{"id":911942,"date":"2025-11-20T06:03:36","date_gmt":"2025-11-20T11:03:36","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\/"},"modified":"2025-11-20T06:03:36","modified_gmt":"2025-11-20T11:03:36","slug":"beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\/","title":{"rendered":"BeOne Medicines Showcases Leadership in B-cell Malignancies at ASH 2025"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }\n.bwblockalignl { margin-left: 0px; margin-right: auto }\n.bwcellpmargin { margin-bottom: 0px; margin-top: 0px }\n.bwleftsingle { border-left: solid black 1pt }\n.bwlistcircle { list-style-type: circle }\n.bwlistdisc { list-style-type: disc }\n.bwpadl0 { padding-left: 0px }\n.bwrightsingle { border-right: solid black 1pt }\n.bwrowaltcolor0 { background-color: #cceeff }\n.bwsinglebottom { border-bottom: solid black 1pt }\n.bwtablemarginb { margin-bottom: 10px }\n.bwtopsingle { border-top: solid black 1pt }\n.bwvertalignt { vertical-align: top }\n.bwwidth100 { width: 100% }\n.bwwidth14 { width: 14% }\n.bwwidth40 { width: 40% }\n.bwwidth46 { width: 46% }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>BeOne Medicines Showcases Leadership in B-cell Malignancies at ASH 2025<\/b><\/p>\n<p class=\"bwalignc\"><i>BRUKINSA now demonstrates best-in-class sustained efficacy and long-term benefit with a favorable safety profile over more than six years of follow-up data in treatment-na\u00efve and R\/R CLL<\/i><\/p>\n<p class=\"bwalignc\"><i>First results from Phase 1\/2 sonrotoclax monotherapy study will demonstrate notable speed and depth of clinical responses in patients with R\/R MCL, a rare, aggressive cancer<\/i><\/p>\n<p class=\"bwalignc\"><i>New efficacy and safety data will highlight the benefits of potential first-in-class BTK degrader BGB-16673 in patients across multiple hematological malignancies<\/i><\/p>\n<p>SAN CARLOS, Calif.&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fbeonemedicines.com%2F&amp;esheet=54361159&amp;newsitemid=20251120303213&amp;lan=en-US&amp;anchor=BeOne+Medicines+Ltd.&amp;index=1&amp;md5=df3884d6e236a59ac88dd6fc56ec79bc\">BeOne Medicines Ltd.<\/a> (Nasdaq: ONC; HKEX: 06160; SSE: 688235), a global oncology company, advances its vision to become the world\u2019s leading oncology company with extensive new data from its differentiated hematology portfolio at the 67<sup>th <\/sup>American Society of Hematology (ASH) Annual Meeting and Exposition in Orlando, Florida, December 6-9. Nearly 50 abstracts have been accepted, including six oral presentations, featuring the company\u2019s three transformative approved and investigational hematology assets \u2013 BTK inhibitor BRUKINSA<sup>\u00ae<\/sup> (zanubrutinib), BCL2 inhibitor sonrotoclax, and BTK degrader BGB-16673.<\/p>\n<p><b>Key presentations include:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li><b>SEQUOIA:<\/b><b>BRUKINSA<\/b> demonstrated sustained overall survival (84%; 88% after COVID adjustment) and landmark progression-free survival (PFS) superiority vs bendamustine + rituximab with an estimated 74% PFS at 6 years in treatment-na\u00efve chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL\/SLL) (Poster Presentation: 2129)\n<\/li>\n<li><b>ALPINE: <\/b>Post-hoc analysis from Phase 3 study of <b>BRUKINSA<\/b> versus ibrutinib in patients with relapsed\/refractory (R\/R) CLL\/SLL,<b \/>using longitudinal patient-reported outcomes (PRO) (Oral Presentation: 711)\n<\/li>\n<li><b>BGB-11417-201: <\/b>Phase 1\/2 study of <b>sonrotoclax<\/b> in patients with R\/R mantle cell lymphoma (MCL) previously treated with a BTK inhibitor (Oral Presentation: 663)\n<\/li>\n<li><b>BGB-11417-101: <\/b>Updated safety and efficacy results, including undetectable minimal residual disease (uMRD) data, from ongoing Phase 1\/1b study of <b>sonrotoclax plus BRUKINSA<\/b> in treatment-na\u00efve CLL\/SLL (Poster Presentation: 3891)\n<\/li>\n<li><b>CaDAnCe-101: <\/b>Updated efficacy and safety results of <b>BGB-16673<\/b> in patients with R\/R CLL\/SLL and R\/R Waldenstr\u00f6m macroglobulinemia (WM) (Oral Presentation: 85; Poster Presentation: 3583)\n<\/li>\n<\/ul>\n<p>\n\u201cOur data at ASH 2025 raises the bar for patient and physician expectations of what\u2019s possible. Our long-term data drives confidence in duration of response in CLL treatment decisions,\u201d said Lai Wang, Ph.D., Global Head of R&amp;D at BeOne. \u201cSix-year SEQUOIA and long-term extension data from patients originally enrolled in ALPINE cement BRUKINSA\u2019s role as the backbone of CLL therapy, and our three innovative B-cell treatment modalities of BTK inhibition, BCL2 inhibition, and BTK degradation have the potential to advance options that evolve with patient needs across all stages of disease.\u201d<\/p>\n<p><b>Additional highlights include:<\/b><\/p>\n<p>\nNever-before-presented clinical data from BeOne\u2019s emerging pipeline will also be shared at the meeting, including in new combinations and disease areas.<\/p>\n<ul class=\"bwlistdisc\">\n<li><b>BGB-11417-101: <\/b>Results from Phase 1\/1b study:\n<ul class=\"bwlistcircle\">\n<li>\nMRD-guided therapy of <b>sonrotoclax<\/b> plus obinutuzumab in patients with treatment-na\u00efve CLL\/SLL (Oral Presentation: 793)<\/p>\n<\/li>\n<li>\nInitial results of treatment with <b>sonrotoclax<\/b> plus<b> BRUKINSA<\/b> plus obinutuzumab in patients with treatment-na\u00efve CLL\/SLL (Poster Presentation: 3890)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li><b>BGB-11417-202: <\/b>Phase 2 study of <b>sonrotoclax <\/b>monotherapy in patients with R\/R CLL\/SLL<b \/>(Poster Presentation: 5666)\n<\/li>\n<li><b>BGB-11417-105: <\/b>Initial results from Phase 1b\/2 study of <b>sonrotoclax <\/b>plus carfilzomib and dexamethasone in patients with t(11;14)-positive R\/R multiple myeloma (Oral Presentation: 102)\n<\/li>\n<li><b>CaDAnCe-101 <\/b>Preliminary results from the ongoing Phase 1 study of <b>BGB-16673<\/b> in patients with R\/R Richter\u2019s transformation (Poster Presentation: 3895)\n<\/li>\n<\/ul>\n<p>\nOngoing clinical data from <b>BRUKINSA <\/b>continue to demonstrate clinically meaningful benefit for patients with CLL\/SLL.<\/p>\n<ul class=\"bwlistdisc\">\n<li><b>SEQUOIA Arm D:<\/b> Single-arm study of<b> BRUKINSA<\/b> plus venetoclax in patients with first-line CLL\/SLL, with del(17p) and\/or TP53 mutation or without both (Poster Presentation: 5669)\n<\/li>\n<li><b>ALPINE thru LTE1: <\/b>Up to<b \/>6 years of follow-up of patients with R\/R CLL\/SLL who were originally randomized to receive <b>BRUKINSA<\/b> as part of the ALPINE study and continued BRUKINSA treatment in a long-term extension study (LTE-1) (Poster Presentation: 2123)\n<\/li>\n<\/ul>\n<p>\nPresentations also include data leveraging real-world evidence and validated modeling approaches to refine understanding of real-world experience and outcomes achieved with covalent BTK inhibitors.<\/p>\n<ul class=\"bwlistdisc\">\n<li><b>Outcomes research:<\/b>\n<ul class=\"bwlistcircle\">\n<li>\nA model analysis of number needed to treat (NNT) estimates that treating patients with <b>BRUKINSA<\/b> instead of ibrutinib for CLL could potentially prevent approximately 255 cardiac deaths in the second-line or later (2L+) setting and 266 in the first-line (1L) setting over a 10-year period. (Abstract Number: 13636)<\/p>\n<\/li>\n<li>\nModel evaluating <b>BRUKINSA<\/b> vs other covalent BTK inhibitors in R\/R CLL and the number of patients needed to treat to avoid progression or death (Poster Presentation: 4553)<\/p>\n<\/li>\n<li>\nObservational study examining patient-reported outcomes in U.S. patients with CLL\/SLL and treated with <b>BRUKINSA<\/b> or acalabrutinib in the community oncology setting (Poster Presentation: 2768)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\n\u201cIn CLL, selecting the right therapy for the right patient at the right time is essential, and continuous treatment with BTK inhibitors like BRUKINSA has become central to achieving enduring disease control,\u201d said Dany Habr, M.D., Senior Vice President and Head of Medical Affairs, North America &amp; International Markets at BeOne. \u201cEmerging data from real-world settings suggest that BRUKINSA may offer a more manageable side effect profile, including for symptoms such as fatigue, pain, headache \u2013 further supporting its role as the BTKi of choice.\u201d<\/p>\n<p><b>BeOne Presentations at ASH 2025 (organized chronologically by asset)<\/b><\/p>\n<p><b>BRUKINSA: The backbone of the hematology franchise<\/b><\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl bwwidth100\">\n<tr>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth46\" style=\"height:15px\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Title<\/b><\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth40\" style=\"height:15px\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Presentation Details<\/b><\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth14\" style=\"height:15px\" rowspan=\"1\" colspan=\"1\"><b>Lead Author<\/b><\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nFinal analysis of the randomized Phase 2 ROSEWOOD study of zanubrutinib + obinutuzumab vs obinutuzumab monotherapy in patients with R\/R follicular lymphoma<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Oral Presentation:<\/b> 227<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Mantle Cell, Follicular, Waldenstrom&#8217;s, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological: FL and WM<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 6, 2025, 2:00-3:30 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nPier Luigi Zinzani<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nSustained efficacy of zanubrutinib vs bendamustine + rituximab in treatment-<i \/>na\u00efve CLL\/SLL with continued favorable survival in non-randomized patients with del(17p): 6-year follow-up<b \/>in the Phase 3 SEQUOIA study<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation<\/b>: 2129<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster I<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 6, 2025, 5:30-7:30 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nConstantine S. Tam<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nLong-term results of patients receiving zanubrutinib in the Phase 3 ALPINE study confirm sustained benefit of zanubrutinib in patients with R\/R CLL\/SLL: Up to 6 years of follow-up with the long-term extension<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation:<\/b> 2123<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster I<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 6, 2025, 5:30-7:30 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nConstantine S. Tam<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nSymptom-based progression-free survival as a clinically relevant and patient-centric endpoint in CLL\/SLL: Results from the ALPINE trial<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Oral Presentation:<\/b> 711<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Quality of Life and Supportive Care in Lymphoid Malignancies<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 7, 2025, 4:30-6:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nJennifer R. Brown<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nProgression-free survival in patients with low health-related quality of life treated with zanubrutinib versus ibrutinib monotherapy: Post-hoc analysis of the ALPINE trial<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation:<\/b> 6275<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Quality of Life and Supportive Care in Lymphoid Malignancies<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 8, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nLoic Ysebaert<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nZanubrutinib + venetoclax for treatment-na\u00efve CLL\/SLL, including patients with del(17p) and\/or TP53 mutation and unmutated immunoglobulin heavy-chain variable status: 3-year results from SEQUOIA arm D<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation:<\/b> 5669<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster III<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 8, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nMazyar Shadman<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nEvaluation of factors from established prognostic models in patients with CLL treated with zanubrutinib: A post-hoc analysis of two Phase 3 studies (SEQUOIA and ALPINE)<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation:<\/b> 5681<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster III<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 8, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nInhye Ahn<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nZanubrutinib is well tolerated and effective in acalabrutinib-intolerant patients with B-cell malignancies: A long-term follow-up<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation:<\/b> 5663<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster III<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 8, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nMazyar Shadman<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nSingle-arm, open-label, multicenter study of the BTKi zanubrutinib in patients with CD79B-mutated R\/R diffuse large B-cell lymphoma<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation:<\/b> 3684<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Aggressive Lymphomas: Targeted and Pharmacologic Therapies: Poster II<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 7, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nLi Wang<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p><b>Sonrotoclax: Potential best-in-class next-generation BCL2 inhibitor<\/b><\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl bwwidth100\">\n<tr>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Title<\/b><\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>\u00a0Presentation Details<\/b><\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>\u00a0Lead Author<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nInitial Phase 1b\/2 study results with sonrotoclax in combination with carfilzomib and dexamethasone in patients with t(11;14)-positive R\/R multiple myeloma<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Oral Presentation: <\/b>102<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Multiple Myeloma: Pharmacologic Therapies: Advancing the Standard: Improving Myeloma Treatment through Diagnosis, Maintenance and Relapse<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 6, 2025, 10:45-11:00 AM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nHang Quach<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nA Phase 3, randomized, open-label, multicenter study of sonrotoclax plus anti-CD20 antibody therapies vs venetoclax plus rituximab in patients with R\/R CLL\/SLL (CLL-RR1\/CELESTIAL-RRCLL)<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Trial-in-progress Poster Presentation:<\/b> 2137<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster I<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 6, 2025, 5:30-7:30 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nOthman Al-Sawaf<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nSonrotoclax monotherapy in patients with relapsed\/refractory mantle cell lymphoma previously treated with BTKi: Early results from a Phase 1\/2 study<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Oral Presentation:<\/b> 663<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Mantle Cell, Follicular, Waldenstrom&#8217;s, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological &#8211; Novel Treatments for and Insights into Mantle Cell Lymphoma<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 7, 2025, 4:30-6:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nMichael Wang<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nFrontline treatment of sonrotoclax and zanubrutinib for CLL\/SLL demonstrates high undetectable minimal residual disease rates with favorable tolerability: Updated data from BGB-11417-101, an ongoing Phase 1\/1b study<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>3891<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster II<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 7, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nConstantine S. Tam<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nZanubrutinib + obinutuzumab + sonrotoclax in patients with treatment-na\u00efve CLL\/SLL: Initial results from an ongoing Phase 1\/1b study, BGB-11417-101<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>3890<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster II<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 7, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nJacob D. Soumerai<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nMRD-guided therapy of sonrotoclax + obinutuzumab in patients with treatment-naive CLL: Initial results from an ongoing Phase 1\/1b study, BGB-11417-101<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Oral Presentation:<\/b> 793<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Chronic Lymphocytic Leukemia: Clinical and Epidemiological: MRD Guided Therapy and Emergence of Resistance<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 8, 2025, 10:30 AM-12:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nMarc S. Hoffmann<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nPrimary analysis of a multicenter, open-label, Phase 2 study of sonrotoclax monotherapy in patients with R\/R CLL\/SLL<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>5666<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster III<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 8, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nShuhua Yi<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p><b>BGB-16673: Potential first-in-class BTK protein degrader<\/b><\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl bwwidth100\">\n<tr>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Title<\/b><\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>\u00a0Presentation Details<\/b><\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>\u00a0Lead Author<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nUpdated efficacy and safety results of the BTK degrader BGB-16673 in patients with R\/R CLL\/SLL from the ongoing Phase 1 CaDAnCe-101 study<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Oral Presentation: <\/b>85<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Treatment of CLL in Relapse and in Richter Transformation<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 6, 2025, 9:30-11:00 AM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nInhye E. Ahn<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nCaDAnCe-104, an ongoing, open-label, Phase 1b\/2 master protocol study of BTK degrader BGB-16673 in combination with other agents in patients with R\/R B-cell malignancies<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Trial-in-Progress Poster Presentation: <\/b>1839<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Mantle Cell, Follicular, Waldenstrom&#8217;s, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological: Poster I<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 6, 2025, 5:30-7:30 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nChan Y. Cheah<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nUpdated efficacy and safety results of the BTK degrader BGB-16673 in patients with R\/R indolent non-Hodgkin lymphoma from the ongoing Phase 1 CaDAnCe-101 study<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>3584<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Mantle Cell, Follicular, Waldenstrom&#8217;s, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological: Poster II<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 7, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nRomain Gui\u00e8ze<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nPreliminary efficacy and safety of the BTK BGB-16673 in patients with R\/R Richter transformation: Results from the ongoing Phase 1 CaDAnCe-101 study<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>3895<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster II<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 7, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nMeghan C. Thompson<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nUpdated efficacy and safety results of the BTK BGB-16673 in patients with R\/R Waldenstr\u00f6m macroglobulinemia from the ongoing Phase 1 CaDAnCe-101 study<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>3583<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Mantle Cell, Follicular, Waldenstrom&#8217;s, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological: Poster II<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 7, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nConstantine S. Tam<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nCaDAnCe-304, a Phase 3, open-label, randomized study to evaluate the safety and efficacy of BTK degrader BGB-16673 compared with pirtobrutinib in patients with R\/R CLL\/SLL<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Trial-in-progress Poster Presentation: <\/b>5691<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster III<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 8, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nMeghan C. Thompson<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p><b>Other hematology assets: BGB-21447, next-generation BCL2 inhibitor<\/b><\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl bwwidth100\">\n<tr>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Title<\/b><\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>\u00a0Presentation Details<\/b><\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>\u00a0Lead Author<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nPreliminary results from a Phase 1\/1b first-in-human study of BGB-21447, a next-generation BCL2 inhibitor, in patients with B-cell non-Hodgkin lymphoma<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation:<\/b> 1910<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Aggressive Lymphomas: Targeted and Pharmacologic Therapies: Poster I<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 6, 2025, 5:30-7:30 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nFei Li<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p><b>Integrative evidence generation and health economics related to BRUKINSA<\/b><\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl bwwidth100\">\n<tr>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Title<\/b><\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>\u00a0Presentation Details<\/b><\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwrowaltcolor0 bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>\u00a0Lead Author<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0\" rowspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Matching-Adjusted Indirect Comparison<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nIndirect comparison of efficacy of zanubrutinib vs ibrutinib for the treatment of R\/R MCL<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>5365<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Mantle Cell, Follicular, Waldenstrom&#8217;s, and Other Indolent B Cell Lymphomas: Clinical and Epidemiological: Poster III<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 8, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nToby A. Eyre<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nA matching-adjusted indirect comparison of zanubrutinib vs venetoclax + ibrutinib in treatment-naive CLL<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number: <\/b>7756<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nTalha Munir<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0\" rowspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Health Economic and Outcomes Research<\/b><\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nOutcomes during BTKi treatment for CLL: Insights from remote therapeutic monitoring<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation:<\/b> 2768<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Poster I<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 6, 2025, 5:30-7:30 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nGurjyot Doshi<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nNumber needed to treat to avoid progression or death: Zanubrutinib vs other covalent BTKis in R\/R CLL<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation:<\/b> 4553<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Poster II<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 7, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nMazyar Shadman<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nEstimated cardiac deaths associated with treating CLL with ibrutinib versus zanubrutinib in the United States<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number:<\/b> 13636<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nJennifer R. Brown<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nNumber of patients needed to treat to prevent one atrial fibrillation event with zanubrutinib versus ibrutinib and acalabrutinib in B-cell malignancies<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number:<\/b> 14445<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nTalha Munir<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nNumber of cardiac deaths associated with ibrutinib versus zanubrutinib for the treatment of CLL: A European risk-based estimation<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number:<\/b> 14028<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nTalha Munir<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0\" rowspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Real-World Evidence<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nMediators of racial and ethnic inequities in access to front-line therapies for CLL in the United States: A real-world evidence study<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>2720<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Poster I<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 6, 2025, 5:30-7:30 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nJacqueline C. Barrientos<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nReal-world treatment patterns and biomarker utilization among patients aged \u226565 years with CLL\/SLL from 2020 to 2024<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>2723<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Poster I<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 6, 2025, 5:30-7:30 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nPaul Hampel<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nChemo \u00b1 immunotherapy remains utilized for CLL in the real-world practice: Unmet needs, treatment patterns, and age disparities in the United States<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>2762<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Poster I<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 6, 2025, 5:30-7:30 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nJavier Pinilla-Ibarz<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nImpact of testing for genetic markers on treatment selection and clinical outcomes among patients with CLL<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>3894<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster II<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 7, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nBrian Koffman<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nTreatment patterns and outcomes among patients treated with second-generation BTK inhibitors in CLL<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>4528<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Poster II<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 7, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nAryan Ayat<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nChanges in real-world treatment patterns over time by patient characteristics and time burden of treatment in CLL\/SLL<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>6283<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Poster III<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 8, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nMengyang Di<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nReal-world treatment patterns and patient characteristics of venetoclax combination time-limited therapy for CLL<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation: <\/b>6317<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title: <\/b>Outcomes Research: Lymphoid Malignancies Excluding Plasma Cell Disorders: Poster III<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time: <\/b>December 8, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nJing-Zhou Hou<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nReal-world treatment utilization, sequencing, and outcomes in mantle cell lymphoma: Emerging treatment patterns in the United States<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number: <\/b>13378<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nAlvaro Alencar<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nReal-world zanubrutinib treatment patterns in CLL\/SLL among a curated sample of US community oncology patients with prior acalabrutinib therapy<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number: <\/b>8798<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nJing-Zhou Hou<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nIncidence of cardiac-related deaths among patients aged \u226565 years with B-cell malignancies treated with ibrutinib<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number:<\/b> 7341<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nRyan Jacobs<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nReal-world CLL-specific biomarker testing patterns and frontline treatment patterns in patients with CLL\/small lymphocytic lymphoma<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number:<\/b> 7773<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nTimothy Reynolds<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nReal-world CLL\/SLL treatment patterns at Florida Cancer Specialists &amp; Research Institute among patients receiving zanubrutinib immediately following prior BTKi therapy<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number: <\/b>13894<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nAmanda Warner<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0\" rowspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Patient Preference<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nPatient preferences and factors affecting patient treatment decisions for CLL in Japan<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Poster Presentation:<\/b> 4406<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Title:<\/b> Health Services and Quality Improvement: Lymphoid Malignancies: Poster II<\/p>\n<p class=\"bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwcellpmargin\"><b>Session Date\/Time:<\/b> December 7, 2025, 6:00-8:00 PM EST<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nSikander Ailawadhi<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nEvaluating patient preferences for CLL in Korea: A discrete choice experiment<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number: <\/b>4019<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nByung Woo Yoon<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0\" rowspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Systemic Literature Review<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0 bwwidth46\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nPatients with high-risk features in mantle cell lymphoma: A systematic literature review of clinical trials and real-world studies<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth40\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Abstract Number: <\/b>14130<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0 bwwidth14\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nChristine E. Ryan<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\nFor additional information about our presence at the 2025 ASH Annual Meeting and Exposition, please visit our meeting hub: <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fcongress.beonemedicines.com%2F&amp;esheet=54361159&amp;newsitemid=20251120303213&amp;lan=en-US&amp;anchor=congress.beonemedicines.com&amp;index=2&amp;md5=24e692a42d6bb5188c119ef090fe5a1c\">congress.beonemedicines.com<\/a>.<\/p>\n<p><b>About Sonrotoclax (BGB-11417)<\/b><\/p>\n<p>\nSonrotoclax is a next-generation and potentially best-in-class investigational B-cell lymphoma 2 (BCL2) inhibitor with a unique pharmacokinetic and pharmacodynamic profile. Studies in the lab and during early drug development have shown that sonrotoclax is a highly potent and specific BCL2 inhibitor with a short half-life and no drug accumulation. Sonrotoclax has shown promising clinical activity across a range of B-cell malignancies and is in development as a monotherapy and in combination with other therapeutics, including BRUKINSA. Notably, in early clinical trials, sonrotoclax plus BRUKINSA has demonstrated rapid and unprecedented undetectable minimal residual disease (uMRD) rates in treatment-na\u00efve patients with CLL. To date, more than 2,200 patients have been enrolled across the broad global development program.<\/p>\n<p>\nThe U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy Designation (BTD) for sonrotoclax for the treatment of adult patients with relapsed or refractory (R\/R) mantle cell lymphoma (MCL). In addition, the FDA has granted sonrotoclax Fast Track Designation for MCL and Waldenstr\u00f6m macroglobulinemia, as well as Orphan Drug Designation for the treatment of adult patients with MCL, WM, multiple myeloma, acute myeloid leukemia, and myelodysplastic syndrome.<\/p>\n<p><b>About BGB-16673<\/b><\/p>\n<p>\nBGB-16673 is a potential first-in-class Bruton\u2019s tyrosine kinase (BTK) protein degrader and is the most advanced protein degrader in the clinic, with nearly 800 patients dosed to date in an extensive global clinical development program. This program includes three randomized Phase 3 trials in R\/R CLL, including the head-to-head Phase 3 trial versus pirtobrutinib which began enrolling in Q4 2025. Originating from BeOne\u2019s chimeric degradation activation compound (CDAC) platform, BGB-16673 is designed to promote the degradation, or breakdown, of both wildtype and mutant forms of BTK, including those that commonly result in resistance to BTK inhibitors in patients who experience progressive disease.<\/p>\n<p>\nThe U.S. Food and Drug Administration (FDA) granted Fast Track Designation to BGB-16673 for the treatment of adult patients with relapsed or refractory (R\/R) chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL\/SLL), and adult patients with R\/R mantle cell lymphoma (MCL). Additionally, the European Medicines Agency (EMA) granted BGB-16673 PRIority MEdicines (PRIME) designation for the treatment of patients with Waldenstrom\u2019s macroglobulinemia (WM) previously treated with a BTK inhibitor.<\/p>\n<p><b>About BRUKINSA<sup>\u00ae<\/sup> (zanubrutinib)<\/b><\/p>\n<p>\nBRUKINSA is an orally available, small molecule inhibitor of Bruton\u2019s tyrosine kinase (BTK) designed to deliver complete and sustained inhibition of the BTK protein by optimizing bioavailability, half-life, and selectivity. With differentiated pharmacokinetics compared with other approved BTK inhibitors, BRUKINSA has been demonstrated to inhibit the proliferation of malignant B cells within a number of disease-relevant tissues.<\/p>\n<p>\nBRUKINSA has the broadest label globally of any BTK inhibitor and is the only BTK inhibitor to provide the flexibility of once or twice daily dosing. BRUKINSA is also the only BTK inhibitor to demonstrate superiority to another BTK inhibitor in a Phase 3 study.<\/p>\n<p>\nThe global BRUKINSA clinical development program includes about 7,100 patients enrolled in 30 countries and regions across more than 35 trials. BRUKINSA is approved in more than 75 markets, and more than 247,000 patients have been treated globally.<\/p>\n<p><b>Select Important Safety Information<\/b><\/p>\n<p>\nSerious adverse reactions, including fatal events, have occurred with BRUKINSA, including hemorrhage, infections, cytopenias, second primary malignancies, cardiac arrhythmias, and hepatotoxicity (including drug-induced liver injury).<\/p>\n<p>\nIn the pooled safety population (N=1729), the most common adverse reactions (\u226530%), including laboratory abnormalities, in patients who received BRUKINSA were neutrophil count decreased (51%), platelet count decreased (41%), upper respiratory tract infection (38%), hemorrhage (32%), and musculoskeletal pain (31%).<\/p>\n<p>\nPlease see full <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.beigene.com%2FPDF%2FBRUKINSAUSPI.pdf&amp;esheet=54361159&amp;newsitemid=20251120303213&amp;lan=en-US&amp;anchor=U.S.+Prescribing+Information&amp;index=3&amp;md5=c4e58c4a250c9b2069f0356bc245b570\">U.S. Prescribing Information<\/a> including <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.beigene.com%2FPDF%2FBRUKINSAUSPPI.pdf&amp;esheet=54361159&amp;newsitemid=20251120303213&amp;lan=en-US&amp;anchor=U.S.+Patient+Information&amp;index=4&amp;md5=5de81becf2d78d0325922fd2c14f372f\">U.S. Patient Information<\/a>.<\/p>\n<p>\nThe information provided in this press release is intended for a global audience. Product indications vary by region.<\/p>\n<p><b>About BeOne<\/b><\/p>\n<p>\nBeOne Medicines is a global oncology company domiciled in Switzerland that is discovering and developing innovative treatments that are more accessible to cancer patients worldwide. With a portfolio spanning hematology and solid tumors, BeOne is expediting development of its diverse pipeline of novel therapeutics through its internal capabilities and collaborations. With a growing global team of nearly 12,000 colleagues spanning six continents, the Company is committed to radically improving access to medicines for far more patients who need them.<\/p>\n<p>\nTo learn more about BeOne, please visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.beonemedicines.com&amp;esheet=54361159&amp;newsitemid=20251120303213&amp;lan=en-US&amp;anchor=www.beonemedicines.com&amp;index=5&amp;md5=816df0e93e9106c9e174affcb1ca9355\">www.beonemedicines.com<\/a> and follow us on <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fbeonemedicines%2F&amp;esheet=54361159&amp;newsitemid=20251120303213&amp;lan=en-US&amp;anchor=LinkedIn&amp;index=6&amp;md5=293e6318cef929ccb8ef009e1f573e14\">LinkedIn<\/a>, <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fx.com%2FBeOneMedicines&amp;esheet=54361159&amp;newsitemid=20251120303213&amp;lan=en-US&amp;anchor=X&amp;index=7&amp;md5=41a1aa2fcaab6cf713342f99849d0b0c\">X<\/a>, <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.facebook.com%2FBeOneMeds&amp;esheet=54361159&amp;newsitemid=20251120303213&amp;lan=en-US&amp;anchor=Facebook&amp;index=8&amp;md5=5de42935102408eb5860d3a97e6a6bd7\">Facebook<\/a> and <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.instagram.com%2Fbeonemedicines%2F&amp;esheet=54361159&amp;newsitemid=20251120303213&amp;lan=en-US&amp;anchor=Instagram&amp;index=9&amp;md5=9723cc0b767be5113ffaa363551ef972\">Instagram<\/a>.<\/p>\n<p><b>Forward-Looking Statement<\/b><\/p>\n<p>\nThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws, including statements regarding the potential benefits of BeOne\u2019s product and product candidates; bringing innovative and transformative medicines to patients; and BeOne\u2019s plans, commitments, aspirations and goals under the caption \u201cAbout BeOne.\u201d Actual results may differ materially from those indicated in the forward-looking statements as a result of various important factors, including BeOne\u2019s ability to demonstrate the efficacy and safety of its drug candidates; the clinical results for its drug candidates, which may not support further development or marketing approval; actions of regulatory agencies, which may affect the initiation, timing and progress of clinical trials and marketing approval; BeOne\u2019s ability to achieve commercial success for its marketed medicines and drug candidates, if approved; BeOne&#8217;s ability to obtain and maintain protection of intellectual property for its medicines and technology; BeOne\u2019s reliance on third parties to conduct drug development, manufacturing, commercialization, and other services; BeOne\u2019s limited experience in obtaining regulatory approvals and commercializing pharmaceutical products; BeOne\u2019s ability to obtain additional funding for operations and to complete the development of its drug candidates and achieve and maintain profitability; and those risks more fully discussed in the section entitled \u201cRisk Factors\u201d in BeOne\u2019s most recent quarterly report on Form 10-Q, as well as discussions of potential risks, uncertainties, and other important factors in BeOne\u2019s subsequent filings with the U.S. Securities and Exchange Commission. All information in this press release is as of the date of this press release, and BeOne undertakes no duty to update such information unless required by law.<\/p>\n<p>\nTo access BeOne media resources, please visit our<b \/><a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fbeonemedicines.com%2Fnewsroom%2F&amp;esheet=54361159&amp;newsitemid=20251120303213&amp;lan=en-US&amp;anchor=Newsroom&amp;index=10&amp;md5=719266799b22099e1014eff643f5459c\"><b>Newsroom<\/b><\/a>.<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20251120303213r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20251120303213\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20251120303213\/en\/<\/a><\/span><\/p>\n<p><b>Investor Contact<br \/>\n<\/b><br \/>Liza Heapes<br \/>\n<br \/>+1 857-302-5663<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:ir@beonemed.com\">ir@beonemed.com<\/a><\/p>\n<p><b>Media Contact<br \/>\n<\/b><br \/>Kyle Blankenship<br \/>\n<br \/>+ 667-351-5176<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:media@beonemed.com\">media@beonemed.com<\/a><\/p>\n<p><b>KEYWORDS:<\/b> California Florida United States North America<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Biotechnology Pharmaceutical Health Oncology<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20251120303213\/en\/2494825\/3\/BGI2404_BeOne_Primary_Logo_RGB_M04_V01.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>BeOne Medicines Showcases Leadership in B-cell Malignancies at ASH 2025 BRUKINSA now demonstrates best-in-class sustained efficacy and long-term benefit with a favorable safety profile over more than six years of follow-up data in treatment-na\u00efve and R\/R CLL First results from Phase 1\/2 sonrotoclax monotherapy study will demonstrate notable speed and depth of clinical responses in patients with R\/R MCL, a rare, aggressive cancer New efficacy and safety data will highlight the benefits of potential first-in-class BTK degrader BGB-16673 in patients across multiple hematological malignancies SAN CARLOS, Calif.&#8211;(BUSINESS WIRE)&#8211;BeOne Medicines Ltd. (Nasdaq: ONC; HKEX: 06160; SSE: 688235), a global oncology company, advances its vision to become the world\u2019s leading oncology company with extensive new data from its differentiated hematology portfolio at &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;BeOne Medicines Showcases Leadership in B-cell Malignancies at ASH 2025&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-911942","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BeOne Medicines Showcases Leadership in B-cell Malignancies at ASH 2025 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BeOne Medicines Showcases Leadership in B-cell Malignancies at ASH 2025 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"BeOne Medicines Showcases Leadership in B-cell Malignancies at ASH 2025 BRUKINSA now demonstrates best-in-class sustained efficacy and long-term benefit with a favorable safety profile over more than six years of follow-up data in treatment-na\u00efve and R\/R CLL First results from Phase 1\/2 sonrotoclax monotherapy study will demonstrate notable speed and depth of clinical responses in patients with R\/R MCL, a rare, aggressive cancer New efficacy and safety data will highlight the benefits of potential first-in-class BTK degrader BGB-16673 in patients across multiple hematological malignancies SAN CARLOS, Calif.&#8211;(BUSINESS WIRE)&#8211;BeOne Medicines Ltd. (Nasdaq: ONC; HKEX: 06160; SSE: 688235), a global oncology company, advances its vision to become the world\u2019s leading oncology company with extensive new data from its differentiated hematology portfolio at &hellip; Continue reading &quot;BeOne Medicines Showcases Leadership in B-cell Malignancies at ASH 2025&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-20T11:03:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20251120303213r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"19 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"BeOne Medicines Showcases Leadership in B-cell Malignancies at ASH 2025\",\"datePublished\":\"2025-11-20T11:03:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\\\/\"},\"wordCount\":3739,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20251120303213r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/beone-medicines-showcases-leadership-in-b-cell-malignancies-at-ash-2025\\\/\",\"name\":\"BeOne Medicines Showcases Leadership in B-cell Malignancies at ASH 2025 - 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