{"id":934335,"date":"2026-02-04T16:52:13","date_gmt":"2026-02-04T21:52:13","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/"},"modified":"2026-02-04T16:52:13","modified_gmt":"2026-02-04T21:52:13","slug":"tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/","title":{"rendered":"Tempest Announces Closing of Strategic Acquisition of Dual-Targeting CAR-T Assets"},"content":{"rendered":"<div class=\"mw_release\">\n<ul>\n<li style=\"text-align:left\">\n          <em>All-stock transaction brings Tempest a portfolio of <\/em><br \/>\n          <em>next-generation CAR-T assets, including TPST-2003, a clinical-stage dual-targeting CD-19\/BCMA CAR-T with strategic partner-funded BLA filing in China planned for 2027<\/em>\n        <\/li>\n<li style=\"margin-bottom:6pt\">\n          <em>Operational runway extended to mid-2027, supporting multiple potential value-generating milestones<\/em>\n        <\/li>\n<li style=\"margin-bottom:6pt;text-align:justify\">\n          <em>Matt Angel, Ph.D., joins Tempest as President and CEO<\/em>\n        <\/li>\n<li>\n          <em>Previously announced transaction closed following stockholder approval of share issuance at the 2025 Annual Meeting on January 27, 2026<\/em>\n        <\/li>\n<\/ul>\n<p align=\"justify\">BRISBANE, Calif., Feb.  04, 2026  (GLOBE NEWSWIRE) &#8212; Tempest Therapeutics, Inc. (Nasdaq: TPST) (\u201cTempest\u201d), a clinical-stage biotechnology company with a pipeline of advanced strategic therapeutic assets, today announced the closing of a previously announced transaction pursuant to which Tempest acquired certain dual-targeting chimeric antigen receptor (CAR)-T programs and obtained financing support from Factor Bioscience Inc. and its affiliates (collectively, \u201cFactor\u201d) in an all-stock transaction resulting in a diverse portfolio including clinical-stage product candidates and an extended runway with multiple potential near-term milestones (the \u201cTransaction\u201d).<\/p>\n<p align=\"justify\">\u201cI am excited to join the Tempest team and to have the opportunity to develop this innovative pipeline of potential therapies to treat a range of solid tumors and hematologic malignancies,\u201d said Dr. Matt Angel, President and Chief Executive Officer of Tempest. \u201cI look forward to advancing the company\u2019s vision of bringing important therapies to patients.\u201d<\/p>\n<p align=\"justify\">\u201cThe Board is pleased to announce the closing of this transaction, which not only provides increased financial stability for Tempest, but also the opportunity for potentially significant milestones over the next 12-18 months from both the legacy small molecule programs and the new cell therapy assets,\u201d said Stephen Brady, Chair of the Board.<\/p>\n<p align=\"justify\">\u201cAs Tempest moves into this next phase, we would like to thank Geoff Nichol and Mike Raab.\u201d Mr. Brady continued. \u201cWe are grateful for Geoff\u2019s support, engagement and inquisitive mind since he joined the Board in 2021, and wish him continued success in his endeavors. Mike Raab has been our Chair since 2018, during which time he provided clear leadership, thoughtful perspectives, and significant contributions to Tempest throughout his tenure. We are thrilled that Mike will continue to serve on the Board, bringing the ongoing benefit of his experience and guidance to the company.\u201d<\/p>\n<p align=\"justify\">Key Takeaways:<\/p>\n<ul type=\"disc\">\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">Amezalpat (TPST-1120) remains Phase 3 ready in first-line liver cancer (\u201cHCC\u201d), supported by global regulatory agreement and positive randomized Phase 2 data. Tempest plans to pursue business development discussions to advance pivotal development.<\/li>\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">TPST-2003: new dual-targeting CD19\/BCMA CAR-T asset\n<ul type=\"circle\">\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">Phase 1 complete in patients with relapsed\/refractory multiple myeloma (\u201crrMM\u201d), with data expected in 2026 and a biologics license application (\u201cBLA\u201d) in China planned for 2027<\/li>\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">Phase 1 currently enrolling patients with POEMS syndrome, with data expected in 2027 and a BLA in China planned for 2028<\/li>\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">Tempest has global rights to TPST-2003 outside of China, India, Turkey and Russia, and plans to pursue a potential registrational study in rrMM in the U.S. starting in 2027<\/li>\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">Pivotal data from the Chinese study expected to validate probability of success for the program, and rights include the right to reference data generated in support of the planned China BLA<\/li>\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">All development activities in China to be funded by strategic partner<\/li>\n<\/ul>\n<\/li>\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">Tempest expects a Phase 2 study of TPST-1495 in familial adenomatous polyposis (\u201cFAP\u201d) to enroll the first patient in Q1\u201926 and to be funded by the National Cancer Institute and operationalized by the Cancer Prevention Clinical Trials Network.<\/li>\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">Plan to continue the development of additional new preclinical and research-stage pipeline programs:\n<ul type=\"circle\">\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">TPST-2206: dual-targeting CD70\/CD70 CAR-T for renal cell carcinoma<\/li>\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">TPST-3003: allogeneic dual-targeting CD19\/BCMA<\/li>\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">TPST-3206: allogeneic dual-targeting CD70\/CD70<\/li>\n<\/ul>\n<\/li>\n<li style=\"margin-top:12pt;margin-bottom:8pt;text-align:justify\">Existing cash and an investment commitment from Factor is expected to provide a runway to mid-2027 and potentially through key data milestones.<\/li>\n<\/ul>\n<p>\n        <strong>Combined Pipeline<\/strong>\n      <\/p>\n<p \/>\n<p align=\"justify\">\n        <strong>Advisors<\/strong>\n      <\/p>\n<p align=\"justify\">MTS Health Partners, L.P.\u00a0served as financial advisor to Tempest, and\u00a0Cooley LLP served as legal advisor. In addition,\u00a0MTS Securities, LLC\u00a0(an affiliate of\u00a0MTS Health Partners, L.P.) provided an opinion to the board of directors of Tempest regarding the fairness of the purchase price to be paid by Tempest to Factor in connection with the Transaction, subject to the qualifications and limitations set forth therein. Morse, Barnes-Brown &amp; Pendleton, P.C. served as legal advisor to Factor.<\/p>\n<p>\n        <strong>About Tempest Therapeutics<\/strong>\n      <\/p>\n<p align=\"justify\">Tempest Therapeutics is a clinical-stage biotechnology company with a diverse portfolio of cell therapy and small molecule product candidates that leverage tumor-targeted and\/or immune-mediated mechanisms to potentially treat a wide range of cancers. Tempest is headquartered in Brisbane, California. More information about Tempest can be found on the company\u2019s website at https:\/\/www.tempesttx.com.<\/p>\n<p>\n        <strong>Forward-Looking Statements <\/strong>\n      <\/p>\n<p align=\"justify\">This press release contains forward-looking statements (including within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended (the \u201cSecurities Act\u201d)) concerning Tempest Therapeutics, Inc. These statements may discuss goals, intentions, and expectations as to future plans, trends, events, results of operations or financial condition, or otherwise, based on current beliefs of the management of Tempest Therapeutics, as well as assumptions made by, and information currently available to, management of Tempest Therapeutics. Forward-looking statements contained in this press release include but are not limited to statements relating to: the investment commitment and extension of Tempest Therapeutics\u2019 cash runway through mid-2027; the potential benefits of the Transaction, including the combination of the programs and ability to benefit patients; the design, initiation, progress, timing, scope and results of clinical trials, including the anticipated Phase 3 study for amezalpat and the advancement of TPST-2003; the expectation that the pivotal data from the Chinese study will validate the probability of success for TPST-2003; the anticipated China BLA; the expected Phase 2 study for TPST-1405 and the timing for first patient enrollment and the funding therefor; the planned continued development of additional new preclinical and research-stage pipeline programs; anticipated therapeutic benefit and regulatory development of Tempest Therapeutics\u2019 product candidates; and Tempest Therapeutics\u2019 ability to achieve its operational plans. Any forward-looking statements in this press release are based on Tempest Therapeutics\u2019 current expectations, estimates and projections about its industry as well as management\u2019s current beliefs and expectations of future events only as of today and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to Tempest Therapeutics\u2019 need for additional capital to fund its planned programs and operations and to continue to operate as a going concern; unexpected safety or efficacy data observed during preclinical or clinical trials; funding from the National Cancer Institute for the expected Phase 2 study of TPST-1405 may not be available at the levels anticipated, or at all, in which case Tempest Therapeutics\u2019 decision and ability to move forward with this trial will be subject to holistic program considerations and capital availability; past results may not be indicative of future results; clinical trial site activation or enrollment rates that are lower than expected; loss of key personnel; changes in expected or existing competition; changes in the regulatory environment; risks relating to volatility and uncertainty in the capital markets for biotechnology companies; and unexpected litigation or other disputes. These and other factors that may cause actual results to differ from those expressed or implied are discussed in greater detail in the \u201cRisk Factors\u201d section of Tempest\u2019s Quarterly Report on Form 10-Q for the quarter ended September 30, 2025, the \u201cRisk Factors\u201d section under Proposal 5 contained in Tempest\u2019s definitive proxy statement on Schedule 14A, filed with the Securities and Exchange Commission (\u201cSEC\u201d) on December 31, 2025, and in other documents filed by Tempest from time to time with the SEC. Except as required by applicable law, Tempest Therapeutics undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise. These forward-looking statements should not be relied upon as representing Tempest Therapeutics\u2019 views as of any date subsequent to the date of this press release and should not be relied upon as prediction of future events. In light of the foregoing, investors are urged not to rely on any forward-looking statement in reaching any conclusion or making any investment decision about any securities of Tempest Therapeutics.<\/p>\n<p>\n        <strong>Investor Contacts:<\/strong>\n      <\/p>\n<p>Sylvia Wheeler<br \/>Wheelhouse Life Science Advisors<br \/><u><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=8zo_pDympRdbLZRZdI8sO5e_w4UDBqbBQurHUZMmjAoxvakEIE5JrPCr2y718PMVBBLGMSvyhj-SuicEHDUpqSeKc8LuEOcTzZzVV9ekztHWi0Kxn4J5o_PvWHLMZ18Z\" rel=\"nofollow\" target=\"_blank\">swheeler@wheelhouselsa.com<\/a><\/u><\/p>\n<p>Aljanae Reynolds <br \/>Wheelhouse Life Science Advisors<br \/><u><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=zGAGi0dYZNpHfzJBq_Cx888QGAAX0CjyF9N-WEJSh7GE_0uQOK1-BihQonfB-bKb3HjbXn7G6Tnlcyb86pfcU9bOMbdxylP2GGvWhUCbnB6Tp0t5lru_9-jAaFzsYYFe\" rel=\"nofollow\" target=\"_blank\">areynolds@wheelhouselsa.com<\/a><\/u><\/p>\n<p>A photo accompanying this announcement is available at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=iF5zXFTJze47DSajL_w8H8JLTMNq91WqfOYYYnycqGxpbGdVXLmBSpjTn-5f5qTxEn1pV-abQp2_LuPaf-M12CDbbxS24VA9RNxf8JTT1x2CL_vETq5ZL2TrmO0AjeerqLmOxs2l8oPlWTojUcfdxXEk-_rrkb5wW_8wypIMafDtOB7th4gTO6syAusOWEHJpGe5sz9yLJfw6mG2FAzgePDTFJwGu3ZcD8GPVm73JTrjiSK1cEhsoIYJS11FcrMp4ETZ7x-rx5aRib8wCSKefQ==\" rel=\"nofollow\" target=\"_blank\">https:\/\/www.globenewswire.com\/NewsRoom\/AttachmentNg\/246ed768-1ec8-4ca2-9d36-d3ca777afad9<\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY0OTE3NCM3NDEwMjAyIzIxODk5MzQ=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/NjdjMTA0NTgtZTA4MC00YTM0LTk4NDMtZmUwNDU1MDA2ZDNiLTEyMDE0ODctMjAyNi0wMi0wNC1lbg==\/tiny\/Tempest-Therapeutics.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>All-stock transaction brings Tempest a portfolio of next-generation CAR-T assets, including TPST-2003, a clinical-stage dual-targeting CD-19\/BCMA CAR-T with strategic partner-funded BLA filing in China planned for 2027 Operational runway extended to mid-2027, supporting multiple potential value-generating milestones Matt Angel, Ph.D., joins Tempest as President and CEO Previously announced transaction closed following stockholder approval of share issuance at the 2025 Annual Meeting on January 27, 2026 BRISBANE, Calif., Feb. 04, 2026 (GLOBE NEWSWIRE) &#8212; Tempest Therapeutics, Inc. (Nasdaq: TPST) (\u201cTempest\u201d), a clinical-stage biotechnology company with a pipeline of advanced strategic therapeutic assets, today announced the closing of a previously announced transaction pursuant to which Tempest acquired certain dual-targeting chimeric antigen receptor (CAR)-T programs and obtained financing support from Factor Bioscience Inc. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Tempest Announces Closing of Strategic Acquisition of Dual-Targeting CAR-T Assets&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-934335","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Tempest Announces Closing of Strategic Acquisition of Dual-Targeting CAR-T Assets - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tempest Announces Closing of Strategic Acquisition of Dual-Targeting CAR-T Assets - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"All-stock transaction brings Tempest a portfolio of next-generation CAR-T assets, including TPST-2003, a clinical-stage dual-targeting CD-19\/BCMA CAR-T with strategic partner-funded BLA filing in China planned for 2027 Operational runway extended to mid-2027, supporting multiple potential value-generating milestones Matt Angel, Ph.D., joins Tempest as President and CEO Previously announced transaction closed following stockholder approval of share issuance at the 2025 Annual Meeting on January 27, 2026 BRISBANE, Calif., Feb. 04, 2026 (GLOBE NEWSWIRE) &#8212; Tempest Therapeutics, Inc. (Nasdaq: TPST) (\u201cTempest\u201d), a clinical-stage biotechnology company with a pipeline of advanced strategic therapeutic assets, today announced the closing of a previously announced transaction pursuant to which Tempest acquired certain dual-targeting chimeric antigen receptor (CAR)-T programs and obtained financing support from Factor Bioscience Inc. &hellip; Continue reading &quot;Tempest Announces Closing of Strategic Acquisition of Dual-Targeting CAR-T Assets&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-04T21:52:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY0OTE3NCM3NDEwMjAyIzIxODk5MzQ=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Tempest Announces Closing of Strategic Acquisition of Dual-Targeting CAR-T Assets\",\"datePublished\":\"2026-02-04T21:52:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\\\/\"},\"wordCount\":1410,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTY0OTE3NCM3NDEwMjAyIzIxODk5MzQ=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\\\/\",\"name\":\"Tempest Announces Closing of Strategic Acquisition of Dual-Targeting CAR-T Assets - 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(Nasdaq: TPST) (\u201cTempest\u201d), a clinical-stage biotechnology company with a pipeline of advanced strategic therapeutic assets, today announced the closing of a previously announced transaction pursuant to which Tempest acquired certain dual-targeting chimeric antigen receptor (CAR)-T programs and obtained financing support from Factor Bioscience Inc. &hellip; Continue reading \"Tempest Announces Closing of Strategic Acquisition of Dual-Targeting CAR-T Assets\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/","og_site_name":"Market Newsdesk","article_published_time":"2026-02-04T21:52:13+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY0OTE3NCM3NDEwMjAyIzIxODk5MzQ=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Tempest Announces Closing of Strategic Acquisition of Dual-Targeting CAR-T Assets","datePublished":"2026-02-04T21:52:13+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/"},"wordCount":1410,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTY0OTE3NCM3NDEwMjAyIzIxODk5MzQ=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/tempest-announces-closing-of-strategic-acquisition-of-dual-targeting-car-t-assets\/","name":"Tempest Announces Closing of Strategic Acquisition of Dual-Targeting CAR-T Assets - 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