{"id":962743,"date":"2026-05-14T08:36:04","date_gmt":"2026-05-14T12:36:04","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/"},"modified":"2026-05-14T08:36:04","modified_gmt":"2026-05-14T12:36:04","slug":"hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/","title":{"rendered":"HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>HCW11-040 is a pembrolizumab-based fusion immunotherapeutic that activates immune cells and eliminates high-oxygen induced senescent cells<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>BPD is a rare pediatric disease affecting underweight premature infants which the Company believes aligns with newly reauthorized rare pediatric disease and review voucher programs<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>BPD causes abnormal lung development in premature infants that leads to long-term health problems that persist into adulthood as well as neurodevelopmental delays<\/em>\n      <\/p>\n<p align=\"justify\">MIRAMAR, Fla., May  14, 2026  (GLOBE NEWSWIRE) &#8212; HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on developing novel fusion immunotherapeutics to treat autoimmune diseases, cancer, and senescence-associated dysplasia, announced today that its scientists and academic collaborators at Queen\u2019s University at Kingston, Ontario discover that HCW11-040, a second-generation, pembrolizumab-based fusion immunotherapeutic, prevents bronchopulmonary dysplasia (\u201cBPD\u201d) during IND-Enabling studies. The Company expects to complete IND-Enabling studies in the second half of 2027 and intends to immediately file an IND application to evaluate HCW11-040 in patients at a high risk of developing BPD.<\/p>\n<p align=\"justify\">BPD in neonates causes long-term health impacts primarily related to chronic lung disease, including reduced lung function, asthma-like symptoms, and higher susceptibility to infections, which can persist into adulthood. Survivors may also face neurodevelopmental delays, impaired exercise tolerance, and in severe cases, pulmonary hypertension, necessitating specialized, multidisciplinary care. There is no known cure for BPD, and it is a high-impact unmet medical need since the premature infants who have BPD have diminished life-long healthspan. In the United States, there are 10,000 \u2013 15,000 cases annually. It is the most common serious complication of prematurity, characterized by lung damage from ventilation and oxygen therapy. Despite advancements in care, the incidence of BPD has remained relatively stable over the last few decades.<\/p>\n<p align=\"justify\">On February 3, 2026, President Donald Trump reauthorized the <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Ql0eZaBYFjtsiOG70hKy2kN0ARzAoGaRAp6bFdCEgIzh3nnjrYMqKzHY8DgChYYqeb3t5roNYDcz6aBnfIaBAfYNnNLDDigjF_xoQGWDsP0PT46s-87ylYj1MRXc0jVvwmNPuG76QTscDwalCEMJLAsywDC5FYp1pnBr-VBcT4EZ12cMA9u6_utRlazWohdnHVAfByOGJGYjKGeAKQlyK9QyGTOgjsFgrPZgUN6xtxy18_yhDjFxSdrqQOf5o5SoVQWAMSclOsJG9BueXk3B5vutvK2Rw9jKaSggNCARnHI=\" rel=\"nofollow\" target=\"_blank\">Mikaela Naylon Give Kids a Chance Act<\/a> and revived the rare pediatric disease (\u201cRPD\u201d) priority review voucher program (\u201cPRV\u201d). The RPD program will now be funded through September 2029. The United States Food and Drug Administration grants RPD Designation for rare pediatric disorders to encourage development of treatments for diseases which are life-threatening conditions with no currently approved, specific drug treatments. The Company believes by focusing on the BPD indication, we can align with the Rare Pediatric Disease PRV program.<\/p>\n<p align=\"justify\">HCW11-040 is a novel fusion immunotherapeutic that is designed to block the checkpoint receptors and engage the costimulatory receptors, analogous to taking the foot off the brake and simultaneously hitting the gas. It is designed to activate exhausted immune cells. While conducting IND-enabling studies with collaborators at Queen\u2019s University at Kingston, Ontario, the Company discovered that a single-dose of HCW11-040 administered subcutaneously also effectively prevented the development of BPD in a clinically relevant and highly stringent animal model.<\/p>\n<p align=\"justify\">Dr. Hing C. Wong, the Company\u2019s Founder and Chief Executive Officer, stated, \u201cWe created HCW11-040 with a generic form of Keytruda\u00ae, the clear leader in immune checkpoint inhibitors. We consider our immunotherapeutic as second generation, since in our preclinical studies, it outperformed pembrolizumab as a monotherapy in immune-cell activation and expansion, enhancement of immune cell infiltration into the tumors, and immune cell cytotoxicity against cancer cells.\u201d<\/p>\n<p align=\"justify\">Dr. Wong continued, \u201cAt the outset on the road to our discovery of the potential for HCW11-040 to treat BPD, our hypothesis was that immune checkpoint inhibitors have the potential to treat diseases beyond cancer, since they have also recently been identified as effective senomorphic drugs for senescent cell removal to treat age-related or stressor-induced related diseases. We are very excited to discover that HCW11-040 could indeed be used to prevent senescence-associated dysplasia such as BPD. We will vigorously pursue the clinical development of HCW11-040 for this indication.\u201d<\/p>\n<p align=\"justify\">KEYTRUDA\u00ae\u00a0is a registered trademark of Merck Sharp &amp; Dohme LLC, a subsidiary of Merck &amp; Co., Inc. and the company is not affiliated with HCWB.<\/p>\n<p align=\"justify\">\n        <strong>About HCW Biologics:<\/strong>\n      <\/p>\n<p align=\"justify\">HCW Biologics Inc. (the \u201cCompany\u201d) (NASDAQ: HCWB) is a clinical-stage biopharmaceutical company developing transformative fusion immunotherapeutics to support or treat diseases promoted by chronic inflammation, including autoimmune diseases, cancer, and senescence-associated dysplasia. The Company\u2019s immunotherapeutics represent a new class of drugs that it believes have the potential to fundamentally change the treatment of proinflammatory and senescence-associated diseases and conditions that are promoted by chronic inflammation &#8212; and in doing so, improve patients\u2019 quality of life and possibly extend longevity. A key aspect of the Company\u2019s clinical development and financing strategy is to focus on its business development programs. To date, the Company has entered into two licensing agreements in which it has licensed exclusive, worldwide rights for some of its proprietary molecules. See the Company Pipeline at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=NEkYp1PZPPh2gy78nmI-khNDyQBif2ijouQXx4_WPqEo-tR630VjT0w8E6X3lvZ1CP-xvEYdYUe-ti-Y-L0hzKynKejubKyW7jxVG4f7lW5HWrgdEN1nnkqeoAm0ABXlS1GPvCEvQ0tlb8RsBQVUHA==\" rel=\"nofollow\" target=\"_blank\">https:\/\/hcwbiologics.com\/pipeline\/.<\/a><\/p>\n<p align=\"justify\">\n        <strong>Forward Looking Statements:<\/strong>\n      <\/p>\n<p align=\"justify\">Statements in this press release contain \u201cforward-looking statements\u201d that are subject to substantial risks and uncertainties. These statements are made under the \u201csafe harbor\u201d provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements contained in this press release may be identified by the use of words such as \u201canticipate,\u201d \u201cexpect,\u201d \u201cbelieve,\u201d \u201cwill,\u201d \u201cmay,\u201d \u201cshould,\u201d \u201cestimate,\u201d \u201cproject,\u201d \u201coutlook,\u201d \u201cforecast\u201d or other similar words and include, the actual success and potency of the Company\u2019s second generation immune checkpoint inhibitor, TRBC fusion molecules; the ability of HCW11-040 to treat bronchopulmonary dysplasia and cancer; the ability of HCW11-040 to qualify for the RPV program; and HCW11-040\u2019s ability to block the checkpoint receptors and engage the costimulatory receptors. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Factors that could cause actual results to differ include, but are not limited to, the risks and uncertainties that are described in the section titled \u201cRisk Factors\u201d in the annual report on Form 10-K filed with the United States Securities and Exchange Commission (the \u201cSEC\u201d) on March 31, 2026 and in other filings filed from time to time with the SEC.<\/p>\n<p align=\"justify\">\n        <strong>Company Contact:<\/strong>\n      <\/p>\n<p align=\"justify\">\n        <strong>Dr. Peter Rhode<\/strong><br \/>\n        <br \/>Chief Scientific Officer and Vice President of Clinical Operations<br \/>HCW Biologics Inc.<br \/>PeterRhode@HCWBiologics.com<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTcyMDA3OSM3NjAyOTIyIzIyMTAxOTg=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/MTlhZWRhYWYtZmQ5OC00MTlkLWEyMmItYjVmMTgyZWE2NTkyLTEyMjE3NTEtMjAyNi0wNS0xNC1lbg==\/tiny\/HCW-Biologics-Inc.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>HCW11-040 is a pembrolizumab-based fusion immunotherapeutic that activates immune cells and eliminates high-oxygen induced senescent cells BPD is a rare pediatric disease affecting underweight premature infants which the Company believes aligns with newly reauthorized rare pediatric disease and review voucher programs BPD causes abnormal lung development in premature infants that leads to long-term health problems that persist into adulthood as well as neurodevelopmental delays MIRAMAR, Fla., May 14, 2026 (GLOBE NEWSWIRE) &#8212; HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on developing novel fusion immunotherapeutics to treat autoimmune diseases, cancer, and senescence-associated dysplasia, announced today that its scientists and academic collaborators at Queen\u2019s University at Kingston, Ontario discover that HCW11-040, a second-generation, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-962743","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"HCW11-040 is a pembrolizumab-based fusion immunotherapeutic that activates immune cells and eliminates high-oxygen induced senescent cells BPD is a rare pediatric disease affecting underweight premature infants which the Company believes aligns with newly reauthorized rare pediatric disease and review voucher programs BPD causes abnormal lung development in premature infants that leads to long-term health problems that persist into adulthood as well as neurodevelopmental delays MIRAMAR, Fla., May 14, 2026 (GLOBE NEWSWIRE) &#8212; HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on developing novel fusion immunotherapeutics to treat autoimmune diseases, cancer, and senescence-associated dysplasia, announced today that its scientists and academic collaborators at Queen\u2019s University at Kingston, Ontario discover that HCW11-040, a second-generation, &hellip; Continue reading &quot;HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-05-14T12:36:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTcyMDA3OSM3NjAyOTIyIzIyMTAxOTg=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies\",\"datePublished\":\"2026-05-14T12:36:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\\\/\"},\"wordCount\":1006,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTcyMDA3OSM3NjAyOTIyIzIyMTAxOTg=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\\\/\",\"name\":\"HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/","og_locale":"en_US","og_type":"article","og_title":"HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies - Market Newsdesk","og_description":"HCW11-040 is a pembrolizumab-based fusion immunotherapeutic that activates immune cells and eliminates high-oxygen induced senescent cells BPD is a rare pediatric disease affecting underweight premature infants which the Company believes aligns with newly reauthorized rare pediatric disease and review voucher programs BPD causes abnormal lung development in premature infants that leads to long-term health problems that persist into adulthood as well as neurodevelopmental delays MIRAMAR, Fla., May 14, 2026 (GLOBE NEWSWIRE) &#8212; HCW Biologics Inc. (the \u201cCompany\u201d or \u201cHCW Biologics\u201d), (NASDAQ: HCWB), a U.S.-based clinical-stage biopharmaceutical company focused on developing novel fusion immunotherapeutics to treat autoimmune diseases, cancer, and senescence-associated dysplasia, announced today that its scientists and academic collaborators at Queen\u2019s University at Kingston, Ontario discover that HCW11-040, a second-generation, &hellip; Continue reading \"HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/","og_site_name":"Market Newsdesk","article_published_time":"2026-05-14T12:36:04+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTcyMDA3OSM3NjAyOTIyIzIyMTAxOTg=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies","datePublished":"2026-05-14T12:36:04+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/"},"wordCount":1006,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTcyMDA3OSM3NjAyOTIyIzIyMTAxOTg=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/hcw-biologics-discovers-that-hcw11-040-prevents-bronchopulmonary-dysplasia-bpd-during-ind-enabling-studies\/","name":"HCW Biologics Discovers that HCW11-040 Prevents Bronchopulmonary Dysplasia (BPD) During IND-Enabling Studies - 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