{"id":940978,"date":"2026-03-02T07:25:35","date_gmt":"2026-03-02T12:25:35","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/"},"modified":"2026-03-02T07:25:35","modified_gmt":"2026-03-02T12:25:35","slug":"novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/","title":{"rendered":"Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>Novocure Announces Optune Lua<sup>\u00ae<\/sup> Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer<\/b><\/p>\n<p class=\"bwalignc\"><i>Novocure to launch Optune Lua in Japan with national reimbursement coverage<\/i><\/p>\n<p>BAAR, Switzerland&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nNovocure (NASDAQ: NVCR) announced today that Japan\u2019s Ministry of Health, Labour and Welfare approved reimbursement for Optune Lua<sup>\u00ae<\/sup> through the country\u2019s National Health Insurance coverage.<\/p>\n<p>\nOptune Lua is approved in Japan for concurrent use with PD-1\/PD-L1 inhibitors in adult patients with unresectable advanced\/recurrent NSCLC who progressed on or after platinum-based chemotherapy.<\/p>\n<p>\n\u201cLung cancer remains one of the leading causes of cancer deaths in Japan. Healthcare providers and people living with this disease have an urgent need for access to approved treatment options,\u201d said Hidehito Kotani, Vice President of Asia Pacific, Novocure. \u201cThe approval by the Ministry of Health, Labour and Welfare of reimbursement for Optune Lua through Japan\u2019s National Health Insurance coverage provides patients with advanced non-small cell lung cancer access to Optune Lua as a treatment option.\u201d<\/p>\n<p>\nOptune Lua is a wearable, portable medical device that produces alternating electric fields known as Tumor Treating Fields (TTFields), which are delivered through non-invasive, wearable arrays. TTFields exert physical forces on the electrically charged components of dividing cancer cells, resulting in cancer cell death.<\/p>\n<p>\nPatients who are eligible to be treated with Optune Lua will be able to access therapy at qualified health centers.<\/p>\n<p><b>About Lung Cancer<\/b><\/p>\n<p>\nLung cancer is the most common cause of cancer-related death worldwide, and non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers.<sup>1<\/sup> It is estimated that approximately 100,000 patients are diagnosed with NSCLC each year in Japan.<sup>2<\/sup><\/p>\n<p>\nPhysicians use different combinations of surgery, radiation and pharmacological therapies to treat NSCLC, depending on the stage of the disease. Surgery, which may be curative in a subset of patients, is usually used in early stages of the disease. Since 1991, radiation with a combination of platinum-based chemotherapy drugs has been the first-line standard of care for locally advanced NSCLC. Certain immune checkpoint inhibitors, including both PD-1 and PD-L1 inhibitors, have been approved for the first-line treatment of NSCLC and the standard of care in this setting continues to evolve rapidly.<\/p>\n<p><b>About Tumor Treating Fields<\/b><\/p>\n<p>\nTumor Treating Fields (TTFields) are electric fields that exert physical forces to kill cancer cells via a variety of mechanisms. TTFields do not significantly affect healthy cells because they have different properties (including division rate, morphology, and electrical properties) than cancer cells. These multiple, distinct mechanisms work together to target and kill cancer cells. Due to these multimechanistic actions, TTFields therapy can be added to cancer treatment modalities in approved indications and demonstrates enhanced effects across solid tumor types when used with chemotherapy, radiotherapy, immune checkpoint inhibition, or targeted therapies in preclinical models. TTFields therapy provides clinical versatility that has the potential to help address treatment challenges across a range of solid tumors.<\/p>\n<p>\nTo learn more about TTFields therapy and its multifaceted effect on cancer cells, visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fnovocure.com%2Fttfields&amp;esheet=54436070&amp;newsitemid=20260302761271&amp;lan=en-US&amp;anchor=novocure.com%2Fttfields&amp;index=1&amp;md5=9afb4669a8aaebc252cda98548796610\">novocure.com\/ttfields<\/a>.<\/p>\n<p><b>About Novocure<\/b><\/p>\n<p>\nNovocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of its innovative therapy, Tumor Treating Fields. Novocure\u2019s commercialized products are approved in certain countries for the treatment of adult patients with glioblastoma, pancreatic cancer, non-small cell lung cancer, malignant pleural mesothelioma and pleural mesothelioma. Novocure has several additional ongoing or completed clinical trials exploring the use of Tumor Treating Fields therapy in the treatment of glioblastoma, non-small cell lung cancer and pancreatic cancer.<\/p>\n<p>\nNovocure\u2019s global headquarters is located in Baar, Switzerland, with U.S. headquarters located in Portsmouth, New Hampshire and research and development facilities located in Haifa, Israel. For additional information about the company, please visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.novocure.com%2F&amp;esheet=54436070&amp;newsitemid=20260302761271&amp;lan=en-US&amp;anchor=Novocure.com&amp;index=2&amp;md5=85721c78f26691ed74a6027766398548\">Novocure.com<\/a> and follow @Novocure on <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fnovocure-inc%2F&amp;esheet=54436070&amp;newsitemid=20260302761271&amp;lan=en-US&amp;anchor=LinkedIn&amp;index=3&amp;md5=b12d9a44d463e5843e8c92193e08a2d2\">LinkedIn<\/a> and X (Twitter).<\/p>\n<p><b>Forward-Looking Statements<\/b><\/p>\n<p>\nIn addition to historical facts or statements of current condition, this press release may contain forward-looking statements. Forward-looking statements provide Novocure\u2019s current expectations or forecasts of future events. These may include statements regarding anticipated scientific progress on its research programs, clinical study progress, development of potential products, interpretation of clinical results, prospects for regulatory approval, manufacturing development and capabilities, market prospects for its products, coverage, collections from third-party payers and other statements regarding matters that are not historical facts. You may identify some of these forward-looking statements by the use of words in the statements such as \u201canticipate,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cproject,\u201d \u201cintend,\u201d \u201cplan,\u201d \u201cbelieve\u201d or other words and terms of similar meaning. Novocure\u2019s performance and financial results could differ materially from those reflected in these forward-looking statements due to general financial, economic, environmental, regulatory and political conditions and other more specific risks and uncertainties facing Novocure such as those set forth in its Annual Report on Form 10-K filed on February 26, 2026, and subsequent flings with the U.S. Securities and Exchange Commission. Given these risks and uncertainties, any or all of these forward-looking statements may prove to be incorrect. Therefore, you should not rely on any such factors or forward-looking statements. Furthermore, Novocure does not intend to update publicly any forward-looking statement, except as required by law. Any forward-looking statements herein speak only as of the date hereof. The Private Securities Litigation Reform Act of 1995 permits this discussion.<\/p>\n<p><sup>1<\/sup> World Health Organization Lung Cancer Fact Sheet. Accessed February 27, 2026. <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Furl.us.m.mimecastprotect.com%2Fs%2FXtGNCgJDYGcNwMpkUoh9I4KkrV%3Fdomain%3Durldefense.com&amp;esheet=54436070&amp;newsitemid=20260302761271&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.who.int%2Fnews-room%2Ffact-sheets%2Fdetail%2Flung-cancer%23%3A%7E%3Atext%3DLung%2520cancer%2520is%2520the%2520leading%2520cause%2520of%2520cancer-related%2520deaths%2520worldwide&amp;index=4&amp;md5=05c5d5271334a878b4ac6a5761d61c9a\">https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/lung-cancer#:~:text=Lung%20cancer%20is%20the%20leading%20cause%20of%20cancer-related%20deaths%20worldwide<\/a>.<br \/>\n<br \/><sup>2<\/sup><a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fganjoho.jp%2Freg_stat%2Fstatistics%2Fstat%2Fcancer%2F12_lung.html%23anchor1&amp;esheet=54436070&amp;newsitemid=20260302761271&amp;lan=en-US&amp;anchor=https%3A%2F%2Fganjoho.jp%2Freg_stat%2Fstatistics%2Fstat%2Fcancer%2F12_lung.html%23anchor1&amp;index=5&amp;md5=2c2fb215f8c05ba92bc682f727f1ce4f\">https:\/\/ganjoho.jp\/reg_stat\/statistics\/stat\/cancer\/12_lung.html#anchor1<\/a>. Accessed February 27, 2026.<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20260302761271r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20260302761271\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20260302761271\/en\/<\/a><\/span><\/p>\n<p><b>INVESTORS:<br \/>\n<\/b><br \/>Adam Daney<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:investorinfo@novocure.com\">investorinfo@novocure.com<\/a><\/p>\n<p><b>MEDIA:<br \/>\n<\/b><br \/>Catherine Falcetti<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:media@novocure.com\">media@novocure.com<\/a><\/p>\n<p><b>KEYWORDS:<\/b> Europe Switzerland Japan Asia Pacific<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Health Clinical Trials Research Pharmaceutical Science Biotechnology<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20260302761271\/en\/721126\/3\/novocure_main-5x.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer Novocure to launch Optune Lua in Japan with national reimbursement coverage BAAR, Switzerland&#8211;(BUSINESS WIRE)&#8211; Novocure (NASDAQ: NVCR) announced today that Japan\u2019s Ministry of Health, Labour and Welfare approved reimbursement for Optune Lua\u00ae through the country\u2019s National Health Insurance coverage. Optune Lua is approved in Japan for concurrent use with PD-1\/PD-L1 inhibitors in adult patients with unresectable advanced\/recurrent NSCLC who progressed on or after platinum-based chemotherapy. \u201cLung cancer remains one of the leading causes of cancer deaths in Japan. Healthcare providers and people living with this disease have an urgent need for access to approved treatment options,\u201d said Hidehito Kotani, Vice President of Asia &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-940978","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer Novocure to launch Optune Lua in Japan with national reimbursement coverage BAAR, Switzerland&#8211;(BUSINESS WIRE)&#8211; Novocure (NASDAQ: NVCR) announced today that Japan\u2019s Ministry of Health, Labour and Welfare approved reimbursement for Optune Lua\u00ae through the country\u2019s National Health Insurance coverage. Optune Lua is approved in Japan for concurrent use with PD-1\/PD-L1 inhibitors in adult patients with unresectable advanced\/recurrent NSCLC who progressed on or after platinum-based chemotherapy. \u201cLung cancer remains one of the leading causes of cancer deaths in Japan. Healthcare providers and people living with this disease have an urgent need for access to approved treatment options,\u201d said Hidehito Kotani, Vice President of Asia &hellip; Continue reading &quot;Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-02T12:25:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20260302761271r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer\",\"datePublished\":\"2026-03-02T12:25:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\\\/\"},\"wordCount\":973,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20260302761271r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\\\/\",\"name\":\"Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/","og_locale":"en_US","og_type":"article","og_title":"Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer - Market Newsdesk","og_description":"Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer Novocure to launch Optune Lua in Japan with national reimbursement coverage BAAR, Switzerland&#8211;(BUSINESS WIRE)&#8211; Novocure (NASDAQ: NVCR) announced today that Japan\u2019s Ministry of Health, Labour and Welfare approved reimbursement for Optune Lua\u00ae through the country\u2019s National Health Insurance coverage. Optune Lua is approved in Japan for concurrent use with PD-1\/PD-L1 inhibitors in adult patients with unresectable advanced\/recurrent NSCLC who progressed on or after platinum-based chemotherapy. \u201cLung cancer remains one of the leading causes of cancer deaths in Japan. Healthcare providers and people living with this disease have an urgent need for access to approved treatment options,\u201d said Hidehito Kotani, Vice President of Asia &hellip; Continue reading \"Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/","og_site_name":"Market Newsdesk","article_published_time":"2026-03-02T12:25:35+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20260302761271r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer","datePublished":"2026-03-02T12:25:35+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/"},"wordCount":973,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20260302761271r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/novocure-announces-optune-lua-receives-reimbursement-approval-in-japan-for-the-treatment-of-non-small-cell-lung-cancer\/","name":"Novocure Announces Optune Lua\u00ae Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer - 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