{"id":966453,"date":"2026-05-22T16:33:06","date_gmt":"2026-05-22T20:33:06","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients\/"},"modified":"2026-05-22T16:33:06","modified_gmt":"2026-05-22T20:33:06","slug":"abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients\/","title":{"rendered":"Abivax Presents First Quarter 2026 Financial Results and Reports Three-Year Interim Data from Study 108, a Phase 2a\/2b Open-Label Extension Trial of Obefazimod Following Dose De-Escalation in Patients with Ulcerative Colitis"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <b>Abivax Presents First Quarter 2026 Financial Results and Reports Three-Year Interim Data from Study 108, a Phase 2a\/2b Open-Label Extension Trial of Obefazimod Following Dose <\/b><br \/>\n        <b>De-Escalation in Patients with Ulcerative Colitis<\/b>\n      <\/p>\n<ul type=\"disc\">\n<li>\n          <i>Interim intent to treat (\u201cITT\u201d) analysis from Study 108 supports strong durable clinical remission in moderately to severely active ulcerative colitis (\u201cUC\u201d) patients treated with obefazimod<\/i><\/p>\n<\/li>\n<li>\n          <i>Following two to four years of open-label treatment with 50 mg, 130 patients <\/i><br \/>\n          <br \/>\n          <i>de-escalated to 25 mg, and at week 144, 68% (88\/130) were in clinical remission and 80% (104\/130) completed 144 weeks of treatment<\/i><\/p>\n<\/li>\n<li>\n          <i>Patients in Study 108 were treated with obefazimod for up to seven years, with no new safety signals observed<\/i><\/p>\n<\/li>\n<li>\n          <i>ABTECT Phase 3 maintenance trial results expected in late Q2 2026 <\/i><\/p>\n<\/li>\n<li>\n          <i>Cash, cash equivalents and short-term investments of \u20ac491.6M as of March 31, 2026; cash runway into Q4 2027<\/i><\/p>\n<\/li>\n<\/ul>\n<p align=\"justify\">\n        <b>PARIS, France \u2013 May 22, 2026 \u2013 10:05 PM CEST <\/b>\u2013 Abivax SA (Euronext Paris: FR0012333284 \u2013 ABVX \/ Nasdaq \u2013 ABVX) (\u201cAbivax\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company focused on developing therapeutics that harness the body\u2019s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases, reported today its financial results for the first quarter ended March 31, 2026. The first quarter financial statements, approved by the Company\u2019s Board of Directors on May 21, 2026, have been reviewed by the Company\u2019s statutory auditors, and the financial reports will be filed with the French and U.S. securities regulatory authorities, respectively, on May 22, 2026.<\/p>\n<p align=\"justify\">\n        <b>Study 108: Three-Year Interim Analysis of Long-Term Obefazimod Treatment and Dose De-Escalation in Patients with Moderately to Severely Active UC<\/b><br \/>\n        <br \/>In this open-label maintenance (\u201cOLM\u201d) trial, patients who had completed the four-year Phase 2a or two-year Phase 2b OLM trials, where they had received 50 mg of once-daily obefazimod, were given the opportunity to continue receiving obefazimod at a reduced dose of 25 mg daily for up to five additional years (provided they met the eligibility criteria of Mayo Endoscopic Subscore = 0 or 1). A total of 130 patients entered the trial and as of the January 5, 2026 cutoff date, 80% (104\/130) were still enrolled and completed the full 144-week evaluation.<\/p>\n<p align=\"justify\">At study baseline, 89% (116\/130) of patients were in clinical remission. At weeks 48, 96 and 144 of treatment, 73% (95\/130), 69% (90\/130), and 68% (88\/130) of patients evaluated were in clinical remission, respectively. Clinical remission, inclusive of endoscopic subscore, was evaluated in the ITT population using non-responder imputation. Similar trends were observed with other efficacy analyses, and no new safety signals were observed.\u00a0\u00a0<\/p>\n<p align=\"justify\">\u201c<i>The durability of clinical remission observed for up to seven years, together with the favorable tolerability profile observed to date, supports the potential of obefazimod as a durable treatment option for people living with ulcerative colitis<\/i>,\u201d said <b>Fabio Cataldi, MD, Chief Medical Officer of Abivax<\/b>. \u201c<i>We look forward to presenting these long<\/i><i>\u2011<\/i><i>term data at an upcoming medical meeting<\/i>.\u201d<\/p>\n<p align=\"justify\">Abivax provided the following updates on its business and operational goals in press releases published:<\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">On January 9, 2026, a press release titled \u201cAbivax Provides 2026 Corporate Outlook\u201d\n<\/li>\n<li style=\"text-align:justify\">On February 21, 2026, a press release titled \u201cAbivax Presents First Evidence of Anti-Fibrotic Activity for Obefazimod Alongside New Clinical Efficacy and Safety Analyses in Inflammatory Bowel Disease at ECCO 2026\u201d\n<\/li>\n<li style=\"text-align:justify\">On March 23, 2026, a press release titled \u201cAbivax Announces Full Year 2025 Financial Results and Provides Business Updates\u201d\n<\/li>\n<li style=\"text-align:justify\">On April 1, 2026, a press release titled \u201cAbivax Publishes Financial Reports with the French and U.S. Securities Regulatory Agencies\u201d\n<\/li>\n<li style=\"text-align:justify\">On April 20, 2026, a press release titled \u201cAbivax Annual Ordinary and Extraordinary General Meeting of May 11, 2026 Availability of Preparatory Documents\u201d\n<\/li>\n<li style=\"text-align:justify\">On April 22, 2026, a press release titled \u201cAbivax to Present Data on Obefazimod at Digestive Disease Week<sup>\u00ae<\/sup>\u201d\n<\/li>\n<li style=\"text-align:justify\">On May 5, 2026, a press release titled \u201cAbivax Announces Repurchase of Royalty Certificates and Pricing of $45M (\u20ac38.5M) Offering of American Depositary Shares\u201d\n<\/li>\n<li style=\"text-align:justify\">On May 11, 2026, a press release titled \u201cAbivax Announces Results of its May 11, 2026 Annual General Meeting\u201d\n<\/li>\n<\/ul>\n<p align=\"justify\">\n        <b>First Quarter 2026 Financial Highlights<\/b>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">\n          <b>Cash Position and Runway:<\/b> The Company had cash, cash equivalents and short-term investments of \u20ac491.6 million as of March 31, 2026, providing a projected cash runway into Q4 2027 based on current operating assumptions.<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">\n          <b>R&amp;D Expenses:<\/b> Research and development (\u201cR&amp;D\u201d) expenses increased by \u20ac10.2 million to \u20ac49.5 million (86.0% of operating expenses) in the first quarter of 2026 compared to \u20ac39.3 million (81.5% of operating expenses) in the first quarter of 2025. This increase was predominantly driven by expenses related to: <\/p>\n<ul type=\"circle\">\n<li style=\"text-align:justify\">A \u20ac8.0 million increase related to new indications (including combination therapy) for obefazimod;<\/li>\n<li style=\"text-align:justify\">A \u20ac2.0 million increase in transversal activities related to increased chemistry, manufacturing and controls and supply chain costs related to the progression of clinical trials and anticipation of potential future commercial launch; and<\/li>\n<li style=\"text-align:justify\">A \u20ac2.0 million increase related to the Company\u2019s Crohn\u2019s disease (\u201cCD\u201d) clinical program, driven by the progression of Phase 2b clinical trials for obefazimod in CD; partially offset by<\/li>\n<li style=\"text-align:justify\">A \u20ac(4.0) million decrease related to the Company\u2019s UC clinical program, driven by nearing the ending of the phase 3 clinical trials.<\/li>\n<li style=\"text-align:justify\">94.5% of R&amp;D expenses related to obefazimod in the first quarter of 2026 compared to 98.5% in the first quarter of 2025.\n<\/li>\n<\/ul>\n<\/li>\n<li style=\"text-align:justify\">\n          <b>G&amp;A Expenses: <\/b>General and administrative expenses decreased by \u20ac(1.7) million to \u20ac6.3 million (10.9% of operating expenses) in the first quarter of 2026 compared to \u20ac8.0 million (16.7% of operating expenses) in the first quarter of 2025. This decrease is primarily due to decrease in personnel costs, attributable to the decrease in employer tax and social contributions related to our AGAs of \u20ac(3.5) million, resulting from the decrease in our share price during the first quarter of 2026 and, to a lesser extent, forfeitures following employee departures and changes in estimates regarding the achievement of vesting conditions. The decrease was partly offset by a \u20ac1.4 million increase in consulting and professional fees, driven by costs associated with building our infrastructure to support future growth in our operations. <\/p>\n<\/li>\n<li style=\"text-align:justify\">\n          <b>Sales and Marketing Expenses: <\/b>Sales and marketing expenses increased by \u20ac0.9 million to \u20ac1.7 million (3.0% of operating expenses) in the first quarter of 2026 compared to \u20ac0.9 million (1.8% of operating expenses) in 2025. The increase was driven by costs related to our preparation for potential future sales and commercialization efforts for obefazimod in the U.S.<\/p>\n<\/li>\n<\/ul>\n<p align=\"justify\">\n        <b>Anticipated Upcoming Key Dates<\/b>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">Topline results of UC ABTECT Phase 3 maintenance trial &#8211; late Q2 2026<\/li>\n<li style=\"text-align:justify\">Half-Year Financial Results &#8211; September 21, 2026<\/li>\n<li style=\"text-align:justify\">Topline results of Phase 2b induction trial for CD &#8211; Q4 2026<\/li>\n<li style=\"text-align:justify\">NDA submission for obefazimod in UC &#8211; Q4 2026 (subject to positive data)<\/li>\n<\/ul>\n<p>\n        <b>First Quarter 2026 Financial Results (IFRS figures)<\/b>\n      <\/p>\n<table style=\"border-collapse: collapse;margin-left:0pt;width:468pt;border-collapse:collapse\">\n<tr>\n<td style=\"width:413px;border-top: solid black 1pt;border-left: solid black 1pt;vertical-align: top\">\n            <b>Statement of Cash Flows<\/b>\n          <\/td>\n<td style=\"width:7px;border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"width:199px;border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: top\">\n            <b>For the three months ended March 31,<\/b>\n          <\/td>\n<td style=\"width:5px;border-top: solid black 1pt;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:413px;border-left: solid black 1pt;vertical-align: top\">\n            <i>in millions of euros<\/i>\n          <\/td>\n<td style=\"width:7px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <b>2025<\/b>\n          <\/td>\n<td style=\"width:5px;border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <b>2026<\/b>\n          <\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:413px;border-left: solid black 1pt;vertical-align: bottom\">Cash flows provided by (used in) operating activities<\/td>\n<td style=\"width:7px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(33.3)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(50.5)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:413px;border-left: solid black 1pt;vertical-align: bottom\">Cash flows provided by (used in) investing activities<\/td>\n<td style=\"width:7px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a01.1\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a00.5\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:413px;border-left: solid black 1pt;vertical-align: bottom\">Cash flows provided by (used in) financing activities<\/td>\n<td style=\"width:7px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(7.8)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a00.1\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:413px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:7px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:413px;border-left: solid black 1pt;vertical-align: bottom\">Effect of movements in exchange rates on cash held<\/td>\n<td style=\"width:7px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(0.7)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a07.4\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:413px;border-left: solid black 1pt;vertical-align: bottom\">Revaluation of cash equivalents measured at fair value<\/td>\n<td style=\"width:7px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a00.1\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a03.3\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:413px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:7px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:413px;border-bottom: solid black 1pt;border-left: solid black 1pt;vertical-align: bottom\">\n            <b>Increase (decrease) in cash and cash equivalents<\/b>\n          <\/td>\n<td style=\"width:7px;border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;border-bottom: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<b>(40.6)<\/b><\/td>\n<td style=\"width:5px;border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:97px;border-bottom: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<b>(39.3)<\/b><\/td>\n<td style=\"width:5px;border-right: solid black 1pt;border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<\/table>\n<p>\n        \n      <\/p>\n<table style=\"border-collapse: collapse;margin-left:0pt;width:468pt;border-collapse:collapse\">\n<tr>\n<td style=\"width:423px;border-top: solid black 1pt;border-left: solid black 1pt;vertical-align: top\">\n            <b>Statement of Income (Loss)<\/b>\n          <\/td>\n<td style=\"width:5px;border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"width:191px;border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: top\">\n            <b>For the three months ended March 31, <\/b>\n          <\/td>\n<td style=\"width:5px;border-top: solid black 1pt;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">\n            <i>in millions of euros<\/i>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <b>2025<\/b>\n          <\/td>\n<td style=\"width:5px;border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <b>2026<\/b>\n          <\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Total operating income<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a01.0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a01.3\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Total operating expenses<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;vertical-align: middle;text-align: left;padding-left: 20.0px;border-left: solid black 1pt;vertical-align: top\">\n            <i>of which Research and Development costs<\/i>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(39.3)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(49.5)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;vertical-align: middle;text-align: left;padding-left: 20.0px;border-left: solid black 1pt;vertical-align: top\">\n            <i>of which Sales and Marketing costs<\/i>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(0.9)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(1.7)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;vertical-align: middle;text-align: left;padding-left: 20.0px;border-left: solid black 1pt;vertical-align: top\">\n            <i>of which General and Administrative costs<\/i>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(8.0)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(6.3)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">\n            <b>Operating loss<\/b>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: top\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<b>(47.2)<\/b><\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: top\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<b>(56.2)<\/b><\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Financial gain (loss)<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(5.2)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a08.0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">\n            <b>Net loss before tax<\/b>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: top\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<b>(52.4)<\/b><\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: top\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<b>(48.2)<\/b><\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Income tax<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u2014\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0(0.2)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-bottom: solid black 1pt;border-left: solid black 1pt;vertical-align: top\">\n            <b>Net loss for the period<\/b>\n          <\/td>\n<td style=\"width:5px;border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-bottom: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: top\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<b>(52.4)<\/b><\/td>\n<td style=\"width:5px;border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-bottom: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: top\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<b>(48.5)<\/b><\/td>\n<td style=\"width:5px;border-right: solid black 1pt;border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<\/table>\n<p>\n        \n      <\/p>\n<table style=\"border-collapse: collapse;margin-left:0pt;width:468pt;border-collapse:collapse\">\n<tr>\n<td style=\"width:423px;border-top: solid black 1pt;border-left: solid black 1pt;vertical-align: top\">\n            <b>Statement of Financial Position<\/b>\n          <\/td>\n<td style=\"width:5px;border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"width:191px;border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: top\">\n            <b>As of<\/b>\n          <\/td>\n<td style=\"width:5px;border-top: solid black 1pt;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">\n            <i>in millions of euros<\/i>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <b>December 31, 2025<\/b>\n          <\/td>\n<td style=\"width:5px;border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <b>March 31, 2026<\/b>\n          <\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Non-current assets<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">33.1<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">33.9<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Cash and cash equivalents<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">516.7<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">477.4<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Other current assets<sup>1<\/sup><\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">34.6<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">35.8<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">\n            <b>Total Assets<\/b>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">\n            <b>584.3<\/b>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">\n            <b>547.1<\/b>\n          <\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Borrowings, notes and derivative instruments<sup>2<\/sup><\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">1.9<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">1.4<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Royalty Certificates<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">30.2<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">32.8<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Other non-current liabilities<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">35.3<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">22.2<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">Other current liabilities<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">61.7<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">61.1<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: top\">\n            <b>Total Liabilities<\/b>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">\n            <b>129.1<\/b>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: top\">\n            <b>117.5<\/b>\n          <\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: middle\">\n            <b>Total Shareholders\u2019 Equity<\/b>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: middle\">\n            <b>455.2<\/b>\n          <\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;text-align: center;vertical-align: middle;vertical-align: middle\">\n            <b>429.6<\/b>\n          <\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-left: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:5px;border-right: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"width:423px;border-bottom: solid black 1pt;border-left: solid black 1pt;vertical-align: middle\">\n            <b>Total Liabilities and Shareholders\u2019 Equity<\/b>\n          <\/td>\n<td style=\"width:5px;border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: middle\">\n            <b>584.3<\/b>\n          <\/td>\n<td style=\"width:5px;border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"width:93px;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: middle\">\n            <b>547.1<\/b>\n          <\/td>\n<td style=\"width:5px;border-right: solid black 1pt;border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<\/table>\n<p align=\"justify\">\n        <sup>1<\/sup><br \/>\n        <i>Includes certain short-term investments (terms of less than 12 months) of \u20ac14.2M, making total cash, cash equivalents and short-term investments of <\/i><br \/>\n        <i>\u20ac491.6M<\/i><br \/>\n        <br \/>\n        <sup>2 <\/sup><br \/>\n        <i>Includes both current and non-current portions of borrowings, convertible loan notes, derivative instruments, and lease liabilities<\/i>\n      <\/p>\n<p align=\"center\">\n        <b>*****<\/b>\n      <\/p>\n<p align=\"justify\">\n        <b>About Abivax <\/b><br \/>\n        <br \/>Abivax is a clinical-stage biotechnology company focused on developing therapeutics that harness the body\u2019s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases. Based in France and the United States, Abivax\u2019s lead drug candidate, obefazimod (ABX464), is in Phase 3 clinical trials for the treatment of moderately to severely active ulcerative colitis.<\/p>\n<table style=\"border-collapse: collapse;border-collapse:collapse\">\n<tr>\n<td style=\"width:319.2px;vertical-align: top\">\n            <b>Contacts:<\/b><br \/>\n            <br \/>Patrick Malloy<br \/>SVP, Investor Relations<br \/>Abivax SA<br \/><a href=\"mailto:patrick.malloy@abivax.com\" rel=\"nofollow\" target=\"_blank\">patrick.malloy@abivax.com<\/a><br \/>+1 847 987 4878<\/td>\n<td style=\"width:319.2px;text-align: justify;vertical-align: middle;vertical-align: top\">\n            <b>Media Contacts:<\/b><br \/>\n            <br \/>\n            <b>LifeSci Communications<\/b><br \/>\n            <br \/>Karissa Cross, PhD<br \/>Associate Director<br \/><a href=\"mailto:LSC_ABIVAX@lifescicomms.com\" rel=\"nofollow\" target=\"_blank\">LSC_ABIVAX@lifescicomms.com<\/a><\/td>\n<\/tr>\n<\/table>\n<p>\n        <b>FORWARD-LOOKING STATEMENTS<\/b>\n      <\/p>\n<p align=\"justify\">\n        <i>This press release contains forward-looking statements, forecasts and estimates, including those relating to the Company\u2019s business. Words such as \u201canticipate,\u201d \u201cexpect,\u201d \u201cfuture,\u201d \u201cpotential,\u201d \u201cwill\u201d and variations of such words and similar expressions are intended to identify forward-looking statements. These forward-looking statements include statements concerning the potential therapeutic benefit of obefazimod, the expected timing for completion of the Phase 3 ABTECT-UC maintenance trial and Phase 2b ENHANCE-CD induction trial of obefazimod and the availability and timing of results therefrom, the timing of regulatory filings including an NDA submission for obefazimod in UC, Abivax\u2019s expectations for regulatory approval and commercialization of obefazimod for UC, Abivax\u2019s cash runway, the timing for reporting Abivax\u2019s half year 2026 financial results, and other statements that are not historical fact. Although Abivax\u2019s management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks, contingencies and uncertainties, many of which are difficult to predict and generally beyond the control of Abivax, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. A description of these risks, contingencies and uncertainties can be found in the documents filed by the Company with the French Autorit\u00e9 des March\u00e9s Financiers pursuant to its legal obligations including its universal registration document (Document d\u2019Enregistrement Universel) and in its Annual Report on Form 20-F for the fiscal year ended December 31, 2025 filed with the U.S. Securities and Exchange Commission under the caption \u201cRisk Factors.\u201d These risks, contingencies and uncertainties include, among other things, the uncertainties inherent in research and development, future clinical data and analysis, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug candidate, as well as their decisions regarding labelling and other matters that could affect the availability or commercial potential of such product candidates, and the availability of funding sufficient for the Company\u2019s foreseeable and unforeseeable operating expenses and capital expenditure requirements. Special consideration should be given to the potential hurdles of clinical and pharmaceutical development, including further assessment by the Company and regulatory agencies and IRBs\/ethics committees following the assessment of preclinical, pharmacokinetic, carcinogenicity, toxicity, CMC and clinical data. Furthermore, these forward-looking statements, forecasts and estimates are made only as of the date of this press release. Readers are cautioned not to place undue reliance on these forward-looking statements. Abivax disclaims any obligation to update these forward-looking statements, forecasts or estimates to reflect any subsequent changes that the Company becomes aware of, except as required by law. Information about pharmaceutical products (including products currently in development) that is included in this press release is not intended to constitute an advertisement. This press release is for information purposes only, and the information contained herein does not constitute either an offer to sell or the solicitation of an offer to purchase or subscribe for securities of the Company in any jurisdiction. Similarly, it does not give and should not be treated as giving investment advice. It has no connection with the investment objectives, financial situation or specific needs of any recipient. It should not be regarded by recipients as a substitute for exercise of their own judgment. All opinions expressed herein are subject to change without notice. The distribution of this document may be restricted by law in certain jurisdictions. Persons into whose possession this document comes are required to inform themselves about and to observe any such restrictions.<\/i>\n      <\/p>\n<p id=\"gnw_attachments_section-header\">\n        <strong>Attachment<\/strong>\n      <\/p>\n<ul id=\"gnw_attachments_section-items\">\n<li>\n          <a target=\"_blank\" href=\"https:\/\/ml-eu.globenewswire.com\/Resource\/Download\/beadf175-9421-4ec1-9b11-e2ab02d9977d\">20260522_Abivax_PR_Q1 2026<\/a>\n        <\/li>\n<\/ul>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=MTAwMTE4MzYzNCM0MDIzOTcxODkjMjAyMDExNw==\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml-eu.globenewswire.com\/media\/ZmVkZWUyYmUtNDBlMC00OTYxLWJlOTktNjdjYmI4NGJhMWE0LTEwMzE2ODktMjAyNi0wNS0yMi1lbg==\/tiny\/Abivax.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abivax Presents First Quarter 2026 Financial Results and Reports Three-Year Interim Data from Study 108, a Phase 2a\/2b Open-Label Extension Trial of Obefazimod Following Dose De-Escalation in Patients with Ulcerative Colitis Interim intent to treat (\u201cITT\u201d) analysis from Study 108 supports strong durable clinical remission in moderately to severely active ulcerative colitis (\u201cUC\u201d) patients treated with obefazimod Following two to four years of open-label treatment with 50 mg, 130 patients de-escalated to 25 mg, and at week 144, 68% (88\/130) were in clinical remission and 80% (104\/130) completed 144 weeks of treatment Patients in Study 108 were treated with obefazimod for up to seven years, with no new safety signals observed ABTECT Phase 3 maintenance trial results expected in late &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Abivax Presents First Quarter 2026 Financial Results and Reports Three-Year Interim Data from Study 108, a Phase 2a\/2b Open-Label Extension Trial of Obefazimod Following Dose De-Escalation in Patients with Ulcerative Colitis&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-966453","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - 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Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Abivax Presents First Quarter 2026 Financial Results and Reports Three-Year Interim Data from Study 108, a Phase 2a\/2b Open-Label Extension Trial of Obefazimod Following Dose De-Escalation in Patients with Ulcerative Colitis Interim intent to treat (\u201cITT\u201d) analysis from Study 108 supports strong durable clinical remission in moderately to severely active ulcerative colitis (\u201cUC\u201d) patients treated with obefazimod Following two to four years of open-label treatment with 50 mg, 130 patients de-escalated to 25 mg, and at week 144, 68% (88\/130) were in clinical remission and 80% (104\/130) completed 144 weeks of treatment Patients in Study 108 were treated with obefazimod for up to seven years, with no new safety signals observed ABTECT Phase 3 maintenance trial results expected in late &hellip; Continue reading &quot;Abivax Presents First Quarter 2026 Financial Results and Reports Three-Year Interim Data from Study 108, a Phase 2a\/2b Open-Label Extension Trial of Obefazimod Following Dose De-Escalation in Patients with Ulcerative Colitis&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-05-22T20:33:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=MTAwMTE4MzYzNCM0MDIzOTcxODkjMjAyMDExNw==\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Abivax Presents First Quarter 2026 Financial Results and Reports Three-Year Interim Data from Study 108, a Phase 2a\\\/2b Open-Label Extension Trial of Obefazimod Following Dose De-Escalation in Patients with Ulcerative Colitis\",\"datePublished\":\"2026-05-22T20:33:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients\\\/\"},\"wordCount\":1915,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=MTAwMTE4MzYzNCM0MDIzOTcxODkjMjAyMDExNw==\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/abivax-presents-first-quarter-2026-financial-results-and-reports-three-year-interim-data-from-study-108-a-phase-2a-2b-open-label-extension-trial-of-obefazimod-following-dose-de-escalation-in-patients\\\/\",\"name\":\"Abivax Presents First Quarter 2026 Financial Results and Reports Three-Year Interim Data from Study 108, a Phase 2a\\\/2b Open-Label Extension Trial of Obefazimod Following Dose De-Escalation in Patients with Ulcerative Colitis - 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