\n\u00a0<\/p>\n<\/td>\n
Prior guidance<\/b><\/p>\n<\/td>\n
\n\u00a0<\/p>\n<\/td>\n
November 10 update<\/b><\/p>\n<\/td>\n
\n\u00a0<\/p>\n<\/td>\n
Change at midpoint<\/b><\/p>\n<\/td>\n
\n\u00a0<\/p>\n<\/td>\n
Y\/Y growth rate<\/b><\/p>\n<\/td>\n<\/tr>\n \nTotal revenue<\/p>\n<\/td>\n \n$3.220 – $3.235 billion<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n$3.220 – $3.235 billion<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n–<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n17%<\/p>\n<\/td>\n<\/tr>\n \nScreening<\/p>\n<\/td>\n \n$2.510 – $2.520 billion<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n$2.510 – $2.520 billion<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n–<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n20%<\/p>\n<\/td>\n<\/tr>\n \nPrecision Oncology<\/p>\n<\/td>\n \n$710 – $715 million<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n$710 – $715 million<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n–<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n9%<\/p>\n<\/td>\n<\/tr>\n \nAdjusted EBITDA<\/p>\n<\/td>\n \n$470 – $480 million<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n$395 – $405 million<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n– $75 million<\/p>\n<\/td>\n \n\u00a0<\/p>\n<\/td>\n \n24%<\/p>\n<\/td>\n<\/tr>\n<\/table>\n About Exact Sciences Corp.<\/b><\/p>\n \nA leading provider of cancer screening and diagnostic tests, Exact Sciences (Nasdaq: EXAS) helps patients and health care providers make timely, informed decisions before, during, and after a cancer diagnosis. The company\u2019s growing portfolio includes well-established brands such as Cologuard\u00ae and Oncotype DX\u00ae, along with innovative solutions like the Cancerguard\u2122 test for multi-cancer early detection and the Oncodetect\u2122 test for molecular residual disease and recurrence monitoring. Exact Sciences continues to invest in a robust pipeline of advanced cancer diagnostics aimed at improving outcomes. For more information, visit ExactSciences.com<\/a>, follow @ExactSciences<\/a> on X, or connect on LinkedIn<\/a> and Facebook<\/a>.<\/p>\n Non-GAAP disclosure<\/b><\/p>\n \nIn addition to the Company’s financial results determined in accordance with U.S. GAAP, the Company provides non-GAAP measures that it determines to be useful in evaluating its operating performance and liquidity, including adjusted EBITDA. The Company defines adjusted EBITDA as net loss adjusted for interest expense, income tax expense or benefit, depreciation expense, amortization of acquired intangible assets, investment income or loss, and certain other items which include significant non-cash items and other charges or benefits resulting from transactions or events that are highly variable, significant in size, and that we do not believe are indicative of ongoing or future business operations.<\/p>\n \nManagement believes that presentation of non-GAAP financial measures provides supplemental information useful to investors in understanding our underlying operating results and trends. Non-GAAP financial information, when taken collectively, maybe helpful to investors because it provides consistency and comparability of the Company’s operating results across reporting periods. Management uses this non-GAAP financial information to establish budgets, manage the Company’s business, and set incentive and compensation arrangements. Non-GAAP financial information is presented for supplemental information purposes only, has limitations as an analytical tool and should not be considered in isolation or as a substitute for financial information presented in accordance with U.S. GAAP. For example, adjusted EBITDA excludes a number of expense items that are included in net loss. As a result, positive adjusted EBITDA may be achieved while a significant net loss persists. For more information on these non-GAAP financial measures, see the tables captioned \u201cU.S. GAAP to Non-GAAP Reconciliation\u201d in the Company\u2019s earnings releases. The Company presents certain forward-looking statements about the Company’s future financial performance that include non-GAAP measures. These non-GAAP measures include adjustments like stock-based compensation, acquisition and integration costs including gains and losses on contingent consideration, and other significant charges or gains that are difficult to predict for future periods because the nature of the adjustments pertain to events that have not yet occurred. Additionally, management does not forecast many of the excluded items for internal use. Information reconciling forward-looking non-GAAP measures to U.S. GAAP measures is therefore not available without unreasonable effort and is not provided. The occurrence, timing, and amount of any of the items excluded from GAAP to calculate non-GAAP could significantly impact the Company’s GAAP results.<\/p>\n Forward-Looking Statement<\/b><\/p>\n \nThis news release contains forward-looking statements concerning our expectations, anticipations, intentions, beliefs, or strategies regarding the future. These forward-looking statements are based on assumptions that we have made as of the date hereof and are subject to known and unknown risks and uncertainties that could cause actual results, conditions and events to differ materially from those anticipated. Therefore, you should not place undue reliance on forward-looking statements. Examples of forward-looking statements include, among others, statements regarding expected future operating results and the anticipated benefits of the license agreement and the parties\u2019 ability to successfully implement the terms of the agreement.<\/p>\n \nImportant factors that could cause actual results, conditions and events to differ materially from those indicated in the forward-looking statements include, among others, the following: our ability to successfully develop and commercialize new products and services and assess potential market opportunities; our ability to successfully and profitably market our products and services; the acceptance of our products and services by patients and healthcare providers; our reliance upon certain suppliers; our ability to retain and hire key personnel; approval and maintenance of adequate reimbursement rates for our products and services within and outside of the U.S.; the amount and nature of competition for our products and services; the effects of any judicial, executive or legislative action affecting us or the healthcare system; government shutdowns and changes in government policies, laws, regulations, and staffing; recommendations, guidelines and quality metrics issued by various organizations regarding cancer screening or our products and services; our ability to obtain and maintain regulatory approvals and comply with applicable regulations; our ability to protect and enforce our intellectual property; our success establishing and maintaining collaborative, licensing, and supplier arrangements; the results of our validation studies and clinical trials, including the risks that the results of future studies and trials may differ materially from the results of previously completed studies and trials; our ability to manage an international business and our expectations regarding our international expansion and opportunities; the potential effects of changing macroeconomic conditions and geopolitical conflict; the possibility that the anticipated benefits from our business acquisitions or collaborative or licensing arrangements will not be realized in full or at all or may take longer to realize than expected; the possibility that the anticipated benefits from our restructuring and cost reduction initiatives will not be realized in full or at all or may take longer to realize than expected; the outcome of any potential litigation or legal proceeding; and our ability to raise the capital necessary to support our operations or meet our payment obligations under our indebtedness. The risks included above are not exhaustive. Other important risks and uncertainties are described in the Risk Factors sections of our most recent Annual Report on Form 10-K and any subsequent Quarterly Reports on Form 10-Q, and in our other reports filed with the Securities and Exchange Commission. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise<\/p>\n View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20251110155808\/en\/<\/a><\/span><\/p>\n Investor Contact: Media Contact: KEYWORDS:<\/b> United States North America Wisconsin<\/p>\n INDUSTRY KEYWORDS:<\/b> Oncology Medical Devices Health Other Health Managed Care General Health<\/p>\n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/p>\n
\n<\/b>
Derek Leckow
\n
608-893-0009
\n
investorrelations@exactsciences.com<\/a><\/p>\n
\n
<\/b>Steph Spanos
\n
608-556-4380
\n
sspanos@exactsciences.com<\/a><\/p>\n
![\"Logo\"](\"https:\/\/mms.businesswire.com\/media\/20251110155808\/en\/2040564\/3\/ES_logo_color_pos_rgb.jpg\"){kind=logo}
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