{"id":982518,"date":"2026-07-17T11:10:29","date_gmt":"2026-07-17T15:10:29","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/"},"modified":"2026-07-17T11:10:29","modified_gmt":"2026-07-17T15:10:29","slug":"agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/","title":{"rendered":"Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026"},"content":{"rendered":"

<\/p>\n

Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026<\/b><\/p>\n

LEXINGTON, Mass.–(BUSINESS WIRE<\/a>)–Agenus<\/b><\/a> Inc. (Nasdaq: AGEN)<\/b>, a leader in immuno-oncology innovation, today announced that three abstracts from investigator-sponsored trials evaluating botensilimab and balstilimab (BOT+BAL) have been accepted for poster presentation at the European Society for Medical Oncology (ESMO) Congress 2026, taking place October 23-27, 2026, in Madrid, Spain. The studies span neoadjuvant colorectal cancer, refractory metastatic colorectal cancer and advanced sarcoma, reflecting continued investigator interest in BOT+BAL across distinct disease settings and tumor types.<\/p>\n

\nThe NEOASIS poster will present updated data from a neoadjuvant cohort in mismatch repair-deficient (dMMR) colorectal cancer. While biologically distinct from the microsatellite-stable\/mismatch repair-proficient (MSS\/pMMR) population planned for ROBBIN, the study contributes to the broader clinical rationale for evaluating BOT+BAL before surgery and moving immunotherapy earlier in colon cancer.<\/p>\n

\nThe two additional posters will present real-world data from investigator-led studies of BOT+BAL in refractory MSS\/pMMR metastatic colorectal cancer and advanced sarcoma, extending the body of independent clinical experience with the combination in heavily pretreated patients.<\/p>\n

Presentation Details:<\/b><\/p>\n

    \n
  1. Abstract Title:<\/b> Neoadjuvant botensilimab plus balstilimab in MMR deficient colorectal cancer: results from the NEOASIS study
    \n
    Presenter:<\/b> Emma Van Den Berg MD; Department of Gastrointestinal Oncology, NKI-AVL – Netherlands Cancer Institute\/Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands
    \n
    Poster Presentation number: <\/b>837P
    \n
    Session Title:<\/b> Colon cancer
    \n
    Date\/Time: <\/b>Sun, 25 Oct 2026; 12:00-12:45 CET | 7:00-7:45AM EST<\/p>\n<\/li>\n
  2. Abstract Title:<\/b> Botensilimab plus balstilimab in advanced sarcoma: real-world data from a Spanish expanded access program
    \n
    Presenter:<\/b> Carlos L\u00f3pez-Jim\u00e9nez MD, PhD; Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Madrid, Spain
    \n
    Poster Presentation number: <\/b>3771P
    \n
    Session Title:<\/b> Sarcoma
    \n
    Date\/Time: <\/b>Mon, 26 Oct 2026: 12:00-12:45 CET | 7:00-7:45AM EST<\/p>\n<\/li>\n
  3. Abstract Title:<\/b> Botensilimab and balstilimab in refractory pMMR\/MSS metastatic colorectal cancer: real-world data from a multicenter AGEO study
    \n
    Presenter:<\/b> Louis Piton, MD, Paris-Cit\u00e9 University, Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, SIRIC CARPEM, Paris, France
    \n
    ePoster Abstract number: <\/b>905eP
    \n
    Session Title:<\/b> Colon cancer<\/p>\n<\/li>\n<\/ol>\n

    About Agenus<\/b><\/p>\n

    \nAgenus is a leading immuno-oncology company targeting cancer with a comprehensive pipeline of immunological agents. The company was founded in 1994 with a mission to expand patient populations benefiting from cancer immunotherapy through combination approaches, using a broad repertoire of antibody therapeutics, adoptive cell therapies (through MiNK Therapeutics) and adjuvants. Agenus has robust end-to-end development capabilities, across commercial and clinical cGMP manufacturing facilities, research and discovery, and a global clinical operations footprint. Agenus is headquartered in Lexington, MA. For more information, visit www.agenusbio.com<\/a> or @agenus_bio. Information that may be important to investors will be routinely posted on our website and social media channels.<\/p>\n

    About Botensilimab (BOT)<\/b><\/p>\n

    \nBotensilimab (BOT) is a human Fc enhanced multifunctional anti-CTLA-4 antibody designed to boost both innate and adaptive anti-tumor immune responses. Its novel design leverages mechanisms of action to extend immunotherapy benefits to \u201ccold\u201d tumors which generally respond poorly to standard of care or are refractory to conventional PD-1\/CTLA-4 therapies and investigational therapies. Botensilimab augments immune responses across a wide range of tumor types by priming and activating T cells, downregulating intratumoral regulatory T cells, activating myeloid cells and inducing long-term memory responses.<\/p>\n

    \nApproximately 1,300 patients have been treated with botensilimab and\/or balstilimab in phase 1 and phase 2 clinical trials. Botensilimab alone, or in combination with Agenus\u2019 investigational PD-1 antibody, balstilimab, has shown clinical responses across nine metastatic, late-line cancers. For more information about botensilimab trials, visit www.clinicaltrials.gov<\/a>.<\/p>\n

    About Balstilimab (BAL)<\/b><\/p>\n

    \nBalstilimab is a novel, fully human monoclonal immunoglobulin G4 (IgG4) designed to block PD-1 (programmed cell death protein 1) from interacting with its ligands PD-L1 and PD-L2. It has been evaluated in more than 900 patients to date and has demonstrated clinical activity and a favorable tolerability profile in several tumor types.<\/p>\n

    Forward-Looking Statements<\/b><\/p>\n

    \nThis press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding its botensilimab and balstilimab programs, expected regulatory timelines and filings, and any other statements containing the words “may,” “believes,” “expects,” “anticipates,” “hopes,” “intends,” “plans,” “forecasts,” “estimates,” “will,” \u201cestablish,\u201d \u201cpotential,\u201d \u201csuperiority,\u201d \u201cbest in class,\u201d and similar expressions are intended to identify forward-looking statements. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include, among others, the factors described under the Risk Factors section of our most recent Annual Report on Form 10-K for 2025, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission. Agenus cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.<\/p>\n

    \"\"<\/p>\n

    View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20260717259706\/en\/<\/a><\/span><\/p>\n

    Investors
    \n<\/b>
    917-362-1370 |     investor@agenusbio.com
    \n<\/a><\/p>\n

    Media
    \n<\/b>
    781-674-4422 |     communications@agenusbio.com<\/a><\/p>\n

    KEYWORDS:<\/b> Massachusetts Europe Spain United States North America<\/p>\n

    INDUSTRY KEYWORDS:<\/b> Oncology Health Genetics Clinical Trials Pharmaceutical Biotechnology<\/p>\n

    MEDIA:<\/b><\/p>\n\n\n\n\n
    Logo<\/b><\/font><\/td>\n<\/tr>\n
    \"Logo\"<\/td>\n<\/tr>\n
    <\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

    Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026 LEXINGTON, Mass.–(BUSINESS WIRE)–Agenus Inc. (Nasdaq: AGEN), a leader in immuno-oncology innovation, today announced that three abstracts from investigator-sponsored trials evaluating botensilimab and balstilimab (BOT+BAL) have been accepted for poster presentation at the European Society for Medical Oncology (ESMO) Congress 2026, taking place October 23-27, 2026, in Madrid, Spain. The studies span neoadjuvant colorectal cancer, refractory metastatic colorectal cancer and advanced sarcoma, reflecting continued investigator interest in BOT+BAL across distinct disease settings and tumor types. The NEOASIS poster will present updated data from a neoadjuvant cohort in mismatch repair-deficient (dMMR) colorectal cancer. While biologically distinct from the microsatellite-stable\/mismatch repair-proficient (MSS\/pMMR) population planned for ROBBIN, … <\/p>\n

    Continue reading “Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-982518","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nAgenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026 LEXINGTON, Mass.–(BUSINESS WIRE)–Agenus Inc. (Nasdaq: AGEN), a leader in immuno-oncology innovation, today announced that three abstracts from investigator-sponsored trials evaluating botensilimab and balstilimab (BOT+BAL) have been accepted for poster presentation at the European Society for Medical Oncology (ESMO) Congress 2026, taking place October 23-27, 2026, in Madrid, Spain. The studies span neoadjuvant colorectal cancer, refractory metastatic colorectal cancer and advanced sarcoma, reflecting continued investigator interest in BOT+BAL across distinct disease settings and tumor types. The NEOASIS poster will present updated data from a neoadjuvant cohort in mismatch repair-deficient (dMMR) colorectal cancer. While biologically distinct from the microsatellite-stable\/mismatch repair-proficient (MSS\/pMMR) population planned for ROBBIN, … Continue reading "Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-07-17T15:10:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20260717259706r1&sid=flmnd&distro=nx&lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026\",\"datePublished\":\"2026-07-17T15:10:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\\\/\"},\"wordCount\":873,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&sty=20260717259706r1&sid=flmnd&distro=nx&lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\\\/\",\"name\":\"Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026 - 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(Nasdaq: AGEN), a leader in immuno-oncology innovation, today announced that three abstracts from investigator-sponsored trials evaluating botensilimab and balstilimab (BOT+BAL) have been accepted for poster presentation at the European Society for Medical Oncology (ESMO) Congress 2026, taking place October 23-27, 2026, in Madrid, Spain. The studies span neoadjuvant colorectal cancer, refractory metastatic colorectal cancer and advanced sarcoma, reflecting continued investigator interest in BOT+BAL across distinct disease settings and tumor types. The NEOASIS poster will present updated data from a neoadjuvant cohort in mismatch repair-deficient (dMMR) colorectal cancer. While biologically distinct from the microsatellite-stable\/mismatch repair-proficient (MSS\/pMMR) population planned for ROBBIN, … Continue reading \"Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/","og_site_name":"Market Newsdesk","article_published_time":"2026-07-17T15:10:29+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20260717259706r1&sid=flmnd&distro=nx&lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026","datePublished":"2026-07-17T15:10:29+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/"},"wordCount":873,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20260717259706r1&sid=flmnd&distro=nx&lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/agenus-announces-three-botbal-presentations-spanning-neoadjuvant-and-late-line-colorectal-cancer-and-advanced-sarcomas-at-esmo-2026\/","name":"Agenus Announces Three BOT+BAL Presentations Spanning Neoadjuvant and Late-Line Colorectal Cancer and Advanced Sarcomas at ESMO 2026 - 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