{"id":953369,"date":"2026-04-21T09:31:09","date_gmt":"2026-04-21T13:31:09","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/"},"modified":"2026-04-21T09:31:09","modified_gmt":"2026-04-21T13:31:09","slug":"akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/","title":{"rendered":"Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>Expands potential opportunities for AKTX-101 and its novel RNA splicing modulator payload in additional tumors beyond current Phase 1 plan<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>Publication to be made available online on May 21, 2026 at 5:00 PM ET<\/em>\n      <\/p>\n<p align=\"justify\">TAMPA, Fla. and LONDON, April  21, 2026  (GLOBE NEWSWIRE) &#8212; Akari Therapeutics, Plc (Nasdaq: AKTX), an oncology biotechnology company developing antibody drug conjugates (ADCs) with novel RNA splicing modulating payloads, today announced that its abstract has been accepted for online publication at the\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ggx5ryyhKPunepFgCmBA1dHs7h5ElZ08CRs-eVd0IOvLD6qcE1ehgnYQ3YBKoFeFn3iKotKrlFRCgqOiKurWnSMsiTmtJWSJm5KSeezRM7A7YqksV1fKL85LdArsVvewEWKbwc9ZgR84iv9FiLBGSQ==\" rel=\"nofollow\" target=\"_blank\">American Society of Clinical Oncology (ASCO) Annual Meeting 2026<\/a>.<\/p>\n<p align=\"justify\">This marks Akari\u2019s first abstract acceptance at ASCO, one of the most highly regarded forums in clinical oncology research, and represents a significant milestone for the Company as it continues to advance its AKTX-101 ADC into Phase 1 clinical development by late 2026\/early 2027.<\/p>\n<p align=\"justify\">Details are as follows:\u00a0<br \/><strong>Abstract Title: <\/strong><em>Combination synergy of spliceosome modulator ADC with a K-Ras inhibitor in KRAS\u2013mutated pancreatic cancers<\/em><br \/><strong>Date and Time:<\/strong> The full publication will be made available on May 21, 2026, at 5:00 PM ET on the ASCO website.<\/p>\n<p align=\"justify\">\u201cThis first ASCO acceptance for Akari is continued validation of our novel RNA splicing modulator payload platform for ADCs, and its broad potential in treating a wide range of cancer tumors, including those with KRAS mutations, a rapidly expanding therapeutic category moving forward,\u201d said Abizer Gaslightwala, President and Chief Executive Officer of Akari Therapeutics. \u201cWe believe this data highlights a growing body of evidence demonstrating that targeting RNA splicing in cancer cells could be a powerful way to attack even the most difficult cancers.\u201d<\/p>\n<p align=\"justify\">Additional details will be disclosed in accordance with ASCO embargo policies.<\/p>\n<p align=\"justify\">For more information about the ASCO Annual Meeting 2026, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=bO-xrp299Yx2dq5YlffQtDcVdc_L3N7xfostXf7H1w--wvkBhI4Rl7VA9ByN8DPx_T7Yzzm7uzGZE5aPPx3BDA==\" rel=\"nofollow\" target=\"_blank\">asco.org<\/a>.<\/p>\n<p align=\"justify\">\n        <strong>About Akari Therapeutics <\/strong>\n      <\/p>\n<p align=\"justify\">Akari Therapeutics is an oncology biotechnology company developing next-generation antibody drug conjugates (ADCs) with a unique payload, PH1, which targets RNA splicing. Utilizing its innovative ADC discovery platform, the Company has the ability to generate ADC candidates and optimize them based on the desired application to any antigen target of interest. Akari\u2019s lead candidate, AKTX-101, targets the Trop2 receptor on cancer cells with a proprietary linker, enabling it to deliver its novel PH1 payload directly into the tumor with minimal off-target effects. Unlike current ADCs that use microtubule inhibitors and DNA-damaging agents as their payloads, PH1 is a novel payload that is a spliceosome modulator designed to disrupt RNA splicing within cancer cells. This splicing modulation has been shown in preclinical animal models to induce cancer cell death while activating both the innate and adaptive immune systems to drive robust and durable activity. In preclinical studies, AKTX-101 has been shown to have significant activity and prolonged survival relative to ADCs with traditional payloads. Additionally, AKTX-101 has the potential to be synergistic with checkpoint inhibitors and has demonstrated prolonged survival as both a single agent and in combination with checkpoint inhibitors. The PH1 payload has also been demonstrated to be very active against cancer cells with key oncogenic drivers such as KRAS, BRAF, ARV7, FGFR3 fusions, and others. The Company has initiated IND enabling studies for AKTX-101 with a goal of starting its First-In-Human trial by late 2026\/early 2027. Akari is also developing AKTX-102, an ADC candidate targeting CEACAM5 (Carcinoembryonic Antigen-related Cell Adhesion Molecule-5), a well-validated tumor antigen broadly expressed across multiple solid tumors. AKTX-102 is designed to leverage Akari\u2019s proprietary PH1 spliceosome-modulating payload and a novel antibody construct to enable differentiated tumor cell killing and immune activation.<\/p>\n<p align=\"justify\">For more information about the Company, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=xXL04nZdfvWbGvg1-vmP4jMF0ireZ7yrDuj2UezzAJ0NEDV4H7KsRWkQcop0n1sHZLLT1z67jALRFkFviO0nrwo_82q9nQf8U6xlw8z7Ljk=\" rel=\"nofollow\" target=\"_blank\">www.akaritx.com<\/a> and connect on <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=D4_zcWk9TANtKNs_yI65FJYEZK0M9oZdpIjQWRhhFcydBs5X5APV9dPwjEyZ9pWoU3lyPorCht1rLhCe2egwJg==\" rel=\"nofollow\" target=\"_blank\">X<\/a> and <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=tgxtR8_Mwc82lUkqCOcbnuPYX5-459vKTEKFyXTeXnPRgpmi0QOF6b6bpIM3vPL1wfxVKErnKbmy-ym_5P1wC0qZCD6w01d_iyWKfnRDEzo=\" rel=\"nofollow\" target=\"_blank\">LinkedIn<\/a>.<\/p>\n<p align=\"justify\">\n        <strong>Cautionary Note Regarding Forward-Looking Statements<\/strong>\n      <\/p>\n<p align=\"justify\">This press release includes express or implied forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, about the Company that involve risks and uncertainties relating to future events and the future performance of the Company. Actual events or results may differ materially from these forward-looking statements. Words such as \u201cwill,\u201d \u201ccould,\u201d \u201cwould,\u201d \u201cshould,\u201d \u201cexpect,\u201d \u201cplan,\u201d \u201canticipate,\u201d \u201cintend,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201cpotential,\u201d \u201ccontinue,\u201d \u201cfuture,\u201d \u201copportunity\u201d \u201cwill likely result,\u201d \u201ctarget,\u201d variations of such words, and similar expressions or negatives of these words are intended to identify such forward-looking statements, although not all forward-looking statements contain these identifying words. Examples of such forward-looking statements include, but are not limited to, express or implied statements regarding the ability of the Company to advance its product candidates for the treatment of cancer and the timing of commencement of a Phase I clinical trial. These statements are based on the Company\u2019s current plans, estimates and projections. By their very nature, forward-looking statements involve inherent risks and uncertainties, both general and specific. A number of important factors, including those described in this communication, could cause actual results to differ materially from those contemplated in any forward-looking statements. Factors that may affect future results and may cause these forward-looking statements to be inaccurate include, without limitation: the Company\u2019s need for additional capital; the potential impact of unforeseen liabilities, future capital expenditures, revenues, costs, expenses, earnings, synergies, economic performance, indebtedness, financial condition and losses on the future prospects, business and management strategies for the management, expansion and growth of the business; risks related to global as well as local political and economic conditions, including interest rate and currency exchange rate fluctuations; potential delays or failures related to research and\/or development of the Company\u2019s programs or product candidates; risks related to any loss of the Company\u2019s patents or other intellectual property rights; any interruptions of the supply chain for raw materials or manufacturing for the Company\u2019s product candidates, including as a result of potential tariffs; the nature, timing, cost and possible success and therapeutic applications of product candidates being developed by the Company and\/or its collaborators or licensees; the extent to which the results from the research and development programs conducted by the Company, and\/or its collaborators or licensees may be replicated in other studies and\/or lead to advancement of product candidates to clinical trials, therapeutic applications, or regulatory approval; uncertainty of the utilization, market acceptance, and commercial success of the Company\u2019s product candidates; risks related to competition for the Company\u2019s product candidates; and the Company\u2019s ability to successfully develop or commercialize its product candidates. While the foregoing list of factors presented here is considered representative, no list should be considered to be a complete statement of all potential risks and uncertainties. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set forth in the Company\u2019s filings with the SEC, copies of which may be obtained from the SEC\u2019s website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=7IBUSxv3Z1ZQSRdAG5chMyHazbDwgt_9qq1NOY4-bPZklttdmlIJNYw-GMrnQCmSSUw8k7rmQaIVHUe_bnkyxA==\" rel=\"nofollow\" target=\"_blank\">www.sec.gov<\/a>. The Company assumes no, and hereby disclaims any, obligation to update the forward-looking statements contained in this press release except as required by law.<\/p>\n<p align=\"justify\">\n        <strong>Investor Relations Contact <\/strong>\n      <\/p>\n<p align=\"justify\">JTC Team, LLC <br \/>Jenene Thomas <br \/>908-824-0775 <br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=WdtHBnPZiCOUj7xg5SQlndnbo1HJ0SaaXHkRvvzPd295SvnDuL8G3KseLeDHyFpMAfY9XVjx7F5MIHeEPY741g==\" rel=\"nofollow\" target=\"_blank\">AKTX@jtcir.com<\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY5MzUzOSM3NTQ2MTA2IzIwMjAyNjM=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/MWRmMjM1NjgtNTIzNi00Y2JhLTg3ZDUtMjM5MDZhMWNkN2IzLTEwMzE4MzUtMjAyNi0wNC0yMS1lbg==\/tiny\/Akari-Therapeutics-Plc.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Expands potential opportunities for AKTX-101 and its novel RNA splicing modulator payload in additional tumors beyond current Phase 1 plan Publication to be made available online on May 21, 2026 at 5:00 PM ET TAMPA, Fla. and LONDON, April 21, 2026 (GLOBE NEWSWIRE) &#8212; Akari Therapeutics, Plc (Nasdaq: AKTX), an oncology biotechnology company developing antibody drug conjugates (ADCs) with novel RNA splicing modulating payloads, today announced that its abstract has been accepted for online publication at the\u00a0American Society of Clinical Oncology (ASCO) Annual Meeting 2026. This marks Akari\u2019s first abstract acceptance at ASCO, one of the most highly regarded forums in clinical oncology research, and represents a significant milestone for the Company as it continues to advance its AKTX-101 ADC &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-953369","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Expands potential opportunities for AKTX-101 and its novel RNA splicing modulator payload in additional tumors beyond current Phase 1 plan Publication to be made available online on May 21, 2026 at 5:00 PM ET TAMPA, Fla. and LONDON, April 21, 2026 (GLOBE NEWSWIRE) &#8212; Akari Therapeutics, Plc (Nasdaq: AKTX), an oncology biotechnology company developing antibody drug conjugates (ADCs) with novel RNA splicing modulating payloads, today announced that its abstract has been accepted for online publication at the\u00a0American Society of Clinical Oncology (ASCO) Annual Meeting 2026. This marks Akari\u2019s first abstract acceptance at ASCO, one of the most highly regarded forums in clinical oncology research, and represents a significant milestone for the Company as it continues to advance its AKTX-101 ADC &hellip; Continue reading &quot;Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-21T13:31:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY5MzUzOSM3NTQ2MTA2IzIwMjAyNjM=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors\",\"datePublished\":\"2026-04-21T13:31:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\\\/\"},\"wordCount\":1160,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTY5MzUzOSM3NTQ2MTA2IzIwMjAyNjM=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\\\/\",\"name\":\"Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/","og_locale":"en_US","og_type":"article","og_title":"Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors - Market Newsdesk","og_description":"Expands potential opportunities for AKTX-101 and its novel RNA splicing modulator payload in additional tumors beyond current Phase 1 plan Publication to be made available online on May 21, 2026 at 5:00 PM ET TAMPA, Fla. and LONDON, April 21, 2026 (GLOBE NEWSWIRE) &#8212; Akari Therapeutics, Plc (Nasdaq: AKTX), an oncology biotechnology company developing antibody drug conjugates (ADCs) with novel RNA splicing modulating payloads, today announced that its abstract has been accepted for online publication at the\u00a0American Society of Clinical Oncology (ASCO) Annual Meeting 2026. This marks Akari\u2019s first abstract acceptance at ASCO, one of the most highly regarded forums in clinical oncology research, and represents a significant milestone for the Company as it continues to advance its AKTX-101 ADC &hellip; Continue reading \"Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/","og_site_name":"Market Newsdesk","article_published_time":"2026-04-21T13:31:09+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY5MzUzOSM3NTQ2MTA2IzIwMjAyNjM=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors","datePublished":"2026-04-21T13:31:09+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/"},"wordCount":1160,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY5MzUzOSM3NTQ2MTA2IzIwMjAyNjM=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/akari-therapeutics-asco-abstract-acceptance-highlights-potential-for-aktx-101-adc-to-treat-kras-mutant-tumors\/","name":"Akari Therapeutics ASCO Abstract Acceptance Highlights Potential for AKTX-101 ADC to Treat KRAS Mutant Tumors - 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