{"id":961699,"date":"2026-05-12T16:17:30","date_gmt":"2026-05-12T20:17:30","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/kura-oncology-reports-first-quarter-2026-financial-results\/"},"modified":"2026-05-12T16:17:30","modified_gmt":"2026-05-12T20:17:30","slug":"kura-oncology-reports-first-quarter-2026-financial-results","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/kura-oncology-reports-first-quarter-2026-financial-results\/","title":{"rendered":"Kura Oncology Reports First Quarter 2026 Financial Results"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>\u2013 $5.8 million in KOMZIFTI\u2122 (ziftomenib) net product revenue in first full quarter of commercialization \u2013<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>\u2013 Robust new patient starts and early launch dynamics, including repeat use, switching and combination adoption, reflect strong early momentum \u2013<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>\u2013 Broad and rapid payer access achieved, with &gt; 93% coverage and favorable positioning across &gt; 12 million lives \u2013<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>\u2013 Multiple 2026 data readouts expected to support ziftomenib as a broadly combinable backbone across AML \u2013<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>\u2013 $580.8 million in cash, cash equivalents and short-term investments, plus $180 million in anticipated collaboration payments, expected to support advancement of ziftomenib AML program through first topline KOMET-017 Phase 3 results \u2013<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>\u2013 Management to host webcast and conference call today at 4:30 p.m. ET \u2013<\/em>\n      <\/p>\n<p>SAN DIEGO, May  12, 2026  (GLOBE NEWSWIRE) &#8212; Kura Oncology, Inc. (Nasdaq: KURA), a biopharmaceutical company focused on precision medicines for cancer, today reported first quarter 2026 financial results and provided a corporate update.<\/p>\n<p>\u201cIn its first full quarter of commercial availability, KOMZIFTI generated $5.8 million in net revenue, with early launch dynamics indicating growing physician adoption and utilization patterns based on product profile. We believe these early signals support KOMZIFTI\u2019s potential to become the leading therapy in relapsed\/refractory <em>NPM1<\/em>-mutant AML,\u201d said Troy Wilson, Ph.D., J.D., President and Chief Executive Officer of Kura Oncology. \u201cSupported by a robust clinical development program designed to establish it as a broadly combinable backbone across the AML treatment continuum, and with multiple data readouts expected this year across frontline and combination settings, we are well positioned for the next phase of growth.\u201d<\/p>\n<p>\n        <strong>Recent Developments<\/strong>\n      <\/p>\n<p>\n        <strong>KOMZIFTI Launch Performance (First Quarter 2026)<\/strong>\n      <\/p>\n<p>KOMZIFTI delivered a strong first full quarter of commercial performance, with early indicators supporting adoption and continued momentum:<\/p>\n<ul type=\"disc\">\n<li>\n          <strong>$5.8 million<\/strong><br \/>\n          <strong>in net product revenue <\/strong>in the first full quarter of commercial sales<\/p>\n<\/li>\n<li>\n          <strong>85 new patient starts<\/strong> and <strong>157 total prescriptions<\/strong>, reflective of both uptake and repeat use<\/p>\n<\/li>\n<li>\n          <strong>&gt; 93% payer coverage achieved<\/strong>, with favorable positioning across<strong> plans covering more than 12 million lives<\/strong><\/li>\n<\/ul>\n<p>Early market dynamics, including repeat prescribing, expanding use across treatment settings, initial combination use and instances of switching from other menin inhibitors, indicate growing physician adoption based on product profile.<\/p>\n<p>\n        <strong>Advancing Ziftomenib Across the Acute Myeloid Leukemia (AML) Treatment Continuum<\/strong>\n      <\/p>\n<p>Kura continues to execute on its strategy to establish ziftomenib as a broadly combinable backbone therapy across AML:<\/p>\n<ul type=\"disc\">\n<li>\n          <strong>KOMET-017 (Phase 3 Frontline Program)<\/strong>: Ongoing site activation and patient enrollment for both studies across global sites with strong early progress <\/p>\n<\/li>\n<li>\n          <strong>KOMET-008 (FLT3 Relapsed\/Refractory [R\/R] Population)<\/strong>: Ongoing enrollment evaluating ziftomenib combined with gilteritinib in patients with R\/R AML harboring <em>FLT3<\/em>-ITD\/<em>NPM1<\/em> co-mutations<\/p>\n<\/li>\n<li>\n          <strong>KOMET-007 (FLT3 Frontline Population)<\/strong>: Ongoing enrollment evaluating ziftomenib combined with quizartinib plus cytarabine and daunorubicin (7+3) induction chemotherapy in patients with newly diagnosed AML harboring <em>FLT3<\/em>-ITD\/<em>NPM1<\/em> co-mutations <\/p>\n<\/li>\n<li>\n          <strong>Japanese Registrational Trial<\/strong>: First patient dosed in Phase 2 trial (jRCT2031250550) for treatment of R\/R\u00a0<em>NPM1<\/em>-m AML, representing a significant step toward bringing a potential new treatment option to patients in Japan<\/li>\n<\/ul>\n<p>Multiple clinical data readouts expected in 2026 across combination regimens and treatment settings, supporting ziftomenib\u2019s potential use broadly across the AML landscape.<\/p>\n<p>\n        <strong>Solid Tumor Pipeline Progress<\/strong>\n      <\/p>\n<p>Kura continues to advance darlifarnib as a novel approach to overcoming resistance in targeted therapy:<\/p>\n<ul type=\"disc\">\n<li>\n          <strong>Proof-of-mechanism data for darlifarnib in combination with cabozantinib: <\/strong>At the 2026 International Kidney Cancer Symposium: Europe (IKCS) conference, Kura presented proof-of-mechanism data for darlifarnib in combination with cabozantinib in patients with clear cell renal cell carcinoma previously treated with cabozantinib<\/p>\n<p>The data support darlifarnib\u2019s potential to <strong>overcome resistance and resensitize tumors<\/strong> to VEGF TKI therapy, with<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type:none\">\n<ul type=\"disc\">\n<li>44% objective response rate (ORR)<\/li>\n<li>94% disease control rate (DCR)<\/li>\n<li>Tumor shrinkage in 75% of patients<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul type=\"disc\">\n<li>\n          <strong>FIT-001 Phase 1b dose expansion<\/strong>: Enrollment is ongoing<\/li>\n<\/ul>\n<p>\n        <strong>2026 Commercial Priorities and Anticipated Development Milestones<\/strong>\n      <\/p>\n<p>Kura expects multiple value-driving catalysts in 2026 across commercial development and clinical development:<\/p>\n<p>\n        <strong>KOMZIFTI Commercial Execution<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>Drive clear differentiation within the menin inhibitor class<\/li>\n<li>Deliver sustained quarter-over-quarter growth in revenue and adoption<\/li>\n<li>Establish leading class share in R\/R\u00a0<em>NPM1<\/em>-m AML<\/li>\n<\/ul>\n<p>\n        <strong>Ziftomenib \u2013 Frontline AML<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>Present updated results for ziftomenib \/ 7+3 combination in frontline <em>NPM1<\/em>-m\/<em>KMT2A<\/em>-r AML (KOMET-007) in an <strong>oral presentation<\/strong> at the European Hematology Association (EHA) 2026 Congress in June 2026<\/li>\n<\/ul>\n<p>\n        <strong>Ziftomenib \u2013 Relapsed\/Refractory AML<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>Publish data for ziftomenib plus venetoclax + azacitidine in R\/R <em>NPM1<\/em>-m AML (1H 2026)<\/li>\n<li>Present preliminary KOMET-008 data for ziftomenib and gilteritinib combination in R\/R <em>NPM1<\/em>-m\/<em>FLT3<\/em>-m AML (2H 2026)<\/li>\n<\/ul>\n<p>\n        <strong>Ziftomenib and Menin Inhibition \u2013 Expansion Beyond AML<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>Continue enrollment of KOMET-015 evaluating ziftomenib + imatinib in gastrointestinal stromal tumors (GIST)<\/li>\n<li>Progress preclinical development of next-generation menin inhibitor for use in other solid tumors<\/li>\n<\/ul>\n<p>\n        <strong>Darlifarnib<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>Present preliminary clinical data for darlifarnib plus adagrasib in <em>KRAS<\/em><sup><em>G12C<\/em><\/sup>-mutated solid tumors at the upcoming American Society of Clinical Oncology (ASCO) 2026 Annual Meeting in May 2026<\/li>\n<li>Present updated Phase 1a data with the first report of long-term follow-up for darlifarnib plus cabozantinib in advanced RCC (2H 2026)<\/li>\n<\/ul>\n<p>\n        <strong>KO-7246 (Next-Generation Menin Inhibitor)<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>Advance KO-7246 into IND-enabling studies for diabetes and cardiometabolic disease<\/li>\n<li>Present additional preclinical data for menin inhibitors in diabetes<\/li>\n<\/ul>\n<p>\n        <strong>First Quarter 2026 Financial Results <\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"margin-bottom:12pt\">\n          <strong>Net product revenue:<\/strong> $5.8 million, compared to none for Q1 2025<\/li>\n<li style=\"margin-bottom:12pt\">\n          <strong>Collaboration revenue:<\/strong> $12.5 million, compared to $14.1 million for Q1 2025<\/li>\n<li style=\"margin-bottom:12pt\">\n          <strong>R&amp;D expenses:<\/strong> $65.3 million, compared to $56.0 million for Q1 2025, primarily driven by advancement of ziftomenib combination trials, including KOMET-017<\/li>\n<li style=\"margin-bottom:12pt\">\n          <strong>SG&amp;A expenses:<\/strong> $31.6 million, compared to $22.8 million for Q1 2025, reflecting commercialization-related investments<\/li>\n<li style=\"margin-bottom:12pt\">\n          <strong>Net loss: <\/strong>$73.3 million, compared to $57.4 million for Q1 2025. Net loss includes $8.4 million in non-cash, share-based compensation expense compared to $7.8 million for the same period in 2025.<\/li>\n<\/ul>\n<p>As of March 31, 2026, Kura had $580.8 million in cash, cash equivalents and short-term investments, compared to $667.2 million as of December 31, 2025.<\/p>\n<p>The Company believes its cash, cash equivalents and short-term investments as of March 31, 2026, when combined with $180 million in anticipated payments under the collaboration agreement with Kyowa Kirin, will be sufficient to fund the ziftomenib AML program through the topline results from the first pivotal Phase 3 KOMET-017 frontline trial, anticipated in 2028.<\/p>\n<p>\n        <strong>Conference Call and Webcast<\/strong>\n      <\/p>\n<p>Kura\u2019s management will host a webcast and conference call at 4:30 p.m. ET \/ 1:30 p.m. PT today, May 12, 2026, to discuss financial results and to provide a corporate update. A live webcast and archived replay of the event will be available <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Jq2abX7qJ9DZ5XTI-DdcLlohRHCvdlL3HwHvgtfmqReqSp8qgGTpCqIuEbzeboJCa8iEgkUBgpmwnucbZSU90eDL7rxzodG6zm6RTvgfrTx8hyraLC3kovC673is59qSdy-9ogC_Bqt_x95eB6ioCA==\" rel=\"nofollow\" target=\"_blank\">here<\/a> or from the Investors section of the Company\u2019s website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ezH1Aoz8lvyr5CSYdpz_DY868ajr6cpI43n-m7uNVSEgYjjkaujSKU8se9wCV6E9szqxtS7-A7PmKmD1Dgrd3bC8mjbdfcjwsQep-LkTP9U=\" rel=\"nofollow\" target=\"_blank\">www.kuraoncology.com<\/a>.<\/p>\n<p>\n        <strong>About Kura Oncology <\/strong>\n      <\/p>\n<p>Kura Oncology\u00a0is a biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer. Kura\u2019s pipeline of small molecule drug candidates is designed to target cancer signaling pathways and address high-need hematologic malignancies and solid tumors. Kura developed and is commercializing KOMZIFTI\u2122 (ziftomenib), the FDA-approved once-daily, oral menin inhibitor for the treatment of adults with relapsed or refractory\u00a0<em>NPM1<\/em>-mutated acute myeloid leukemia, and continues to pioneer advancements in menin inhibition and farnesyl transferase inhibition. For additional information, please visit the <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=iMDjD2nI6s6ipLICiuX4WZlYD1ETLOPkKESfFezRc8J4z6O10tsnQ2OAbnzIXJZikV70c3wBNm0hiZJtH4wM9g==\" rel=\"nofollow\" target=\"_blank\">Kura website<\/a> and follow us on\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=FZXc4vy-joJGF9mnLN6Rw9_cY21mFL7TF6uGQN-PhPCqJFgfwkoVgZN7NUs1TZ3Ae1XwdK-1v3_dnm7gO7XQv0ZlMNz0LI5HnXLy2ELVkvyMxttwJ_k1pUquz832ZBQnyWsjBezAnIyMaWXJN8fSNdTIvezoFMqgQW8-_93lylcvvuoP45y4vusj776GWDGFqHFpqtAii6pf5ujZlElLFw==\" rel=\"nofollow\" target=\"_blank\">X<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=QjHg3-fWX4A6U206Wq9MH6RHDT6__IGCySKMGR-oIqncGVvrnK8N1TEBhT-NPmbidVFHzD5H7ScYx-cd-IHBnIMEesK4n0Vi_3GmLBqRAodYkin-FlLlr_UBbKmY3j1Eu-TzFBbMygpxUBNrr52ajsHc5fN71IENJ3Ja4DWx-HkeToTPQVllVojaltmTUr01Jy0lx0z2HD-oyDFgiq5eB7_tTK18jIzM1Woh6NjDZnhisA_yRAyqda3F1R0gZd3I3CxwdS9AnXmePmNMTkXmmA==\" rel=\"nofollow\" target=\"_blank\">LinkedIn<\/a>.<\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong>\n      <\/p>\n<p>This news release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. Such forward-looking statements include statements regarding, among other things, Kura\u2019s future performance in 2026; the commercial potential of KOMZIFTI; KOMZIFTI\u2019s potential market leadership in R\/R <em>NPM1<\/em>-m AML; KOMZIFTI\u2019s potential as a broadly combinable backbone across the AML treatment continuum; Kura\u2019s research, preclinical and clinical development activities; plans and projected timelines for ziftomenib, darlifarnib, KO-7246 and other preclinical assets; the expected timing and presentation of results and data from clinical trials; and Kura\u2019s anticipated cash runway. Factors that may cause actual results to differ materially include risks associated with market competition, market acceptance and commercialization of KOMZIFTI; risks associated with the conduct of preclinical studies and clinical trials; risks that Kura\u2019s actual future financial and operating results may differ from its expectations or goals; the risk that Kura\u2019s product candidates may not receive regulatory approval; the potential for KOMZIFTI or Kura\u2019s product candidates to have unexpected adverse side effects; the risk that Kura may not be able to obtain additional financing; the risk that the collaboration with Kyowa Kirin is unsuccessful; and other risks associated with the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. You are urged to consider statements that include the words \u201cmay,\u201d \u201cwill,\u201d \u201cwould,\u201d \u201ccould,\u201d \u201cshould,\u201d \u201cbelieves,\u201d \u201cestimates,\u201d \u201cprojects,\u201d \u201cpromise,\u201d \u201cpotential,\u201d \u201cexpects,\u201d \u201cplans,\u201d \u201canticipates,\u201d \u201cintends,\u201d \u201ccontinues,\u201d \u201cdesigned,\u201d \u201cgoal,\u201d or the negative of those words or other comparable words to be uncertain and forward-looking. For a further list and description of the risks and uncertainties the Company faces, please refer to the Company&#8217;s periodic and other filings with the Securities and Exchange Commission, which are available at www.sec.gov. Such forward-looking statements are current only as of the date they are made, and Kura assumes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.<\/p>\n<p>\n        <em>FLT3,<\/em> Fms-like tyrosine kinase 3 gene; <em>KMT2A<\/em>, lysine methyltransferase 2A gene; <em>NPM1, <\/em>nucleophosmin 1 gene; -m, mutant; -r, rearranged; ITD, Internal Random Duplication; KRAS, Kirsten Rat Sarcoma Virus oncogene homolog.<\/p>\n<table align=\"center\" style=\"border-collapse: collapse;width:100%;border-collapse:collapse\">\n<tr>\n<td colspan=\"17\" style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"17\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\n            <strong>KURA ONCOLOGY, INC.<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"17\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\n            <strong>Statements of Operations Data<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"17\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\n            <strong>(unaudited)<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"17\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\n            <strong>(in thousands, except per share data)<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"5\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"11\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\n            <strong>Three Months Ended<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"11\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\n            <strong>March 31,<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"5\" style=\"border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>2026<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"border-top: solid black 1pt;border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>2025<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: middle;vertical-align: bottom\">Revenue<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"5\" style=\"border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"max-width:67%;width:67%;min-width:67%;vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;vertical-align: bottom\">Product revenue, net<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">$<\/td>\n<td colspan=\"4\" style=\"max-width:13%;width:13%;min-width:13%;text-align: right;vertical-align: middle;vertical-align: bottom\">5,766<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:2%;width:2%;min-width:2%;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">$<\/td>\n<td colspan=\"3\" style=\"max-width:13%;width:13%;min-width:13%;text-align: right;vertical-align: middle;vertical-align: bottom\">\u2014<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;vertical-align: bottom\">Collaboration revenue<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"border-bottom: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">12,499<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"border-bottom: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">14,108<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 30.0px;vertical-align: middle;vertical-align: bottom\">Total revenue<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">18,265<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">14,108<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: middle;vertical-align: bottom\">Operating expenses<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"5\" style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;vertical-align: bottom\">Cost of product sales<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">262<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">\u2014<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;vertical-align: bottom\">Research and development<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">65,263<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">55,973<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;vertical-align: bottom\">Selling, general and administrative<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"border-bottom: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">31,555<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"border-bottom: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">22,835<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 30.0px;vertical-align: middle;vertical-align: bottom\">Total operating expenses<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">97,080<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">78,808<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: middle;vertical-align: bottom\">Other income, net<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">5,490<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">7,497<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: middle;vertical-align: bottom\">Income tax expense<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"border-bottom: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">8<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-bottom: solid black 1pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"border-bottom: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">226<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: bottom\">Net loss<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;border-bottom: double black 3pt;vertical-align: bottom\">$<\/td>\n<td colspan=\"4\" style=\"border-top: solid black 1pt;border-bottom: double black 3pt;text-align: right;vertical-align: middle;vertical-align: bottom\">(73,333<\/td>\n<td style=\"vertical-align: bottom\">)<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: solid black 1pt;border-bottom: double black 3pt;vertical-align: bottom\">$<\/td>\n<td colspan=\"3\" style=\"border-top: solid black 1pt;border-bottom: double black 3pt;text-align: right;vertical-align: middle;vertical-align: bottom\">(57,429<\/td>\n<td style=\"vertical-align: bottom\">)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: bottom\">Net loss per share, basic and diluted<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double black 3pt;vertical-align: bottom\">$<\/td>\n<td colspan=\"4\" style=\"border-top: double black 3pt;border-bottom: double black 3pt;text-align: right;vertical-align: middle;vertical-align: bottom\">(0.83<\/td>\n<td style=\"vertical-align: bottom\">)<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double black 3pt;vertical-align: bottom\">$<\/td>\n<td colspan=\"3\" style=\"border-top: double black 3pt;border-bottom: double black 3pt;text-align: right;vertical-align: middle;vertical-align: bottom\">(0.66<\/td>\n<td style=\"vertical-align: bottom\">)<\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: bottom\">Weighted average number of shares used in computing net loss per share, basic and diluted<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double black 3pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"4\" style=\"border-top: double black 3pt;border-bottom: double black 3pt;text-align: right;vertical-align: middle;vertical-align: bottom\">88,610<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"border-top: double black 3pt;border-bottom: double black 3pt;vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"3\" style=\"border-top: double black 3pt;border-bottom: double black 3pt;text-align: right;vertical-align: middle;vertical-align: bottom\">87,415<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<\/table>\n<p>\n        \n      <\/p>\n<table align=\"center\" style=\"border-collapse: collapse;width:100%;border-collapse:collapse\">\n<tr>\n<td colspan=\"8\" style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\n            <strong>KURA ONCOLOGY, INC.<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\n            <strong>Balance Sheet Data<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\n            <strong>(unaudited)<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"8\" style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\n            <strong>(in thousands)<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>March 31,<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>December 31,<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>2026<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td colspan=\"2\" style=\"border-bottom: solid black 1pt;text-align: center;vertical-align: middle;vertical-align: bottom\">\n            <strong>2025<\/strong>\n          <\/td>\n<td style=\"text-align: center;vertical-align: middle;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"max-width:67%;width:67%;min-width:67%;vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: middle;vertical-align: bottom\">Cash, cash equivalents and short-term investments<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;border-top: solid black 1pt;vertical-align: bottom\">$<\/td>\n<td style=\"max-width:13%;width:13%;min-width:13%;border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">580,823<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:2%;width:2%;min-width:2%;vertical-align: bottom\">\u00a0<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;border-top: solid black 1pt;vertical-align: bottom\">$<\/td>\n<td style=\"max-width:13%;width:13%;min-width:13%;border-top: solid black 1pt;text-align: right;vertical-align: middle;vertical-align: bottom\">667,240<\/td>\n<td style=\"max-width:1%;width:1%;min-width:1%;vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: middle;vertical-align: bottom\">Working capital<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">522,286<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">591,689<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: middle;vertical-align: bottom\">Total assets<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">652,551<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">738,363<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: middle;vertical-align: bottom\">Long-term liabilities<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">443,172<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">447,254<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: middle;vertical-align: bottom\">Accumulated deficit<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">(1,247,421<\/td>\n<td style=\"vertical-align: bottom\">)<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">(1,174,088<\/td>\n<td style=\"vertical-align: bottom\">)<\/td>\n<\/tr>\n<tr>\n<td style=\"vertical-align: middle;text-align: left;padding-left: 10.0px;vertical-align: middle;vertical-align: bottom\">Stockholders\u2019 equity<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">107,883<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<td style=\"text-align: right;vertical-align: middle;vertical-align: bottom\">174,135<\/td>\n<td style=\"vertical-align: bottom\">\u00a0<\/td>\n<\/tr>\n<\/table>\n<p>\n        <strong><br \/>\n          <br \/>\n        <\/strong>\n      <\/p>\n<p>\n        <strong>About KOMZIFTI\u2122 (ziftomenib)<\/strong><br \/>\n        <br \/>KOMZIFTI (ziftomenib) is an oral menin inhibitor approved for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with a susceptible <em>NPM1<\/em> mutation who have no satisfactory alternative treatment options.<\/p>\n<p>Ziftomenib is in development for the treatment of frontline and R\/R AML harboring <em>NPM1 <\/em>mutations, <em>KMT2A<\/em> translocations and <em>FLT3<\/em> mutations, with the potential to be combined with approved therapies and benefit a broad spectrum of patients.<\/p>\n<p>\n        <strong>IMPORTANT SAFETY INFORMATION FOR KOMZIFTI FROM THE U.S. PRESCRIBING INFORMATION<\/strong>\n      <\/p>\n<p>\n        <strong>Boxed WARNING: DIFFERENTIATION SYNDROME<\/strong>\n      <\/p>\n<p>\n        <strong>Differentiation syndrome, which can be fatal, has occurred with KOMZIFTI. Signs and symptoms may include fever, joint pain, hypotension, hypoxia, dyspnea, rapid weight gain or peripheral edema, pleural or pericardial effusions, pulmonary infiltrates, acute kidney injury, and rashes. If differentiation syndrome is suspected, interrupt KOMZIFTI, and initiate oral or intravenous corticosteroids with hemodynamic and laboratory monitoring until symptom resolution; resume KOMZIFTI upon symptom improvement.<\/strong>\n      <\/p>\n<p>\n        <strong>WARNINGS AND PRECAUTIONS<\/strong>\n      <\/p>\n<p>\n        <strong>Differentiation Syndrome <\/strong>\n      <\/p>\n<p>KOMZIFTI can cause fatal or life-threatening differentiation syndrome (DS). DS is associated with rapid proliferation and differentiation of myeloid cells. Symptoms of DS, including those seen in patients treated with KOMZIFTI, may include fever, hypoxia, joint pain, hypotension, dyspnea, rapid weight gain or peripheral edema, pleural or pericardial effusions, acute kidney injury, and rashes.<\/p>\n<p>In the clinical trial, DS occurred in 29 (26%) of 112 patients with R\/R AML with an <em>NPM1<\/em> mutation who were treated with KOMZIFTI at the recommended dosage. DS was Grade 3 in 13% and fatal in two patients. In broader evaluation of all patients with any genetic form of AML treated with KOMZIFTI monotherapy in clinical trials, DS occurred in 25% of patients. Four fatal cases of DS occurred out of 39 patients with <em>KMT2A<\/em>-rearranged AML treated with KOMZIFTI. KOMZIFTI is not approved for use in patients with <em>KMT2A<\/em>-rearranged AML.<\/p>\n<p>In the 112 patients with an <em>NPM1<\/em> mutation, DS was observed with and without concomitant hyperleukocytosis, in as early as 3 days and up to 46 days after KOMZIFTI initiation. The median time to onset was 15 days. Two patients experienced more than one DS event. Treatment was interrupted and resumed in 15 (13%) patients, while it was permanently discontinued in 2 (2%) patients.<\/p>\n<p>Prior to starting treatment with KOMZIFTI, reduce the WBC counts to less than 25 x 10\u2079\/L. If DS is suspected, interrupt KOMZIFTI, initiate oral or intravenous corticosteroids (e.g., dexamethasone 10 mg every 12 hours) for a minimum of 3 days with hemodynamic and laboratory monitoring. Resume treatment with KOMZIFTI at the same dose level when signs and symptoms improve and are Grade 2 or lower. Taper corticosteroids over a minimum of 3 days after adequate control or resolution of symptoms. Symptoms of DS may recur with premature discontinuation of corticosteroid treatment.<\/p>\n<p>\n        <strong>QTc Interval Prolongation <\/strong>\n      <\/p>\n<p>KOMZIFTI can cause QTc interval prolongation. In the clinical trial, QTc interval prolongation was reported as an adverse reaction in 12% of 112 patients treated with KOMZIFTI at the recommended dosage for R\/R AML with an <em>NPM1<\/em> mutation. QTc interval prolongation was Grade 3 in 8% of patients. The heart-rate corrected QT interval (using Fridericia\u2019s method) (QTcF) was greater than 500 msec in 9% of patients, and the increase from baseline QTcF was greater than 60 msec in 12% of patients. KOMZIFTI dose reduction was required for 1% of patients due to QTc interval prolongation. QTc prolongation occurred in 14% of the 42 patients less than 65 years of age and in 10% of the 70 patients 65 years of age or older.<\/p>\n<p>Correct electrolyte abnormalities, including hypokalemia and hypomagnesemia, prior to treatment with KOMZIFTI. Perform an ECG prior to initiation of treatment with KOMZIFTI, and do not initiate KOMZIFTI in patients with QTcF &gt; 480 msec. Perform an ECG at least once weekly for the first four weeks on treatment, and at least monthly thereafter. Interrupt KOMZIFTI if the QTc interval is &gt; 500 ms or the change from baseline is &gt; 60 ms (Grade 3). In patients with congenital long QTc syndrome, congestive heart failure, electrolyte abnormalities, or those who are taking medications known to prolong the QTc interval, more frequent ECG monitoring may be necessary. Concomitant use of KOMZIFTI with drugs known to prolong the QTc interval may increase the risk of QTc interval prolongation, result in a greater increase in the QTc interval and adverse reactions associated with QTc interval prolongation, including Torsades de Pointes, other serious arrhythmias, and sudden death.<\/p>\n<p>\n        <strong>Embryo-Fetal Toxicity<\/strong>\n      <\/p>\n<p>Based on findings in animals and its mechanism of action, KOMZIFTI can cause embryo-fetal harm when administered to a pregnant woman. Advise pregnant women of the potential risk to the fetus. Advise females of reproductive potential to use effective contraception during treatment with KOMZIFTI and for 6 months after the last dose. Advise males with female partners of reproductive potential to use effective contraception during treatment with KOMZIFTI and for 3 months after the last dose.<\/p>\n<p>\n        <strong>ADVERSE REACTIONS<\/strong>\n      <\/p>\n<p>Fatal adverse reactions occurred in 4 (4%) patients who received KOMZIFTI, including 2 with differentiation syndrome, 1 with infection, and 1 with sudden death. Serious adverse reactions were reported in 79% of patients who received KOMZIFTI. Serious adverse reactions occurring in \u2265 5% of patients included infection without an identified pathogen (29%), febrile neutropenia (18%), bacterial infection (16%), differentiation syndrome (16%), and dyspnea (6%).<\/p>\n<p>Dosage interruption of KOMZIFTI due to an adverse reaction occurred in 54% of patients. Adverse reactions that required dose interruption in \u2265 2% of patients included infection without an identified pathogen (15%), differentiation syndrome (13%), febrile neutropenia (5%), pyrexia (4%), electrocardiogram QT prolonged (4%), leukocytosis (4%), bacterial infection (3%), cardiac failure (2%), cholecystitis (2%), diarrhea (2%), pruritus (2%), and thrombosis (2%). Dose reduction of KOMZIFTI due to an adverse reaction occurred in 4% of patients. Permanent discontinuation of KOMZIFTI due to an adverse reaction occurred in 21% of patients. Adverse reactions that required permanent discontinuation of KOMZIFTI in \u2265 2% of patients were infection without an identified pathogen (8%), bacterial infection (4%), cardiac arrest (2%), and differentiation syndrome (2%).<\/p>\n<p>\n        <strong>Most common (\u2265 20%) adverse reactions, including laboratory abnormalities<\/strong>, were aspartate aminotransferase increased (53%), infection without an identified pathogen (52%), potassium decreased (52%), albumin decreased (51%), alanine aminotransferase increased (50%), sodium decreased (49%), creatinine increased (45%), alkaline phosphatase increased (41%), hemorrhage (38%), diarrhea (36%), nausea (35%), fatigue (34%), edema (30%), bacterial infection (28%), musculoskeletal pain (28%), bilirubin increased (27%), potassium increased (26%), differentiation syndrome (26%), pruritus (23%), febrile neutropenia (22%), and transaminases increased (21%).<\/p>\n<p>\n        <strong>DRUG INTERACTIONS<\/strong>\n      <\/p>\n<p>Drug interactions may occur when KOMZIFTI is concomitantly used with:<\/p>\n<ul type=\"disc\">\n<li>Strong or Moderate CYP3A4 Inhibitors: Monitor patients more frequently for KOMZIFTI-associated adverse reactions.<\/li>\n<li>Strong or Moderate CYP3A4 Inducers: Avoid concomitant use of KOMZIFTI.<\/li>\n<li>Gastric Acid Reducing Agents: Avoid concomitant use of KOMZIFTI with proton pump inhibitors (PPIs), H2 receptor antagonists (H2RAs), or locally acting antacids. If concomitant use with H2RAs or locally acting antacids cannot be avoided, modify KOMZIFTI administration time.\n<ul type=\"circle\">\n<li>Take KOMZIFTI 2 hours before or 10 hours after administration of an H2 receptor antagonist.<\/li>\n<li>Take KOMZIFTI 2 hours before or 2 hours after administration of a locally acting antacid.<\/li>\n<\/ul>\n<\/li>\n<li>Drugs that Prolong the QTc Interval: Avoid concomitant use of KOMZIFTI. If concomitant use cannot be avoided, obtain ECGs when initiating, during concomitant use, and as clinically indicated. Interrupt KOMZIFTI if the QTc interval is &gt; 500 ms or the change from baseline is &gt; 60 ms.<\/li>\n<\/ul>\n<p>\n        <strong>USE IN SPECIFIC POPULATIONS<\/strong>\n      <\/p>\n<p>\n        <strong>Pregnancy: <\/strong>Based on findings in animals and its mechanism of action, KOMZIFTI can cause embryo-fetal harm when administered to a pregnant woman. Advise pregnant women of the potential risk to a fetus. Verify pregnancy status in females of reproductive potential prior to starting KOMZIFTI.<\/p>\n<p>\n        <strong>Lactation:<\/strong> Because of the potential for adverse reactions in the breastfed child, advise women not to breastfeed during treatment with KOMZIFTI and for 2 weeks after the last dose.<\/p>\n<p>\n        <strong>Infertility:<\/strong> Based on findings in animals, KOMZIFTI may impair fertility in females and males of reproductive potential.<\/p>\n<p>Please see full <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=0fxGNiq-fqQ3s6uDiTXA42NcJGjQnP21L7lpHuL0YOJWKuEaR4dj_2poxxYj3G2ExmGBBCkXTCchobzm3VtJcYKGAFBEHbrPhqVPQEXxmDgANDt4SaZM7PuFpS62i3uSOEahK0gV4yoBZCLb_hPJZw==\" rel=\"nofollow\" target=\"_blank\">Prescribing Information<\/a>, including <strong>Boxed WARNING<\/strong>.<\/p>\n<p>\n        <strong>Contacts<\/strong>\n      <\/p>\n<p>Investors and media: <br \/>Greg Mann<br \/>858-987-4046<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=si0igHJgCqJnoSYHP54CpA6rrI_-3EXgZIs15YK99rOcoEpioslxtWqoEwkzYwX7RebHjQnUpwSEI0Qkij85EtPE6MDU7CKY_TKTFbXNoMM=\" rel=\"nofollow\" target=\"_blank\">gmann@kuraoncology.com<\/a>\u00a0<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTcxODY0NyM3NTk3OTc2IzIwMTcxOTU=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/MzcwMWY3MjQtNzFkNS00YTM3LTgzM2EtN2NmYTNlOTZmZjI4LTEwMjg3NjgtMjAyNi0wNS0xMi1lbg==\/tiny\/Kura-Oncology-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u2013 $5.8 million in KOMZIFTI\u2122 (ziftomenib) net product revenue in first full quarter of commercialization \u2013 \u2013 Robust new patient starts and early launch dynamics, including repeat use, switching and combination adoption, reflect strong early momentum \u2013 \u2013 Broad and rapid payer access achieved, with &gt; 93% coverage and favorable positioning across &gt; 12 million lives \u2013 \u2013 Multiple 2026 data readouts expected to support ziftomenib as a broadly combinable backbone across AML \u2013 \u2013 $580.8 million in cash, cash equivalents and short-term investments, plus $180 million in anticipated collaboration payments, expected to support advancement of ziftomenib AML program through first topline KOMET-017 Phase 3 results \u2013 \u2013 Management to host webcast and conference call today at 4:30 p.m. ET &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/kura-oncology-reports-first-quarter-2026-financial-results\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Kura Oncology Reports First Quarter 2026 Financial Results&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-961699","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - 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