{"id":984597,"date":"2026-07-24T08:23:01","date_gmt":"2026-07-24T12:23:01","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma\/"},"modified":"2026-07-24T08:23:01","modified_gmt":"2026-07-24T12:23:01","slug":"estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma\/","title":{"rendered":"Estrella Immunopharma Announces First Patient Dosed in Dose-Expansion Phase of STARLIGHT-1 Trial and Reports Durable Response Rate in Advanced B-Cell Non-Hodgkin\u2019s Lymphoma"},"content":{"rendered":"

<\/p>\n

Estrella Immunopharma Announces First Patient Dosed in Dose-Expansion Phase of STARLIGHT-1 Trial and Reports Durable Response Rate in Advanced B-Cell Non-Hodgkin\u2019s Lymphoma<\/b><\/p>\n

EMERYVILLE, Calif.–(BUSINESS WIRE<\/a>)–
\nEstrella Immunopharma, Inc. (NASDAQ: ESLA) (\u201cEstrella\u201d or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company developing CD19 and CD22-targeted ARTEMIS\u00ae<\/sup> T-cell therapies to treat cancer and autoimmune diseases, today announced that the first patient has been successfully dosed in the dose-expansion phase of its ongoing STARLIGHT-1 Phase I\/II clinical trial evaluating EB103, a CD19-redirected ARTEMIS\u00ae<\/sup> T-cell therapy, in patients with relapsed\/refractory (R\/R) B-cell non-Hodgkin\u2019s lymphoma (NHL).<\/p>\n

\nEstrella\u2019s dosing of the first patient in the dose-expansion cohort follows encouraging efficacy data from the dose-escalation cohort. At the 6-month assessment of evaluable Phase I patients with no CNS involvement, all patients who achieved complete response (CR) remained in CR.<\/p>\n

\n\u201cThis marks an important milestone for Estrella and STARLIGHT-1,\u201d said Cheng Liu, PhD, Chief Executive Officer of Estrella. \u201cThe sustained complete responses observed to date reinforce EB103\u2019s potential to deliver best-in-class outcomes for patients with R\/R B-cell NHL. We remain deeply committed to advancing EB103.\u201d<\/p>\n

\nThe expansion phase is designed as a multi-center, open-label study intended to further evaluate the safety and efficacy of EB103 at the recommended Phase II dose (RP2D) in subjects (\u2265 18 years of age) who have R\/R B-cell NHL. Data from this expansion cohort will be used to determine the pivotal trial strategy for EB103. Current active sites include UC Davis Comprehensive Cancer Center and Baylor Scott & White Research Institute. Further details of the trial can be found at www.clinicaltrials.gov<\/a> under NCT identifier: NCT06343311.<\/p>\n

About EB103<\/b><\/p>\n

\nEB103, a T-cell therapy, also referred to as Estrella\u2019s \u201cCD19-Redirected ARTEMIS\u00ae<\/sup> T-Cell Therapy,\u201d utilizes ARTEMIS\u00ae<\/sup> technology licensed from Eureka Therapeutics, Inc. (\u201cEureka\u201d), Estrella\u2019s parent company. Unlike a traditional CAR-T cell, the unique design of an ARTEMIS\u00ae<\/sup> T-Cell, like EB103 T-cell, allows it to be activated and regulated upon engagement with cancer targets that use a cellular mechanism more closely resembling the one from an endogenous T-cell receptor. Once infused, EB103 T cells bind to and destroy CD19-positive cancer cells.<\/p>\n

About Estrella Immunopharma<\/b><\/p>\n

\nEstrella is a clinical-stage biopharmaceutical company developing CD19 and CD22-targeted ARTEMIS\u00ae<\/sup> T-cell therapies to treat cancers and autoimmune diseases. Estrella\u2019s mission is to harness the evolutionary power of the human immune system to transform the lives of patients fighting cancer and other diseases. To accomplish this mission, Estrella\u2019s lead product candidate, EB103, utilizes Eureka\u2019s ARTEMIS\u00ae<\/sup> technology to target CD19, a protein expressed on the surface of almost all B-cell leukemias and lymphomas. Estrella is also developing EB104, which also utilizes Eureka\u2019s ARTEMIS\u00ae<\/sup> technology to target not only CD19, but also CD22, another protein expressed on the surface of most B-cell malignancies.<\/p>\n

\nFor more information about Estrella, please visit www.estrellabio.com<\/a>.<\/p>\n

Forward Looking Statements<\/b><\/p>\n

\nThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements, including but not limited to those regarding the potential safety, efficacy and therapeutic benefits of EB103 and Estrella\u2019s other ARTEMIS\u00ae<\/sup> T-cell product candidates; the design, conduct, progress and timing of the STARLIGHT-1 Phase I\/II clinical trial and any future clinical trials of EB103; Estrella\u2019s expectations regarding the Recommended Phase II Dose, the expansion phase and the use of data from the expansion phase to inform any future pivotal trial strategy; Estrella\u2019s ability to advance EB103 and EB104 in development; and Estrella\u2019s beliefs regarding EB103\u2019s potential to address high-risk patient populations and expand access to CD19-directed cell therapies. These statements may be identified by the use of forward-looking expressions, including, but not limited to, \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccould,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201cshould,\u201d \u201ctarget,\u201d \u201cwill,\u201d \u201cwould\u201d and similar expressions and the negatives of those terms. These statements relate to future events or our financial performance and involve known and unknown risks, uncertainties, and other factors that could cause actual results, levels of activity, performance, or achievements to differ materially from those expressed or implied by these forward-looking statements. Factors that may cause actual results to differ materially from current expectations include, among other things, those listed under \u201cRisk Factors\u201d and elsewhere in our filings with the Securities and Exchange Commission. The forward-looking statements in this press release represent our views as of the date of this press release. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we have no current intention of doing so except to the extent required by applicable law. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release. Information contained on, or accessible through, Estrella\u2019s website or the websites referenced in this press release is not incorporated by reference into, and does not form a part of, this press release.<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20260724356360\/en\/<\/a><\/span><\/p>\n

\nInvestor Relations
\n
Estrella Immunopharma, Inc.
\n
IR@estrellabio.com<\/a><\/p>\n

KEYWORDS:<\/b> California United States North America<\/p>\n

INDUSTRY KEYWORDS:<\/b> Oncology Health Clinical Trials Research Science Pharmaceutical Biotechnology<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
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Estrella Immunopharma Announces First Patient Dosed in Dose-Expansion Phase of STARLIGHT-1 Trial and Reports Durable Response Rate in Advanced B-Cell Non-Hodgkin\u2019s Lymphoma EMERYVILLE, Calif.–(BUSINESS WIRE)– Estrella Immunopharma, Inc. (NASDAQ: ESLA) (\u201cEstrella\u201d or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company developing CD19 and CD22-targeted ARTEMIS\u00ae T-cell therapies to treat cancer and autoimmune diseases, today announced that the first patient has been successfully dosed in the dose-expansion phase of its ongoing STARLIGHT-1 Phase I\/II clinical trial evaluating EB103, a CD19-redirected ARTEMIS\u00ae T-cell therapy, in patients with relapsed\/refractory (R\/R) B-cell non-Hodgkin\u2019s lymphoma (NHL). Estrella\u2019s dosing of the first patient in the dose-expansion cohort follows encouraging efficacy data from the dose-escalation cohort. At the 6-month assessment of evaluable Phase I patients with no CNS involvement, … <\/p>\n

Continue reading “Estrella Immunopharma Announces First Patient Dosed in Dose-Expansion Phase of STARLIGHT-1 Trial and Reports Durable Response Rate in Advanced B-Cell Non-Hodgkin\u2019s Lymphoma”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-984597","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nEstrella Immunopharma Announces First Patient Dosed in Dose-Expansion Phase of STARLIGHT-1 Trial and Reports Durable Response Rate in Advanced B-Cell Non-Hodgkin\u2019s Lymphoma - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Estrella Immunopharma Announces First Patient Dosed in Dose-Expansion Phase of STARLIGHT-1 Trial and Reports Durable Response Rate in Advanced B-Cell Non-Hodgkin\u2019s Lymphoma - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Estrella Immunopharma Announces First Patient Dosed in Dose-Expansion Phase of STARLIGHT-1 Trial and Reports Durable Response Rate in Advanced B-Cell Non-Hodgkin\u2019s Lymphoma EMERYVILLE, Calif.–(BUSINESS WIRE)– Estrella Immunopharma, Inc. (NASDAQ: ESLA) (\u201cEstrella\u201d or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company developing CD19 and CD22-targeted ARTEMIS\u00ae T-cell therapies to treat cancer and autoimmune diseases, today announced that the first patient has been successfully dosed in the dose-expansion phase of its ongoing STARLIGHT-1 Phase I\/II clinical trial evaluating EB103, a CD19-redirected ARTEMIS\u00ae T-cell therapy, in patients with relapsed\/refractory (R\/R) B-cell non-Hodgkin\u2019s lymphoma (NHL). Estrella\u2019s dosing of the first patient in the dose-expansion cohort follows encouraging efficacy data from the dose-escalation cohort. 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(NASDAQ: ESLA) (\u201cEstrella\u201d or the \u201cCompany\u201d), a clinical-stage biopharmaceutical company developing CD19 and CD22-targeted ARTEMIS\u00ae T-cell therapies to treat cancer and autoimmune diseases, today announced that the first patient has been successfully dosed in the dose-expansion phase of its ongoing STARLIGHT-1 Phase I\/II clinical trial evaluating EB103, a CD19-redirected ARTEMIS\u00ae T-cell therapy, in patients with relapsed\/refractory (R\/R) B-cell non-Hodgkin\u2019s lymphoma (NHL). Estrella\u2019s dosing of the first patient in the dose-expansion cohort follows encouraging efficacy data from the dose-escalation cohort. At the 6-month assessment of evaluable Phase I patients with no CNS involvement, … Continue reading \"Estrella Immunopharma Announces First Patient Dosed in Dose-Expansion Phase of STARLIGHT-1 Trial and Reports Durable Response Rate in Advanced B-Cell Non-Hodgkin\u2019s Lymphoma\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma\/","og_site_name":"Market Newsdesk","article_published_time":"2026-07-24T12:23:01+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20260724356360r1&sid=flmnd&distro=nx&lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Estrella Immunopharma Announces First Patient Dosed in Dose-Expansion Phase of STARLIGHT-1 Trial and Reports Durable Response Rate in Advanced B-Cell Non-Hodgkin\u2019s Lymphoma","datePublished":"2026-07-24T12:23:01+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma\/"},"wordCount":903,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20260724356360r1&sid=flmnd&distro=nx&lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/estrella-immunopharma-announces-first-patient-dosed-in-dose-expansion-phase-of-starlight-1-trial-and-reports-durable-response-rate-in-advanced-b-cell-non-hodgkins-lymphoma\/","name":"Estrella Immunopharma Announces First Patient Dosed in Dose-Expansion Phase of STARLIGHT-1 Trial and Reports Durable Response Rate in Advanced B-Cell Non-Hodgkin\u2019s Lymphoma - 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