{"id":984153,"date":"2026-07-23T11:44:17","date_gmt":"2026-07-23T15:44:17","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/"},"modified":"2026-07-23T11:44:17","modified_gmt":"2026-07-23T15:44:17","slug":"hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/","title":{"rendered":"HCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027"},"content":{"rendered":"
\n

\n Company requested Type B pre-IND meeting with U.S. FDA to discuss development and regulatory strategy for its investigational tetravalent T-cell engager, HCW11-018b<\/em>\n <\/p>\n

\n HCW11-018b has demonstrated potential for treating solid tumors that overexpress human tissue factor, including gynecologic and pancreatic cancers<\/em>\n <\/p>\n

\n Company has developed a streamlined, robust manufacturing process designed to produce high-quality cGMP material at a lower cost than current methods<\/em>\n <\/p>\n

MIRAMAR, Fla., July 23, 2026 (GLOBE NEWSWIRE) — HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to treat diseases promoted by chronic inflammation, focusing on autoimmune disorders and other inflammatory diseases, cancer and senescence-associated dysplasia, today announced that it has requested a Type B (pre-IND application) meeting with the U.S. FDA to discuss the development and regulatory strategy for its investigational lead product candidate, HCW11-018b, a tetravalent T-cell engager (\u201cTCE\u201d) constructed with the Company\u2019s proprietary TRBC drug development platform.\u00a0\u00a0<\/p>\n

HCW11-018b is intended to treat solid tumors and is administered by subcutaneous injection. In preclinical studies, it has shown the ability to target tissue factor-expressing cancer cells and activate CD3-positive effector T cells, while simultaneously reducing immunosuppression in the tumor microenvironment. Immunosuppression in the tumor microenvironment can limit effector T-cell infiltration and antitumor activity in solid tumors, particularly in gynecologic and pancreatic cancers.<\/p>\n

TCEs have emerged as a potent therapeutic modality to treat cancer. First-generation TCEs represented a breakthrough in immunotherapy but they continue to face significant challenges, including antigen selection, limited efficacy in solid tumors, tolerability and safety concerns, and require a complex manufacturing process. Extensive preclinical studies of HCW11-018b –including assessments of\u00a0in vitro<\/em> and in vivo<\/em> potency, antigen specificity, pharmacokinetics, toxicity in nonhuman primates, and its therapeutic window — suggest that it may be able to overcome the limitations of earlier-generation TCEs.<\/p>\n

Currently, the U.S. FDA and other regulatory agencies have approved eight TCEs to be used to treat 12 indications. Even with a very limited number of approved indications, approved TCEs generate multi-billion-dollar annual sales. The level of interest for this area from major pharmaceutical companies remains strong over many years, as indicated by the large number of high-value partnerships formed with innovative biotechnology companies developing second-generation TCEs. These partnerships have likely been driven by TCE\u2019s potential in both oncology and autoimmune diseases.<\/p>\n

Dr. Hing C. Wong, the Company\u2019s Founder and CEO, stated, \u201cWe are pleased to have reached this important milestone in the development of HCW11-018b and look forward to discussing our proposed clinical trial designs, nonclinical testing programs, and CMC data with the FDA.\u00a0\u00a0 HCW11-018b exhibits remarkable anti-tumor activities with high tolerability in animal models. We discovered that it can penetrate into the tumor microenvironment with potent and antigen-specific anti-pancreatic cancer activities.\u201d<\/p>\n

Dr. Wong continued, \u201cWe believe we have established a robust, streamlined, and cost-efficient manufacturing process capable of producing high-quality cGMP material to support HCW11-018b in clinical development and potential future commercialization. Our manufacturing process is based on high-producing recombinant CHO cell lines and a proprietary monoclonal antibody needed for the affinity purification process. The monoclonal antibody is currently being manufactured under GMP standards using a top-tier CDMO.\u201d<\/p>\n

\n About HCW11-018b:<\/strong>\n <\/p>\n

HCW11-108b is designed to treat a wide spectrum of solid tumors with enhanced anti-tumor activities and tolerability. HCW Biologics has identified HCW11-018b as the lead candidate in its Tetravalent T-Cell Engager Program, known as the \u201cBig BiTE.\u201d The unique structure of the Big BiTE combines a tumor-associated tissue factor-targeting BiTE with IL-15 immune stimulation, in addition to a TGF-\u03b2 trap to address immunosuppression in the tumor microenvironment. HCW11-018b was created using the Company\u2019s proprietary TRBC drug development platform, without using the Fc fusion technology commonly found in bi-specific or tri-specific fusion molecules. In extensive preclinical studies, HCW11-018b demonstrated that it induces robust, sustained, antigen-specific tumor killing, enhances CD8\u207a T-cell activation, survival, and effector functions and promotes tumor infiltration into solid tumors. Further, HCW11-018b demonstrated in preclinical studies that it does not trigger cytokine release syndrome, a major concern of using BiTEs, when used in its therapeutic dose range.<\/p>\n

\n About HCW Biologics:<\/strong>\n <\/p>\n

HCW Biologics Inc. (the \u201cCompany\u201d) (NASDAQ: HCWB) is a clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to treat diseases promoted by chronic inflammation, including autoimmune diseases, cancer, and senescence-associated dysplasia. The Company\u2019s immunotherapeutics represent a new class of drugs that it believes have the potential to fundamentally change the treatment of proinflammatory and senescence-associated diseases and conditions that are promoted by chronic inflammation \u2014and in doing so, improve patients\u2019 quality of life and possibly extend longevity. A key aspect of the Company\u2019s clinical development and financing strategy is to focus on its business development programs. See the Company Pipeline at https:\/\/hcwbiologics.com\/pipeline\/<\/a><\/p>\n

\n Forward Looking Statements:<\/strong>\n <\/p>\n

Statements in this press release contain \u201cforward-looking statements\u201d that are subject to substantial risks and uncertainties. These statements are made under the \u201csafe harbor\u201d provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements contained in this press release may be identified by the use of words such as \u201canticipate,\u201d \u201cexpect,\u201d \u201cbelieve,\u201d \u201cwill,\u201d \u201cmay,\u201d \u201cshould,\u201d \u201cestimate,\u201d \u201cproject,\u201d \u201coutlook,\u201d \u201cforecast\u201d or other similar words and include, the actual success and potency of the Company\u2019s TCE-based TRBC fusion molecules, including HCW11-018b, the ability of the Company\u2019s TCE\u2019s to target cancer antigens, CD3 activation of effector T cells, and reduce immunosuppression in the tumor microenvironment; the ability of the Company\u2019s TCEs to exhibit potent and antigen-specific anti-pancreatic cancer activities both in vitro<\/em> and in humanized mouse models; the ability realize cost savings in the manufacture of HCW11-018b; and whether the Company\u2019s TCEs are effective in treatment of solid tumors and pancreatic cancers. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Factors that could cause actual results to differ include, but are not limited to, the risks and uncertainties that are described in the section titled \u201cRisk Factors\u201d in the annual report on Form 10-K filed with the United States Securities and Exchange Commission (the \u201cSEC\u201d) on March 31, 2026, the quarterly report on Form 10-Q filed with the SEC on May 14, 2026, and in other filings filed from time to time with the SEC.<\/p>\n

\n Company Contact:<\/strong>\n <\/p>\n

\n Dr. Peter Rhode<\/strong>
\n
Chief Scientific Officer and Vice President of Clinical Operations
HCW Biologics Inc.
PeterRhode@HCWBiologics.com<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Company requested Type B pre-IND meeting with U.S. FDA to discuss development and regulatory strategy for its investigational tetravalent T-cell engager, HCW11-018b HCW11-018b has demonstrated potential for treating solid tumors that overexpress human tissue factor, including gynecologic and pancreatic cancers Company has developed a streamlined, robust manufacturing process designed to produce high-quality cGMP material at a lower cost than current methods MIRAMAR, Fla., July 23, 2026 (GLOBE NEWSWIRE) — HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to treat diseases promoted by chronic inflammation, focusing on autoimmune disorders and other inflammatory diseases, cancer and senescence-associated dysplasia, today announced that it has requested a Type B (pre-IND application) meeting with … <\/p>\n

Continue reading “HCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-984153","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nHCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Company requested Type B pre-IND meeting with U.S. FDA to discuss development and regulatory strategy for its investigational tetravalent T-cell engager, HCW11-018b HCW11-018b has demonstrated potential for treating solid tumors that overexpress human tissue factor, including gynecologic and pancreatic cancers Company has developed a streamlined, robust manufacturing process designed to produce high-quality cGMP material at a lower cost than current methods MIRAMAR, Fla., July 23, 2026 (GLOBE NEWSWIRE) — HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to treat diseases promoted by chronic inflammation, focusing on autoimmune disorders and other inflammatory diseases, cancer and senescence-associated dysplasia, today announced that it has requested a Type B (pre-IND application) meeting with … Continue reading "HCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-23T15:44:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTc2NjY4MyM3NzE4NTQ2IzIyMTAxOTg=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"HCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027\",\"datePublished\":\"2026-07-23T15:44:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\\\/\"},\"wordCount\":1104,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTc2NjY4MyM3NzE4NTQ2IzIyMTAxOTg=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\\\/\",\"name\":\"HCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027 - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/","og_locale":"en_US","og_type":"article","og_title":"HCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027 - Market Newsdesk","og_description":"Company requested Type B pre-IND meeting with U.S. FDA to discuss development and regulatory strategy for its investigational tetravalent T-cell engager, HCW11-018b HCW11-018b has demonstrated potential for treating solid tumors that overexpress human tissue factor, including gynecologic and pancreatic cancers Company has developed a streamlined, robust manufacturing process designed to produce high-quality cGMP material at a lower cost than current methods MIRAMAR, Fla., July 23, 2026 (GLOBE NEWSWIRE) — HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to treat diseases promoted by chronic inflammation, focusing on autoimmune disorders and other inflammatory diseases, cancer and senescence-associated dysplasia, today announced that it has requested a Type B (pre-IND application) meeting with … Continue reading \"HCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/","og_site_name":"Market Newsdesk","article_published_time":"2026-07-23T15:44:17+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTc2NjY4MyM3NzE4NTQ2IzIyMTAxOTg=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"HCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027","datePublished":"2026-07-23T15:44:17+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/"},"wordCount":1104,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTc2NjY4MyM3NzE4NTQ2IzIyMTAxOTg=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-reaches-milestones-for-its-proprietary-tetravalent-second-generation-t-cell-engager-program-on-track-to-initiate-clinical-trials-in-first-half-2027\/","name":"HCW Biologics Reaches Milestones\u00a0for Its Proprietary Tetravalent Second-Generation T-Cell Engager Program On Track To Initiate Clinical Trials in First Half 2027 - 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