{"id":953830,"date":"2026-04-22T16:32:05","date_gmt":"2026-04-22T20:32:05","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/abivax-to-present-data-on-obefazimod-at-digestive-disease-week\/"},"modified":"2026-04-22T16:32:05","modified_gmt":"2026-04-22T20:32:05","slug":"abivax-to-present-data-on-obefazimod-at-digestive-disease-week","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/abivax-to-present-data-on-obefazimod-at-digestive-disease-week\/","title":{"rendered":"Abivax to Present Data on Obefazimod at Digestive Disease Week\u00ae"},"content":{"rendered":"
\n

\n Abivax to Present Data on Obefazimod at <\/b>
\n Digestive Disease Week<\/b>
\n
\n \u00ae<\/b>
\n <\/sup>\n <\/p>\n

\n Presentations Highlight Comprehensive Efficacy, Safety, and Patient-Reported Outcomes from the Phase 3 ABTECT Program and Preclinical Anti-Fibrotic Models in Inflammatory Bowel Disease<\/i>\n <\/p>\n

\n PARIS, France \u2013 April 22, 2026 \u2013 10:05 pm CEST<\/b> \u2013 Abivax SA<\/a> (Euronext Paris: FR0012333284 \u2013 ABVX \/ Nasdaq: ABVX) (\u201cAbivax\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company focused on developing therapeutics that harness the body\u2019s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases, today announced that nine scientific abstracts on obefazimod, its lead drug candidate for the treatment of moderately to severely active ulcerative colitis (UC), will be presented at the 2026 Digestive Disease Week (DDW) taking place May 2-5, 2026 in Chicago, IL. These presentations will highlight data from the Phase 3 ABTECT program, including efficacy, safety, and patient-reported outcomes, along with preclinical anti-fibrotic activity in two preclinical fibrosis models.<\/p>\n

\n Fabio Cataldi, MD, Chief Medical Officer of Abivax, said:<\/b>
\n \u201cThe data being presented at this conference reinforce our confidence in obefazimod as a meaningful advancement for patients living with ulcerative colitis. From histologic and endoscopic outcomes to patient-reported improvements in fatigue and quality of life, these abstracts paint a comprehensive picture of a therapy with potential to address what matters most to patients and clinicians alike. We continue to be encouraged by the findings across the spectrum of disease severity and line of therapy.”<\/i>\n <\/p>\n

\n Marc de Garidel, MBA, Chief Executive Officer of Abivax, added: <\/b>
\n \u201cOur presence at DDW with nine abstracts highlights the depth and growing strength of the obefazimod dataset we are building in inflammatory bowel disease. These findings contribute to a more comprehensive understanding of its potential and support our ongoing efforts to bring meaningful innovation to patients.\u201d<\/i>\n <\/p>\n

Visit the publications page of our website to view the presentations after the conclusion of the meeting.<\/p>\n

\n Obefazimod Data to be Presented: <\/b>\n <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n Date & Time <\/b>\n <\/td>\n\n Session<\/b>\n <\/td>\n\n Abstract #<\/b>\n <\/td>\n\n Title<\/b>\n <\/td>\n\n Presenter<\/b>\n <\/td>\n<\/tr>\n
\n Oral Presentation<\/b>\n <\/td>\n<\/tr>\n
Mon, May 4
10:00-10:15<\/td>\n		Controlled Clinical Trials 1<\/td>\n4470489<\/td>\nImpact of obefazimod treatment on histologic and combined histologic-endoscopic outcomes in patients with moderately to severely active UC: results from the ABTECT-1 and ABTECT-2 phase 3, double-blind, placebo-controlled induction trials<\/td>\nProf. Fernando Magro, MD, PhD<\/p>\n

Head of the Department of Clinical Pharmacology and Professor of Pharmacology and Therapeutics at University Hospital S\u00e3o Jo\u00e3o in Porto, Portugal<\/td>\n<\/tr>\n

\n Poster Presentation<\/b>\n <\/td>\n<\/tr>\n
Mon, May 4
12:30-1:30<\/td>\n		Controlled Clinical Trials of IBD Treatment<\/p>\n<\/td>\nMo1513<\/p>\n<\/td>\nEarly symptomatic improvement with obefazimod in patients with moderately to severely active UC: pooled results from the ABTECT-1 and ABTECT-2 phase 3, double-blind, placebo-controlled induction trials<\/p>\n<\/td>\nProf. Marla Dubinsky, MD<\/p>\n

Professor of Pediatrics and Medicine, Chief, Division of Pediatric Gastroenterology and Nutrition<\/p>\n<\/td>\n<\/tr>\n

Mon, May 4
12:30-1:30<\/td>\n		Controlled Clinical Trials of IBD Treatment<\/p>\n<\/td>\nMo1533<\/td>\nEfficacy and safety of obefazimod in an elderly population with moderately to severely active UC: week 8 results from the ABTECT-1 and ABTECT-2 phase 3, double-blind, placebo-controlled induction trials<\/p>\n<\/td>\nAndres J Yarur, MD<\/p>\n

Associate Professor of Medicine, Cedars-Sinai Medical Center<\/td>\n<\/tr>\n

Mon, May 4
12:30-1:30<\/td>\n		Controlled Clinical Trials of IBD Treatment<\/p>\n<\/td>\nMo1522<\/p>\n<\/td>\nEfficacy of obefazimod in patients with moderately to severely active ulcerative colitis: results in subgroups of prior inadequate response to advanced therapy (AT-IR) including or excluding patients with prior JAK-IR from ABTECT phase 3 induction trials<\/p>\n<\/td>\nProf. Bruce E Sands, MD, MS<\/p>\n

Professor of Medicine, Icahn School of Medicine at Mount Sinai<\/p>\n<\/td>\n<\/tr>\n

Mon, May 4
12:30-1:30<\/p>\n<\/td>\n		Controlled Clinical Trials of IBD Treatment<\/p>\n<\/td>\nMo1525<\/td>\nIntegrated summary of safety of obefazimod in phase 3 ABTECT induction trials<\/p>\n<\/td>\nProf. Bruce E Sands, MD, MS<\/p>\n

Professor of Medicine, Icahn School of Medicine at Mount Sinai<\/p>\n<\/td>\n<\/tr>\n

Mon, May 4
12:30-1:30<\/p>\n<\/td>\n		Quality of Life and Psychosocial Outcomes<\/td>\nMo1677<\/p>\n<\/td>\nImprovements in patient-reported fatigue among patients with moderately to severely active UC treated with obefazimod: pooled results from the 8-week ABTECT-1 and ABTECT-2 phase 3 double-blind, placebo-controlled induction trials<\/p>\n<\/td>\nProf. Marla Dubinsky, MD<\/p>\n

Professor of Pediatrics and Medicine, Chief, Division of Pediatric Gastroenterology and Nutrition<\/p>\n<\/td>\n<\/tr>\n

Mon, May 4
12:30-1:30<\/p>\n<\/td>\n		Quality of Life and Psychosocial Outcomes<\/td>\nMo1667<\/p>\n<\/td>\nImprovements in patient-reported, disease-specific and overall quality-of-life among patients with moderately to severely active UC treated with obefazimod: pooled results from the 8-week ABTECT-1 and ABTECT-2 phase 3 induction trials<\/p>\n<\/td>\nProf. Bruce E Sands, MD, MS<\/p>\n

Professor of Medicine, Icahn School of Medicine at Mount Sinai<\/td>\n<\/tr>\n

Tue, May 5
12:30-1:30<\/p>\n<\/td>\n		Mechanisms of IBD Therapeutics<\/p>\n<\/td>\nTu1433<\/p>\n<\/td>\nObefazimod shows first evidence of dual anti-inflammatory and anti-fibrotic activity in murine in vivo and human in vitro models<\/p>\n<\/td>\nProf. Silvio Danese, MD, PhD<\/p>\n

Director of Gastroenterology and Gastrointestinal Endoscopy Unit at IRCCS San. Raffaele Hospital<\/p>\n<\/td>\n<\/tr>\n

Tue, May 5
12:30-1:30<\/p>\n<\/td>\n		Mechanisms of IBD Therapeutics<\/td>\nTu1449<\/td>\nObefazimod enhances mir-124 expression in blood and colon tissue and reduces the key inflammatory cytokines IL-17A and
IL-6 in serum of patients with moderate-to-severely active UC: results from the phase 3 ABTECT induction trials<\/td>\n		Parambir S Dulai, MD<\/p>\n

Associate Professor, Feinberg School of Medicine at Northwestern University<\/td>\n<\/tr>\n<\/table>\n

\n
\n
About Abivax<\/b>\n <\/p>\n

Abivax is a clinical-stage biotechnology company focused on developing therapeutics that harness the body\u2019s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases. Based in France and the United States, Abivax\u2019s lead drug candidate, obefazimod (ABX464), is in Phase 3 clinical trials for the treatment of moderately to severely active ulcerative colitis.<\/p>\n

\n Contact:<\/b>
\n
Patrick Malloy
SVP, Investor Relations
Abivax SA
patrick.malloy@abivax.com<\/a>
+1 847 987 4878<\/p>\n

\n Media Contact:<\/b>
\n
\n LifeSci Communications<\/b>
\n
Karissa Baltz, Ph.D.
Associate Director
LSC_ABIVAX@lifescicomms.com<\/a><\/p>\n

\n FORWARD-LOOKING STATEMENTS<\/b>\n <\/p>\n

\n This press release contains forward-looking statements, forecasts and estimates, including those relating to the Company\u2019s business. Words such as \u201canticipate,\u201d \u201cexpect,\u201d \u201con track,\u201d \u201cpotential,\u201d \u201cwill\u201d and variations of such words and similar expressions are intended to identify forward-looking statements. These forward-looking statements include statements concerning the potential therapeutic benefit of obefazimod and other statements that are not historical fact. Although Abivax\u2019s management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks, contingencies and uncertainties, many of which are difficult to predict and generally beyond the control of Abivax, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. A description of these risks, contingencies and uncertainties can be found in the documents filed by the Company with the French Autorit\u00e9 des March\u00e9s Financiers pursuant to its legal obligations including its universal registration document (Document d\u2019Enregistrement Universel) and in its Annual Report on Form 20-F for the fiscal year ended December 31, 2025 <\/i>
\n filed with the U.S. Securities and Exchange Commission on March 23, 2026 under the caption \u201cRisk Factors.\u201d <\/i>
\n These risks, contingencies and uncertainties include, among other things, the uncertainties inherent in research and development, future clinical data and analysis, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug candidate, as well as their decisions regarding labelling and other matters that could affect the availability or commercial potential of such product candidates, and the availability of funding sufficient for the Company\u2019s foreseeable and unforeseeable operating expenses and capital expenditure requirements. Special consideration should be given to the potential hurdles of clinical and pharmaceutical development, including further assessment by the Company and regulatory agencies and IRBs\/ethics committees following the assessment of preclinical, pharmacokinetic, carcinogenicity, toxicity, CMC and clinical data. Furthermore, these forward-looking statements, forecasts and estimates are made only as of the date of this press release. Readers are cautioned not to place undue reliance on these forward-looking statements. Abivax disclaims any obligation to update these forward-looking statements, forecasts or estimates to reflect any subsequent changes that the Company becomes aware of, except as required by law. Information about pharmaceutical products (including products currently in development) that is included in this press release is not intended to constitute an advertisement. This press release is for information purposes only, and the information contained herein does not constitute either an offer to sell or the solicitation of an offer to purchase or subscribe for securities of the Company in any jurisdiction. Similarly, it does not give and should not be treated as giving investment advice. It has no connection with the investment objectives, financial situation or specific needs of any recipient. It should not be regarded by recipients as a substitute for exercise of their own judgment. All opinions expressed herein are subject to change without notice. The distribution of this document may be restricted by law in certain jurisdictions. Persons into whose possession this document comes are required to inform themselves about and to observe any such restrictions.<\/i>\n <\/p>\n

\n Attachment<\/strong>\n <\/p>\n