{"id":950637,"date":"2026-04-13T06:03:06","date_gmt":"2026-04-13T10:03:06","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026\/"},"modified":"2026-04-13T06:03:06","modified_gmt":"2026-04-13T10:03:06","slug":"personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026\/","title":{"rendered":"Personalis and Collaborators to Highlight Ultrasensitive ctDNA Data and New Therapy Resistance Tracking Capabilities at AACR 2026"},"content":{"rendered":"

<\/p>\n

Personalis and Collaborators to Highlight Ultrasensitive ctDNA Data and New Therapy Resistance Tracking Capabilities at AACR 2026<\/b><\/p>\n

Oral podium presentation to highlight NeXT Personal<\/i>\u00ae<\/sup> in colorectal cancer; Personalis to debut first data for Real-Time Variant Tracker<\/i>\u2122<\/sup><\/i> to monitor therapy resistance during NeXT Personal MRD testing<\/i><\/p>\n

FREMONT, Calif.–(BUSINESS WIRE<\/a>)–Personalis, Inc<\/a>. (Nasdaq: PSNL), a leader in advanced genomics for precision oncology, announced today that an oral podium presentation featuring colorectal cancer data for the company\u2019s NeXT Personal ultrasensitive ctDNA assay and three posters will be presented at the American Association for Cancer Research (AACR) Annual Meeting April 17-22, 2026, in San Diego, California.<\/p>\n

\nA focus of this year\u2019s data is the introduction of a new NeXT Personal MRD test option, Real-Time Variant Tracker<\/b>, a first-of-its-kind feature in tumor-informed clinical MRD testing, designed to longitudinally track therapy resistance mutations.<\/p>\n

\n“We are thrilled to present the first NeXT Personal data on the Real-Time Variant Tracker. The AACR data highlights how tracking therapy resistance mutations like ESR1 during MRD testing has the potential to inform patient management once cancer recurrence is detected,” said Dr. Richard Chen, President and Chief Medical Officer at Personalis. \u201cIn addition, the data presented at AACR further reinforces that ultrasensitive ctDNA detection with NeXT Personal can impact how colorectal cancer is monitored and managed. Both of these studies are examples of our unwavering commitment to innovation to drive better outcomes for patients.”<\/p>\n

\nPresentations at AACR highlighting the use and clinical impact of the ultrasensitive NeXT Personal MRD test include:<\/p>\n

Oral Podium Presentation<\/b>: Neoadjuvant pembrolizumab stratified by tumor mutation burden in high-risk stage II-III dMMR\/MSI colorectal cancer (NEOPRISM-CRC): Perioperative ultrasensitive ctDNA monitoring and tumor-infiltrating TCR repertoire for treatment response prediction.
\n
Focus: <\/b>Highlights the ultrasensitive ctDNA detection of NeXT Personal for predicting and tracking response to neoadjuvant immunotherapy in CRC patients.
\n
Time:<\/b> April 20, 2026, 2:35 PM\u20132:45 PM
\n
Location:<\/b> Room Hall H – Ground Level<\/p>\n

Poster Presentation:<\/b> Monitoring ESR1 and other mutations linked to resistance with a tumor-informed MRD test: Analytical validation and real world data.
\n
Focus:<\/b> Presents the analytical validation and real-world case studies of the new Real-Time Variant Tracker feature of NeXT Personal enabling detection of resistance and other clinical mutations during MRD testing.
\n
Time:<\/b> April 20, 2026, 9:00 AM\u201312:00 PM
\n
Location:<\/b> Section 46, Poster #2588<\/p>\n

Poster Presentation: <\/b>Enhancing MRD detection through an ultrasensitive ctDNA test: Insights from real-world clinical data.
\n
Focus: <\/b>A deep analysis of the real-world clinical performance of NeXT Personal across a large patient cohort. The data highlights the ability for NeXT Personal to consistently achieve ultrasensitive ctDNA detection levels below 100 parts per million (ppm) and 10 ppm, across a diverse set of solid tumor types, stages, and challenging real-world testing conditions.
\n
Time:<\/b> April 20, 2026, 2:00 PM\u20135:00 PM
\n
Location:<\/b> Section 45, Poster #8225<\/p>\n

Poster Presentation: <\/b>Ultrasensitive ctDNA monitoring predicts early response of immunotherapy in recurrent metastatic non-small cell lung cancer.
\n
Focus: <\/b>Demonstrates the performance of NeXT Personal for predicting relapse and outcomes in advanced NSCLC patients receiving immunotherapy.
\n
Time:<\/b> April 20, 2026, 2:00 PM\u20135:00 PM
\n
Location:<\/b> Section 45, Poster #3851<\/p>\n

About Personalis, Inc.<\/b><\/p>\n

\nAt Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care throughout the patient journey. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. To learn more, visit www.personalis.com<\/a> and connect with us on LinkedIn<\/a> and X (Twitter<\/a>).<\/p>\n

Forward-Looking Statements<\/b><\/p>\n

\nThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include all statements that are not historical facts and can generally be identified by terms such as \u201cbelieve,\u201d \u201cexpect,\u201d \u201cif,\u201d \u201cmay,\u201d \u201cwill\u201d or similar expressions. These statements include those relating to: the use, clinical impact or real-world clinical performance of NeXT Personal, the ability of NeXT Personal or the Real-Time Variant Tracker feature to inform cancer monitoring or patient management, predict or track therapy response, detect resistance or other clinical mutations, predict relapse, or predict or impact patient outcomes. Such forward-looking statements involve known and unknown risks and uncertainties and other factors that may cause actual results to differ materially from any anticipated results or expectations expressed or implied by such statements, including the risks, uncertainties and other factors that relate to Personalis\u2019 ability to demonstrate attributes, advantages or clinical validity or utility of the NeXT Personal test and the Real-Time Variant Tracker option, including the NeXT Personal MRD assay remaining unique in its ability to detect traces of cancer in the ultrasensitive range and its ability to monitor mutations; future clinical data differing from the clinical data previously presented or expected results; the rate of adoption and use of the NeXT Personal test; changes in health care policy, which could increase Personalis\u2019 costs, decrease Personalis\u2019 revenue, and impact sales of and reimbursement for Personalis\u2019 tests; the impact of competition and macroeconomic factors on Personalis\u2019 business; the partnering and\/or collaboration arrangements that Personalis has entered into or may enter into in the future may not be successful, or may terminate, which could adversely impact Personalis\u2019 business or affect its ability to develop and commercialize its services and products; having a limited number of suppliers; and customer concentration. These and other potential risks and uncertainties that could cause actual results to differ materially from the results predicted in these forward-looking statements are described under the captions \u201cRisk Factors\u201d and \u201cManagement\u2019s Discussion and Analysis of Financial Condition and Results of Operations\u201d in Personalis\u2019 Annual Report on Form 10-K for the year ended December 31, 2025, filed with the Securities and Exchange Commission on February 26, 2026. All information provided in this release is as of the date of this press release, and any forward-looking statements contained herein are based on assumptions that we believe to be reasonable as of this date. Undue reliance should not be placed on the forward-looking statements in this press release, which are based on information available to us on the date hereof. Personalis undertakes no duty to update this information unless required by law.<\/p>\n

\nNot affiliated with or endorsed by AACR.<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20260413770148\/en\/<\/a><\/span><\/p>\n

Investors:
\n<\/b>
Caroline Corner
\n
investors@personalis.com
\n<\/a>
415-202-5678<\/p>\n

Media Contact
\n<\/b>
pr@personalis.com<\/a><\/p>\n

KEYWORDS:<\/b> California United States North America<\/p>\n

INDUSTRY KEYWORDS:<\/b> Oncology Health Genetics Clinical Trials Pharmaceutical Biotechnology<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
Logo<\/b><\/font><\/td>\n<\/tr>\n
\"Logo\"<\/td>\n<\/tr>\n
<\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Personalis and Collaborators to Highlight Ultrasensitive ctDNA Data and New Therapy Resistance Tracking Capabilities at AACR 2026 Oral podium presentation to highlight NeXT Personal\u00ae in colorectal cancer; Personalis to debut first data for Real-Time Variant Tracker\u2122 to monitor therapy resistance during NeXT Personal MRD testing FREMONT, Calif.–(BUSINESS WIRE)–Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for precision oncology, announced today that an oral podium presentation featuring colorectal cancer data for the company\u2019s NeXT Personal ultrasensitive ctDNA assay and three posters will be presented at the American Association for Cancer Research (AACR) Annual Meeting April 17-22, 2026, in San Diego, California. A focus of this year\u2019s data is the introduction of a new NeXT Personal MRD test option, Real-Time Variant … <\/p>\n

Continue reading “Personalis and Collaborators to Highlight Ultrasensitive ctDNA Data and New Therapy Resistance Tracking Capabilities at AACR 2026”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-950637","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nPersonalis and Collaborators to Highlight Ultrasensitive ctDNA Data and New Therapy Resistance Tracking Capabilities at AACR 2026 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Personalis and Collaborators to Highlight Ultrasensitive ctDNA Data and New Therapy Resistance Tracking Capabilities at AACR 2026 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Personalis and Collaborators to Highlight Ultrasensitive ctDNA Data and New Therapy Resistance Tracking Capabilities at AACR 2026 Oral podium presentation to highlight NeXT Personal\u00ae in colorectal cancer; Personalis to debut first data for Real-Time Variant Tracker\u2122 to monitor therapy resistance during NeXT Personal MRD testing FREMONT, Calif.–(BUSINESS WIRE)–Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for precision oncology, announced today that an oral podium presentation featuring colorectal cancer data for the company\u2019s NeXT Personal ultrasensitive ctDNA assay and three posters will be presented at the American Association for Cancer Research (AACR) Annual Meeting April 17-22, 2026, in San Diego, California. 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(Nasdaq: PSNL), a leader in advanced genomics for precision oncology, announced today that an oral podium presentation featuring colorectal cancer data for the company\u2019s NeXT Personal ultrasensitive ctDNA assay and three posters will be presented at the American Association for Cancer Research (AACR) Annual Meeting April 17-22, 2026, in San Diego, California. A focus of this year\u2019s data is the introduction of a new NeXT Personal MRD test option, Real-Time Variant … Continue reading \"Personalis and Collaborators to Highlight Ultrasensitive ctDNA Data and New Therapy Resistance Tracking Capabilities at AACR 2026\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026\/","og_site_name":"Market Newsdesk","article_published_time":"2026-04-13T10:03:06+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20260413770148r1&sid=flmnd&distro=nx&lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Personalis and Collaborators to Highlight Ultrasensitive ctDNA Data and New Therapy Resistance Tracking Capabilities at AACR 2026","datePublished":"2026-04-13T10:03:06+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026\/"},"wordCount":1098,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20260413770148r1&sid=flmnd&distro=nx&lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-and-collaborators-to-highlight-ultrasensitive-ctdna-data-and-new-therapy-resistance-tracking-capabilities-at-aacr-2026\/","name":"Personalis and Collaborators to Highlight Ultrasensitive ctDNA Data and New Therapy Resistance Tracking Capabilities at AACR 2026 - 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