{"id":915455,"date":"2025-12-02T17:09:27","date_gmt":"2025-12-02T22:09:27","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/jazz-pharmaceuticals-to-present-pivotal-phase-3-results-of-ziihera-zanidatamab-hrii-combinations-in-first-line-her2-positive-locally-advanced-or-metastatic-gastroesophageal-adenocarcinoma-at-t\/"},"modified":"2025-12-02T17:09:27","modified_gmt":"2025-12-02T22:09:27","slug":"jazz-pharmaceuticals-to-present-pivotal-phase-3-results-of-ziihera-zanidatamab-hrii-combinations-in-first-line-her2-positive-locally-advanced-or-metastatic-gastroesophageal-adenocarcinoma-at-t","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/jazz-pharmaceuticals-to-present-pivotal-phase-3-results-of-ziihera-zanidatamab-hrii-combinations-in-first-line-her2-positive-locally-advanced-or-metastatic-gastroesophageal-adenocarcinoma-at-t\/","title":{"rendered":"Jazz Pharmaceuticals to Present Pivotal Phase 3 Results of Ziihera\u00ae (zanidatamab-hrii) Combinations in First-Line HER2-Positive Locally Advanced or Metastatic Gastroesophageal Adenocarcinoma at the 2026 ASCO Gastrointestinal Cancers Symposium"},"content":{"rendered":"
\n

PR Newswire<\/p>\n<\/p><\/div>\n

\n

\n Late-breaking HERIZON-GEA-01 presentation highlights the expanding clinical profile of Ziihera across HER2-driven gastrointestinal cancers<\/i>\n <\/p>\n

\n Jazz to host investor webcast on\u00a0Friday, January 9, 2026,\u00a0to review data<\/i>\n <\/p>\n

\n For U.S. media and investors only<\/i>\n <\/p>\n

\n
\n DUBLIN<\/span>
\n <\/span>, Dec. 2, 2025<\/span><\/span> \/PRNewswire\/ —\u00a0Jazz Pharmaceuticals plc\u00a0(Nasdaq: JAZZ) today announced two abstracts featuring key data for Ziihera\u00ae<\/sup><\/i> (zanidatamab-hrii) have been accepted for presentation at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO GI) from January 8-10, 2026<\/span>, in San Francisco<\/span>. The Phase 3 HERIZON-GEA-01 trial results in\u00a0first-line HER2-positive (HER2+) locally advanced or metastatic gastroesophageal adenocarcinoma (GEA) were accepted as a late-breaking presentation. Additionally, a new post-hoc overall survival (OS) analysis from the HERIZON-BTC-01 Phase 2b<\/span> trial in\u00a0previously treated HER2+ biliary tract cancer (BTC) will be presented, providing further information for this approved indication.<\/p>\n

“We look forward to sharing the clinically meaningful results from the Phase 3 HERIZON-GEA-01 trial with the oncology community at ASCO GI,” said Rob Iannone<\/span>, M.D., M.S.C.E., executive vice president, global head of research and development, and chief medical officer of Jazz Pharmaceuticals. “Advanced HER2+ GEA, which includes cancers of the stomach, gastroesophageal junction and esophagus, remains an aggressive cancer with a poor prognosis and continues to be an area with limited progress for patients. This trial was designed to evaluate whether Ziihera<\/i> plus chemotherapy, with or without tislelizumab, could improve on the current standard of care in first-line therapy. We believe these positive results support Ziihera <\/i>as the HER2-targeted agent-of-choice and the Ziihera <\/i>combinations to become the new standard of care for patients with HER2+ first-line metastatic GEA regardless of PD-L1 status. Alongside new analyses from the HERIZON-BTC-01 Phase 2b<\/span> trial, these presentations highlight the continued impact of our broad zanidatamab clinical program and our commitment to advancing innovation across HER2-targeted cancers.”<\/p>\n

The Phase 3 HERIZON-GEA-01 trial, conducted jointly with BeOne Medicines, is evaluating Ziihera<\/i> in combination with chemotherapy, with or without the PD-1 inhibitor Tevimbra\u00ae<\/sup>\u00a0(tislelizumab), as first-line treatment for HER2+ locally advanced or metastatic GEA. As previously announced<\/a>, both Ziihera <\/i>plus chemotherapy and Ziihera<\/i> plus tislelizumab and chemotherapy demonstrated highly statistically significant and clinically meaningful improvements in progression-free survival (PFS) compared to the control arm, trastuzumab plus chemotherapy. Ziihera <\/i>plus tislelizumab and chemotherapy also demonstrated clinically meaningful and statistically significant improvements in overall survival (OS), and Ziihera <\/i>plus chemotherapy demonstrated a clinically meaningful effect with a strong trend toward statistical significance for OS compared to the control arm at the time of this first analysis.<\/p>\n

Jazz Pharmaceuticals will host an investor webcast on Friday, January 9<\/span>, at 6:30 a.m. PT<\/span>\/ 9:30 a.m. ET<\/span> to review the Ziihera<\/i> data presented at the meeting. The webcast will include commentary from the company’s senior management and Dr. Geoffrey Ku<\/span>, Associate Attending physician on the Gastrointestinal Oncology Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center. The webcast may be accessed from the Investors section of the Jazz Pharmaceuticals website at www.jazzpharmaceuticals.com<\/a>. To ensure a timely connection, it is recommended that participants register at least 15 minutes prior to the scheduled webcast.<\/p>\n

A replay of the webcast will be available via the Investors section of the Jazz Pharmaceuticals website.<\/p>\n

Details for both presentations can be found online<\/a>\u00a0and below:<\/p>\n

\n\n\n\n\n
\n

\n
\n Presentation Title<\/b>
\n <\/span>\n <\/p>\n<\/td>\n

\n

\n
\n Authors<\/b>
\n <\/span>\n <\/p>\n<\/td>\n

\n

\n
\n Presentation Details<\/b>
\n <\/span>\n <\/p>\n<\/td>\n<\/tr>\n

\n

\n Zanidatamab (zani) +
chemotherapy
(chemo) \u00b1 tislelizumab
(tisle) for first-line (1L)
HER2-positive
(HER2+)
advanced\/metastatic
gastroesophageal
adenocarcinoma
(mGEA): first results
from the phase 3
HERIZON-GEA-01
study<\/span>\n <\/p>\n<\/td>\n

\n

\n Elena Elimova, Sun Young Rha, Kohei
Shitara, Tianshu Liu, Josep Tabernero,
Keun-Wook Lee, Michael Schenker, Niall
Tebbutt, Jaffer Ajani, Norhidayu Bt
Salimin, Geoffrey Ku, Jong Gwang Kim,
Inmaculada Ales Diaz, Jingdong Zhang,\u00a0
Filippo Pietrantonio, Li-Yuan Bai, Samuel
Le Sourd, Ye Chen, Jonathan Grim, Lin
Shen, on behalf of the HERIZON-GEA-01
study group<\/span>\n <\/p>\n<\/td>\n

\n

\n
\n Type:<\/b> Late-Breaking Abstract
Oral Presentation<\/p>\n

<\/span>\n <\/p>\n

\n
\n Session:<\/b> Oral Abstract Session
A: Cancers of the Esophagus
and Stomach<\/p>\n

<\/span>\n <\/p>\n

\n
\n Date:<\/b>\u00a0Thursday, Jan. 8, 8:57-
9:07 a.m. PST<\/p>\n

<\/span>\n <\/p>\n

\n
\n Abstract number:<\/b>\u00a0LBA285<\/span>\n <\/p>\n<\/td>\n<\/tr>\n

\n

\n Landmark analysis\u00a0of
overall survival (OS)\u00a0
by objective response
in patients (pts) with
previously treated,
advanced HER2-
positive biliary tract
cancer (BTC): post
hoc analysis of the
HERIZON-BTC-01
trial<\/span>\n <\/p>\n<\/td>\n

\n

\n James J Harding, Jia Fan, Do-Youn Oh,
Hye Jin Choi, Jin Won Kim, Heung-Moon
Chang, Lequn Bao, Hui-Chuan Sun,
Teresa Macarulla, Feng Xie, Jean-
Philippe Metges, Jie’er Ying, John
Bridgewater, Harpreet Singh Wasan,
Michel Pierre Ducreux, Zinan Bao, Phillip
M Garfin, Douglas S Fuller, Parveen
Jayia, Shubham Pant<\/span>\n <\/p>\n<\/td>\n

\n

\n
\n Type:<\/b> Poster Session<\/p>\n

<\/span>\n <\/p>\n

\n
\n Session:<\/b>\u00a0Poster Session B:
Cancers of the Pancreas, Small
Bowel, and Hepatobiliary Tract<\/p>\n

<\/span>\n <\/p>\n

\n
\n Date:\u00a0<\/b>Friday, Jan. 9, 11:30 a.m.-1:00\u00a0
p.m. PST<\/p>\n

<\/span>\n <\/p>\n

\n
\n Abstract number:<\/b>\u00a0545<\/span>\n <\/p>\n<\/td>\n<\/tr>\n<\/table><\/div>\n

The majority of abstracts accepted to ASCO GI will be released at 2:00 p.m. PT<\/span>\/ 5:00 p.m. ET<\/span> on January 5, 2026<\/span>. Late-breaking abstracts will be released at 7:00 a.m. PT<\/span> \/ 10:00 a.m. ET<\/span> on their day of presentation at the Symposium and made publicly available online at that time.<\/p>\n

\n About Gastroesophageal Adenocarcinoma\u00a0\u00a0
<\/b>GEA, including cancers of the stomach, gastroesophageal junction, and esophagus, is the fifth most common cancer worldwide, and approximately 20% of patients have HER2+ disease.1,2,3 <\/sup>HER2+ GEA has high morbidity and mortality, and patients are urgently in need of new treatment options. The overall prognosis for patients with GEA remains poor, with a global five-year survival rate of less than 30% for gastric cancer and about 19% for GEA.4<\/sup><\/p>\n

\n About Biliary Tract Cancer
<\/b>BTC, which includes gallbladder cancer and intrahepatic and extrahepatic cholangiocarcinoma, are rare and aggressive epithelial tumors often associated with poor prognosis.5,6<\/sup>\u00a0Although they account for less than 1% of all human cancers, cholangiocarcinoma is the second most common primary liver cancer after hepatocellular carcinoma and comprises approximately 10\u201315% of all primary liver cancers. Global mortality from BTC has risen in recent decades.7<\/sup><\/p>\n

Because early symptoms are often vague or nonspecific, most BTCs are diagnosed at an advanced stage,8<\/sup> when curative surgery is not an option.6,9,10<\/sup>\u00a0While chemotherapy and, more recently, immunotherapy-based combinations are used in the first-line setting, disease progression is common. In the absence of molecular profiling, treatment options following first-line therapy are largely limited to chemotherapy.7,9,11<\/sup><\/p>\n

HER2 overexpression or amplification defines a distinct molecular subtype of BTC12<\/sup> and is observed in approximately 26% of patients globally.13<\/sup> HER2-positive BTC is associated with worse prognosis than HER2-negative disease.14<\/sup> Across the U.S., Europe<\/span>, and Japan<\/span>, an estimated 12,000 people are diagnosed with HER2-positive BTC each year.15<\/sup><\/p>\n

\n About Ziihera\u00ae<\/sup>\u00a0(zanidatamab-hrii)\u00a0\u00a0<\/b>
\n
\n Ziihera<\/i>\u00a0(zanidatamab-hrii) is a bispecific HER2-directed antibody that binds to two extracellular sites on HER2. Binding of zanidatamab-hrii with HER2 results in internalization leading to a reduction in HER2 expression of the receptor on the tumor cell surface. Zanidatamab-hrii induces complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent cellular phagocytosis (ADCP). These mechanisms result in tumor growth inhibition and cell death in vitro and in vivo.16<\/sup> In the United States<\/span>, Ziihera<\/i>\u00a0is indicated for the treatment of adults with previously treated, unresectable or metastatic HER2-positive (IHC 3+) BTC, as detected by an FDA-approved test.16\u00a0The\u00a0U.S. FDA granted accelerated approval for this indication based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).16<\/sup>\u00a0<\/p>\n

Zanidatamab is being developed in multiple clinical trials as a targeted treatment option for patients with solid tumors that express HER2. Zanidatamab is being developed by\u00a0Jazz\u00a0Pharmaceuticals and BeOne Medicines under license agreements from Zymeworks Inc., which first developed the molecule.\u00a0\u00a0\u00a0<\/p>\n

The FDA granted Breakthrough Therapy designation for zanidatamab’s development in patients with previously treated HER2 gene-amplified BTC, and two\u00a0Fast Track\u00a0designations for zanidatamab: one as a single agent for refractory BTC and one in combination with standard-of-care chemotherapy for first-line GEA. Additionally, zanidatamab has received Orphan Drug designations from the FDA for the treatment of BTC and GEA, as well as Orphan Drug designation from the\u00a0European Medicines Agency\u00a0for the treatment of BTC and gastric cancer.\u00a0\u00a0\u00a0<\/p>\n

\n \u00a0Important Safety Information for ZIIHERA<\/u>\u00a0\u00a0<\/b>\u00a0<\/p>\n

\n\n\n
\n

\n \u00a0WARNING: EMBRYO-FETAL\u00a0TOXICITY\u00a0<\/b>
Exposure to\u00a0ZIIHERA during pregnancy can cause embryo-fetal harm. Advise patients\u00a0<\/b>
of the risk and need for effective contraception.\u00a0<\/b>\u00a0\u00a0<\/span>\n <\/p>\n<\/td>\n<\/tr>\n<\/table><\/div>\n

\n WARNINGS AND PRECAUTIONS\u00a0<\/b>\n <\/p>\n

\n Embryo-Fetal Toxicity
<\/b>ZIIHERA can cause fetal harm when administered to a pregnant woman. In literature reports, use of a HER2-directed antibody during pregnancy resulted in cases of oligohydramnios and oligohydramnios sequence manifesting as pulmonary hypoplasia, skeletal abnormalities, and neonatal death.\u00a0<\/p>\n

Verify the pregnancy status of females of reproductive potential prior to the initiation of ZIIHERA. Advise pregnant women and females of reproductive potential that exposure to ZIIHERA during pregnancy or within 4 months prior to conception can result in fetal harm. Advise females of reproductive potential to use effective contraception during treatment with ZIIHERA and for 4 months following the last dose of ZIIHERA.\u00a0<\/p>\n

\n Left Ventricular Dysfunction
<\/b>ZIIHERA can cause decreases in left ventricular ejection fraction (LVEF). LVEF declined by >10% and decreased to <50% in 4.3% of 233 patients. Left ventricular dysfunction (LVD) leading to permanent discontinuation of ZIIHERA was reported in 0.9% of patients. The median time to first occurrence of LVD was 5.6 months (range: 1.6 to 18.7). LVD resolved in 70% of patients.\u00a0<\/p>\n

Assess LVEF prior to initiation of ZIIHERA and at regular intervals during treatment. Withhold dose or permanently discontinue ZIIHERA based on severity of adverse reactions.\u00a0<\/p>\n

The safety of ZIIHERA has not been established in patients with a baseline ejection fraction that is below 50%.\u00a0<\/p>\n

\n Infusion-Related Reactions
<\/b>ZIIHERA can cause infusion-related reactions (IRRs). An IRR was reported in 31% of 233 patients treated with ZIIHERA as a single agent in clinical studies, including Grade 3 (0.4%), and Grade 2 (25%). IRRs leading to permanent discontinuation of ZIIHERA were reported in 0.4% of patients. IRRs occurred on the first day of dosing in 28% of patients; 97% of IRRs resolved within one day.\u00a0<\/p>\n

Prior to each dose of ZIIHERA, administer premedications to prevent potential IRRs. Monitor patients for signs and symptoms of IRR during ZIIHERA administration and as clinically indicated after completion of infusion. Have medications and emergency equipment to treat IRRs available for immediate use.\u00a0<\/p>\n

If an IRR occurs, slow, or stop the infusion, and administer appropriate medical management. Monitor patients until complete resolution of signs and symptoms before resuming. Permanently discontinue ZIIHERA in patients with recurrent severe or life-threatening IRRs.\u00a0<\/p>\n

\n Diarrhea
<\/b>ZIIHERA can cause severe diarrhea.\u00a0<\/p>\n

Diarrhea was reported in 48% of 233 patients treated in clinical studies, including Grade 3 (6%) and Grade 2 (17%). If diarrhea occurs, administer antidiarrheal treatment as clinically indicated. Perform diagnostic tests as clinically indicated to exclude other causes of diarrhea. Withhold or permanently discontinue ZIIHERA based on severity.\u00a0<\/p>\n

\n ADVERSE REACTIONS
<\/b>Serious adverse reactions occurred in 53% of 80 patients with unresectable or metastatic HER2-positive BTC who received ZIIHERA. Serious adverse reactions in >2% of patients included biliary obstruction (15%), biliary tract infection (8%), sepsis (8%), pneumonia (5%), diarrhea (3.8%), gastric obstruction (3.8%), and fatigue (2.5%). A fatal adverse reaction of hepatic failure occurred in one patient who received ZIIHERA.\u00a0<\/p>\n

The most common adverse reactions in 80 patients with unresectable or metastatic HER2-positive BTC who received ZIIHERA (\u226520%) were diarrhea (50%), infusion-related reaction (35%), abdominal pain (29%), and fatigue (24%).\u00a0<\/p>\n

\n USE IN SPECIFIC POPULATIONS\u00a0<\/b>\n <\/p>\n

\n Pediatric Use
<\/b>Safety and efficacy of ZIIHERA have not been established in pediatric patients.\u00a0<\/p>\n

\n Geriatric Use
<\/b>Of the 80 patients who received ZIIHERA for unresectable or metastatic HER2-positive BTC, there were 39 (49%) patients 65 years of age and older. Thirty-seven (46%) were aged 65-74 years old and 2 (3%) were aged 75 years or older.\u00a0<\/p>\n

No overall differences in safety or efficacy were observed between these patients and younger adult patients.\u00a0<\/p>\n

\n The full\u00a0U.S.\u00a0Prescribing Information for\u00a0ZIIHERA, including BOXED Warning, is available at:\u00a0https:\/\/pp.jazzpharma.com\/pi\/ziihera.en.USPI.pdf<\/a>\u00a0<\/b>\n <\/p>\n

\u00ae TEVIMBRA (tislelizumab)\u00a0is a registered trademark of BeOne Medicines.<\/p>\n

\n About\u00a0Jazz Pharmaceuticals<\/b>
\n
Jazz Pharmaceuticals\u00a0plc\u00a0(Nasdaq: JAZZ) is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing potentially life-changing medicines for people with serious diseases \u2014 often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in\u00a0Dublin, Ireland\u00a0with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit\u00a0www.jazzpharmaceuticals.com<\/a>\u00a0for more information.\u00a0<\/p>\n

\n Cautionary Note Concerning Forward-Looking Statements\u00a0<\/b>
\n
This press release contains forward-looking statements, including, but not limited to, statements related to the potential therapeutic benefits of Ziihera, Ziihera’s potential as a new standard of care in HER2+ first-line GEA and other HER2-expressing cancers,\u00a0 and other statements that are not historical facts. These forward-looking statements are based on\u00a0Jazz Pharmaceuticals’\u00a0current plans, objectives, estimates, expectations and intentions and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks and uncertainties associated with the successful completion of regulatory activities and uncertain regulatory approval, risks related to failure or delays in successfully initiating or completing clinical trials and assessing patients and other risks and uncertainties affecting\u00a0Jazz Pharmaceuticals\u00a0and its development programs, including those described from time to time under the caption “Risk Factors” and elsewhere in\u00a0Jazz Pharmaceuticals’s\u00a0Securities and Exchange Commission\u00a0filings and reports (Commission File No. 001-33500), including\u00a0Jazz Pharmaceuticals’\u00a0Annual Report on Form 10-K for the year ended\u00a0December 31, 2024, as supplemented by\u00a0Jazz Pharmaceuticals’\u00a0Quarterly Report on Form 10-Q for the quarter ended\u00a0September 30, 2025, and future filings and reports by\u00a0Jazz Pharmaceuticals. Other risks and uncertainties of which\u00a0Jazz Pharmaceuticals\u00a0is not currently aware may also affect\u00a0Jazz Pharmaceuticals’\u00a0forward-looking statements and may cause actual results and the timing of events to differ materially from those anticipated. The forward-looking statements herein are made only as of the date hereof or as of the dates indicated in the forward-looking statements, even if they are subsequently made available by\u00a0Jazz Pharmaceuticals\u00a0on its website or otherwise.\u00a0Jazz Pharmaceuticals\u00a0undertakes no obligation to update or supplement any forward-looking statements to reflect actual results, new information, future events, changes in its expectations or other circumstances that exist after the date as of which the forward-looking statements were made.\u00a0<\/p>\n

\n Contacts:
<\/b>
\n Media Contact:<\/b>\u00a0
Kristin Bhavnani<\/span>
Head of\u00a0Global Corporate Communications
Jazz Pharmaceuticals plc
CorporateAffairsMediaInfo@jazzpharma.com
<\/a>Ireland\u00a0+353 1 637 2141
U.S.\u00a0+1 215 867 4948<\/p>\n

\n Jazz Investor Contact:<\/b>\u00a0
Jack Spinks\u00a0
Executive Director, Investor Relations\u00a0
Jazz Pharmaceuticals plc
InvestorInfo@jazzpharma.com
<\/a>Ireland\u00a0+353 1 634 3211
U.S.\u00a0+1 650 496 2717<\/p>\n

\n References<\/b>\n <\/p>\n

\n 1<\/sup>
\n Abrahao-Machado I.F<\/span>., et al. HER2 testing in gastric cancer: An update WorldJGastroenterol. 2016;22(19):4619-4625.
2<\/sup> Van\u00a0Custem E., et al. HER2 screening data from ToGA: targeting HER2 in gastric and gastroesophageal junction cancer. Gastric Cancer. 2015;18(3):476-484.
3<\/sup> Stroes, C.I., et al. A systematic review of HER2 blockade for the curative treatment of gastroesophageal adenocarcinoma: Successes achieved and opportunities ahead. CancerTreatRev. 2021;99:102249.
4<\/sup> Battaglin F, et al. Molecular biomarkers in gastro-esophageal cancer: recent developments, current trends and future directions. Cancer Cell International. 2018;18(99).
5<\/sup> Mirallas O, L\u00f3pez-Valbuena D, Garc\u00eda-Illescas D, et al. Advances in the systemic treatment of therapeutic approaches in biliary tract cancer. ESMO Open. 2022;7(3):100503. doi:10.1016\/j.esmoop.2022.100503.
6<\/sup> Kam A, et al. Current and emerging therapies for advanced biliary tract cancers. Lancet Gastroenterol Hepatol. 2021;6(11):956-69. doi:10.1016\/S2468-1253(21)00171-0.
7<\/sup> Vogel A, Bridgewater J, Edeline J, et al. Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment, and follow-up. Ann Oncol. 2023;34(2):127-40. doi:10.1016\/j.annonc.2022.10.506.
8<\/sup> Rimassa, L., Khan, S., Koerkamp, B. G., Roessler, S.,et al. Mapping the landscape of biliary tract cancer in Europe<\/span>: challenges and controversies. The Lancet Regional Health\u2013Europe. 2025;\u00a0 50, 101171. doi.org\/10.1016\/j.lanepe.2024.101171.
9<\/sup> Chakrabarti, S., Kamgar, M., Mahipal, A. Targeted therapies in advanced biliary tract cancer: an evolving paradigm. Cancers. 2020;12(8), 2039. doi.org\/10.3390\/cancers12082039.
10<\/sup> Valle JW, Kelley RK, et al. Biliary tract cancer. Lancet. 2021;397(10272):428-44. doi:10.1016\/S0140-6736(21)00153-7.
11<\/sup>\u00a0Lamarca, A., Hubner, R. A., Ryder,\u00a0W. D., et al. Second-line chemotherapy in advanced biliary cancer: a systematic review.\u00a0Annals of Oncology<\/i>. 2025;\u00a025<\/i>(12), 2328-2338.\u00a0doi.org\/10.1093\/annonc\/mdu162<\/a>.
12<\/sup> Hechtman, J. F., Liu, W., Sadowska, J.,et al. Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of ERBB2 (HER2).\u00a0Modern Pathology<\/i>. 2015;28<\/i>(8), 1123-1129. \u00a0doi: 10.1038\/modpathol.2015.57.
13<\/sup> Galdy S, Lamarca A, et al. HER2\/HER3 pathway in biliary tract malignancies; systematic review and meta-analysis: a potential therapeutic target?\u00a0Cancer Metastas Rev<\/i>. 2017; doi: 10.1007\/s10555-016-9645-x.
14<\/sup> Vivaldi, C. HER2 overexpression as a poor prognostic determinant in resected biliary tract cancer.\u00a0Oncologist<\/i>. 2020;25(10):886-893. doi:10.1634\/theoncologist.2019-0922.
15<\/sup> Jazz Pharmaceuticals, Inc, Data on file.
16<\/sup> ZIIHERA (zanidatamab-hrii) Prescribing Information. Palo Alto, CA<\/span>: Jazz Pharmaceuticals, Inc.)<\/p>\n

\n

\n
\n \"Jazz
\n <\/a>\n <\/p>\n<\/p><\/div>\n

<\/div>\n

\n \"Cision\" View original content to download multimedia:https:\/\/www.prnewswire.com\/news-releases\/jazz-pharmaceuticals-to-present-pivotal-phase-3-results-of-ziihera-zanidatamab-hrii-combinations-in-first-line-her2-positive-locally-advanced-or-metastatic-gastroesophageal-adenocarcinoma-at-the-2026-asco-gastrointestinal-cance-302630956.html<\/a><\/p>\n

SOURCE Jazz Pharmaceuticals plc<\/p>\n<\/p><\/div>\n

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PR Newswire Late-breaking HERIZON-GEA-01 presentation highlights the expanding clinical profile of Ziihera across HER2-driven gastrointestinal cancers Jazz to host investor webcast on\u00a0Friday, January 9, 2026,\u00a0to review data For U.S. media and investors only DUBLIN , Dec. 2, 2025 \/PRNewswire\/ —\u00a0Jazz Pharmaceuticals plc\u00a0(Nasdaq: JAZZ) today announced two abstracts featuring key data for Ziihera\u00ae (zanidatamab-hrii) have been accepted for presentation at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO GI) from January 8-10, 2026, in San Francisco. The Phase 3 HERIZON-GEA-01 trial results in\u00a0first-line HER2-positive (HER2+) locally advanced or metastatic gastroesophageal adenocarcinoma (GEA) were accepted as a late-breaking presentation. Additionally, a new post-hoc overall survival (OS) analysis from the HERIZON-BTC-01 Phase 2b trial in\u00a0previously treated HER2+ biliary tract cancer (BTC) … <\/p>\n

Continue reading “Jazz Pharmaceuticals to Present Pivotal Phase 3 Results of Ziihera\u00ae (zanidatamab-hrii) Combinations in First-Line HER2-Positive Locally Advanced or Metastatic Gastroesophageal Adenocarcinoma at the 2026 ASCO Gastrointestinal Cancers Symposium”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-915455","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nJazz Pharmaceuticals to Present Pivotal Phase 3 Results of Ziihera\u00ae (zanidatamab-hrii) Combinations in First-Line HER2-Positive Locally Advanced or Metastatic Gastroesophageal Adenocarcinoma at the 2026 ASCO Gastrointestinal Cancers Symposium - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/jazz-pharmaceuticals-to-present-pivotal-phase-3-results-of-ziihera-zanidatamab-hrii-combinations-in-first-line-her2-positive-locally-advanced-or-metastatic-gastroesophageal-adenocarcinoma-at-t\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jazz Pharmaceuticals to Present Pivotal Phase 3 Results of Ziihera\u00ae (zanidatamab-hrii) Combinations in First-Line HER2-Positive Locally Advanced or Metastatic Gastroesophageal Adenocarcinoma at the 2026 ASCO Gastrointestinal Cancers Symposium - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"PR Newswire Late-breaking HERIZON-GEA-01 presentation highlights the expanding clinical profile of Ziihera across HER2-driven gastrointestinal cancers Jazz to host investor webcast on\u00a0Friday, January 9, 2026,\u00a0to review data For U.S. media and investors only DUBLIN , Dec. 2, 2025 \/PRNewswire\/ —\u00a0Jazz Pharmaceuticals plc\u00a0(Nasdaq: JAZZ) today announced two abstracts featuring key data for Ziihera\u00ae (zanidatamab-hrii) have been accepted for presentation at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO GI) from January 8-10, 2026, in San Francisco. 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