{"id":954750,"date":"2026-04-27T08:50:21","date_gmt":"2026-04-27T12:50:21","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/"},"modified":"2026-04-27T08:50:21","modified_gmt":"2026-04-27T12:50:21","slug":"neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/","title":{"rendered":"NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026"},"content":{"rendered":"

<\/p>\n

NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology<\/i> and NAUTILUS Presentation at AAN 2026<\/b><\/p>\n

\u2014<\/i>Published 3-year Post-Approval Study results show 82% median seizure reduction in drug-resistant focal epilepsy <\/i>\u2014<\/i><\/p>\n

\u2014<\/i> American Academy of Neurology (AAN) presentation featured 12- and 18-month NAUTILUS data, the first randomized controlled trial of neuromodulation in drug-resistant idiopathic generalized epilepsy (IGE) <\/i>\u2014<\/i><\/p>\n

\u2014<\/i>Growing body of high-quality clinical evidence reinforces the RNS System\u2019s differentiated position across focal and generalized epilepsy <\/i>\u2014<\/i><\/p>\n

MOUNTAIN VIEW, Calif.–(BUSINESS WIRE<\/a>)–
\nNeuroPace, Inc. (Nasdaq: NPCE), a medical device company focused on transforming the lives of people living with drug resistant epilepsy, today announced a major milestone in its clinical evidence program with the publication of 3-year results from the RNS\u00ae<\/sup> System Post-Approval Study (PAS) in Neurology<\/i>, alongside the Company\u2019s recent presentation of 12- and 18-month data from its ongoing NAUTILUS trial at the 2026 American Academy of Neurology Annual Meeting.<\/p>\n

\nTogether, these milestones underscore the breadth and strength of NeuroPace\u2019s clinical evidence leadership in epilepsy. The published PAS results reinforce the RNS System\u2019s well-established value in drug-resistant focal epilepsy, while the NAUTILUS presentation highlights continued progress in expanding the reach of responsive neurostimulation into idiopathic generalized epilepsy (IGE).<\/p>\n

\nThe RNS System PAS is the largest FDA-reviewed prospective neuromodulation study for focal drug-resistant epilepsy, enrolling 324 implanted patients across 32 U.S. centers. Published 3-year results demonstrated an 82% median seizure reduction, providing further evidence of the RNS System\u2019s strong and durable clinical benefit in a broad real-world adult focal epilepsy population.<\/p>\n

\nIn addition, NeuroPace recently presented 12- and 18-month data from its ongoing NAUTILUS study evaluating the RNS System as an adjunctive therapy for the treatment of antiseizure medication-resistant idiopathic generalized epilepsy with generalized tonic-clonic (GTC) seizures. 18-month results showed a 77% median reduction in GTC seizures compared with baseline, with rapid and sustained reductions over time. Reductions were also observed across other seizure types, including absence and myoclonic seizures, with reductions in both seizure types exceeding those observed for GTC seizures. The data also showed that injury events declined by approximately 30% following treatment and that the use of a benzodiazepine as a rescue medication for a GTC seizure were 44% lower compared with baseline (p<0.001). The benefits of treatment were strongly endorsed by physicians and patients, with Clinical Global Impression of Change exceeding 80% in both groups at 18 months.<\/p>\n

\n\u201cThe publication of the 3-year PAS results in Neurology <\/i>represents an important milestone for the epilepsy community and adds to the robust body of evidence supporting the RNS System in drug-resistant focal epilepsy,\u201d said Martha Morrell, MD, Chief Medical Officer of NeuroPace. \u201cAt the same time, the NAUTILUS dataset continues to mature, and we remain encouraged by the durability of the treatment effect and safety profile observed to date in idiopathic generalized epilepsy. These data highlight the broad potential of responsive neurostimulation to address meaningful unmet needs across epilepsy populations.\u201d1<\/sup><\/p>\n

\n\u201cNeuroPace continues to lead the field in developing high-quality clinical evidence for neuromodulation in epilepsy,\u201d said Joel Becker, President and Chief Executive Officer of NeuroPace. \u201cThe publication of our 3-year PAS results in Neurology<\/i> and the presentation of NAUTILUS data at AAN reflect the depth of our evidence base and our commitment to advancing the RNS System across both established and emerging patient populations.\u201d<\/p>\n

\nSlides from Dr. Morrell\u2019s AAN presentation are available on the NeuroPace corporate website at www.neuropace.com\/providers\/clinical-trials\/nautilus\/<\/a>.<\/p>\n

About NeuroPace, Inc.<\/b><\/p>\n

\nBased in Mountain View, Calif., NeuroPace is a medical device company focused on transforming the lives of people living with epilepsy by reducing or eliminating the occurrence of debilitating seizures. Its novel and differentiated RNS System is the first and only commercially available, brain-responsive platform that delivers personalized, real-time treatment at the seizure source. This platform can drive a better standard of care for patients living with drug-resistant epilepsy and has the potential to offer a more personalized solution and improved outcomes to the large population of patients suffering from other brain disorders.<\/p>\n

Forward Looking Statements<\/b><\/p>\n

This press release may contain forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as \u201caims,\u201d \u201canticipates,\u201d \u201cbelieves,\u201d \u201ccould,\u201d \u201cestimates,\u201d \u201cexpects,\u201d \u201cforecasts,\u201d \u201cgoal,\u201d \u201cintends,\u201d \u201cmay,\u201d \u201cplans,\u201d \u201cpossible,\u201d \u201cpotential,\u201d \u201cseeks,\u201d \u201cwill\u201d and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. NeuroPace may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Forward-looking statements in this press release include, but are not limited to, statements regarding: NeuroPace\u2019s expectations, forecasts and beliefs with respect to potential indication expansion for its RNS System and increasing access to and adoption of RNS therapy as the standard of care in drug-resistant epilepsy. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including: actual operating results may differ significantly from any guidance provided; uncertainties related to market acceptance and adoption of NeuroPace\u2019s RNS System risks related to regulatory compliance and expectations for regulatory submissions and approvals to expand the market for NeuroPace\u2019s RNS System, including risks related to the NAUTILUS clinical trial; risks related to NeuroPace\u2019s reliance on contractors and other third parties, including single-source suppliers and vendors; and other important factors. These and other risks and uncertainties include those described more fully in the section titled \u201cRisk Factors\u201d and \u201cManagement\u2019s Discussion and Analysis of Financial Condition and Results of Operations\u201d and elsewhere in NeuroPace\u2019s public filings with the U.S. Securities and Exchange Commission (SEC), including its Annual Report on Form 10-K for the year ended December 31, 2025, filed with the SEC on March 3, 2026, as well as any other reports that it may file with the SEC in the future. Forward-looking statements contained in this announcement are based on information available to NeuroPace as of the date hereof. NeuroPace undertakes no obligation to update such information except as required under applicable law. These forward-looking statements should not be relied upon as representing NeuroPace\u2019s views as of any date subsequent to the date of this press release and should not be relied upon as a prediction of future events. In light of the foregoing, investors are urged not to rely on any forward-looking statement in reaching any conclusion or making any investment decision about any securities of NeuroPace.<\/i><\/p>\n

1<\/sup> The Premarket Approval Supplement (PMA-S) application to the FDA seeking to expand the labeled indication for its RNS System to include patients with antiseizure-medication (ASM) resistant idiopathic generalized epilepsy (IGE) with generalized tonic-clonic seizures was submitted to the FDA in December of 2025 and is currently under review.<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20260423994564\/en\/<\/a><\/span><\/p>\n

Investor Contact:
\n<\/b>
Scott Schaper
\n
Head of Investor Relations
\n
sschaper@neuropace.com
\n<\/a>
investors@neuropace.com<\/a><\/p>\n

KEYWORDS:<\/b> California New York United States North America<\/p>\n

INDUSTRY KEYWORDS:<\/b> Research Medical Devices FDA Neurology Clinical Trials Health Pharmaceutical General Health Science<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
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NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026 \u2014Published 3-year Post-Approval Study results show 82% median seizure reduction in drug-resistant focal epilepsy \u2014 \u2014 American Academy of Neurology (AAN) presentation featured 12- and 18-month NAUTILUS data, the first randomized controlled trial of neuromodulation in drug-resistant idiopathic generalized epilepsy (IGE) \u2014 \u2014Growing body of high-quality clinical evidence reinforces the RNS System\u2019s differentiated position across focal and generalized epilepsy \u2014 MOUNTAIN VIEW, Calif.–(BUSINESS WIRE)– NeuroPace, Inc. (Nasdaq: NPCE), a medical device company focused on transforming the lives of people living with drug resistant epilepsy, today announced a major milestone in its clinical evidence program with the publication of 3-year … <\/p>\n

Continue reading “NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-954750","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nNeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026 \u2014Published 3-year Post-Approval Study results show 82% median seizure reduction in drug-resistant focal epilepsy \u2014 \u2014 American Academy of Neurology (AAN) presentation featured 12- and 18-month NAUTILUS data, the first randomized controlled trial of neuromodulation in drug-resistant idiopathic generalized epilepsy (IGE) \u2014 \u2014Growing body of high-quality clinical evidence reinforces the RNS System\u2019s differentiated position across focal and generalized epilepsy \u2014 MOUNTAIN VIEW, Calif.–(BUSINESS WIRE)– NeuroPace, Inc. (Nasdaq: NPCE), a medical device company focused on transforming the lives of people living with drug resistant epilepsy, today announced a major milestone in its clinical evidence program with the publication of 3-year … Continue reading "NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-27T12:50:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20260423994564r1&sid=flmnd&distro=nx&lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026\",\"datePublished\":\"2026-04-27T12:50:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\\\/\"},\"wordCount\":1199,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&sty=20260423994564r1&sid=flmnd&distro=nx&lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\\\/\",\"name\":\"NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026 - 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(Nasdaq: NPCE), a medical device company focused on transforming the lives of people living with drug resistant epilepsy, today announced a major milestone in its clinical evidence program with the publication of 3-year … Continue reading \"NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/","og_site_name":"Market Newsdesk","article_published_time":"2026-04-27T12:50:21+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20260423994564r1&sid=flmnd&distro=nx&lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026","datePublished":"2026-04-27T12:50:21+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/"},"wordCount":1199,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20260423994564r1&sid=flmnd&distro=nx&lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/neuropace-highlights-expanding-clinical-evidence-leadership-with-published-3-year-post-approval-study-pas-results-in-neurology-and-nautilus-presentation-at-aan-2026\/","name":"NeuroPace Highlights Expanding Clinical Evidence Leadership with Published 3-Year Post-Approval Study (PAS) Results in Neurology and NAUTILUS Presentation at AAN 2026 - 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