{"id":945237,"date":"2026-03-18T07:03:19","date_gmt":"2026-03-18T11:03:19","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/"},"modified":"2026-03-18T07:03:19","modified_gmt":"2026-03-18T11:03:19","slug":"bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/","title":{"rendered":"Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026<\/b><\/p>\n<p>CAMBRIDGE, England &amp; BOSTON&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nBicycle Therapeutics plc (NASDAQ: BCYC), a pharmaceutical company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle<sup>\u00ae<\/sup>) technology, today announced an oral presentation and multiple poster presentations of five abstracts at the American Association for Cancer Research (AACR) Annual Meeting 2026, taking place April 17-22 in San Diego.<\/p>\n<p><b>Presentation Details:<\/b><\/p>\n<p><b>Title<\/b>: Preclinical assessment of BT5528 anti-tumor activity in cell-line-derived xenograft (CDX) models of head and neck squamous cell carcinoma (HNSCC)<br \/>\n<br \/><b>Type<\/b>: Oral Presentation<br \/>\n<br \/><b>Session:<\/b> Advanced Antibody, Conjugate, and Targeted Therapeutic Platforms<br \/>\n<br \/><b>Date and Time<\/b>: Sunday, April 19, 4:05-4:20 p.m. PT<br \/>\n<br \/><b>Abstract Number<\/b>: 1325<br \/>\n<br \/><b>Lead Author<\/b>: Lukas Stanczuk, Ph.D., Bicycle Therapeutics<\/p>\n<p><b>Title<\/b>: EphA2 expression across molecular and histological subtypes in muscle-invasive bladder cancer (MIBC) and its association with Nectin-4 and HER2<br \/>\n<br \/><b>Type<\/b>: Poster Presentation<br \/>\n<br \/><b>Session: <\/b>Clinical Research 1<br \/>\n<br \/><b>Date and Time<\/b>: Sunday, April 19, 2-5 p.m. PT<br \/>\n<br \/><b>Abstract Number<\/b>: LB012<br \/>\n<br \/><b>Lead Author<\/b>: Markus Eckstein, M.D., University Hospital Erlangen (FAU Erlangen -N\u00fcrnberg)<\/p>\n<p><b>Title<\/b>: An EphA2-targeting Bicycle Drug Conjugate (BDC), BT5528, in combination with nivolumab in patients (pts) with advanced solid tumors: results from a Phase 1\/2 study<br \/>\n<br \/><b>Type<\/b>: Poster Presentation<br \/>\n<br \/><b>Session: <\/b>First-in-Human Phase I Clinical Trials<br \/>\n<br \/><b>Date and Time<\/b>: Monday, April 20, 9 a.m.-12 p.m. PT<br \/>\n<br \/><b>Abstract Number<\/b>: CT063<br \/>\n<br \/><b>Lead Author<\/b>: Babar Bashir, M.D., Thomas Jefferson University<\/p>\n<p><b>Title<\/b>: Preclinical assessment of BT5528 anti-tumor activity in patient-derived xenograft (PDX) models of pancreatic ductal adenocarcinoma (PDAC)<br \/>\n<br \/><b>Type<\/b>: Poster Presentation<br \/>\n<br \/><b>Session: <\/b>Hematologic Malignancies and Novel Therapeutic Modalities<br \/>\n<br \/><b>Date and Time<\/b>: Tuesday, April 21, 9 a.m.-12 p.m. PT<br \/>\n<br \/><b>Abstract Number<\/b>: 4518<br \/>\n<br \/><b>Lead Author<\/b>: Lukas Stanczuk, Ph.D., Bicycle Therapeutics<\/p>\n<p><b>Title<\/b>: Development and first clinical experiences of a phage display derived bicyclic peptide for EphA2-specific PET imaging<br \/>\n<br \/><b>Type<\/b>: Poster Presentation<br \/>\n<br \/><b>Session:<\/b> Diagnostic Biomarkers 2<br \/>\n<br \/><b>Date and Time<\/b>: Tuesday, April 21, 2-5 p.m. PT<br \/>\n<br \/><b>Abstract Number<\/b>: 6520<br \/>\n<br \/><b>Lead Author<\/b>: Ann-Christin Eder, Ph.D., University of Freiberg and German Cancer Consortium (DKTK)<\/p>\n<p>\nThe presentations will be made available in the Publications section of the Bicycle Therapeutics website at the beginning of the poster session.<\/p>\n<p><b>About Bicycle Therapeutics<\/b><\/p>\n<p>\nBicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle<sup>\u00ae<\/sup> molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating nuzefatide pevedotin, formerly BT5528, a Bicycle<sup>\u00ae<\/sup> Drug Conjugate (BDC<sup>\u00ae<\/sup>) targeting EphA2, a historically undruggable target; a pipeline of other bicycle-based conjugate molecules, including Bicycle<sup>\u00ae<\/sup> Radioconjugates (BRC<sup>\u00ae<\/sup>) for radiopharmaceutical use; zelenectide pevedotin (formerly BT8009), a BDC<sup>\u00ae<\/sup> targeting Nectin-4, a well-validated tumor antigen; BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist<sup>\u00ae<\/sup> (Bicycle TICA<sup>\u00ae<\/sup>) targeting Nectin-4 and agonizing CD137; and, through various partnerships, is exploring the use of Bicycle<sup>\u00ae<\/sup> technology to develop therapies for diseases in additional therapeutic areas.<\/p>\n<p>\nBicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Mass. For more information, visit bicycletherapeutics.com.<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20260318186024r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20260318186024\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20260318186024\/en\/<\/a><\/span><\/p>\n<p><b>Investors:<br \/>\n<\/b><br \/>Matthew DeYoung<br \/>\n<br \/>Argot Partners<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:ir@bicycletx.com\">ir@bicycletx.com<br \/>\n<\/a><br \/>212-600-1902<\/p>\n<p><b>Media:<br \/>\n<\/b><br \/>Argot Partners<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:media@bicycletx.com\">media@bicycletx.com<\/a><\/p>\n<p><b>KEYWORDS:<\/b> Europe United States United Kingdom North America California Massachusetts<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Health Clinical Trials Research Pharmaceutical Science Biotechnology<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20260318186024\/en\/2750593\/3\/BCYC_Logo_2026.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026 CAMBRIDGE, England &amp; BOSTON&#8211;(BUSINESS WIRE)&#8211; Bicycle Therapeutics plc (NASDAQ: BCYC), a pharmaceutical company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle\u00ae) technology, today announced an oral presentation and multiple poster presentations of five abstracts at the American Association for Cancer Research (AACR) Annual Meeting 2026, taking place April 17-22 in San Diego. Presentation Details: Title: Preclinical assessment of BT5528 anti-tumor activity in cell-line-derived xenograft (CDX) models of head and neck squamous cell carcinoma (HNSCC) Type: Oral Presentation Session: Advanced Antibody, Conjugate, and Targeted Therapeutic Platforms Date and Time: Sunday, April 19, 4:05-4:20 p.m. PT Abstract Number: 1325 Lead Author: Lukas &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-945237","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026 CAMBRIDGE, England &amp; BOSTON&#8211;(BUSINESS WIRE)&#8211; Bicycle Therapeutics plc (NASDAQ: BCYC), a pharmaceutical company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle\u00ae) technology, today announced an oral presentation and multiple poster presentations of five abstracts at the American Association for Cancer Research (AACR) Annual Meeting 2026, taking place April 17-22 in San Diego. Presentation Details: Title: Preclinical assessment of BT5528 anti-tumor activity in cell-line-derived xenograft (CDX) models of head and neck squamous cell carcinoma (HNSCC) Type: Oral Presentation Session: Advanced Antibody, Conjugate, and Targeted Therapeutic Platforms Date and Time: Sunday, April 19, 4:05-4:20 p.m. PT Abstract Number: 1325 Lead Author: Lukas &hellip; Continue reading &quot;Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-18T11:03:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20260318186024r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026\",\"datePublished\":\"2026-03-18T11:03:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\\\/\"},\"wordCount\":587,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20260318186024r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\\\/\",\"name\":\"Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026 - 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Presentation Details: Title: Preclinical assessment of BT5528 anti-tumor activity in cell-line-derived xenograft (CDX) models of head and neck squamous cell carcinoma (HNSCC) Type: Oral Presentation Session: Advanced Antibody, Conjugate, and Targeted Therapeutic Platforms Date and Time: Sunday, April 19, 4:05-4:20 p.m. PT Abstract Number: 1325 Lead Author: Lukas &hellip; Continue reading \"Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/","og_site_name":"Market Newsdesk","article_published_time":"2026-03-18T11:03:19+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20260318186024r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026","datePublished":"2026-03-18T11:03:19+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/"},"wordCount":587,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20260318186024r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/bicycle-therapeutics-announces-oral-and-poster-presentations-at-the-aacr-annual-meeting-2026\/","name":"Bicycle Therapeutics Announces Oral and Poster Presentations at the AACR Annual Meeting 2026 - 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