{"id":966691,"date":"2026-05-26T07:46:44","date_gmt":"2026-05-26T11:46:44","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases\/"},"modified":"2026-05-26T07:46:44","modified_gmt":"2026-05-26T11:46:44","slug":"plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases\/","title":{"rendered":"Plus&#8217; CNSide Diagnostic Platform Demonstrates Substantial Healthcare Cost Reduction in Patients with Leptomeningeal Metastases"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>Plus and Harvard analysis shows CNSide enables early diagnosis and better clinical decision-making\u00a0<\/em><br \/>\n        <br \/>\n        <em>reducing healthcare costs by 40%<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>Presentation receives blue-ribbon recognition at the ISPOR Annual Meeting, the premier global gathering for health economics and outcomes research<\/em>\n      <\/p>\n<p align=\"justify\">HOUSTON, May  26, 2026  (GLOBE NEWSWIRE) &#8212; Plus Therapeutics, Inc. (Nasdaq: PSTV) (\u201cPlus\u201d or the \u201cCompany\u201d), a healthcare company developing and commercializing precision diagnostics and radiopharmaceuticals for central nervous system (CNS) cancers, today announced the presentation of a new health economics study evaluating the economic impact of earlier detection and therapeutic management of LM using the CNSide cerebrospinal fluid (CSF) assay. The Company believes that this cost-of-care analysis underscores that earlier LM diagnosis and therapeutic management enabled by CNSide may reduce overall LM-related healthcare costs by approximately 33-47%. These savings are driven by earlier therapeutic intervention, improved treatment precision, and reduced hospitalizations. Further, the recently announced payer agreements validate the findings as Plus continues commercialization of the assay in the United States.<\/p>\n<p align=\"justify\">The data was presented at the ISPOR 2026 Annual Meeting, the leading global scientific conference focused on health economics and outcomes research (HEOR), bringing together researchers, healthcare decision-makers, and payer stakeholders. The meeting took place May 17-20, 2026, in Philadelphia, PA.<\/p>\n<p align=\"justify\">\u201cThese findings are confirmation of discussions we have had with payers regarding the value provided by CNSide\u2019s ability to detect and monitor tumor cells in cerebrospinal fluid, providing clinicians with actionable information earlier in the disease course,\u201d said\u00a0Randy Goodman, Ph.D., MHA, Vice President of Value Strategy &amp; HEOR. \u201cHealth economics data are an important determinant in payer decision making and these data suggest the potential cost savings associated with earlier intervention and optimized management.\u201d<\/p>\n<p align=\"justify\">\n        <strong>Presentation Highlights<\/strong><br \/>\n        <br \/>The poster, titled, \u201c<em>Economic Impact of Earlier Detection and Therapeutic Management of Leptomeningeal Metastases Using CNSide: A Cost-of-Care Analysis,<\/em>\u201d co-authored by CNSide Diagnostics and Harvard T.H. Chan School of Public Health, highlighted the following:<\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">Late-stage LM diagnosis is associated with substantial healthcare costs, including median inpatient admissions of ~$20,000 (Interquartile range (IQR) $10,000-$30,000)<\/li>\n<li style=\"text-align:justify\">Total LM-related costs may exceed $100,000 per month, driven by repeated imaging, LM-directed therapies, and palliative care<\/li>\n<li style=\"text-align:justify\">Earlier detection and treatment optimization enabled by CNSide may reduce overall LM-related healthcare costs by ~40% (33%-47%)<\/li>\n<li style=\"text-align:justify\">Potential savings are driven by earlier therapeutic intervention, improved treatment precision, reduced adverse events and hospitalizations, and potential improvements in quality-adjusted outcomes<\/li>\n<li style=\"text-align:justify\">The analysis also highlights the challenges of quantifying LM costs due to claims bundling with primary cancer treatment<\/li>\n<\/ul>\n<p align=\"justify\">Notably, the poster received Blue Ribbon recognition, an honor awarded to the top 5% of presentations at ISPOR. The analysis utilized published literature, real-world data, and healthcare claims databases to estimate direct and indirect costs associated with late-stage LM diagnosis.\u00a0\u00a0 Additional information on ISPOR 2026 and the poster can be found <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=G76tOylbMvPG7kt090KieN5nRvogScKnRjfU09wwkweaPvTDgzX4KyD1Szzuv1wCsd5U8uBD8nqGfWy7jq64-icvTQyN7jhZKMKGIsW0L-5kIhmHgQcXZDw1aGXEI6nJE754kpGYXiYb8Vr4tjK6cPODCPd8F-4Blf_S2vFgKgnJ6RYncvH9EK5Hs4pDRfWMJmDj5uqRaRCKm_jRoUuWNk6vsHzbKKbwyitJUv2ROb0S0KeawWcK4Igg6Lut60OZaXscjz98vwKV4sl99iWZzZHV0NnKqXgiBoOjaJLUFsPv8dmo8OWogf1uSI-6P8_ejfphyDwT2ctzAinjnkptL5ziy1jtKnn5GV4Ih7LGsbQ=\" rel=\"nofollow\" target=\"_blank\">here<\/a>.<\/p>\n<p align=\"justify\">\n        <strong>About Leptomeningeal Metastases<\/strong><br \/>\n        <br \/>Leptomeningeal metastases (LM) are a rare but severe complication of advanced cancer, affecting the fluid-lined structures of the central nervous system. LM occurs in approximately 5% of patients with metastatic cancer, with breast cancer, lung cancer, and melanoma being the most common sources. Median survival is typically 2-6 months, and effective treatment options are limited, highlighting the urgent need for novel therapies.<\/p>\n<p align=\"justify\">\n        <strong>About CNSide Diagnostics, LLC<\/strong><br \/>\n        <br \/>CNSide Diagnostics, LLC is a wholly owned subsidiary of Plus Therapeutics, Inc. that develops and commercializes proprietary laboratory-developed tests, such as CNSide\u00ae, designed to identify tumor cells that have metastasized to the central nervous system in patients with carcinomas and melanomas. The CNSide\u00ae CSF Assay Platform enables quantitative analysis of the cerebrospinal fluid (CSF) that informs and improves the management of patients with leptomeningeal metastases.<\/p>\n<p align=\"justify\">\n        <strong>About Plus Therapeutics<\/strong><br \/>\n        <br \/>Headquartered in Houston, Texas, Plus Therapeutics, Inc. is a healthcare company developing and commercializing precision diagnostics and radiopharmaceuticals for central nervous system (CNS) cancers. The Company\u2019s commercial diagnostic, CNSide\u00ae, is a high-complexity cerebrospinal fluid (CSF) assay platform that supports the detection and management of leptomeningeal metastases (LM). The Company\u2019s lead therapeutic candidate, REYOBIQ\u2122 (rhenium Re186 obisbemeda), is in clinical development for LM and recurrent glioblastoma (GBM), combining image-guided local beta radiation with targeted drug delivery. Plus has built a supply chain through strategic partnerships that enable the development, manufacturing, and potential future commercialization of its products. For more information, visit www.plustherapeutics.com.<\/p>\n<p align=\"justify\">\n        <strong>Forward-Looking Statements<\/strong><br \/>\n        <br \/>This press release contains statements that may be deemed \u201cforward-looking statements\u201d within the meaning of U.S. securities laws. All statements in this press release other than statements of historical fact are forward-looking statements. These forward-looking statements may be identified by future verbs, as well as terms such as &#8220;expect,&#8221; &#8220;anticipate&#8221; &#8220;intend,&#8221; &#8220;believe,&#8221; &#8220;estimate,&#8221; &#8220;will,&#8221; and similar expressions or the negatives thereof. Such statements are based upon certain assumptions and assessments made by management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate. The forward-looking statements included in this press release could differ materially from those expressed or implied by these forward-looking statements because of risks, uncertainties, and other factors that include, but are not limited to, the following: the Company\u2019s ability to commercialize CNSide and to achieve and sustain payer coverage and reimbursement for the assay; the timing, scope and outcomes of the Company\u2019s clinical studies, including ReSPECT-LM and ReSPECT-GBM; the Company\u2019s ability to obtain regulatory approvals; the Company\u2019s reliance on third-party manufacturers and supply chain partners; the Company\u2019s ability to raise additional capital on reasonable terms or at all; available cash on hand; and changes in local or national economic conditions. This list of risks, uncertainties, and other factors is not complete. Any or all forward-looking statements the Company makes may turn out to be wrong and can be affected by inaccurate assumptions the Company might make or by known or unknown risks, uncertainties, and other factors, including those identified in this press release. Plus Therapeutics discusses some of these matters more fully, as well as certain risk factors that could affect Plus Therapeutics\u2019 business, financial condition, results of operations, and prospects, in its reports filed with the SEC, including Plus Therapeutics\u2019 annual report on Form 10-K for the fiscal year ended December 31, 2025, quarterly reports on Form 10-Q, and current reports on Form 8-K. These filings are available for review through the SEC\u2019s website at www.sec.gov. Accordingly, you should not place undue reliance on the forward-looking statements made in this press release, which speak only as of its date. There may be events in the future that the Company is unable to predict, or over which it has no control, and its business, financial condition, results of operations and prospects may change in the future. The Company assumes no responsibility to update or revise any forward-looking statements to reflect events, trends or circumstances after the date they are made unless the Company has an obligation under U.S. federal securities laws to do so.<\/p>\n<p>\n        <strong>Investor Contact<\/strong><br \/>\n        <br \/>CORE IR<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=-fPAKdoMxmZEfJdANOEL5VJ4tYRQG6kyYm0JQW3ecuLi9vHITRqi9TsSH3w6UevHP9JpAmExtfcDKCjKiWBHbr9sHACQfC2QCDbcA9W7zIuzYjGvOSEGkyjfa5lWP06I\" rel=\"nofollow\" target=\"_blank\">investor@plustherapeutics.com<\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTcyNTU0MSM3NjE4MjExIzIwMDQ4MDU=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/OTI5MmI2MzYtZDJmYy00MTQ5LThmNTMtNDJmOTQ3MDA3MDZlLTEwMTYzNzgtMjAyNi0wNS0yNi1lbg==\/tiny\/Plus-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Plus and Harvard analysis shows CNSide enables early diagnosis and better clinical decision-making\u00a0 reducing healthcare costs by 40% Presentation receives blue-ribbon recognition at the ISPOR Annual Meeting, the premier global gathering for health economics and outcomes research HOUSTON, May 26, 2026 (GLOBE NEWSWIRE) &#8212; Plus Therapeutics, Inc. (Nasdaq: PSTV) (\u201cPlus\u201d or the \u201cCompany\u201d), a healthcare company developing and commercializing precision diagnostics and radiopharmaceuticals for central nervous system (CNS) cancers, today announced the presentation of a new health economics study evaluating the economic impact of earlier detection and therapeutic management of LM using the CNSide cerebrospinal fluid (CSF) assay. The Company believes that this cost-of-care analysis underscores that earlier LM diagnosis and therapeutic management enabled by CNSide may reduce overall LM-related &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Plus&#8217; CNSide Diagnostic Platform Demonstrates Substantial Healthcare Cost Reduction in Patients with Leptomeningeal Metastases&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-966691","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Plus&#039; CNSide Diagnostic Platform Demonstrates Substantial Healthcare Cost Reduction in Patients with Leptomeningeal Metastases - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Plus&#039; CNSide Diagnostic Platform Demonstrates Substantial Healthcare Cost Reduction in Patients with Leptomeningeal Metastases - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Plus and Harvard analysis shows CNSide enables early diagnosis and better clinical decision-making\u00a0 reducing healthcare costs by 40% Presentation receives blue-ribbon recognition at the ISPOR Annual Meeting, the premier global gathering for health economics and outcomes research HOUSTON, May 26, 2026 (GLOBE NEWSWIRE) &#8212; Plus Therapeutics, Inc. (Nasdaq: PSTV) (\u201cPlus\u201d or the \u201cCompany\u201d), a healthcare company developing and commercializing precision diagnostics and radiopharmaceuticals for central nervous system (CNS) cancers, today announced the presentation of a new health economics study evaluating the economic impact of earlier detection and therapeutic management of LM using the CNSide cerebrospinal fluid (CSF) assay. The Company believes that this cost-of-care analysis underscores that earlier LM diagnosis and therapeutic management enabled by CNSide may reduce overall LM-related &hellip; Continue reading &quot;Plus&#8217; CNSide Diagnostic Platform Demonstrates Substantial Healthcare Cost Reduction in Patients with Leptomeningeal Metastases&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-05-26T11:46:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTcyNTU0MSM3NjE4MjExIzIwMDQ4MDU=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Plus&#8217; 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Plus Therapeutics, Inc. (Nasdaq: PSTV) (\u201cPlus\u201d or the \u201cCompany\u201d), a healthcare company developing and commercializing precision diagnostics and radiopharmaceuticals for central nervous system (CNS) cancers, today announced the presentation of a new health economics study evaluating the economic impact of earlier detection and therapeutic management of LM using the CNSide cerebrospinal fluid (CSF) assay. The Company believes that this cost-of-care analysis underscores that earlier LM diagnosis and therapeutic management enabled by CNSide may reduce overall LM-related &hellip; Continue reading \"Plus&#8217; CNSide Diagnostic Platform Demonstrates Substantial Healthcare Cost Reduction in Patients with Leptomeningeal Metastases\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases\/","og_site_name":"Market Newsdesk","article_published_time":"2026-05-26T11:46:44+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTcyNTU0MSM3NjE4MjExIzIwMDQ4MDU=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-cnside-diagnostic-platform-demonstrates-substantial-healthcare-cost-reduction-in-patients-with-leptomeningeal-metastases\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Plus&#8217; 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