{"id":906251,"date":"2025-11-05T18:52:30","date_gmt":"2025-11-05T23:52:30","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\/"},"modified":"2025-11-05T18:52:30","modified_gmt":"2025-11-05T23:52:30","slug":"tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\/","title":{"rendered":"Tevogen Reports Major Clinical Milestone: Expands HLA Coverage of its Investigational Precision T Cell Therapy for Acute and Long COVID"},"content":{"rendered":"<div class=\"mw_release\">\n<ul>\n<li style=\"text-align:left\">This milestone expands patient eligibility through multi-HLA targeting<\/li>\n<li style=\"text-align:left\">Builds on completed TVGN 489 trial demonstrating 100% viral clearance, no reinfections, and no cases of Long COVID in high-risk patients<\/li>\n<li style=\"text-align:left\">TVGN 489 utilizes off-the-shelf, genetically unmodified allogeneic T cells<\/li>\n<li style=\"text-align:left\">TVGN 489 is designed to address both acute COVID-19 infection and Long COVID<\/li>\n<\/ul>\n<p align=\"left\">WARREN, N.J., Nov.  05, 2025  (GLOBE NEWSWIRE) &#8212; <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=IF8SXFxZC6mDAgNCwqmntyGcRHeBM16xaQ5UVh8wG3Z4Prm_yvtZYhl4pp7VQ5v71fmiV6R497EqRn_TitEQVg==\" rel=\"nofollow\" target=\"_blank\"><u>Tevogen<\/u><\/a> (\u201cTevogen Bio Holdings Inc.\u201d or \u201cCompany\u201d) (Nasdaq: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=N2DmUxESQQYVFvxX5KjM1Pz5Jzur5uYWvy8Mgql06vddg3PlisXn0Z34_YXf4WIfozw9lgbK5RFwt6XdTeRg3w_gQjn1ZwLBpnXlDqvVMx7DM5bgNpVd-1oRBV1_W7U1\" rel=\"nofollow\" target=\"_blank\"><u>TVGN<\/u><\/a>), today announced a clinical milestone in the evolution of its proprietary ExacTcell\u2122 platform: completion of T cell target identification for an additional five human leukocyte antigen (HLA) restrictions. This advancement significantly broadens the accessibility of Tevogen\u2019s investigational precision T cell therapies by extending therapeutic reach beyond the single HLA-A*02:01 restriction used in the Company\u2019s initial proof-of-concept (POC) clinical trial, the results of which were published in <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=URskSbvy8AN7CEFKHxEKvGGQgf4EHMZk3skQv7JmZix6LKdCOVdFRska-SL13feZNFO3CREMPYmkGQZD_qzdRGmWHcdvkhlKl8M7IW4m9Rdbrw0BOH3WDiU3tmID5Z5_oTbBv-jowac0FNav0ln-z4U7duugVB9tDrEZf5YDKmacTx4j6q41UzbAbj_-1MrAkYMca18fLsksho9cgJScjA==\" rel=\"nofollow\" target=\"_blank\"><u>Blood Advances<\/u><\/a>. That study demonstrated the safety and feasibility of Tevogen\u2019s third-party cytotoxic T lymphocyte (CTL) therapy, TVGN 489, in high-risk patients with COVID-19.<\/p>\n<p align=\"left\">HLA type varies widely among individuals and population groups. HLA-A*02:01 was selected for the proof-of-concept trial because it is one of the most common HLA types in the United States, present in approximately 25% of the population. Collectively, the identification of five additional HLA targets will allow the manufacture of CTLs which would extend treatment to approximately 65% of the US population, bolstering coverage for minority populations with less common HLA types.<\/p>\n<p align=\"left\">\u201cThe selection of additional HLA targets for Tevogen\u2019s ExacTcell products was performed with the goal of enfranchising as many patients as possible regardless of their race or ethnicity. Achieving multi-HLA coverage marks an essential step toward the path of truly universal T cell therapeutics,\u201d said Dr. Neal Flomenberg, Chief Scientific Officer of Tevogen Bio. \u201cThis scientific progress brings us closer to a future in which patients, regardless of genetic background, can benefit from precise and durable immune-based treatments.\u201d<\/p>\n<p align=\"left\">The ability to treat additional patients with TVGN 489 applies to high-risk immunocompromised patients with an acute COVID-19 infection as well as those suffering from Long COVID. Long COVID affected approximately 35 million U.S. adults as of 2023 resulting in an estimated economic burden of $2.6 trillion to $3.7 trillion, encompassing lost earnings, healthcare costs, and diminished quality of life according to <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=DdSsUvM4gF428kDRhucPXDcHKvGzW7ThNp4DRX7y8op5HPHaKFP7xw3VtIflggNU6gO7skfP_V9aPNZ7p1wKQNMipl8LlgTZ-B1Hnr3MSVyRJItif6NxicZKSPGth3EGp63z-WaMUEyokRprlsDgsw==\" rel=\"nofollow\" target=\"_blank\"><u>JAMA Network<\/u><\/a>. These figures underscore the urgent need for durable, accessible solutions such as Tevogen\u2019s investigational T cell therapies.<\/p>\n<p align=\"left\">The ExacTcell\u2122 platform utilizes advanced immunological screening as well as laboratory testing to identify key targets recognized by the immune system across different HLA types. With this expanded coverage, Tevogen\u2019s next generation of T cell therapies aims to reach a much wider range of patients affected by infectious diseases and cancers.<\/p>\n<p align=\"left\">\n        <strong>Forward Looking Statements<\/strong>\n      <\/p>\n<p align=\"left\">This press release contains certain forward-looking statements, including without limitation statements relating to: Tevogen\u2019s plans for its research and manufacturing capabilities; expectations regarding future growth; expectations regarding the healthcare and biopharmaceutical industries; and Tevogen\u2019s development of, the potential benefits of, and patient access to its product candidates for the treatment of infectious diseases and cancer. Forward-looking statements can sometimes be identified by words such as \u201cmay,\u201d \u201ccould,\u201d \u201cwould,\u201d \u201cexpect,\u201d \u201canticipate,\u201d \u201cpossible,\u201d \u201cpotential,\u201d \u201cgoal,\u201d \u201copportunity,\u201d \u201cproject,\u201d \u201cbelieve,\u201d \u201cfuture,\u201d and similar words and expressions or their opposites. These statements are based on management\u2019s expectations, assumptions, estimates, projections and beliefs as of the date of this press release and are subject to a number of factors that involve known and unknown risks, delays, uncertainties and other factors not under the company\u2019s control that may cause actual results, performance or achievements of the company to be materially different from the results, performance or other expectations expressed or implied by these forward-looking statements.<\/p>\n<p align=\"left\">Factors that could cause actual results, performance, or achievements to differ from those expressed or implied by forward-looking statements include, but are not limited to: changes in the markets in which Tevogen competes, including with respect to its competitive landscape, technology evolution, or regulatory changes; changes in domestic and global general economic conditions; the risk that Tevogen may not be able to execute its growth strategies or may experience difficulties in managing its growth and expanding operations; the risk that Tevogen may not be able to develop and maintain effective internal controls; the failure to achieve Tevogen\u2019s commercialization and development plans and identify and realize additional opportunities, which may be affected by, among other things, competition, the ability of Tevogen to grow and manage growth economically and hire and retain key employees; the risk that Tevogen may fail to keep pace with rapid technological developments to provide new and innovative products and services or make substantial investments in unsuccessful new products and services; that Tevogen will need to raise additional capital to fully realize its business plans; risks related to the ability to develop, license or acquire new therapeutics; the risk of regulatory lawsuits or proceedings relating to Tevogen\u2019s business; uncertainties inherent in the execution, cost, and completion of preclinical studies and clinical trials; risks related to regulatory review, approval and commercial development; risks associated with intellectual property protection; Tevogen\u2019s limited operating history; and those factors discussed or incorporated by reference in Tevogen\u2019s Annual Report on Form 10-K and subsequent filings with the SEC.<\/p>\n<p align=\"left\">You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. Tevogen undertakes no obligation to update any forward-looking statements, except as required by applicable law.<\/p>\n<p align=\"left\">\n        <strong>Contacts<\/strong>\n      <\/p>\n<p align=\"left\">Tevogen Bio Communications<br \/>T: 1 877 TEVOGEN, Ext 701 <br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=vQGYuX69Et-0r2KTVPEAxkkAElYbk5v9_sGCDlu9aIpk7gPlCkVD49rb1icFyS9Uv5c0Q1SIrYhTjnvz1s34FYElnODNQ33ZBBRG0p7O_iIR6ty6mlNSsr5QKKbBL2dG\" rel=\"nofollow\" target=\"_blank\"><u>Communications@Tevogen.com<\/u><\/a><\/p>\n<p>A photo accompanying this announcement is available at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=GM_iRJOlrT2BKRqT_wVc0isY1J6Nb68CHCSfTzJtsTwafi06fR00AYggL4QIy8twYD9cweVocrOb2odBHVAdkV8mBh9ZANUQWlVDWJCHkFa04l_YtSS_m0VIvSmdd3Sc51OuvQF6ngLFXYwGKw4DqAMJ19qfMR8bxg0w5JpGq7r1exnKaqbqgyHZHU4P1rzeEnE_w8DoyYPXkCApxOMnK5oif7IadIhQReuRLqcL7-nQt6M_Wd4cctwYRUrqgvclGBNy4lVmcDu4pODaMLBaVw==\" rel=\"nofollow\" target=\"_blank\">https:\/\/www.globenewswire.com\/NewsRoom\/AttachmentNg\/2bf7fd67-e990-400f-a1b5-46672a093364<\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU2OTcxMCM3MjQ3MjMyIzIyODk5MTc=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/ODc5OGRlOTktMWRiMC00NzNjLTlhMTgtMzdiZWYwNjE1NGRhLTEzMDE0NjctMjAyNS0xMS0wNS1lbg==\/tiny\/Tevogen-Bio-Inc.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>This milestone expands patient eligibility through multi-HLA targeting Builds on completed TVGN 489 trial demonstrating 100% viral clearance, no reinfections, and no cases of Long COVID in high-risk patients TVGN 489 utilizes off-the-shelf, genetically unmodified allogeneic T cells TVGN 489 is designed to address both acute COVID-19 infection and Long COVID WARREN, N.J., Nov. 05, 2025 (GLOBE NEWSWIRE) &#8212; Tevogen (\u201cTevogen Bio Holdings Inc.\u201d or \u201cCompany\u201d) (Nasdaq: TVGN), today announced a clinical milestone in the evolution of its proprietary ExacTcell\u2122 platform: completion of T cell target identification for an additional five human leukocyte antigen (HLA) restrictions. This advancement significantly broadens the accessibility of Tevogen\u2019s investigational precision T cell therapies by extending therapeutic reach beyond the single HLA-A*02:01 restriction used in &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Tevogen Reports Major Clinical Milestone: Expands HLA Coverage of its Investigational Precision T Cell Therapy for Acute and Long COVID&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-906251","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Tevogen Reports Major Clinical Milestone: Expands HLA Coverage of its Investigational Precision T Cell Therapy for Acute and Long COVID - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tevogen Reports Major Clinical Milestone: Expands HLA Coverage of its Investigational Precision T Cell Therapy for Acute and Long COVID - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"This milestone expands patient eligibility through multi-HLA targeting Builds on completed TVGN 489 trial demonstrating 100% viral clearance, no reinfections, and no cases of Long COVID in high-risk patients TVGN 489 utilizes off-the-shelf, genetically unmodified allogeneic T cells TVGN 489 is designed to address both acute COVID-19 infection and Long COVID WARREN, N.J., Nov. 05, 2025 (GLOBE NEWSWIRE) &#8212; Tevogen (\u201cTevogen Bio Holdings Inc.\u201d or \u201cCompany\u201d) (Nasdaq: TVGN), today announced a clinical milestone in the evolution of its proprietary ExacTcell\u2122 platform: completion of T cell target identification for an additional five human leukocyte antigen (HLA) restrictions. This advancement significantly broadens the accessibility of Tevogen\u2019s investigational precision T cell therapies by extending therapeutic reach beyond the single HLA-A*02:01 restriction used in &hellip; Continue reading &quot;Tevogen Reports Major Clinical Milestone: Expands HLA Coverage of its Investigational Precision T Cell Therapy for Acute and Long COVID&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-05T23:52:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU2OTcxMCM3MjQ3MjMyIzIyODk5MTc=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Tevogen Reports Major Clinical Milestone: Expands HLA Coverage of its Investigational Precision T Cell Therapy for Acute and Long COVID\",\"datePublished\":\"2025-11-05T23:52:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\\\/\"},\"wordCount\":942,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTU2OTcxMCM3MjQ3MjMyIzIyODk5MTc=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/tevogen-reports-major-clinical-milestone-expands-hla-coverage-of-its-investigational-precision-t-cell-therapy-for-acute-and-long-covid\\\/\",\"name\":\"Tevogen Reports Major Clinical Milestone: Expands HLA Coverage of its Investigational Precision T Cell Therapy for Acute and Long COVID - 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