{"id":935827,"date":"2026-02-10T18:03:09","date_gmt":"2026-02-10T23:03:09","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/"},"modified":"2026-02-10T18:03:09","modified_gmt":"2026-02-10T23:03:09","slug":"upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/","title":{"rendered":"Upstream Bio to Host Webcast to Report Top-Line Results from the Phase 2 VALIANT Trial of Verekitug in Patients with Severe Asthma"},"content":{"rendered":"<h2>\n\u2013 Webcast to be held Wednesday, February 11, 2026, at 8:00 a.m. ET \u2013<br \/>\n<\/h2>\n<div class=\"mw_release\">\n<p>WALTHAM, Mass., Feb.  10, 2026  (GLOBE NEWSWIRE) &#8212; <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=qem2T2TJEIc-wvx-Yol1vW46A1N1kS632z9_6vk6Yx5U-7aOajuz-_OUlWxwXN4s-B7N5rD_rMUoLCdFLGfSrP5avn8Yx_gbmijwe7pLIaI=\" rel=\"nofollow\" target=\"_blank\"><u>Upstream Bio, Inc.<\/u><\/a> (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, today announced it will report top-line results from the Phase 2 VALIANT trial of verekitug, the only known antagonist currently in clinical development that targets and inhibits the thymic stromal lymphopoietin (TSLP) receptor, on Wednesday, February 11, 2026 at 8:00 a.m. ET.<\/p>\n<p>The VALIANT trial (NCT06196879) is a Phase 2 global, randomized, double-blind, placebo-controlled, dose-ranging, parallel group clinical trial that evaluated the safety and efficacy of verekitug for up to 60 weeks, with a minimum of 24 weeks of treatment, in 478 patients with severe asthma. Participants were randomized into one of four groups, receiving either 100 mg of verekitug every 24 weeks, 400 mg of verekitug every 24 weeks, 100 mg of verekitug every 12 weeks, or placebo, administered subcutaneously.<\/p>\n<p>\n        <strong>Webcast Information<\/strong><br \/>\n        <br \/>Upstream Bio\u2019s webcast to discuss the top-line results from the Phase 2 VALIANT trial will begin Wednesday, February 11, 2026, at 8:00 a.m. ET. The live webcast can be accessed via this <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=qgNvLx06jxmGqYZpSC4h8SnBTXLiikmJ6VHaeJnH0pn9aOWjuLHx7kVnYPr-u-S1NCr7GeVqhbgWkvBKqJyXesUxa-Cqt2uxCuZbI2VnwCg=\" rel=\"nofollow\" target=\"_blank\">link<\/a> or on the Events tab on the Investors section of the Company\u2019s website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=7nv_T9_TmTz9kVsCp4tdCMnZoVud1XxaHm8bj7WPmkX6KVgklUnKS-ZiklNwu7kJsgjZq_fxv3MMxk5B2VAVrmRPEb8lsHIbFySa3PNAMygMJwBgNXu4x_-zQloTPcKbSiXhWuSnYMG01yHG_PYgSqlxD8sZJfIc0zOYy8zPXnTHra_kAOW2RiKItrydRVxb\" rel=\"nofollow\" target=\"_blank\">https:\/\/investors.upstreambio.com\/news-events\/events<\/a>. A replay of the webcast will be available on the website following the call.<\/p>\n<p>\n        <strong>About Upstream Bio<\/strong><br \/>\n        <br \/>Upstream Bio is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The Company is developing verekitug, the only known antagonist currently in clinical development that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. The Company has advanced this highly potent monoclonal antibody into separate Phase 2 trials for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP), severe asthma, and chronic obstructive pulmonary disease (COPD). Upstream Bio\u2019s team is committed to maximizing verekitug\u2019s unique attributes to address the substantial unmet needs for patients underserved by today\u2019s standard of care. To learn more, please visit\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=F4EYhuBB7lRcVD5cmzp-JF51UP0aCA0_8_hADgFEMlc8KU3Q2BMFj_S9jKwsg7uCsCWJowFDmC6qMcCnfgwAOEKwumTbJQ5FqNkMNa92j3bX-mPs-etzsiGvQoiuceKE9eaNtMsqBl00mtKVaMJlMvrdaNeFXJXwPuEFeMNCPoY26b_D56nvxceQmhcpmnqszkUP9atz24GOvGbpPBsBvZB3mSgjrJ8mbDO8v0GsHpOve1f485yMCPsyNg8TC1_cXVO3kEzmXW1tc_tshNI5VIPsaR6zsUMSn__PJMLLGNIcHG6E0KbgrMXQcgoZ3uoYPI-Uj9-x31kM30ONqbxTO0ERdVifiCiACthbOWbSOHxrruwUKAcvOxxzGONiddm-lwgqACICo92gigCeIfV148n-jIv-J4u22Hx3lE5X1YdfZeCg4boRC8CeU1gTw-Y4Hh5RvDFIdvrZFO_8ZDlrZbc4jCH7Elzp87O995xO2GsO0sjWIjrIKzGuudzesOKylQd0LOf2Du7wlVmhCIAk86D345dFxFYseRvBwBi9Nc1tEikaydcWkh4sSEqqMPrXUiP2meXY7PoyWHBJdaU47fORChdGjJS0I2yan_XGLauLdMqo3zvG1Kw_yLxL9ABmeC6OEIc9volA7DCY6JgAixuDfrOzjCsiG1DEBisYm9rrFOChQcpM1-Do7LcDpeLZO-S2VBfSGD3lx8FOb5vTsQDbUjyBznChYI3Id-3RMAwl5LWWJSjAYZr-qC6shr5amZeySPeCXpVCtVbSkfr1pg==\" rel=\"nofollow\" target=\"_blank\"><u>www.upstreambio.com<\/u><\/a>.<\/p>\n<p>\n        <strong>Investor and Media Contact:<\/strong><br \/>\n        <br \/>Meggan Buckwell<br \/>Director, Corporate Communications and Investor Relations<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=-II9eYfL4oO2ITrlEZwP2klbjDZE1UIZ2cB35EErwbkHHD-WxfJ8MGuA5s-7BxNMQvamF_GRNbwBNISQCwAo1q5fq4d9azS2SLB2UmCmvuM=\" rel=\"nofollow\" target=\"_blank\"><u>ir@upstreambio.com<\/u><\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY1MjQ1NiM3NDE5ODkyIzIyOTI3NDE=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/YWIxODg5MGMtOGQzZC00ZDhjLTk0M2EtYjExYjVhNTc3NmZjLTEzMDQyOTEtMjAyNi0wMi0xMC1lbg==\/tiny\/Upstream-Bio.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u2013 Webcast to be held Wednesday, February 11, 2026, at 8:00 a.m. ET \u2013 WALTHAM, Mass., Feb. 10, 2026 (GLOBE NEWSWIRE) &#8212; Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, today announced it will report top-line results from the Phase 2 VALIANT trial of verekitug, the only known antagonist currently in clinical development that targets and inhibits the thymic stromal lymphopoietin (TSLP) receptor, on Wednesday, February 11, 2026 at 8:00 a.m. ET. The VALIANT trial (NCT06196879) is a Phase 2 global, randomized, double-blind, placebo-controlled, dose-ranging, parallel group clinical trial that evaluated the safety and efficacy of verekitug for up to 60 weeks, with a minimum of 24 &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Upstream Bio to Host Webcast to Report Top-Line Results from the Phase 2 VALIANT Trial of Verekitug in Patients with Severe Asthma&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-935827","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Upstream Bio to Host Webcast to Report Top-Line Results from the Phase 2 VALIANT Trial of Verekitug in Patients with Severe Asthma - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Upstream Bio to Host Webcast to Report Top-Line Results from the Phase 2 VALIANT Trial of Verekitug in Patients with Severe Asthma - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"\u2013 Webcast to be held Wednesday, February 11, 2026, at 8:00 a.m. ET \u2013 WALTHAM, Mass., Feb. 10, 2026 (GLOBE NEWSWIRE) &#8212; Upstream Bio, Inc. (Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, today announced it will report top-line results from the Phase 2 VALIANT trial of verekitug, the only known antagonist currently in clinical development that targets and inhibits the thymic stromal lymphopoietin (TSLP) receptor, on Wednesday, February 11, 2026 at 8:00 a.m. ET. The VALIANT trial (NCT06196879) is a Phase 2 global, randomized, double-blind, placebo-controlled, dose-ranging, parallel group clinical trial that evaluated the safety and efficacy of verekitug for up to 60 weeks, with a minimum of 24 &hellip; Continue reading &quot;Upstream Bio to Host Webcast to Report Top-Line Results from the Phase 2 VALIANT Trial of Verekitug in Patients with Severe Asthma&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-10T23:03:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY1MjQ1NiM3NDE5ODkyIzIyOTI3NDE=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Upstream Bio to Host Webcast to Report Top-Line Results from the Phase 2 VALIANT Trial of Verekitug in Patients with Severe Asthma\",\"datePublished\":\"2026-02-10T23:03:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\\\/\"},\"wordCount\":384,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTY1MjQ1NiM3NDE5ODkyIzIyOTI3NDE=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\\\/\",\"name\":\"Upstream Bio to Host Webcast to Report Top-Line Results from the Phase 2 VALIANT Trial of Verekitug in Patients with Severe Asthma - 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(Nasdaq: UPB), a clinical-stage company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders, today announced it will report top-line results from the Phase 2 VALIANT trial of verekitug, the only known antagonist currently in clinical development that targets and inhibits the thymic stromal lymphopoietin (TSLP) receptor, on Wednesday, February 11, 2026 at 8:00 a.m. ET. The VALIANT trial (NCT06196879) is a Phase 2 global, randomized, double-blind, placebo-controlled, dose-ranging, parallel group clinical trial that evaluated the safety and efficacy of verekitug for up to 60 weeks, with a minimum of 24 &hellip; Continue reading \"Upstream Bio to Host Webcast to Report Top-Line Results from the Phase 2 VALIANT Trial of Verekitug in Patients with Severe Asthma\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/","og_site_name":"Market Newsdesk","article_published_time":"2026-02-10T23:03:09+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY1MjQ1NiM3NDE5ODkyIzIyOTI3NDE=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Upstream Bio to Host Webcast to Report Top-Line Results from the Phase 2 VALIANT Trial of Verekitug in Patients with Severe Asthma","datePublished":"2026-02-10T23:03:09+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/"},"wordCount":384,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY1MjQ1NiM3NDE5ODkyIzIyOTI3NDE=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/upstream-bio-to-host-webcast-to-report-top-line-results-from-the-phase-2-valiant-trial-of-verekitug-in-patients-with-severe-asthma\/","name":"Upstream Bio to Host Webcast to Report Top-Line Results from the Phase 2 VALIANT Trial of Verekitug in Patients with Severe Asthma - 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