{"id":953132,"date":"2026-04-21T06:03:54","date_gmt":"2026-04-21T10:03:54","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-highlights-clinical-impact-of-ultrasensitive-ctdna-monitoring-and-new-therapy-resistance-tracking-at-aacr-2026\/"},"modified":"2026-04-21T06:03:54","modified_gmt":"2026-04-21T10:03:54","slug":"personalis-highlights-clinical-impact-of-ultrasensitive-ctdna-monitoring-and-new-therapy-resistance-tracking-at-aacr-2026","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-highlights-clinical-impact-of-ultrasensitive-ctdna-monitoring-and-new-therapy-resistance-tracking-at-aacr-2026\/","title":{"rendered":"Personalis Highlights Clinical Impact of Ultrasensitive ctDNA Monitoring and New Therapy Resistance Tracking at AACR 2026"},"content":{"rendered":"

<\/p>\n

Personalis Highlights Clinical Impact of Ultrasensitive ctDNA Monitoring and New Therapy Resistance Tracking at AACR 2026<\/b><\/p>\n

Podium presentation on NeXT Personal\u00ae monitoring neoadjuvant therapy in colorectal cancer;<\/i><\/p>\n

Real-world data from 10,000 patients reinforce industry-leading sensitivity;<\/i><\/p>\n

Data presented for a new NeXT Personal feature for monitoring resistance mutations<\/i><\/p>\n

FREMONT, Calif.–(BUSINESS WIRE<\/a>)–
\nPersonalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for precision oncology, today announced the successful presentation of clinical data at the American Association for Cancer Research (AACR) Annual Meeting. The data, spanning one oral podium presentation and three posters, underscore the use of the NeXT Personal ultrasensitive ctDNA assay in monitoring treatment response, identifying early recurrence, and tracking the emergence of therapy resistance.<\/p>\n

Neoadjuvant Monitoring in Colorectal Cancer.<\/b> A highlight was the oral podium presentation of the NEOPRISM-CRC<\/b> trial, delivered by Dr. Jiang from the University College London, which utilized NeXT Personal to monitor patients with high-risk stage II-III dMMR\/MSI-H colorectal cancer (CRC) receiving neoadjuvant pembrolizumab. In addition to 100% sensitivity for disease at baseline, the study identified three distinct groups of patient response to neoadjuvant treatment: super molecular responders, dynamic molecular responders, and poor molecular responders. Notably, 100% of “super molecular responders”\u2014those who cleared ctDNA by the second cycle of treatment\u2014also achieved pathological complete response (pCR). Conversely, of \u201cpoor molecular responders\u201d\u2014patients with relatively stable ctDNA levels during neoadjuvant treatment\u2014100% did not achieve pCR. These findings could provide clinicians with a critical window to adjust treatment strategies prior to surgery. Post-surgery, the test achieved a 100% negative predictive value (NPV) and 100% specificity for disease relapse.<\/p>\n

\n“The data presented at AACR confirm ultrasensitive ctDNA detection with NeXT Personal as a promising therapy monitoring tool in neoadjuvant colorectal cancer treatment,\u201d said Dr. Richard Chen, President and Chief Medical Officer at Personalis. “By measuring molecular response with high resolution, we are providing the tools needed to explore ctDNA-guided management of colorectal cancer patients receiving neoadjuvant therapy.”<\/p>\n

Ultrasensitivity in Real-World Data.<\/b> In a large-scale analysis of nearly 25,000 plasma samples from 10,000 real-world patients<\/b>, NeXT Personal demonstrated consistent ultrasensitive performance with a median limit of detection of 1.92 PPM. The study also revealed that 39% of all positive MRD detections occurred in the ultrasensitive range below 100 PPM, with 14.6% below 10 PPM\u2014detections that could be missed with less sensitive assays. This study also highlights the robust ultrasensitive performance of the NeXT Personal assay in real-world testing conditions across more than 14 cancer types, stage I-IV disease, and a variety of challenging sample types.<\/p>\n

Innovation in Therapy Resistance Tracking.<\/b> Personalis also debuted analytical validation and real-world data for a new opt-in feature of its NeXT Personal MRD test: Real-Time Variant Tracker\u2122<\/b>. This feature allows for the simultaneous monitoring of MRD and the longitudinal tracking of specific resistance-associated mutations, such as ESR1. With a specificity of >99.9%, resistance and other clinical mutations were identified in 38% of MRD-positive patients across the real-world cohort, offering a new tool for tracking treatment resistance as it emerges.<\/p>\n

Monitoring Immunotherapy Response in NSCLC.<\/b> The DARWIN 2<\/b> study results in metastatic non-small cell lung cancer (NSCLC) demonstrated NeXT Personal\u2019s ability to stratify risk in patients receiving immunotherapy. Patients who achieved a durable molecular complete response (dmCR) remained 100% progression-free at three years, whereas patients who failed to achieve molecular clearance were five times more likely to experience disease progression.<\/p>\n

\nTogether, these studies illustrate Personalis\u2019 commitment to improving cancer management through ultrasensitive MRD testing throughout the patient journey.<\/p>\n

About Personalis, Inc.<\/b><\/p>\n

\nAt Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care throughout the patient journey. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. To learn more, visit www.personalis.com<\/a> and connect with us on LinkedIn and X (Twitter).<\/p>\n

Forward-Looking Statements<\/b><\/p>\n

\nThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include all statements that are not historical facts and can generally be identified by terms such as \u201cbelieve,\u201d \u201cexpect,\u201d \u201cif,\u201d \u201cmay,\u201d \u201cwill\u201d or similar expressions. These statements include those relating to: the use, clinical impact or real-world clinical performance of NeXT Personal, the ability of NeXT Personal or the Real-Time Variant Tracker feature to inform cancer monitoring or patient management, predict or track therapy response, detect resistance or other clinical mutations, predict relapse, or predict or impact patient outcomes. Such forward-looking statements involve known and unknown risks and uncertainties and other factors that may cause actual results to differ materially from any anticipated results or expectations expressed or implied by such statements, including the risks, uncertainties and other factors that relate to Personalis\u2019 ability to demonstrate attributes, advantages or clinical validity or utility of the NeXT Personal test and the Real-Time Variant Tracker option, including the NeXT Personal MRD assay remaining unique in its ability to detect traces of cancer in the ultrasensitive range and its ability to monitor mutations; future clinical data differing from the clinical data previously presented or expected results; the rate of adoption and use of the NeXT Personal test; changes in health care policy, which could increase Personalis\u2019 costs, decrease Personalis\u2019 revenue, and impact sales of and reimbursement for Personalis\u2019 tests; the impact of competition and macroeconomic factors on Personalis\u2019 business; the partnering and\/or collaboration arrangements that Personalis has entered into or may enter into in the future may not be successful, or may terminate, which could adversely impact Personalis\u2019 business or affect its ability to develop and commercialize its services and products; having a limited number of suppliers; and customer concentration. These and other potential risks and uncertainties that could cause actual results to differ materially from the results predicted in these forward-looking statements are described under the captions \u201cRisk Factors\u201d and \u201cManagement\u2019s Discussion and Analysis of Financial Condition and Results of Operations\u201d in Personalis\u2019 Annual Report on Form 10-K for the year ended December 31, 2025, filed with the Securities and Exchange Commission on February 26, 2026. All information provided in this release is as of the date of this press release, and any forward-looking statements contained herein are based on assumptions that we believe to be reasonable as of this date. Undue reliance should not be placed on the forward-looking statements in this press release, which are based on information available to us on the date hereof. Personalis undertakes no duty to update this information unless required by law.<\/p>\n

\nNot affiliated with or endorsed by AACR.<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20260421790003\/en\/<\/a><\/span><\/p>\n

Investors:
\n<\/b>
Caroline Corner
\n
investors@personalis.com
\n<\/a>
415-202-5678<\/p>\n

Media Contact:
\n<\/b>
pr@personalis.com<\/a><\/p>\n

KEYWORDS:<\/b> California United States North America<\/p>\n

INDUSTRY KEYWORDS:<\/b> Oncology Health Genetics Clinical Trials Pharmaceutical Biotechnology<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
Logo<\/b><\/font><\/td>\n<\/tr>\n
\"Logo\"<\/td>\n<\/tr>\n
<\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Personalis Highlights Clinical Impact of Ultrasensitive ctDNA Monitoring and New Therapy Resistance Tracking at AACR 2026 Podium presentation on NeXT Personal\u00ae monitoring neoadjuvant therapy in colorectal cancer; Real-world data from 10,000 patients reinforce industry-leading sensitivity; Data presented for a new NeXT Personal feature for monitoring resistance mutations FREMONT, Calif.–(BUSINESS WIRE)– Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for precision oncology, today announced the successful presentation of clinical data at the American Association for Cancer Research (AACR) Annual Meeting. The data, spanning one oral podium presentation and three posters, underscore the use of the NeXT Personal ultrasensitive ctDNA assay in monitoring treatment response, identifying early recurrence, and tracking the emergence of therapy resistance. Neoadjuvant Monitoring in Colorectal Cancer. A … <\/p>\n

Continue reading “Personalis Highlights Clinical Impact of Ultrasensitive ctDNA Monitoring and New Therapy Resistance Tracking at AACR 2026”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-953132","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nPersonalis Highlights Clinical Impact of Ultrasensitive ctDNA Monitoring and New Therapy Resistance Tracking at AACR 2026 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-highlights-clinical-impact-of-ultrasensitive-ctdna-monitoring-and-new-therapy-resistance-tracking-at-aacr-2026\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Personalis Highlights Clinical Impact of Ultrasensitive ctDNA Monitoring and New Therapy Resistance Tracking at AACR 2026 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Personalis Highlights Clinical Impact of Ultrasensitive ctDNA Monitoring and New Therapy Resistance Tracking at AACR 2026 Podium presentation on NeXT Personal\u00ae monitoring neoadjuvant therapy in colorectal cancer; Real-world data from 10,000 patients reinforce industry-leading sensitivity; Data presented for a new NeXT Personal feature for monitoring resistance mutations FREMONT, Calif.–(BUSINESS WIRE)– Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for precision oncology, today announced the successful presentation of clinical data at the American Association for Cancer Research (AACR) Annual Meeting. The data, spanning one oral podium presentation and three posters, underscore the use of the NeXT Personal ultrasensitive ctDNA assay in monitoring treatment response, identifying early recurrence, and tracking the emergence of therapy resistance. Neoadjuvant Monitoring in Colorectal Cancer. 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(Nasdaq: PSNL), a leader in advanced genomics for precision oncology, today announced the successful presentation of clinical data at the American Association for Cancer Research (AACR) Annual Meeting. The data, spanning one oral podium presentation and three posters, underscore the use of the NeXT Personal ultrasensitive ctDNA assay in monitoring treatment response, identifying early recurrence, and tracking the emergence of therapy resistance. Neoadjuvant Monitoring in Colorectal Cancer. 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