{"id":971886,"date":"2026-06-15T06:33:20","date_gmt":"2026-06-15T10:33:20","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\/"},"modified":"2026-06-15T06:33:20","modified_gmt":"2026-06-15T10:33:20","slug":"context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\/","title":{"rendered":"Context Therapeutics Announces Positive Interim Efficacy and Safety Results from Ongoing Phase 1 Clinical Trial for CTIM-76"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>29% confirmed overall response rate per RECIST v1.1 in patients with platinum-resistant ovarian cancer (\u201cPROC\u201d) who progressed on a median of 7 prior lines of therapy<\/em>\n      <\/p>\n<p align=\"center\">Cytokine Release Syndrome (\u201cCRS\u201d) in PROC limited to Grade 1 in 11% of patients<\/p>\n<p align=\"center\">\n        <em>Pharmacokinetic<\/em> (\u201c<em>PK\u201d) profile supports exploration of Q3W dosing in 2H 2026<\/em><\/p>\n<p align=\"center\">\n        <em>CTIM-76 has been granted FDA Fast Track Designation in PROC<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>Company to host conference call on Monday, June 15 at 8:00 a.m. ET<\/em>\n      <\/p>\n<p>PHILADELPHIA, June  15, 2026  (GLOBE NEWSWIRE) &#8212; Context Therapeutics Inc. (\u201cContext\u201d or the \u201cCompany\u201d) (Nasdaq: CNTX), a clinical-stage biopharmaceutical company advancing T cell engaging (\u201cTCE\u201d) bispecific antibodies for solid tumors, today announced positive interim Phase 1 clinical data for its CLDN6 x CD3 T cell engaging bispecific antibody, CTIM-76, in advanced, late-line platinum-resistant ovarian cancer (\u201cPROC\u201d). The data are as of a May 29, 2026 data cutoff from the ongoing CTIM-76 Phase 1 study.<\/p>\n<p>\u201cWe are encouraged by the continued development of CTIM-76 as a potentially best-in-class CLDN6 T cell engager that may offer a much-needed new therapeutic approach for patients with platinum-resistant ovarian cancer,\u201d said Martin Lehr, Chief Executive Officer of Context. \u201cIn our first clinical presentation of dose-escalation data, weekly administration of CTIM-76 produced compelling anti-tumor activity and a well-tolerated safety profile in heavily pretreated patients, many of whom had extensive prior exposure to antibody-drug conjugates. Building on this encouraging data, we have advanced into the next phase of development, where we will evaluate CTIM-76 administered every three weeks (\u201cQ3W\u201d). These results are expected to inform subsequent Phase 1b dose expansion in 2027.\u201d<\/p>\n<p>\n        <strong>CTIM-76 Phase 1a Interim Data Summary:<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>21 patients with PROC (n=14), testicular (n=4), and endometrial (n=3) cancer were treated with CTIM-76 at doses ranging from 22.5\u00b5g to 560\u00b5g every week (\u201cQW\u201d).<\/li>\n<li>At the active doses of 140\u00b5g to 280\u00b5g, 13 patients were treated in total, 10 of whom were efficacy evaluable, having had at least one post-baseline tumor assessment as of the data cutoff.<\/li>\n<li>560\u00b5g exceeded target exposures with QW dosing and was not pursued further.<\/li>\n<\/ul>\n<p>\n        <strong>PROC Patient Characteristics: <\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>Patients (n=9) received a median of 7 prior lines of therapy (range 5-16).<\/li>\n<li>Prior patient treatments included ADC (89%), checkpoint inhibitor (55%), VEGF (100%), or DNA repair agent (78%).<\/li>\n<li>44% of patients had liver metastases.<\/li>\n<\/ul>\n<p>\n        <strong>Efficacy Results: <\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>As of the data cutoff, 7 PROC patients were efficacy-evaluable at doses of 140\u00b5g to 280\u00b5g.<\/li>\n<li>Overall response rate (ORR): 29% of PROC patients (2\/7) achieved confirmed partial RECIST v. 1.1 responses.<\/li>\n<li>Disease control rate (DCR)<sup>1<\/sup>: 57% (4\/7)<\/li>\n<li>In early cohort patients who achieved confirmed stable disease or partial response, treatment durability was sustained for at least 6 months (n=3).<\/li>\n<\/ul>\n<p>\n        <strong>Safety Results: <\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>At active dose levels, CTIM-76 produced a favorable safety profile that is consistent with the expected mechanism of action for a T cell engager and supports continued clinical development.<\/li>\n<li>Adverse events generally occurred during the first or second dose and were predominantly low grade, with the majority of events reported as Grade 1 or Grade 2 and reversible with standard management.<\/li>\n<li>CRS events were infrequent and limited to Grade 1 (11%, n=1\/9) at active dose levels in PROC patients, which may be supportive of outpatient dosing in future trials.<\/li>\n<\/ul>\n<p>\n        <strong>Pharmacokinetic Results: <\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>Approximately dose-dependent increases in CTIM-76 exposure with increasing dose level.<\/li>\n<li>Preliminary PK supports exploration of Q3W dosing schedule.<\/li>\n<\/ul>\n<p>\n        <strong>Investor Webcast and Conference Call Information<\/strong><br \/>\n        <br \/>The Company will host a conference call to discuss these data at 8:00 a.m. ET today, June 15, 2026. Participants may access the live webcast of the conference call from the \u201c<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=PA8gdYZ1cEFXQ--W2uuR5XQThAgCH3CYuWpBZPE7dDQbzvryDBWIs2MSYOI_yE9xxapxFD9r9pnjoQJ9MJe5QRXZvkPZoQaijHAA3KapSl0jCyZoMZPvPolQRMZVYr_2rGGtJAmalk_h_LJVXceFfgs8NxEXeibNlURuUiK7JTU=\" rel=\"nofollow\" target=\"_blank\">News &amp; Events<\/a>\u201d page of the Company\u2019s website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Ss9sH1wrkypsq53ubXPhLbYCcFZd_blFcShCpLcW0lCzPuIqoXrw0AFrLzC-3WzGl2zw5zMhlbENeZ1uJhFq5i2fVpeXNEESdDpH3cQRyb6NWgK-JLSvQx3Ik0ESUO7U\" rel=\"nofollow\" target=\"_blank\">www.contexttherapeutics.com<\/a>. Participants may register for the conference call <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=7pNVSyCvgDSp9HJ5Ui2yud3u8jRm1YXA_EBN0CSp8_cm7JV1PNV53fMe2Dd5c_3Qt1H2PSUqh7WUAQ7_RZam0AnT4WHGAy0fgVC97sZIhT4=\" rel=\"nofollow\" target=\"_blank\">here<\/a> and are advised to do so at least 10 minutes prior to joining the call. The webcast will be available for replay for at least 90 days on the Company\u2019s website.<\/p>\n<p>\n        <strong>About CTIM-76<\/strong><br \/>\n        <br \/>CTIM-76 is a CLDN6 x CD3 T cell engaging bispecific antibody. CLDN6 is enriched in a wide range of solid tumors, including ovarian, endometrial, lung, gastric, and testicular. Preclinical research suggests the potential for convenient dosing with low immunogenicity risk and scalable manufacturing to address the significant number of patients who are potentially eligible for CTIM-76 therapy. More information about the CTIM-76 clinical trial (NCT06515613) can be found on\u202f<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=fwy7VzEUWt8ICyUvMA7wawqHPyoMgsux8szVHyKLqzWd1jJ2xzHkg_R35_cX1SnH9War3D29xK3Ctpw8gaGzuHH-BbRcmjaPFVF7fikHyM7AmSD5jXtHhB7OqxK1VwT3Mbb61MTWNmJF9IaxVu66XLZ5iYJ-vpIgce4Wn7G1zKM=\" rel=\"nofollow\" target=\"_blank\">https:\/\/clinicaltrials.gov\/<\/a>.<\/p>\n<p>\n        <strong>About Context Therapeutics<\/strong><br \/>\n        <sup>\u00ae<\/sup><br \/>\n        <br \/>Context Therapeutics Inc. (Nasdaq: CNTX)\u00a0is a clinical-stage biopharmaceutical company advancing T cell engaging (\u201cTCE\u201d) bispecific antibodies for solid tumors. Context\u2019s goal is to build an innovative portfolio of TCE bispecific therapeutics, including CTIM-76, a Claudin 6 x CD3 TCE, CT-95, a Mesothelin x CD3 TCE, and CT-202, a Nectin-4 x CD3 TCE. Context is headquartered in Philadelphia. For more information, please visit\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Ss9sH1wrkypsq53ubXPhLbYCcFZd_blFcShCpLcW0lB2-DXvWTIuf1WQTtQ_sB47z0MhcpR_2tk-BFD3LUz3ta4nPNvVgqfgegMrozt9H9QCXtdxEYX2ugON8CEmuhCz\" rel=\"nofollow\" target=\"_blank\">www.contexttherapeutics.com<\/a>\u00a0or follow the Company on\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=9WIMQmTPLLQ_llYVS0_8ljTGM6fsXjl0UJzahrGrGBoVH9yS6iNjPUhRTgfdt0OFsBbxOulKW2H8ztqF8H3KwQ==\" rel=\"nofollow\" target=\"_blank\">X<\/a> (formerly\u00a0Twitter)\u00a0and\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=dUj0DSUslerzCo46xv6pE8wuxnC-xMDT0ndlGCMwPHKO58QuK5PuQ0U1IgC5grdK0N2_gh5v2kgK7k1SVSqhJan1kWI_ipT05VDw2inhijcy9tQOo4akO9w-0zbB5ROF\" rel=\"nofollow\" target=\"_blank\">LinkedIn<\/a>.<\/p>\n<p>\n        <strong>Forward-looking Statements<\/strong><br \/>\n        <br \/>This press release contains \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact, including statements regarding the Company\u2019s strategy, future operations, prospects, and plans and objectives of management, are forward-looking statements. These statements may be identified by words such as \u201cmay,\u201d \u201cwill,\u201d \u201cexpect,\u201d \u201cbelieve,\u201d \u201ccould,\u201d \u201cestimate,\u201d \u201cpotential,\u201d \u201canticipate,\u201d \u201clook forward,\u201d \u201cplan,\u201d \u201cintend,\u201d and similar expressions.<\/p>\n<p>Forward-looking statements in this press release include, without limitation, statements regarding (i) expectations of CTIM-76 Q3W dosing in the second half of 2026 and that CTIM-76 Q3W data will be available to inform subsequent dose expansion, (ii) expectations of CTIM-76 Phase 1b clinical trial development to occur in 2027; (iii) expectations that CTIM-76 may potentially be a best-in-class CLDN6 T cell engager; (iv) expectations that CTIM-76 could be a new therapeutic approach for patients with platinum-resistant ovarian cancer; and (v) other non-historical statements.<\/p>\n<p>These forward-looking statements involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied, and the Company cannot assure that its plans, intentions, expectations, or strategies will be achieved. These risks and uncertainties include, without limitation: (i) uncertainties regarding the Company\u2019s expectations, projections, and estimates of future costs and expenses, capital requirements, the availability of additional financing and the Company\u2019s capital requirements; (ii) the timing, progress, and results of the Company\u2019s discovery, preclinical and clinical development activities; (iii) clinical trial site activation and enrollment; (iv) unexpected safety or efficacy data observed during preclinical studies or clinical trials; (v) the risk that results from nonclinical or clinical studies may not be predictive of future results, and that interim data are subject to further analysis; (vi) uncertainties related to the regulatory approval process; (vii) the Company\u2019s reliance on third parties; (viii) macroeconomic conditions; and (ix) whether the Company has sufficient funding to meet future operating expenses and capital expenditure requirements. Additional factors that may cause actual results to differ materially from those expressed or implied in the forward-looking statements in this press release are described under the heading \u201cRisk Factors\u201d in the Company\u2019s Annual Report on Form 10-K for the year ended December 31, 2025, as filed with the U.S. Securities and Exchange Commission (the \u201cSEC\u201d), and in the Company\u2019s other filings with the SEC, including future reports.<\/p>\n<p>Except as required by law, the Company undertakes no obligation to update or revise any forward-looking statements, which speak only as of the date of this press release, whether as a result of new information, future events or otherwise.<\/p>\n<p>\n        <strong>Investor Relations Contact:<\/strong><br \/>\n        <br \/>Jennifer Minai-Azary<br \/>Chief Financial Officer<br \/>Context Therapeutics<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=-aBkDE1qsXGbPQQzAOiGL2NU9ru_rgmZDyJLpcPb3NuaFNoZvVUqrt2oWPTNq9FeJKPzN_6he7cfgF1VgrzLITAtMZKWvupV7N1A2bgk9d5V0utUQ0sMcPNeL-NzDuBJ\" rel=\"nofollow\" target=\"_blank\">IR@contexttherapeutics.com<\/a><\/p>\n<p>\n        <sup>1<\/sup>\u00a0Disease Control Rate: Patients achieving a confirmed response of stable disease, partial response, or complete response.<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTc0NjcxOCM3NjYwMjkxIzIyMDkxMDE=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/OGY0ZGU4YjktMDczZi00YTIwLWFjNDItYzM2YTY2NTEzNDU2LTEyMjA2NTQtMjAyNi0wNi0xNS1lbg==\/tiny\/Context-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>29% confirmed overall response rate per RECIST v1.1 in patients with platinum-resistant ovarian cancer (\u201cPROC\u201d) who progressed on a median of 7 prior lines of therapy Cytokine Release Syndrome (\u201cCRS\u201d) in PROC limited to Grade 1 in 11% of patients Pharmacokinetic (\u201cPK\u201d) profile supports exploration of Q3W dosing in 2H 2026 CTIM-76 has been granted FDA Fast Track Designation in PROC Company to host conference call on Monday, June 15 at 8:00 a.m. ET PHILADELPHIA, June 15, 2026 (GLOBE NEWSWIRE) &#8212; Context Therapeutics Inc. (\u201cContext\u201d or the \u201cCompany\u201d) (Nasdaq: CNTX), a clinical-stage biopharmaceutical company advancing T cell engaging (\u201cTCE\u201d) bispecific antibodies for solid tumors, today announced positive interim Phase 1 clinical data for its CLDN6 x CD3 T cell engaging &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Context Therapeutics Announces Positive Interim Efficacy and Safety Results from Ongoing Phase 1 Clinical Trial for CTIM-76&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-971886","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Context Therapeutics Announces Positive Interim Efficacy and Safety Results from Ongoing Phase 1 Clinical Trial for CTIM-76 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Context Therapeutics Announces Positive Interim Efficacy and Safety Results from Ongoing Phase 1 Clinical Trial for CTIM-76 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"29% confirmed overall response rate per RECIST v1.1 in patients with platinum-resistant ovarian cancer (\u201cPROC\u201d) who progressed on a median of 7 prior lines of therapy Cytokine Release Syndrome (\u201cCRS\u201d) in PROC limited to Grade 1 in 11% of patients Pharmacokinetic (\u201cPK\u201d) profile supports exploration of Q3W dosing in 2H 2026 CTIM-76 has been granted FDA Fast Track Designation in PROC Company to host conference call on Monday, June 15 at 8:00 a.m. ET PHILADELPHIA, June 15, 2026 (GLOBE NEWSWIRE) &#8212; Context Therapeutics Inc. (\u201cContext\u201d or the \u201cCompany\u201d) (Nasdaq: CNTX), a clinical-stage biopharmaceutical company advancing T cell engaging (\u201cTCE\u201d) bispecific antibodies for solid tumors, today announced positive interim Phase 1 clinical data for its CLDN6 x CD3 T cell engaging &hellip; Continue reading &quot;Context Therapeutics Announces Positive Interim Efficacy and Safety Results from Ongoing Phase 1 Clinical Trial for CTIM-76&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-06-15T10:33:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTc0NjcxOCM3NjYwMjkxIzIyMDkxMDE=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Context Therapeutics Announces Positive Interim Efficacy and Safety Results from Ongoing Phase 1 Clinical Trial for CTIM-76\",\"datePublished\":\"2026-06-15T10:33:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\\\/\"},\"wordCount\":1228,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTc0NjcxOCM3NjYwMjkxIzIyMDkxMDE=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/context-therapeutics-announces-positive-interim-efficacy-and-safety-results-from-ongoing-phase-1-clinical-trial-for-ctim-76\\\/\",\"name\":\"Context Therapeutics Announces Positive Interim Efficacy and Safety Results from Ongoing Phase 1 Clinical Trial for CTIM-76 - 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