to rise in the U.S. largely driven by HPV infection. The disease primarily affects men in their 50s and 60s who have little or no history of smoking or heavy alcohol use. Each year approximately 14,000 OPSCC patients are estimated to be eligible for 2L treatment and approximately 7,000 patients are estimated to succumb to the disease in the United States alone.<\/p>\n<p align=\"justify\">The FDA&#8217;s decision to allow the registrational study to proceed was supported by results from Corbus&#8217; ongoing Phase 1\/2 clinical study of CRB-701, presented at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting. In an analysis of patients with 2L+ OPSCC treated at the 3.6 mg\/kg dose, CRB-701 achieved a confirmed ORR of <strong>42.9%<\/strong>, with a median duration of response (DoR) of <strong>6.3 months<\/strong> and a median progression-free survival (PFS) of <strong>5.6 months<\/strong> (ongoing).<\/p>\n<p align=\"justify\">\u201cThe data presented at ASCO provided important insight into the potential clinical path for CRB-701 in 2L oropharyngeal cancer, a distinct tumor-type that is on the rise due to HPV infections,\u201d said Yuval Cohen, Ph.D., Chief Executive Officer of Corbus. \u201cUnfortunately, current treatment options have shown limited efficacy underscoring the need for additional therapeutic options. OPSCC represents a significant commercial opportunity.\u201d<\/p>\n<p align=\"justify\">\n        <strong>About CRB-701<\/strong><br \/>\n        <br \/>CRB-701 (SYS6002) is a next-generation antibody drug conjugate targeting Nectin-4, that contains a site-specific, cleavable linker and a homogenous drug antibody ratio of 2, using monomethyl auristatin E (MMAE) as the payload. Nectin-4 is a clinically validated, tumor-associated antigen in urothelial cancer and highly expressed in other tumor types such as cervical and head and neck squamous cell carcinoma (HNSCC). The FDA has granted two Fast Track designations to CRB-701 in HNSCC and cervical cancer.<\/p>\n<p align=\"justify\">\n        <strong>About Corbus<\/strong><br \/>\n        <br \/>Corbus Pharmaceuticals Holdings, Inc. is a clinical-stage company focused on developing new therapies in oncology and obesity and is committed to helping people defeat serious illness by bringing innovative scientific approaches to well-understood biological pathways. Corbus\u2019 pipeline includes CRB-701, a next-generation antibody drug conjugate for the treatment of Nectin-4-expressing tumors, and CRB-913, an orally delivered highly peripherally restricted CB1 inverse agonist for the treatment of obesity. Corbus is headquartered in Norwood, Massachusetts. For more information on Corbus, visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=MYdfVWzyXFF6zJuMQBGpQ41CTEXungAAjp7XzzIJfflIX0z4lNNMBjWCB-8eFfIVwz6HXJjpHygAffb5H8xFJ0_0u8N6AALjKTU6YJ0JZMu_qgeUq-cwqwb5CxfdpzyxBMb8K3BD2lPqBGujYHa-4ohQp_GhH8rgs6GToloQ91AG2_Fes8ucLowiHsdUPhwldtZYHFgK_cl1JVF-KSSsgKtUqYUZ_Rh7_XIgX57WOVZ20G2W3AFlTlCscbZ_nWRhoJDr8QjwNV0M599TmyJPZAkSZReGh_pj41W_88uCZ2k_lb_WIKJmvAtQhQlz4appzqqaI-HUQV4q7k3XmXrMRHdRjsnh4uYJ9G1wvKSkMbspKPgzYPJ0xdSCw9kwG4Rb8lw4OCzb7N8PeCPuNRnuHC4Dg-FOMMEmioBEt75Iv9P6IW_KG7ZjjeoLgH-YEc7NMIG-ddc2cZep8tzyA861seJqLmv4ddkOHeF7LcZ2xMM-bGdWXeHFB2aUuEamWXCuU2sSYm95FDY0NBpIVELCLOe573zlx6YRDZJ3L4TXC9OSpI4UpNVE2cfe3BiGf_tCSbKh9WuyzyDErI6gmclT46bDWcC3uz1CUx63HarshlgI1sSdRdNb02ontXe1-KfR6EzBDO6S73VtiIxLNumbuj6Xz0CLItL6tLxTaNfBi55aFRhIVaHvA6h57HR_Qdkxg_E2SiZa14cv6NYpkRETXcgjOnZEdpfVp9ZITJeDKuEC3JrRE7EovUXtpzHmvo0JPQN9FOYfUk67o-yM1uXSZA==\" rel=\"nofollow\" target=\"_blank\">corbuspharma.com<\/a>. Connect with us on <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=k5IWsTarzYLHhNp1-n2ecGa8P4GfPiSWn9Tju8ik06olKGzbQ3TEzli0OZARQvlJYwXS36zJbmfTYUONb7OhXvOUEgfLprQ5SONzspsd-aK-Sedl1ErqvNt8uxiIpeU06QQ15aAxCUMG87fNUAPnzqPrBKXOPNgipPTXIz9_M5riCQk3fIpBv2xWRzfuh-TPYLdG6UsxYFBtrD3UHTVpf2mlqds-V_DJE7EJlQ18hBXoz6VQfDXbHhGDm8m2MquaXNyHrfpW7USBKpLBLF1aEQRgeI6nFmjNp_zksWyD8b_2VyNOKxw5YR21haDQn9ac3qQghhlWr2xXTqx0D30zyxoL8MOyV9zKBp2nwuCo9fNOWDpI_VuiZPc3SB3nW9Q1DnXsnWWp6TS5GRb6mcjox4vyfY0Kt1rWUaL5fO-NHrlTvF9H4SzDyED47m7m7DGgyHU2OGa8lt9sVudxcxWlbrfNtgaocT2X__059vCB2ynPBlAyPpWStxvRdKvv5ha64GPrSGXi5dcR94b6vBaGa6dfYKMXDH1heo3w1HK3BtUKu_zW9Hsd6X1-KALeyuIRrkxSFaKNjSViYLGvdF5Ochv_dWYnNjZmHIiU0nU7nMw=\" rel=\"nofollow\" target=\"_blank\">X<\/a>, <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ZGPX0WsV1NlJ34c8N803WKLv3m7mwtr5g1ZIfpTW5sCXX-uw1GcVWu0fammlpBN23XGNedCDePbvif-kAb4plW0q20guZ_KHHxYuCzLWTq6f0s62gYERJFvjeKgGrlkdvhb6TMBwhdm5Ikwo_sd8j2kfvPoAMpXsGg4KV15cGhuQGyfc2JFIDlkKSDHjx93RfOQX59To3jhgBcCU4isnoNB16GsHCVyV8-gIoXkIEWHBhxAd2Y4DeZzAQn5xSJc4UXK96ilvhaM0xzkAKt783XnPxWFU9WRILG_uhUa14ikHdkcdmwQnTajeXCYmyrxuGCLssT0BCAT2Tk25sIsc_6ysjsENxA0mtRTJpTCgCcvokg8gmnDBYnaAfz7zd4uJJ_9l3IiCdkYBdjxL-3xsGOEgemqw7cmxxIp5Bm67NErmBQrCJytYzRJuG4Aj6Kw2ZtkKcK-2cXgk2C-Q84ukHWIptAtna2vx3DnpM03sp9RaEKWfm4ctEjh0N2CBw6oHBIURB1qQKx_4wIb90QX73PSJ7i_VFGnvf8Yx35eJG9wPeU2tiGUL2dmzkoAK21xm5QHyeDnFCBs5xFa5PenYKkuu9CgO990KRpCGgkbrhi5u1rXlirRReBTUx5U9p1d-qC8nWqRhUg3QNK2Jwff2Vm8KOvLGBWvFi2M6_Etdu2rEE99wRHzGGXzRRt2sx_nW76KAD5HkY-Pge5qwwF_n0as3JAxH9cJO1U3u3CntxtQF8KwzNdnu_fQjOZmv5yZE\" rel=\"nofollow\" target=\"_blank\">LinkedIn<\/a> and <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=u9OwKnpsA1jbw64qitVvLmUmy6NplPB1bH5dq7U6HDv0L5UDs-JDPMzl_05vkIospk07DGyhRhs0tKaXsBqRo4Q8VwCcfTKxVKRWpJlR-XpyUYoCp7llt7JhdhsTaysNSi37E1DlyLKHWHAMUTatv1Bs6TP9PYV8aleWmWs8156ScnekR38dWFsrMbIsxQHghI-LjbgU1c7_Hmp-sGpAQUNTQzIdc4lFO1P-FII8sQ-4Xzyqf3PmhOQ36_FjxeVBkNJ-rha8jgjbpb-4Q4_g5Fv5nkmbU-4usPh1AMFucQpJ4UcOhvD6zi_d77Zkivf4ztsayMBlIvNYZ5NycGW-0v3t9jfsHKLfLgu6IRnk1GT1gSFBe45LtRxXKEZEGXgcPj462NTDm8c81CjhhdYnj9NwFd6o6QAgN76YFKu2jSVhu3uAKCalyeX4DGRzJB1RvkoAxOFfbz4hLxaD3KVWLCmZ9KLsUTuWE1i-AUlNaEkJzZuQf4Yoq86nJVFkmijTCaZRkEHs1QIK7zI3KG_XhR-B1ru4Fl4fIEZ5fTN3IATJkEjEPj09DxReQqLnglC4HaJmtg1JIZoIwtoR3So4DbB51naKMXD15tx428-ITxOa5smvQ--P7pPAu9Vg8YP_fL-7QAOxeKYRucDgkGBvGOcqyT2mverIc7dvJ05HhCRvprQPuPLC-yDfUkRYXqWF\" rel=\"nofollow\" target=\"_blank\">Facebook<\/a>.<\/p>\n<p align=\"justify\">\n        <strong>Forward-Looking Statements<\/strong><br \/>\n        <br \/>This press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and Private Securities Litigation Reform Act of 1995, as amended, including those relating to the Company&#8217;s trial results, product development, clinical and regulatory timelines, including timing for completion of trials and presentation of data, anticipated timing for initiation of clinical trials, anticipated regulatory interactions and outcomes,\u00a0including alignment with FDA on trial design, potential accelerated approval, market opportunity, competitive position, possible or assumed future results of operations, business strategies, potential growth opportunities, sufficiency of cash runway\u00a0 and other statements that are predictive in nature. These forward-looking statements are based on current expectations, estimates, forecasts and projections about the industry and markets in which we operate and management&#8217;s current beliefs and assumptions.<\/p>\n<p align=\"justify\">These statements may be identified by the use of forward-looking expressions, including, but not limited to, &#8220;expect,&#8221; &#8220;anticipate,&#8221; &#8220;intend,&#8221; &#8220;plan,&#8221; &#8220;believe,&#8221; &#8220;estimate,&#8221; &#8220;potential,\u201d &#8220;predict,&#8221; &#8220;project,&#8221; &#8220;should,&#8221; &#8220;would&#8221; and similar expressions and the negatives of those terms. These statements relate to future events or our financial performance and involve known and unknown risks, uncertainties, and other factors on our operations, clinical development plans and timelines, which may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Such factors include those set forth in the Company&#8217;s filings with the Securities and Exchange Commission including those described in our Annual Report on Form 10-K for the year ended December 31, 2025, and other filings we make with the Securities and Exchange Commission. Prospective investors are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date of this press release. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.<\/p>\n<p align=\"justify\">All product names, logos, brands and company names are trademarks or registered trademarks of their respective owners. Their use does not imply affiliation or endorsement by these companies.<\/p>\n<p align=\"justify\">\n        <strong><br \/>\n          <u>INVESTOR CONTACTS<\/u><br \/>\n        <\/strong><br \/>\n        <strong>: <\/strong>\n      <\/p>\n<p align=\"justify\">\n        <strong>Sean Moran<\/strong><br \/>\n        <br \/>\n        <em>Chief Financial Officer<\/em><br \/>\n        <br \/>Corbus Pharmaceuticals<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=JpHR48bR_50s49LzJQpb1kipNqnPCzg-pdFZ7dK5dHLvODLTijBtQMPXfoF3V4php8svSvrGTSsr4Zvzz9WUbT-BpF7xlwpJzVxgZgBN9RqXRcFepWeLy0sWSZoswLK5\" rel=\"nofollow\" target=\"_blank\">smoran@corbuspharma.com<\/a><\/p>\n<p>\n        <strong>Dan Ferry<\/strong><br \/>\n        <br \/>\n        <em>Managing Director<\/em><br \/>\n        <br \/>LifeSci Advisors, LLC<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=-qFHxz2SPeIDV8DlmXWfVH2h6IF9i-gktirrQfQHeP-0REEjZDS9uFawOe23aTi8k8Wfs648cOYruJSK0VcAxolDuaGYEQ2MfcbQ_qvG9co8CBdywOhkD3CG04uKFWDWtd5SxFZVCIWeMUSjrHrGuzSbo6wkA6vLr4fWynmlkebVqroMRMs_5g2hJGxFBQIHEyc1aAO50cBpn0aHJA3Hm1GI1UOWPu2wnSzw13IQIOvJ_OEMAqcdmNy1kim84JD_OjsxOLYuo3sRONyS9mE1664Rf6XZpkTfO42SrfA-RNMqeFo9QudHLwmgO_pbWLS_\" rel=\"nofollow\" target=\"_blank\">daniel@lifesciadvisors.com<\/a><\/p>\n<p align=\"justify\">\n        <strong><br \/>\n          <u>MEDIA CONTACT<\/u><br \/>\n        <\/strong><br \/>\n        <strong>:<\/strong>\n      <\/p>\n<p align=\"justify\">\n        <strong>Liz Melone<\/strong><br \/>\n        <br \/>\n        <em>Founder &amp; Principal <\/em><br \/>\n        <br \/>Melone Communications, LLC<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=pW88MgI6PtV_Q2TTfaBeNX6o6v8R9PrmUonBMmAAAGh3WY9LziJpVvT8aHYPV-rzyNs_UcoX83S-pBFl5_DRoYOhzIlE5v3HpTRdNPCmnjY=\" rel=\"nofollow\" target=\"_blank\">Liz@melonecomm.com<\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTc5OTA3MSM3NzQ2MDMyIzUwMDExODg0MA==\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/YjdmNmM2NjktYTcyYi00NzM2LTk3N2MtOGZhOGViYjQyZmMxLTUwMDExODg0MC0yMDI2LTA3LTI4LWVu\/tiny\/Corbus-Pharmaceuticals-Holding.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Company expects to initiate enrollment in TEMPO-1 in September 2026 OPSCC is estimated to represent 1 in 2 head and neck cancer patients in the 2L setting in the U.S. with approximately 14,000 patients eligible annually for treatment NORWOOD, Mass., July 28, 2026 (GLOBE NEWSWIRE) &#8212; Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) (\u201cCorbus\u201d or the \u201cCompany\u201d) a clinical-stage company focusing on developing new therapies in oncology and obesity, today announced that the U.S. Food and Drug Administration (FDA) has cleared the start of the Company\u2019s registrational study (\u201cTEMPO-1\u201d) of CRB-701, a next-generation Nectin-4 targeted antibody drug conjugate (ADC), in second-line (2L) oropharyngeal squamous cell carcinoma (OPSCC). TEMPO-1 is a randomized controlled study (n=250) designed to evaluate the efficacy and safety &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Corbus Pharmaceuticals Announces FDA Clearance to Initiate TEMPO-1 Registrational Study of CRB-701 in Patients with 2L Oropharyngeal Cancer&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-985543","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Corbus Pharmaceuticals Announces FDA Clearance to Initiate TEMPO-1 Registrational Study of CRB-701 in Patients with 2L Oropharyngeal Cancer - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Corbus Pharmaceuticals Announces FDA Clearance to Initiate TEMPO-1 Registrational Study of CRB-701 in Patients with 2L Oropharyngeal Cancer - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Company expects to initiate enrollment in TEMPO-1 in September 2026 OPSCC is estimated to represent 1 in 2 head and neck cancer patients in the 2L setting in the U.S. with approximately 14,000 patients eligible annually for treatment NORWOOD, Mass., July 28, 2026 (GLOBE NEWSWIRE) &#8212; Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) (\u201cCorbus\u201d or the \u201cCompany\u201d) a clinical-stage company focusing on developing new therapies in oncology and obesity, today announced that the U.S. Food and Drug Administration (FDA) has cleared the start of the Company\u2019s registrational study (\u201cTEMPO-1\u201d) of CRB-701, a next-generation Nectin-4 targeted antibody drug conjugate (ADC), in second-line (2L) oropharyngeal squamous cell carcinoma (OPSCC). TEMPO-1 is a randomized controlled study (n=250) designed to evaluate the efficacy and safety &hellip; Continue reading &quot;Corbus Pharmaceuticals Announces FDA Clearance to Initiate TEMPO-1 Registrational Study of CRB-701 in Patients with 2L Oropharyngeal Cancer&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-28T12:14:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTc5OTA3MSM3NzQ2MDMyIzUwMDExODg0MA==\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Corbus Pharmaceuticals Announces FDA Clearance to Initiate TEMPO-1 Registrational Study of CRB-701 in Patients with 2L Oropharyngeal Cancer\",\"datePublished\":\"2026-07-28T12:14:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\\\/\"},\"wordCount\":930,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTc5OTA3MSM3NzQ2MDMyIzUwMDExODg0MA==\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\\\/\",\"name\":\"Corbus Pharmaceuticals Announces FDA Clearance to Initiate TEMPO-1 Registrational Study of CRB-701 in Patients with 2L Oropharyngeal Cancer - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/corbus-pharmaceuticals-announces-fda-clearance-to-initiate-tempo-1-registrational-study-of-crb-701-in-patients-with-2l-oropharyngeal-cancer\/","og_locale":"en_US","og_type":"article","og_title":"Corbus Pharmaceuticals Announces FDA Clearance to Initiate TEMPO-1 Registrational Study of CRB-701 in Patients with 2L Oropharyngeal Cancer - Market Newsdesk","og_description":"Company expects to initiate enrollment in TEMPO-1 in September 2026 OPSCC is estimated to represent 1 in 2 head and neck cancer patients in the 2L setting in the U.S. with approximately 14,000 patients eligible annually for treatment NORWOOD, Mass., July 28, 2026 (GLOBE NEWSWIRE) &#8212; Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) (\u201cCorbus\u201d or the \u201cCompany\u201d) a clinical-stage company focusing on developing new therapies in oncology and obesity, today announced that the U.S. Food and Drug Administration (FDA) has cleared the start of the Company\u2019s registrational study (\u201cTEMPO-1\u201d) of CRB-701, a next-generation Nectin-4 targeted antibody drug conjugate (ADC), in second-line (2L) oropharyngeal squamous cell carcinoma (OPSCC). 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