{"id":970068,"date":"2026-06-03T08:35:41","date_gmt":"2026-06-03T12:35:41","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/"},"modified":"2026-06-03T08:35:41","modified_gmt":"2026-06-03T12:35:41","slug":"in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/","title":{"rendered":"IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies"},"content":{"rendered":"<h2>\nReview Highlights Emerging Engineering Strategies Including Combination Approaches Designed to Enhance Anti-Tumor Activity, Gamma-Delta T cell Engagers, CAR-Gamma-Delta T Cells and Cytokine-Armored Cells<br \/>\n<\/h2>\n<div class=\"mw_release\">\n<p>NEW YORK, June  03, 2026  (GLOBE NEWSWIRE) &#8212; IN8bio, Inc. (NASDAQ: INAB), a clinical-stage biopharmaceutical company developing innovative gamma-delta (\u03b3\u03b4) T cell therapies and T cell engagers (TCEs) for cancer and autoimmune diseases, today announced the publication of a review article titled: \u201c<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Gl8nFHVHCrDdxw6N9pwiWsqcp2uT2TcdZufvAEod1KIpByoLjZyDu_wkaXN6seHQzzC5qEd_bGnJRQmGCKYynktXAN61DqiECA_60HUOR4AbgFz6ItY89__wMLZq5MlDQRodAigPe9gbznujwtUsiBy4AAPdNUjLYQJKGFFR_K8s4kKgwbBDHxG59jhhZl7RllwGgnXeae2bmxbgfdF9dw==\" rel=\"nofollow\" target=\"_blank\">Harnessing \u03b3\u03b4 T cells through engineering and combination therapies<\/a>\u201d in the journal <em>Nature Communications<\/em>. IN8bio Chief Scientific Officer (CSO) Lawrence Lamb, Ph.D. was a contributing author to the review, which highlights advances in \u03b3\u03b4 T cell engineering, combination approaches, and clinical development strategies designed to improve anti-tumor efficacy across both solid tumors and hematologic cancers.<\/p>\n<p>\u03b3\u03b4 T cells differ from conventional alpha-beta T cells through their ability to recognize stress-associated signals independent of major histocompatibility complex (MHC) restriction. This potentially solves problems associated with therapeutic development and enables them to target tumors that evade traditional immune responses. The publication reviews emerging engineering strategies, including CAR-\u03b3\u03b4 T cells, cytokine-armored \u03b3\u03b4 T cells, TCE approaches, and antibody-secreting \u03b3\u03b4 T cells, as well as combination approaches involving checkpoint inhibitors, chemotherapy, cytokines, and bispecific antibodies.<\/p>\n<p>\u201cWe are pleased <em>Nature Communications<\/em> published this review highlighting the rapid progress and growing momentum across the \u03b3\u03b4 T cell field,\u201d said Lawrence Lamb, CSO and scientific co-founder of IN8bio. \u201cThe publication highlights the unique biological properties of \u03b3\u03b4 T cells and their potential to address important limitations associated with current immunotherapy approaches, particularly in difficult-to-treat solid tumors. We believe advances in engineering, manufacturing, and combination strategies are continuing to expand the therapeutic potential of \u03b3\u03b4 T cells across oncology and autoimmune diseases.\u201d<\/p>\n<p>The publication also highlights the potential for allogeneic \u201coff-the-shelf\u201d \u03b3\u03b4 T cell therapies due to the cells\u2019 lack of graft-versus-host disease (GvHD)-associated alloreactivity, as well as growing clinical evidence supporting \u03b3\u03b4 T cell therapies across hematologic malignancies and solid tumors, including glioblastoma.<\/p>\n<p>In addition, the review discusses how \u03b3\u03b4 T cells may function as orchestrators of immune surveillance through their ability to recognize heterogeneous tumor-associated stress signals and potentially overcome mechanisms of immune escape commonly observed in advanced cancers.<\/p>\n<p>This review was authored by an international group of five highly respected oncologists and immunologists including Lawrence Lamb, PhD and IN8bio\u2019s Scientific Advisory Board (SAB) member Jonathan Fisher, BM, PhD, MRCPCH from University College London. There are an increasing number of actively recruiting \u03b3\u03b4 T cell clinical trials globally, reflecting growing academic and industry interest in the platform across cancer and autoimmune diseases.<\/p>\n<p>Access: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=thVgYkPjUX7zV85JST67MW7caVUuHjH5tuhcFvl4iBsuLSDReQauG0SN1LKUMjooiRodtACHhmWiyRqAg1_6xntQ7m1DfSt5bc3eTCTYzXRJi4frFDRWo2Ixq7glyALzT6MEAsnOkQgJvsOH2m8V3A==\" rel=\"nofollow\" target=\"_blank\">https:\/\/doi.org\/10.1038\/s41467-026-73451-z<\/a><\/p>\n<p>\n        <strong>About IN8bio<\/strong>\n      <\/p>\n<p>IN8bio is a clinical-stage biopharmaceutical company developing \u03b3\u03b4 T cell and \u03b3\u03b4 T cell\u00a0engager (TCE) product candidates to address unmet medical needs. \u03b3\u03b4 T cells are\u00a0a specialized population of T cells that possess unique properties, including the ability to differentiate between healthy and diseased tissue. The Company\u2019s pipeline is anchored by INB-600, a novel \u03b3\u03b4 T cell engager platform with potential applications across oncology and autoimmune indications. IN8bio is also advancing INB-100, an allogeneic \u03b3\u03b4 T cell candidate for adult patients with high-risk leukemias undergoing haploidentical stem cell transplantation, and INB-200\/400, an autologous genetically modified \u03b3\u03b4 T cell candidate for newly diagnosed glioblastoma (GBM). For more information about IN8bio, visit\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=zcKoWPRpywpMIFf6tTFt3vMI8YWc0KX1dXex0aBoId4g3F0_47416nW69BO_HEiM3RTIgpMF75ND_CDISVyg_W9eIZfJrK-TaGfayxwpjeQLHbdABNgxv1E0XypyeekXQf8MDZrjiTbriOfWrZ8uhaGMF8xqgCkRar3prrEu5iHBaIk3dhczlATvA6QlmcVdg_15krCfnOqTbqGk7_RfRVJONB9MlD8Bbh5mAhBjOnMSbmDejVxZuKwhj5w2dGbriaRLDSP0UV0anTJA3O2IV5kOMG4TBM433HzDijtT7rrNugowPgxyH4-P3CDyfuh2boXzOqimEYRIc7rueOG4oZMTVI2XDw3dii-_QQ-u-0QVNBfYnIBrUOw6SC9Q1IBdh77AwhYCYhGz-1pQXD56Vg93VCebgcv1zIIq90uUce4=\" rel=\"nofollow\" target=\"_blank\">www.IN8bio.com<\/a>.<\/p>\n<p>\n        <strong>Investors &amp; Company Contacts:<\/strong>\n      <\/p>\n<p>\n        <strong>IN8bio, Inc.<\/strong><br \/>\n        <br \/>Patrick McCall<br \/>646.933.5603<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ZmjmmeFYWuHeK9OSN8ROwdAE3Wx605lTAehwWBNJVHuQohScwQAVr-c9R3kCYipeZB5DI1wsRUzvkDb3TDQgd7_WMU4slEzctxw5HPeQn5hHV2yQ80vSvX4dl-DLAbN7H5ZrJpY8KE-Z1loIKoOS3cmem1oL6hvl4DXc7s1iv5T8mB8I3SbCIeT4Jfb-P2moOVYCHIxeKT4YOnobpDUyH6RvB4U2gTG8p-aFk0aEv57w90JPPrfQyQWLwzAnfflmevWnrTrBQSkh1FXhL3L6HKUsp_atJmWGQH_OVCZb1nmjVh6rJfGmuL3DskhDogBjgLBiEu-X51glBwGzeueAm8YYaZcig4i1i7DXok7uARhGGNM4ODRDku8D3oU0W2bbPJeivYTvdxk12HWlyVE8epPY-b6Qzi5CLRmCLyZZXdPWbNzBvX-72s4nJXB_Gx5s5DU_h5V8uI6ftTU5WCWujwfX1hMXm7KajvPEeEVSm_QD8tTSgH5xZAYiBgjF8P8s\" rel=\"nofollow\" target=\"_blank\">pfmccall@IN8bio.com<\/a><\/p>\n<p>\n        <strong>Media Contact<\/strong><br \/>\n        <br \/>Kimberly Ha<br \/>KKH Advisors<br \/>917.291.5744<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=1QZJvW8Oc2o8SE2ALtH2rh7Q6nUo2SRKSch1_P5yZeCTf01L9NGTuSKHH1UTPYD1OWEBtSW5rofpASLqMu3DgspQbagwDuKl4xyYfbaP-KCLOSZlo13wKGfD9PPP3-N0bEb8jWOZbpAZAv51uW_rqIn6KK1oZ_B70R35wh3e2lg0rBdlYxt8Q7WJ2AIezWoLMGFihur8WH_V_VuGToIXjhkAZCcw2NhVRPydQ77-ud_TAn4R-4d9luGW3Bhty5WVl3U9Q9MvzGXRQWbLTqkF028LbAnPV7XHdQDdM4Cr6MyeK1QLJFmxDXD7NzWRiLKsvvLntENpgR6tAjiyb-xOwUx2e-OMixuuvzukPF9riao4tumaaiTSuucVdVW0M1rA60IGsAXQrGowmYk6tmgrCE-SnTJlptFBfW4SsnaH-YxMoKOpeGMK11kpN0JGTFe8bybrp35wqi_ioXUmMLLjCgdt7ma1NxUBxCffAjKTRvIhiHvNhX1kXOT8Whso9Buby5nBI_tRMaDdanr6oHdUzM2_lk2bBil06SjKFK3jJcbIa_gIa2ELQgBiOEvXaSUr\" rel=\"nofollow\" target=\"_blank\">kimberly.ha@kkhadvisors.com<\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTczMDk4MSM3NjM0MDgyIzIxMjMwMDY=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/MGRmYTM2NTktZWM4MC00MTlkLTg0YWUtZGQyYzllODhiNWZlLTExMzQ1NzctMjAyNi0wNi0wMy1lbg==\/tiny\/IN8bio-Inc.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Review Highlights Emerging Engineering Strategies Including Combination Approaches Designed to Enhance Anti-Tumor Activity, Gamma-Delta T cell Engagers, CAR-Gamma-Delta T Cells and Cytokine-Armored Cells NEW YORK, June 03, 2026 (GLOBE NEWSWIRE) &#8212; IN8bio, Inc. (NASDAQ: INAB), a clinical-stage biopharmaceutical company developing innovative gamma-delta (\u03b3\u03b4) T cell therapies and T cell engagers (TCEs) for cancer and autoimmune diseases, today announced the publication of a review article titled: \u201cHarnessing \u03b3\u03b4 T cells through engineering and combination therapies\u201d in the journal Nature Communications. IN8bio Chief Scientific Officer (CSO) Lawrence Lamb, Ph.D. was a contributing author to the review, which highlights advances in \u03b3\u03b4 T cell engineering, combination approaches, and clinical development strategies designed to improve anti-tumor efficacy across both solid tumors and hematologic cancers. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-970068","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Review Highlights Emerging Engineering Strategies Including Combination Approaches Designed to Enhance Anti-Tumor Activity, Gamma-Delta T cell Engagers, CAR-Gamma-Delta T Cells and Cytokine-Armored Cells NEW YORK, June 03, 2026 (GLOBE NEWSWIRE) &#8212; IN8bio, Inc. (NASDAQ: INAB), a clinical-stage biopharmaceutical company developing innovative gamma-delta (\u03b3\u03b4) T cell therapies and T cell engagers (TCEs) for cancer and autoimmune diseases, today announced the publication of a review article titled: \u201cHarnessing \u03b3\u03b4 T cells through engineering and combination therapies\u201d in the journal Nature Communications. IN8bio Chief Scientific Officer (CSO) Lawrence Lamb, Ph.D. was a contributing author to the review, which highlights advances in \u03b3\u03b4 T cell engineering, combination approaches, and clinical development strategies designed to improve anti-tumor efficacy across both solid tumors and hematologic cancers. &hellip; Continue reading &quot;IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-06-03T12:35:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTczMDk4MSM3NjM0MDgyIzIxMjMwMDY=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies\",\"datePublished\":\"2026-06-03T12:35:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\\\/\"},\"wordCount\":577,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTczMDk4MSM3NjM0MDgyIzIxMjMwMDY=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\\\/\",\"name\":\"IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/","og_locale":"en_US","og_type":"article","og_title":"IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies - Market Newsdesk","og_description":"Review Highlights Emerging Engineering Strategies Including Combination Approaches Designed to Enhance Anti-Tumor Activity, Gamma-Delta T cell Engagers, CAR-Gamma-Delta T Cells and Cytokine-Armored Cells NEW YORK, June 03, 2026 (GLOBE NEWSWIRE) &#8212; IN8bio, Inc. (NASDAQ: INAB), a clinical-stage biopharmaceutical company developing innovative gamma-delta (\u03b3\u03b4) T cell therapies and T cell engagers (TCEs) for cancer and autoimmune diseases, today announced the publication of a review article titled: \u201cHarnessing \u03b3\u03b4 T cells through engineering and combination therapies\u201d in the journal Nature Communications. IN8bio Chief Scientific Officer (CSO) Lawrence Lamb, Ph.D. was a contributing author to the review, which highlights advances in \u03b3\u03b4 T cell engineering, combination approaches, and clinical development strategies designed to improve anti-tumor efficacy across both solid tumors and hematologic cancers. &hellip; Continue reading \"IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/","og_site_name":"Market Newsdesk","article_published_time":"2026-06-03T12:35:41+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTczMDk4MSM3NjM0MDgyIzIxMjMwMDY=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies","datePublished":"2026-06-03T12:35:41+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/"},"wordCount":577,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTczMDk4MSM3NjM0MDgyIzIxMjMwMDY=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/in8bio-announces-publication-in-nature-communications-highlighting-advances-in-gamma-delta-t-cell-engineering-and-combination-therapies\/","name":"IN8bio Announces Publication in Nature Communications Highlighting Advances in Gamma-Delta T Cell Engineering and Combination Therapies - 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