{"id":927710,"date":"2026-01-15T10:42:32","date_gmt":"2026-01-15T15:42:32","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/"},"modified":"2026-01-15T10:42:32","modified_gmt":"2026-01-15T15:42:32","slug":"n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/","title":{"rendered":"N2OFF:\u00a0MitoCareX Bio Spotlights Co-Founder&#8217;s Pioneering Research on Mitochondrial Carriers in Spaceflight Stress Conditions"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"justify\">Neve Yarak, Israel, Jan.  15, 2026  (GLOBE NEWSWIRE) &#8212; N2OFF, Inc. (NASDAQ: NITO) (\u201cN2OFF\u201d and the \u201cCompany\u201d), a drug discovery company that is also investing in solar energy assets based on the <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=opp6UA0l6Ov5friJUWSw0JG1hYO05sHtFw6xf51oPRT9vg4EYOQYSwyx9fsoVF6KwluMHaumpHfo1Lp_ALOF33ODW0cWdfka2jCbHS6bPeaphbH4DwarLuann2P4wfslfgPoKuTit7HZ3seRdF0xlDBztFyRaxSzD7Mw2Wkxa7I=\" rel=\"nofollow\" target=\"_blank\"><u>RTB (Ready to Build)<\/u><\/a> business model, today highlighted a newly published peer-reviewed study co-authored by Prof. Ciro Leonardo Pierri, co-founder of MitoCareX Bio Ltd. (\u201cMitoCareX Bio\u201d), N2OFF\u2019s wholly-owned subsidiary. The article, appearing in the Journal of Translational Medicine, investigates SLC25A mitochondrial carriers as potential biomarkers and therapeutic targets for dysfunctions induced by spaceflight conditions, including microgravity and cosmic radiation.<\/p>\n<p align=\"justify\">The study, titled \u201cSLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP\/ATP carrier (AAC3) as a structural case study,\u201d was published online on December 30, 2025 (DOI: 10.1186\/s12967-025-07505-z). The work integrates transcriptomic data from NASA&#8217;s Open Science Data Repository (OSDR), examining the expression of 53 SLC25A genes in osteocytes, human bone marrow-derived mesenchymal stem cells (hBMSCs), and mouse brain tissue exposed to microgravity and spaceflight-related stressors.<\/p>\n<p align=\"justify\">The analysis identified differential regulation of multiple SLC25A carriers under spaceflight conditions, supporting their potential utility as biomarkers of mitochondrial and metabolic dysfunction.<\/p>\n<p align=\"justify\">The ADP\/ATP carrier AAC3 was further examined as a structural case study, based on comparative modeling and structure\u2013function analyses to illustrate how carrier conformational features may be targeted to rescue mitochondrial bioenergetics under stress.<\/p>\n<p align=\"justify\">While this independent academic research\u2014conducted in collaboration with the University of Bari \u201cAldo Moro\u201d and the University of Pittsburgh\u2014was not performed under MitoCareX Bio&#8217;s auspices, it directly aligns with the Company&#8217;s core scientific focus on mitochondrial carrier biology. MitoCareX Bio applies proprietary computational approaches, including the MITOLINE<sup>\u2122<\/sup> algorithm, to model and virtually screen small-molecule modulators targeting the SLC25A family of mitochondrial carriers. These proteins, central to cellular energy metabolism, play critical roles in tumor metabolic adaptation and therapy resistance in hard-to-treat cancers, such as pancreatic and non-small cell lung cancer, and are also implicated in rare inherited disorders associated with neuromuscular degeneration, which share mechanistic similarities with physiologicl alterations observed in astronauts.<\/p>\n<p align=\"justify\">Prof. Ciro Leonardo Pierri&#8217;s expertise in structural biology, mitochondrial carrier modeling, and drug targeting\u2014demonstrated through his contributions to this and other related publications\u2014underpins the foundational science driving MitoCareX Bio&#8217;s precision oncology pipeline.<\/p>\n<p align=\"justify\">The full article is available open access at: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=qLRnYjlCzgZ7Xj2WWy6fIgYjglB-z9jca2F4ibylCvgwPlgNOPCsNo6qXkGihAKzhaor4FONfkH1UaWMiDOKoFGAt-Xbv6U53EsHmVv3LKQlsR0DVY-KUoYR2CrXlih9Ld3LgUQQEU3URupzn-X7TA==\" rel=\"nofollow\" target=\"_blank\">https:\/\/doi.org\/10.1186\/s12967-025-07505-z<\/a>.<br \/><b><br \/>About N2OFF Inc:<\/b><\/p>\n<p align=\"justify\">N2OFF owns 100% of<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=cUgwsE_CQONUPgMAkNCKZOm4ey4u3_H4SxiwckxOUwuASdAEjJfaC_ZO3AbYFyqz8nIXUoVWd4sem3bfxWO2Qq-j2q6pRh0rgPelWOOIKP4=\" rel=\"nofollow\" target=\"_blank\"> MitoCareX Bio Ltd<\/a>, a drug delivery company engaged in drug discovery targeting cancer therapeutics and other diseases through the mitochondrial SLC25 protein family. Additionally, N2OFF adopted an investment strategy focused on European renewable energy assets utilizing a <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=opp6UA0l6Ov5friJUWSw0CPDoyC_2ychk6dpeGuj7xiIKKcizSggqL86gcSFOcFygw0FPOeBT6pktLfxsnvdvgQ9iZIOztwbxAtoUBri7pPrAVbuixTfYYUY2EvRRzNSf4aIyxoMbBX6_st3Ltntq5AE34VjfZRFB6dpLFXGbz0=\" rel=\"nofollow\" target=\"_blank\"><u>RTB (Ready to Build )<\/u><\/a> business model. The Company is currently the lead investor in four solar projects across three European Union countries, all introduced by Solterra Renewable Energy Ltd., a wholly owned subsidiary of Solterra Energy Ltd<\/p>\n<p align=\"justify\">N2OFF also controls approximately 98% of Save Foods Ltd., an Israeli company focused on post-harvest treatment technologies designed to reduce pathogen contamination in fruits and vegetables.<\/p>\n<p align=\"justify\">For more information, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=hdSj-0lSDpYyYUWEL0Ptyd9y5dEUIDfENmotnqb9KIgYFH_vvPHisOkjaoZSprGEMnfSYLQUGGrvkhfOJWt7OA==\" rel=\"nofollow\" target=\"_new\"><u>www.n2off.com<\/u><\/a>.<\/p>\n<p align=\"justify\">\n        <b>Forward-looking Statements:<\/b>\n      <\/p>\n<p align=\"justify\">This press release contains forward-looking statements within the meaning of the \u201csafe harbor\u201d provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. Words such as \u201cexpects,\u201d \u201canticipates,\u201d \u201cintends,\u201d \u201cplans,\u201d \u201cbelieves,\u201d \u201cseeks,\u201d \u201cestimates\u201d and similar expressions or variations of such words are intended to identify forward-looking statements. Forward-looking statements in this communication may include, among other things, statements about N2OFF\u2019s strategic and business plans, technology, relationships, objectives and expectations for its business, the impact of trends on and interest in its business, intellectual property or products and its future results, operations and financial performance and condition. Because such statements deal with future events and are based on our current expectations, they are subject to various risks and uncertainties. Actual results, performance or achievements could differ materially from those described in or implied by the statements in this press release. The forward-looking statements contained or implied in this press release are subject to other risks and uncertainties, including market conditions as well as those discussed under the heading \u201cRisk Factors\u201d in N2OFF\u2019s Annual Report on Form 10-K filed with the SEC on March 31, 2025, and in any subsequent filings with the SEC. Except as otherwise required by law, we undertake no obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. We are not responsible for the contents of third-party websites.<\/p>\n<p align=\"justify\">Investor Relations Contact:<br \/>Michal Efraty<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=6xPGLPp1too26XBjuhge-RtfgO5rvvZHWIlmrl2c7zki2lF2QR3IgiKgwBQ2reX4k9raCVbAyenPNXsqaTNbbKAGzZ4H8-_TuYGtIT0gsE0=\" rel=\"nofollow\" target=\"_blank\"><u>michal@efraty.com<\/u><\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTYyNjQzNSM3MzYzNTM1IzUwMDA1MzY2Ng==\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/NmEyMTYxMTMtYzM1MC00YTdkLWI0NjgtZGY2N2ExNWQ3NTQ4LTUwMDA1MzY2Ni0yMDI2LTAxLTE1LWVu\/tiny\/N2OFF-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Neve Yarak, Israel, Jan. 15, 2026 (GLOBE NEWSWIRE) &#8212; N2OFF, Inc. (NASDAQ: NITO) (\u201cN2OFF\u201d and the \u201cCompany\u201d), a drug discovery company that is also investing in solar energy assets based on the RTB (Ready to Build) business model, today highlighted a newly published peer-reviewed study co-authored by Prof. Ciro Leonardo Pierri, co-founder of MitoCareX Bio Ltd. (\u201cMitoCareX Bio\u201d), N2OFF\u2019s wholly-owned subsidiary. The article, appearing in the Journal of Translational Medicine, investigates SLC25A mitochondrial carriers as potential biomarkers and therapeutic targets for dysfunctions induced by spaceflight conditions, including microgravity and cosmic radiation. The study, titled \u201cSLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP\/ATP carrier (AAC3) as a structural case study,\u201d was published online on December 30, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;N2OFF:\u00a0MitoCareX Bio Spotlights Co-Founder&#8217;s Pioneering Research on Mitochondrial Carriers in Spaceflight Stress Conditions&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-927710","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>N2OFF:\u00a0MitoCareX Bio Spotlights Co-Founder&#039;s Pioneering Research on Mitochondrial Carriers in Spaceflight Stress Conditions - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"N2OFF:\u00a0MitoCareX Bio Spotlights Co-Founder&#039;s Pioneering Research on Mitochondrial Carriers in Spaceflight Stress Conditions - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Neve Yarak, Israel, Jan. 15, 2026 (GLOBE NEWSWIRE) &#8212; N2OFF, Inc. (NASDAQ: NITO) (\u201cN2OFF\u201d and the \u201cCompany\u201d), a drug discovery company that is also investing in solar energy assets based on the RTB (Ready to Build) business model, today highlighted a newly published peer-reviewed study co-authored by Prof. Ciro Leonardo Pierri, co-founder of MitoCareX Bio Ltd. (\u201cMitoCareX Bio\u201d), N2OFF\u2019s wholly-owned subsidiary. The article, appearing in the Journal of Translational Medicine, investigates SLC25A mitochondrial carriers as potential biomarkers and therapeutic targets for dysfunctions induced by spaceflight conditions, including microgravity and cosmic radiation. The study, titled \u201cSLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP\/ATP carrier (AAC3) as a structural case study,\u201d was published online on December 30, &hellip; Continue reading &quot;N2OFF:\u00a0MitoCareX Bio Spotlights Co-Founder&#8217;s Pioneering Research on Mitochondrial Carriers in Spaceflight Stress Conditions&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-15T15:42:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTYyNjQzNSM3MzYzNTM1IzUwMDA1MzY2Ng==\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"N2OFF:\u00a0MitoCareX Bio Spotlights Co-Founder&#8217;s Pioneering Research on Mitochondrial Carriers in Spaceflight Stress Conditions\",\"datePublished\":\"2026-01-15T15:42:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\\\/\"},\"wordCount\":805,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTYyNjQzNSM3MzYzNTM1IzUwMDA1MzY2Ng==\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\\\/\",\"name\":\"N2OFF:\u00a0MitoCareX Bio Spotlights Co-Founder's Pioneering Research on Mitochondrial Carriers in Spaceflight Stress Conditions - 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(NASDAQ: NITO) (\u201cN2OFF\u201d and the \u201cCompany\u201d), a drug discovery company that is also investing in solar energy assets based on the RTB (Ready to Build) business model, today highlighted a newly published peer-reviewed study co-authored by Prof. Ciro Leonardo Pierri, co-founder of MitoCareX Bio Ltd. (\u201cMitoCareX Bio\u201d), N2OFF\u2019s wholly-owned subsidiary. The article, appearing in the Journal of Translational Medicine, investigates SLC25A mitochondrial carriers as potential biomarkers and therapeutic targets for dysfunctions induced by spaceflight conditions, including microgravity and cosmic radiation. The study, titled \u201cSLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP\/ATP carrier (AAC3) as a structural case study,\u201d was published online on December 30, &hellip; Continue reading \"N2OFF:\u00a0MitoCareX Bio Spotlights Co-Founder&#8217;s Pioneering Research on Mitochondrial Carriers in Spaceflight Stress Conditions\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/","og_site_name":"Market Newsdesk","article_published_time":"2026-01-15T15:42:32+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTYyNjQzNSM3MzYzNTM1IzUwMDA1MzY2Ng==","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"N2OFF:\u00a0MitoCareX Bio Spotlights Co-Founder&#8217;s Pioneering Research on Mitochondrial Carriers in Spaceflight Stress Conditions","datePublished":"2026-01-15T15:42:32+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/"},"wordCount":805,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTYyNjQzNSM3MzYzNTM1IzUwMDA1MzY2Ng==","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/n2off-mitocarex-bio-spotlights-co-founders-pioneering-research-on-mitochondrial-carriers-in-spaceflight-stress-conditions\/","name":"N2OFF:\u00a0MitoCareX Bio Spotlights Co-Founder's Pioneering Research on Mitochondrial Carriers in Spaceflight Stress Conditions - 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