{"id":976058,"date":"2026-06-26T07:39:15","date_gmt":"2026-06-26T11:39:15","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/axsome-therapeutics-initiates-focus-3-phase-3-trial-of-solriamfetol-in-adolescents-with-attention-deficit-hyperactivity-disorder-adhd\/"},"modified":"2026-06-26T07:39:15","modified_gmt":"2026-06-26T11:39:15","slug":"axsome-therapeutics-initiates-focus-3-phase-3-trial-of-solriamfetol-in-adolescents-with-attention-deficit-hyperactivity-disorder-adhd","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/axsome-therapeutics-initiates-focus-3-phase-3-trial-of-solriamfetol-in-adolescents-with-attention-deficit-hyperactivity-disorder-adhd\/","title":{"rendered":"Axsome Therapeutics Initiates FOCUS-3 Phase 3 Trial of Solriamfetol in Adolescents with Attention Deficit Hyperactivity Disorder (ADHD)"},"content":{"rendered":"
\n

NEW YORK, June 26, 2026 (GLOBE NEWSWIRE) — Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) disorders, today announced that the first patient has been dosed in the FOCUS-3 Phase 3 trial evaluating solriamfetol as a treatment for adolescents with attention deficit hyperactivity disorder (ADHD).<\/p>\n

FOCUS-3 (Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol) is a Phase 3, randomized, double-blind, placebo-controlled, multicenter trial to assess the efficacy and safety of solriamfetol in adolescents aged 12 to less than 18 years with ADHD. Approximately 468 patients will be randomized in a 1:1:1 ratio to receive one of two doses of solriamfetol or placebo for 6 weeks. The primary endpoint will be the change from baseline to week 6 in the ADHD Rating Scale (ADHD-RS-5) total score.<\/p>\n

\n About Attention Deficit Hyperactivity Disorder (ADHD)<\/strong>\n <\/p>\n

Attention deficit hyperactivity disorder (ADHD) is a chronic neurobiological and developmental disorder characterized by a persistent pattern of inattention, hyperactivity, or impulsivity, that interferes with functioning or development.1<\/sup>\u00a0Impairments in cognition are apparent in attention, planning and problem solving, working memory, and behavioral inhibition.2,3<\/sup>\u00a0An estimated 15.5 million adults and 7 million children in the U.S. are affected by ADHD,4,5<\/sup>\u00a0with approximately two-thirds or more of children with ADHD continuing to experience symptoms into adulthood.6<\/sup>\u00a0The total annual societal excess cost associated with adult ADHD in the U.S. has been estimated at over $120 billion.7<\/sup><\/p>\n

\n About Solriamfetol<\/strong>\n <\/p>\n

Solriamfetol is a dopamine and norepinephrine reuptake inhibitor (DNRI), TAAR1 agonist, and 5-HT1A<\/sub>\u00a0agonist being developed for the treatment of attention deficit hyperactivity disorder (ADHD), major depressive disorder (MDD) with excessive daytime sleepiness (EDS), binge eating disorder (BED), and excessive sleepiness associated with shift work disorder (SWD).<\/p>\n

\n About Axsome Therapeutics<\/strong>\n <\/p>\n

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer\u2019s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, as well as multiple novel product candidates addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain\u2019s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com<\/a> and follow us on LinkedIn<\/a> and X<\/a>.<\/p>\n

\n Forward Looking Statements<\/strong>\n <\/p>\n

Certain matters discussed in this press release are \u201cforward-looking statements\u201d. The Company may, in some cases, use terms such as \u201cpredicts,\u201d \u201cbelieves,\u201d \u201cpotential,\u201d \u201ccontinue,\u201d \u201cestimates,\u201d \u201canticipates,\u201d \u201cexpects,\u201d \u201cplans,\u201d \u201cintends,\u201d \u201cmay,\u201d \u201ccould,\u201d \u201cmight,\u201d \u201cwill,\u201d \u201cshould\u201d or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. In particular, the Company\u2019s statements regarding trends and potential future results are examples of such forward-looking statements. The forward-looking statements include risks and uncertainties, including, but not limited to, the commercial success of the Company\u2019s SUNOSI\u00ae<\/sup>, AUVELITY\u00ae<\/sup>, and SYMBRAVO\u00ae<\/sup> products and the success of the Company\u2019s efforts to obtain any additional indication(s) with respect to solriamfetol and\/or AXS-05; the Company\u2019s ability to maintain and expand payer coverage; the success, timing and cost of the Company\u2019s ongoing clinical trials and anticipated clinical trials for the Company\u2019s current product candidates, including statements regarding the timing of initiation, pace of enrollment and completion of the trials (including the Company\u2019s ability to fully fund the Company\u2019s disclosed clinical trials, which assumes no material changes to the Company\u2019s currently projected revenues or expenses), futility analyses and receipt of interim results, which are not necessarily indicative of the final results of the Company\u2019s ongoing clinical trials, and\/or data readouts, and the number or type of studies or nature of results necessary to support the filing of a new drug application (\u201cNDA\u201d) for any of the Company\u2019s current product candidates; the Company\u2019s ability to fund additional clinical trials to continue the advancement of the Company\u2019s product candidates; the timing of and the Company\u2019s ability to obtain and maintain U.S. Food and Drug Administration (\u201cFDA\u201d) or other regulatory authority approval of, or other action with respect to, the Company\u2019s product candidates, including statements regarding the timing of any NDA submission; the Company\u2019s ability to successfully defend its intellectual property or obtain the necessary licenses at a cost acceptable to the Company, if at all; the Company\u2019s ability to successfully resolve any intellectual property litigation, and even if such disputes are settled, whether the applicable federal agencies will approve of such settlements; the successful implementation of the Company\u2019s research and development programs and collaborations; the success of the Company\u2019s license agreements; the acceptance by the market of the Company\u2019s products and product candidates, if approved; the Company\u2019s anticipated capital requirements, including the amount of capital required for the commercialization of SUNOSI, AUVELITY, and SYMBRAVO and for the Company\u2019s commercial launch of its other product candidates, if approved, and the potential impact on the Company\u2019s anticipated cash runway; the Company\u2019s ability to convert sales to recognized revenue and maintain a favorable gross to net sales; unforeseen circumstances or other disruptions to normal business operations arising from or related to domestic political climate, geo-political conflicts or a global pandemic and other factors, including general economic conditions and regulatory developments, not within the Company\u2019s control. The factors discussed herein could cause actual results and developments to be materially different from those expressed in or implied by such statements. The forward-looking statements are made only as of the date of this press release and the Company undertakes no obligation to publicly update such forward-looking statements to reflect subsequent events or circumstances.<\/p>\n

\n Investors:<\/strong>\n <\/p>\n

Ashley Dong
Senior Director, Investor Relations
(929) 687-1614
adong@axsome.com<\/a><\/p>\n

\n Media:<\/strong>
\n
Darren Opland
Senior Director, Corporate Communications
(929) 837-1065
dopland@axsome.com<\/a><\/p>\n

References:<\/p>\n

    \n
  1. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 5 ed., Arlington, VA: American Psychiatric Publishing, 2013.<\/li>\n
  2. Brown TE. ADD\/ADHD and Impaired Executive Function in Clinical Practice. Curr Psychiatry Rep. 2008 Oct;10(5):407-11.<\/li>\n
  3. Nestler E., Hyman S., and Malenka R. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, Second Edition, 2nd<\/sup>\u00a0ed., New York: McGraw-Hill Professional, 2008.<\/li>\n
  4. Facts About ADHD in Adults. CDC. 2024.<\/li>\n
  5. Data and Statistics on ADHD. CDC. 2024.<\/li>\n
  6. Sibley MH et al. Variable Patterns of Remission From ADHD in the Multimodal Treatment Study of ADHD. Am J Psychiatry. 2022 Feb;179(2):142-151.<\/li>\n
  7. Schein J et al. Economic burden of attention-deficit\/hyperactivity disorder among adults in the United States: a societal perspective. J Manag Care Spec Pharm. 2022 Feb;28(2):168-179.<\/li>\n<\/ol>\n

    \"\"
    \n
    \n \"\"\n <\/div>\n

    <\/div>\n","protected":false},"excerpt":{"rendered":"

    NEW YORK, June 26, 2026 (GLOBE NEWSWIRE) — Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) disorders, today announced that the first patient has been dosed in the FOCUS-3 Phase 3 trial evaluating solriamfetol as a treatment for adolescents with attention deficit hyperactivity disorder (ADHD). FOCUS-3 (Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol) is a Phase 3, randomized, double-blind, placebo-controlled, multicenter trial to assess the efficacy and safety of solriamfetol in adolescents aged 12 to less than 18 years with ADHD. Approximately 468 patients will be randomized in a 1:1:1 ratio to receive one of two doses of solriamfetol or placebo for 6 weeks. The primary … <\/p>\n

    Continue reading “Axsome Therapeutics Initiates FOCUS-3 Phase 3 Trial of Solriamfetol in Adolescents with Attention Deficit Hyperactivity Disorder (ADHD)”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-976058","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nAxsome Therapeutics Initiates FOCUS-3 Phase 3 Trial of Solriamfetol in Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/axsome-therapeutics-initiates-focus-3-phase-3-trial-of-solriamfetol-in-adolescents-with-attention-deficit-hyperactivity-disorder-adhd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Axsome Therapeutics Initiates FOCUS-3 Phase 3 Trial of Solriamfetol in Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"NEW YORK, June 26, 2026 (GLOBE NEWSWIRE) — Axsome Therapeutics, Inc. 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(NASDAQ: AXSM), a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) disorders, today announced that the first patient has been dosed in the FOCUS-3 Phase 3 trial evaluating solriamfetol as a treatment for adolescents with attention deficit hyperactivity disorder (ADHD). FOCUS-3 (Forward Treatment of Attention Deficit and Hyperactivity Using Solriamfetol) is a Phase 3, randomized, double-blind, placebo-controlled, multicenter trial to assess the efficacy and safety of solriamfetol in adolescents aged 12 to less than 18 years with ADHD. Approximately 468 patients will be randomized in a 1:1:1 ratio to receive one of two doses of solriamfetol or placebo for 6 weeks. 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