{"id":973358,"date":"2026-06-17T17:40:09","date_gmt":"2026-06-17T21:40:09","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/corcept-resubmits-new-drug-application-for-relacorilant-as-a-treatment-for-patients-with-cushings-syndrome\/"},"modified":"2026-06-17T17:40:09","modified_gmt":"2026-06-17T21:40:09","slug":"corcept-resubmits-new-drug-application-for-relacorilant-as-a-treatment-for-patients-with-cushings-syndrome","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/corcept-resubmits-new-drug-application-for-relacorilant-as-a-treatment-for-patients-with-cushings-syndrome\/","title":{"rendered":"Corcept Resubmits New Drug Application for Relacorilant as a Treatment for Patients with Cushing\u2019s Syndrome"},"content":{"rendered":"

<\/p>\n

Corcept Resubmits New Drug Application for Relacorilant as a Treatment for Patients with Cushing\u2019s Syndrome<\/b><\/p>\n

REDWOOD CITY, Calif.–(BUSINESS WIRE<\/a>)–Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, today announced it has resubmitted its New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for relacorilant as a treatment for patients with Cushing\u2019s syndrome.<\/p>\n

As requested by the FDA, the resubmission includes additional analyses of data included in the original NDA submission. Corcept expects the resubmission to receive a six-month review.<\/p>\n

\u201cWe are pleased to return relacorilant\u2019s NDA to the review process and look forward to working with the Agency to advance relacorilant toward approval as a treatment for patients with Cushing\u2019s syndrome,\u201d said Joseph K. Belanoff, M.D., Corcept\u2019s Chief Executive Officer. \u201cRelacorilant has the potential to benefit many patients and it\u2019s important we make it available as quickly as possible. We appreciate the FDA\u2019s ongoing engagement with our application.\u201d<\/p>\n

Corcept\u2019s resubmission is based on positive data from its pivotal GRACE trial, the double-blind, placebo-controlled Phase III GRADIENT trial, relacorilant\u2019s long-term extension study and earlier-stage development data. Corcept believes that these data show that relacorilant provides meaningful, durable improvements in the signs and symptoms of Cushing’s syndrome, without causing some of the serious adverse events associated with currently approved medications \u2013 termination of pregnancy, hypokalemia, endometrial hypertrophy, vaginal bleeding, adrenal insufficiency and QT prolongation.<\/p>\n

About Hypercortisolism (Cushing\u2019s Syndrome)<\/b><\/p>\n

Hypercortisolism, also known as Cushing\u2019s syndrome, is caused by excessive activity of the hormone cortisol. Symptoms vary, but most patients experience one or more of the following manifestations: hypertension, central obesity, elevated blood sugar and difficult-to-control type 2 diabetes, severe fatigue and weak muscles. Irritability, anxiety, depression and cognitive disturbances are common. Hypercortisolism can affect every organ system and can be fatal if not treated effectively. Cardiovascular events are the most common cause of death among patients with hypercortisolism. Recent research<\/a> shows that endogenous hypercortisolism is more prevalent than previously believed.<\/p>\n

About Relacorilant<\/b><\/p>\n

Relacorilant, an oral therapy, is a selective glucocorticoid receptor (GR) antagonist that modulates cortisol activity by binding to the GR but not to the body’s other hormone receptors. Relacorilant is proprietary to Corcept and is protected by composition of matter, method of use and other patents. It has been designated an orphan drug by the FDA and the European Commission (EC) for the treatment of hypercortisolism and by the EC for the treatment of ovarian cancer. Under the brand name Lifyorli\u2122, relacorilant was approved in combination with nab-paclitaxel for adults with platinum-resistant ovarian cancer by the FDA in 2026. Corcept has submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) for relacorilant to treat patients with platinum-resistant ovarian cancer.<\/p>\n

About Corcept Therapeutics<\/b><\/p>\n

For over 25 years, Corcept has focused on cortisol modulation and its potential to treat patients with a wide variety of serious disorders, leading to the discovery of more than 1,000 proprietary selective cortisol modulators and glucocorticoid receptor antagonists. Corcept is conducting advanced clinical trials in patients with Cushing\u2019s syndrome, solid tumors, ALS and liver disease. In 2012, the company introduced Korlym\u00ae<\/sup>, the first medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients with endogenous Cushing\u2019s syndrome, and in 2026, the company introduced Lifyorli\u2122, approved in combination with nab-paclitaxel, the first FDA-approved selective glucocorticoid receptor antagonist for adults with platinum-resistant ovarian cancer. Corcept is headquartered in Redwood City, California. For more information, visit Corcept.com<\/a>.<\/p>\n

Forward-Looking Statements<\/b><\/p>\n

Statements in this press release, other than statements of historical fact, are forward-looking statements based on our current plans and expectations and are subject to risks and uncertainties that might cause our actual results to differ materially from any future results expressed or implied by such forward-looking statements.<\/p>\n

In this press release, forward-looking statements include statements concerning: Corcept\u2019s resubmission of its NDA to the FDA for relacorilant as a treatment for patients with Cushing\u2019s syndrome; Corcept\u2019s expectation that this resubmission will receive a six-month review; Corcept\u2019s intent to work with the FDA to advance relacorilant toward approval as a treatment for patients with Cushing\u2019s syndrome; relacorilant\u2019s potential to benefit many patients; and Corcept\u2019s belief regarding the importance of making relacorilant available as quickly as possible.<\/p>\n

A further description of risks and uncertainties can be found in our SEC filings, which are available at our website and the SEC\u2019s website. These risks and uncertainties include, but are not limited to, those related to: our ability to operate our business; our efforts to study and develop Korlym, relacorilant, miricorilant, dazucorilant, nenocorilant and our other product candidates; those molecules\u2019 clinical attributes; regulatory approvals, mandates, oversight and other requirements imposed on our products or our business by laws, regulations or discretion of government authorities; and the scope and protective power of our intellectual property. We disclaim any intention or duty to update forward-looking statements made in this press release.<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20260617001418\/en\/<\/a><\/span><\/p>\n

Investor inquiries:
ir@corcept.com<\/a>
Media inquiries:
communications@corcept.com<\/a>
www.corcept.com<\/a><\/p>\n

KEYWORDS:<\/b> United States North America California<\/p>\n

INDUSTRY KEYWORDS:<\/b> Biotechnology FDA Health General Health Pharmaceutical Oncology Neurology Other Science Research Science Clinical Trials<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
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Corcept Resubmits New Drug Application for Relacorilant as a Treatment for Patients with Cushing\u2019s Syndrome REDWOOD CITY, Calif.–(BUSINESS WIRE)–Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, today announced it has resubmitted its New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for relacorilant as a treatment for patients with Cushing\u2019s syndrome. As requested by the FDA, the resubmission includes additional analyses of data included in the original NDA submission. Corcept expects the resubmission to receive a six-month review. \u201cWe are pleased to return relacorilant\u2019s NDA to the review process and look forward … <\/p>\n

Continue reading “Corcept Resubmits New Drug Application for Relacorilant as a Treatment for Patients with Cushing\u2019s Syndrome”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-973358","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nCorcept Resubmits New Drug Application for Relacorilant as a Treatment for Patients with Cushing\u2019s Syndrome - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/corcept-resubmits-new-drug-application-for-relacorilant-as-a-treatment-for-patients-with-cushings-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Corcept Resubmits New Drug Application for Relacorilant as a Treatment for Patients with Cushing\u2019s Syndrome - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Corcept Resubmits New Drug Application for Relacorilant as a Treatment for Patients with Cushing\u2019s Syndrome REDWOOD CITY, Calif.–(BUSINESS WIRE)–Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic and neurologic disorders by modulating the effects of the hormone cortisol, today announced it has resubmitted its New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for relacorilant as a treatment for patients with Cushing\u2019s syndrome. As requested by the FDA, the resubmission includes additional analyses of data included in the original NDA submission. 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