{"id":914589,"date":"2025-12-01T08:23:37","date_gmt":"2025-12-01T13:23:37","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/"},"modified":"2025-12-01T08:23:37","modified_gmt":"2025-12-01T13:23:37","slug":"salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/","title":{"rendered":"Salarius Pharmaceuticals to Collaborate with Texas Biomedical Research Institute on Avian Flu Study"},"content":{"rendered":"
\n

\n Salarius subsidiary Decoy Therapeutics\u2019 influenza fusion inhibitors, designed using its proprietary IMP<\/em>
\n
\n 3<\/em>
\n <\/sup>
\n ACT\u2122 platform, show excellent in silico free energy binding to the viral target entry protein, supporting potential for anti-flu activity<\/em>\n <\/p>\n

\n IMP<\/em>
\n
\n 3<\/em>
\n <\/sup>
\n ACT\u2019s demonstrated capability to create a single antiviral therapeutic against influenza, COVID and RSV has potential to position Salarius to address large existing global commercial opportunity<\/em>\n <\/p>\n

CAMBRIDGE, Mass. and HOUSTON, Dec. 01, 2025 (GLOBE NEWSWIRE) — Decoy Therapeutics, Inc. (Decoy), a preclinical biopharmaceutical subsidiary of Salarius Pharmaceuticals, Inc. (Nasdaq: SLRX) that is engineering the next generation of peptide conjugate therapeutics, and Texas Biomedical Research Institute (Texas Biomed), one of the world\u2019s foremost independent biomedical research institutions dedicated to eradicating infection and advancing health, announce a collaboration to conduct\u00a0in vitro<\/em> testing of Decoy\u2019s peptide conjugate fusion inhibitors across several influenza strains including H5N1 avian flu.<\/p>\n

\u201cWe are highly optimistic our pan-influenza inhibitors will show in vitro <\/em>activity in influenza regardless of strain due to in silico<\/em> testing showing their strong binding affinity to the viral target. In fact, the in silico<\/em> free energy of our influenza inhibitors is at least as good as our pan-coronavirus inhibitors, which have demonstrated excellent in vitro<\/em> and in vivo<\/em> activity,\u201d stated Salarius Chief Scientific Officer Barbara Hibner, Ph.D.<\/p>\n

\u201cOur IMP3<\/sup>ACT platform is built around a rapid design-build-test-learn loop enabled by machine learning and rapid synthesis for the \u2018design\u2019 and \u2018build\u2019 steps,\u201d Dr. Hibner added. \u201cBy working with Texas Biomed we are adding world-class capabilities for the \u2018test\u2019 step. We are proud to collaborate with Texas Biomed\u2019s renowned scientists and to leverage their leading in vitro <\/em>virology testing capabilities and look forward to expanding our relationship with their world-class scientific and medical resources as we advance our pipeline.\u201d<\/p>\n

\u201cSeasonal influenza continues to be a global health concern, and the recent rise of H5N1 strains of avian flu currently circulating in the U.S. is heightening concern of another pandemic,\u201d said Luis Martinez-Sobrido, Ph.D., a professor at Texas Biomed. \u201cThe rapid speed at which the avian virus can mutate when introduced to a new host increases its potential for human-to-human transmission. This underscores the pressing need for potent inhibitors with activity against multiple influenza strains and their mutations.\u201d<\/p>\n

The addition of pan-influenza inhibitors to Salarius\u2019 previously designed pan-coronavirus and pan-paramyxovirus inhibitors supports the Company\u2019s goal of using its IMP3<\/sup>ACT platform to create a single antiviral inhibitor that is broadly effective against the three viral families that are responsible for the majority of serious seasonal respiratory viral infections. Additionally, Salarius intends to explore the use of these peptides for agricultural health applications such as the treatment of egg-laying poultry flocks.<\/p>\n

\u201cSeasonal influenza-like illness \u2013 from flu to RSV and COVID \u2013 continue to be an enormous unmet medical need, responsible for more than 10 million medical visits every year in the U.S. alone. Merck’s recent $9.2 billion acquisition of Cidara Therapeutics, maker of the long-acting antiviral for flu CD388 after Phase 2 trials, clearly demonstrates big pharma and investor interest in novel antivirals,\u201d said Salarius Chief Executive Officer Rick Pierce. \u201cWe are leveraging the strengths of our IMP3<\/sup>ACT platform to create a single antiviral therapeutic that is broadly active across these respiratory viruses, positioning Salarius to potentially address a very large global commercial opportunity and possible future global respiratory viral pandemic threats.\u201d<\/p>\n

On November 13, 2025, Salarius completed an underwritten public offering raising gross proceeds of $8 million and consummated the previously announced merger with Decoy Therapeutics. The company is focused on advancing Decoy\u2019s pipeline of peptide conjugate therapeutics engineered through its IMP3<\/sup>ACT platform that reduces the complexity of drug development and manufacturing.<\/p>\n

During the next 12 months, Decoy expects to advance its lead asset, a pan-coronavirus antiviral, to the filing of an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA), and to make progress on other programs including a novel broad-acting antiviral to treat flu, COVID-19 and respiratory syncytial virus (RSV), and a peptide drug conjugate targeting GI cancers.<\/p>\n

\n About Influenza<\/strong>\n <\/p>\n

Influenza is a major global health threat that may become more challenging to treat due to emerging influenza virus strains and mutations, including highly pathogenic avian influenza viruses, and the growing resistance to approved influenza antivirals. According to the World Health Organization, there are around a billion cases of seasonal influenza annually, including 3 million – 5 million cases of severe illness contributing to 290,000 to 650,000 respiratory deaths. An influenza pandemic is predicted to cost $60 billion annually.<\/p>\n

\n About Decoy\u2019s Peptide Conjugate Technology<\/strong>\n <\/p>\n

Decoy\u2019s\u2019 drug design engine uses the power of computational tools and fast peptide synthesis technology pioneered in the laboratory of Brad Pentelute, Ph.D., Professor of Chemistry at MIT and Decoy co-founder, to rapidly engineer and synthesize novel antivirals that directly target highly conserved viral machinery. Its proprietary IMP3<\/sup>ACT peptide conjugate drug design and manufacturing platform leverages machine learning (ML) and artificial intelligence (AI) tools. IMP3<\/sup>ACT allows for the rapid computational design and manufacturing of innovative peptide conjugate therapeutics including rapid response to novel viral pathogens including H5N1 avian flu. Peptide conjugates are a new class of drug, perhaps best known for the popular diabetes and weight loss medications, that takes advantage of the strong activity and selectivity of peptides, and improves their targeting and durability by adding a lipid molecule. Salarius is expanding the use of this new drug class to indications including infectious diseases and cancer.<\/p>\n

The IMP3<\/sup>ACT platform leverages peptide chemistry to design \u03b1-helical peptides using computational and machine learning tools. These peptides are transformed into multimeric conjugates by chemically linking a defined number of copies to lipids or other suitable membrane anchor moieties, enhancing their drug-like properties and dosing flexibility with extended pharmacokinetics. Salarius\u2019 technology has produced peptide conjugates effective in vitro<\/em> against multiple human coronaviruses, including all SARS-CoV-2 major variants of concern to date, and against RSV A, RSV B and hPIV3, and in vivo<\/em> against the SARS-CoV-2 delta variant. By integrating machine learning algorithms in peptide design and synthesis, Salarius\u2019 platform accelerates the creation of lead molecules for preclinical evaluations, simultaneously optimizing peptide conjugates for enhanced affinity, binding specificity, resistance to proteases, pharmacokinetic properties and manufacturability at early commercial scale.<\/p>\n

\n About Texas Biomedical Research Institute<\/strong>\n <\/p>\n

Texas Biomed is a nonprofit research institute dedicated to protecting the global community from infectious diseases. Through basic research, preclinical testing and innovative partnerships, we accelerate diagnostics, therapies and vaccines for the world\u2019s deadliest pathogens. Our San Antonio campus hosts high containment laboratories and the Southwest National Primate Research Center. Our scientists collaborate with industry and researchers globally and have helped deliver the first COVID-19 vaccine, the first Ebola treatment and first Hepatitis C therapy. Learn more at txbiomed.org<\/u><\/a>.<\/p>\n

\n About Salarius Pharmaceuticals, Inc.<\/strong>\n <\/p>\n

Salarius Pharmaceuticals subsidiary Decoy Therapeutics is a preclinical-stage biotechnology company that is leveraging ML and AI tools alongside high-speed synthesis techniques to rapidly design, engineer and manufacture peptide conjugate drug candidates that target serious unmet medical needs. The company\u2019s initial pipeline is focused on respiratory viruses and GI cancers. Decoy has attracted financing from institutional investors as well as significant non-dilutive capital from the Massachusetts Life Sciences Seed Fund, the Google AI startup program and the NVIDIA Inception program among other sources. The company has also received QuickFire Challenge award funding provided by the Biomedical Advanced Research and Development Authority (BARDA) through BLUE KNIGHT\u2122, a collaboration between Johnson & Johnson Innovation \u2013 JLABS and BARDA within the Administration for Strategic Preparedness and Response.<\/p>\n

\n Forward-Looking Statements <\/strong>
\n
This press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Statements in this press release that are not statements of historical fact are forward-looking statements. Words such as \u201cmay,\u201d \u201cwill,\u201d \u201cshould,\u201d \u201cexpect,\u201d \u201cplan,\u201d \u201canticipate,\u201d \u201ccould,\u201d \u201cintend,\u201d \u201ctarget,\u201d \u201cproject,\u201d \u201cestimate,\u201d \u201cbelieve,\u201d \u201cpredict,\u201d \u201cpotential,\u201d or \u201ccontinue\u201d or the negative of these terms or other similar expressions are intended to identify forward-looking statements, though not all forward-looking statements contain these identifying words. Forward-looking statements in this press release contains \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995 regarding the combined company, including without limitation, express or implied statements relating to, among other things, the Company\u2019s combined business; the Company\u2019s ability to engineer the next generation of peptide conjugate therapeutics, the Company\u2019s product candidates and lead assets, including its influenza fusion inhibitors and IMP3<\/sup>ACT platform; expectations regarding preclinical and clinical milestones and future plans for its lead assets and product candidates; the Company\u2019s ability to leverage the capability of its IMP3<\/sup>ACT platform to create a single antiviral therapeutic that is broadly effective against the three viral families that are responsible for the majority of serious seasonal respiratory viral infections; the Company\u2019s ability to explore the use of its product candidates and technology for agricultural health applications; expectations regarding unmet medical need and potential commercial market opportunity for the Company\u2019s product candidates and lead assets; the Company\u2019s belief that the respiratory virus families are a likely source of the next viral pandemic; expectations regarding the Texas Biomedical Research Institute collaboration and the Company\u2019s ability to leverage their leading in vitro <\/em>virology testing capabilities; the Company\u2019s belief that its pan-influenza inhibitors will show in vitro <\/em>activity in influenza regardless of strain due to in silico<\/em> testing showing their strong binding affinity to the viral target; the Company\u2019s belief that in the next 12 months, it will advance its lead asset, a pan-coronavirus antiviral, to the filing of an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA), and make progress on other programs including a novel broad-acting antiviral to treat flu, COVID-19 and respiratory syncytial virus (RSV), and a peptide drug conjugate targeting GI cancers; and the Company’s expectations, beliefs, intentions, and strategies regarding the future and other statements that are not historical fact.<\/p>\n

The Company may not actually achieve the plans, intentions, or expectations disclosed in the forward-looking statements, and you should not place undue reliance on the forward-looking statements.\u00a0 These forward-looking statements involve risks and uncertainties that could cause the Company’s actual results to differ materially from the results described in or implied by the forward-looking statements, including, without limitation: risks that the combined company will not achieve the anticipated synergies expected from the merger; risks that the combined company will not obtain sufficient financing to execute on their business plans; and risks related to the combined company\u2019s product candidates, lead assets and related development plans, including unanticipated issues with any IND application process or future filings with the U.S. Food and Drug Administration, and the potential of the IMP3<\/sup>ACT platform. Readers are urged to carefully review and consider all additional risk factors that may cause the Company’s actual results to differ materially from those expressed or implied in the forward-looking statements in this press release are described under the heading \u201cRisk Factors\u201d in the Company’s most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the \u201cSEC\u201d), in the Company’s other filings with the SEC, and in the Company’s future reports to be filed with the SEC and available at www.sec.gov<\/u><\/a>. Forward-looking statements contained in this news release are made as of this date. Unless required to do so by law, we undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.<\/p>\n

\n CONTACTS:<\/strong>\n <\/p>\n

\n Salarius Pharmaceuticals<\/strong>
\n
Rick Pierce, CEO
Pierce@decoytx.com<\/u><\/a>
617-447-8299<\/p>\n

\n Business Development:<\/strong>
\n
Peter Marschel, CBO
Peter@Decoytx.com<\/u><\/a>
617-943-6305<\/p>\n

\n Investor and Media<\/strong>
\n
Alliance Advisors IR
Jody Cain
jcain@allianceadvisors.com<\/u><\/a>
310-691-7100<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Salarius subsidiary Decoy Therapeutics\u2019 influenza fusion inhibitors, designed using its proprietary IMP 3 ACT\u2122 platform, show excellent in silico free energy binding to the viral target entry protein, supporting potential for anti-flu activity IMP 3 ACT\u2019s demonstrated capability to create a single antiviral therapeutic against influenza, COVID and RSV has potential to position Salarius to address large existing global commercial opportunity CAMBRIDGE, Mass. and HOUSTON, Dec. 01, 2025 (GLOBE NEWSWIRE) — Decoy Therapeutics, Inc. (Decoy), a preclinical biopharmaceutical subsidiary of Salarius Pharmaceuticals, Inc. (Nasdaq: SLRX) that is engineering the next generation of peptide conjugate therapeutics, and Texas Biomedical Research Institute (Texas Biomed), one of the world\u2019s foremost independent biomedical research institutions dedicated to eradicating infection and advancing health, announce a … <\/p>\n

Continue reading “Salarius Pharmaceuticals to Collaborate with Texas Biomedical Research Institute on Avian Flu Study”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-914589","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nSalarius Pharmaceuticals to Collaborate with Texas Biomedical Research Institute on Avian Flu Study - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salarius Pharmaceuticals to Collaborate with Texas Biomedical Research Institute on Avian Flu Study - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Salarius subsidiary Decoy Therapeutics\u2019 influenza fusion inhibitors, designed using its proprietary IMP 3 ACT\u2122 platform, show excellent in silico free energy binding to the viral target entry protein, supporting potential for anti-flu activity IMP 3 ACT\u2019s demonstrated capability to create a single antiviral therapeutic against influenza, COVID and RSV has potential to position Salarius to address large existing global commercial opportunity CAMBRIDGE, Mass. and HOUSTON, Dec. 01, 2025 (GLOBE NEWSWIRE) — Decoy Therapeutics, Inc. 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(Nasdaq: SLRX) that is engineering the next generation of peptide conjugate therapeutics, and Texas Biomedical Research Institute (Texas Biomed), one of the world\u2019s foremost independent biomedical research institutions dedicated to eradicating infection and advancing health, announce a … Continue reading "Salarius Pharmaceuticals to Collaborate with Texas Biomedical Research Institute on Avian Flu Study"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-01T13:23:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU5NDIxOCM3Mjk3MjA1IzIwMTY3Nzc=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"10 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Salarius Pharmaceuticals to Collaborate with Texas Biomedical Research Institute on Avian Flu Study\",\"datePublished\":\"2025-12-01T13:23:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\\\/\"},\"wordCount\":1956,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTU5NDIxOCM3Mjk3MjA1IzIwMTY3Nzc=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\\\/\",\"name\":\"Salarius Pharmaceuticals to Collaborate with Texas Biomedical Research Institute on Avian Flu Study - 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(Decoy), a preclinical biopharmaceutical subsidiary of Salarius Pharmaceuticals, Inc. (Nasdaq: SLRX) that is engineering the next generation of peptide conjugate therapeutics, and Texas Biomedical Research Institute (Texas Biomed), one of the world\u2019s foremost independent biomedical research institutions dedicated to eradicating infection and advancing health, announce a … Continue reading \"Salarius Pharmaceuticals to Collaborate with Texas Biomedical Research Institute on Avian Flu Study\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/","og_site_name":"Market Newsdesk","article_published_time":"2025-12-01T13:23:37+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU5NDIxOCM3Mjk3MjA1IzIwMTY3Nzc=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"10 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Salarius Pharmaceuticals to Collaborate with Texas Biomedical Research Institute on Avian Flu Study","datePublished":"2025-12-01T13:23:37+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/"},"wordCount":1956,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU5NDIxOCM3Mjk3MjA1IzIwMTY3Nzc=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/salarius-pharmaceuticals-to-collaborate-with-texas-biomedical-research-institute-on-avian-flu-study\/","name":"Salarius Pharmaceuticals to Collaborate with Texas Biomedical Research Institute on Avian Flu Study - 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