{"id":905273,"date":"2025-11-04T15:07:09","date_gmt":"2025-11-04T20:07:09","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/"},"modified":"2025-11-04T15:07:09","modified_gmt":"2025-11-04T20:07:09","slug":"cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/","title":{"rendered":"CytomX Therapeutics to Present CX-801 Phase 1 Monotherapy Biomarker Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting"},"content":{"rendered":"
\n

\n – CX-801 (PROBODY\u00ae<\/sup> interferon alpha-2b) Phase 1 data demonstrate activation of tumor-selective<\/em>
\n interferon signaling in patients with advanced melanoma – <\/em>\n <\/p>\n

\n – Data supportive of CX-801\u2019s mechanism of action and the ongoing Phase 1 combination study with KEYTRUDA\u00ae<\/sup> (pembrolizumab) –<\/em>\n <\/p>\n

SOUTH SAN FRANCISCO, Calif., Nov. 04, 2025 (GLOBE NEWSWIRE) — CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of masked, conditionally activated biologics, today announced that initial translational data from the ongoing Phase 1 study of CX-801 in patients with advanced melanoma will be presented at the Society for Immunotherapy of Cancer (SITC) 40th<\/sup> Anniversary Annual Meeting, being held in National Harbor, MD on November 7-9, 2025.<\/p>\n

\u201cCX-801 was intentionally designed to unlock the powerful immune-modulating effects of interferon alpha-2b by leveraging our PROBODY\u00ae<\/sup> therapeutic platform. We are excited to share initial Phase 1 biomarker data for CX-801 which suggest the molecule is working as designed by inducing tumor-localized activation of immune cell populations and interferon-stimulated genes in paired tumor biopsies, including PD-1 and PD-L1,\u201d said Marcia Belvin, Ph.D. SVP, chief scientific officer of CytomX Therapeutics.<\/p>\n

\u201cWe are pleased with the Phase 1 progress for CX-801 to-date, including initial evidence that CX-801 is generally well tolerated and can modulate the immune tumor microenvironment in patients with metastatic melanoma refractory to prior immune checkpoint inhibitor therapy. These initial data support the rationale for the ongoing Phase 1 combination study of CX-801 combined with KEYTRUDA\u00ae<\/sup> in melanoma, an area of significant unmet need. We look forward to providing Phase 1 clinical data of CX-801 combined with KEYTRUDA\u00ae<\/sup> in 2026,\u201d said\u00a0Dr. Wayne Chu, M.D., chief medical officer of\u00a0CytomX Therapeutics.<\/p>\n

KEYTRUDA\u00ae<\/sup> is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA<\/p>\n

\n Details for CytomX Therapeutics Presentations at SITC 2025<\/strong>\n <\/p>\n

\n CX-801 poster presentation<\/strong>:
Presentation Title: Pharmacodynamic Activity of CX-801, a Masked IFN\u03b12b PROBODY\u00ae<\/sup> Cytokine, in Patients with Advanced Melanoma
Abstract Number: 606
Session Date and Time: Saturday, November 8, 2025, 5:10 pm \u2013 6:35 pm ET<\/p>\n

\n Preclinical Masked T-cell Engager Targeting CDH3<\/strong>:
Presentation Title: CX-908, a PROBODY\u00ae<\/sup> T Cell Engager Targeting CDH3 and CD3, Induces Tumor Regressions and Improves the Therapeutic Window in Preclinical Studies
Abstract Number: 961
Session Date and Time: Friday, November 7, 2025, 5:35 pm \u2013 7:00 pm ET<\/p>\n

\n About\u00a0CytomX Therapeutics<\/strong>\n <\/p>\n

CytomX is a clinical-stage, oncology-focused biopharmaceutical company focused on developing novel conditionally activated, masked biologics designed to be localized to the tumor microenvironment. By pioneering a novel pipeline of localized biologics, powered by its PROBODY\u00ae<\/sup>\u00a0therapeutic platform, CytomX\u2019s vision is to create safer, more effective therapies for the treatment of cancer. CytomX\u2019s multi-modality technology platform has produced therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (ADCs), T-cell engagers, and immune modulators such as cytokines. CytomX\u2019s current clinical-stage pipeline includes CX-2051 and CX-801. CX-2051 is a masked, conditionally activated ADC directed toward epithelial cell adhesion molecule (EpCAM), armed with a topoisomerase-1 inhibitor payload. CX-2051 has potential applicability across multiple EpCAM-expressing epithelial cancers, including CRC, and was discovered in collaboration with ImmunoGen. CX-801 is a masked interferon alpha-2b PROBODY\u00ae<\/sup>\u00a0cytokine with broad potential applicability in traditionally immuno-oncology sensitive as well as insensitive (cold) tumors. CytomX has established strategic collaborations with multiple leaders in oncology, including Amgen, Astellas,\u00a0Bristol Myers Squibb, Regeneron and Moderna. For more information about CytomX and how it is working to make conditionally activated treatments the new standard-of-care in the fight against cancer, visit\u00a0www.cytomx.com<\/strong><\/a>\u00a0and follow us on\u00a0LinkedIn<\/strong><\/a>\u00a0and\u00a0X<\/strong> (formerly Twitter)<\/strong><\/a>.<\/p>\n

\n CytomX Therapeutics Forward-Looking Statements<\/strong>\n <\/p>\n

This press release includes forward-looking statements. Such forward-looking statements involve known and unknown risks, uncertainties and other important factors that are difficult to predict, may be beyond our control, and may cause the actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied in such statements, including those related to CX-801. Accordingly, you should not rely on any of these forward-looking statements, including those relating to the potential benefits, safety and efficacy or progress of CytomX\u2019s or any of its collaborative partners\u2019 product candidates, including CX-801, the potential benefits or applications of CytomX\u2019s PROBODY\u00ae<\/sup> therapeutic platform, CytomX\u2019s or its collaborative partners\u2019 ability to develop and advance product candidates into and successfully complete clinical trials, including the ongoing and planned clinical trials of CX-801 and the timing of initial and ongoing data availability for our clinical trials, including CX-801, and other development milestones. Risks and uncertainties that contribute to the uncertain nature of the forward-looking statements include: the unproven nature of CytomX\u2019s novel PROBODY\u00ae<\/sup> therapeutic technology; uncertainties around the Company\u2019s ability to raise sufficient funds to carry out its planned research and development; CytomX\u2019s clinical trial product candidates are in the initial stages of clinical development and its other product candidates are currently in preclinical development, and the process by which preclinical and clinical development could potentially lead to an approved product is long and subject to significant risks and uncertainties, including the possibility that the results of preclinical research and early clinical trials, may not be predictive of future results; the possibility that CytomX\u2019s clinical trials will not be successful; the possibility that current preclinical research may not result in additional product candidates; CytomX\u2019s dependence on the success of CX-2051 and CX-801; CytomX\u2019s reliance on third parties for the manufacture of the Company\u2019s product candidates; possible regulatory developments in the United States and foreign countries, including China and the European Union; and the risk that we may incur higher costs than expected for research and development or unexpected costs and expenses. Additional applicable risks and uncertainties include those relating to our preclinical research and development, clinical development, and other risks identified under the heading \u201cRisk Factors\u201d included in CytomX\u2019s Quarterly Report on Form 10-Q filed with the SEC on August 7, 2025. The forward-looking statements contained in this press release are based on information currently available to CytomX and speak only as of the date on which they are made. CytomX does not undertake and specifically disclaims any obligation to update any forward-looking statements, whether as a result of any new information, future events, changed circumstances or otherwise.<\/p>\n

PROBODY is a U.S. registered trademark of CytomX Therapeutics, Inc. All other trademarks are the properties of their respective owners.<\/p>\n

\n Company Contact:<\/strong>
\n
Chris Ogden
SVP, Chief Financial Officer
cogden@cytomx.com<\/a><\/p>\n

\n Investor Contact:<\/strong>
\n
Precision AQ (formerly Stern Investor Relations)
Stephanie Ascher
stephanie.ascher@precisionaq.com<\/a><\/p>\n

\n Media Contact:<\/strong>
\n
Redhouse Communications
Teri Dahlman
teri@redhousecomms.com<\/a><\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

– CX-801 (PROBODY\u00ae interferon alpha-2b) Phase 1 data demonstrate activation of tumor-selective interferon signaling in patients with advanced melanoma – – Data supportive of CX-801\u2019s mechanism of action and the ongoing Phase 1 combination study with KEYTRUDA\u00ae (pembrolizumab) – SOUTH SAN FRANCISCO, Calif., Nov. 04, 2025 (GLOBE NEWSWIRE) — CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of masked, conditionally activated biologics, today announced that initial translational data from the ongoing Phase 1 study of CX-801 in patients with advanced melanoma will be presented at the Society for Immunotherapy of Cancer (SITC) 40th Anniversary Annual Meeting, being held in National Harbor, MD on November 7-9, 2025. \u201cCX-801 was intentionally designed to unlock the powerful immune-modulating effects of interferon … <\/p>\n

Continue reading “CytomX Therapeutics to Present CX-801 Phase 1 Monotherapy Biomarker Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-905273","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nCytomX Therapeutics to Present CX-801 Phase 1 Monotherapy Biomarker Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CytomX Therapeutics to Present CX-801 Phase 1 Monotherapy Biomarker Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"– CX-801 (PROBODY\u00ae interferon alpha-2b) Phase 1 data demonstrate activation of tumor-selective interferon signaling in patients with advanced melanoma – – Data supportive of CX-801\u2019s mechanism of action and the ongoing Phase 1 combination study with KEYTRUDA\u00ae (pembrolizumab) – SOUTH SAN FRANCISCO, Calif., Nov. 04, 2025 (GLOBE NEWSWIRE) — CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of masked, conditionally activated biologics, today announced that initial translational data from the ongoing Phase 1 study of CX-801 in patients with advanced melanoma will be presented at the Society for Immunotherapy of Cancer (SITC) 40th Anniversary Annual Meeting, being held in National Harbor, MD on November 7-9, 2025. \u201cCX-801 was intentionally designed to unlock the powerful immune-modulating effects of interferon … Continue reading "CytomX Therapeutics to Present CX-801 Phase 1 Monotherapy Biomarker Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-04T20:07:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU2NTI2MSM3MjMyNTc3IzIwMjAyMjc=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"CytomX Therapeutics to Present CX-801 Phase 1 Monotherapy Biomarker Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting\",\"datePublished\":\"2025-11-04T20:07:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\\\/\"},\"wordCount\":1087,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTU2NTI2MSM3MjMyNTc3IzIwMjAyMjc=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\\\/\",\"name\":\"CytomX Therapeutics to Present CX-801 Phase 1 Monotherapy Biomarker Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting - 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(Nasdaq: CTMX), a leader in the field of masked, conditionally activated biologics, today announced that initial translational data from the ongoing Phase 1 study of CX-801 in patients with advanced melanoma will be presented at the Society for Immunotherapy of Cancer (SITC) 40th Anniversary Annual Meeting, being held in National Harbor, MD on November 7-9, 2025. \u201cCX-801 was intentionally designed to unlock the powerful immune-modulating effects of interferon … Continue reading \"CytomX Therapeutics to Present CX-801 Phase 1 Monotherapy Biomarker Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/","og_site_name":"Market Newsdesk","article_published_time":"2025-11-04T20:07:09+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU2NTI2MSM3MjMyNTc3IzIwMjAyMjc=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"CytomX Therapeutics to Present CX-801 Phase 1 Monotherapy Biomarker Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting","datePublished":"2025-11-04T20:07:09+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/"},"wordCount":1087,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU2NTI2MSM3MjMyNTc3IzIwMjAyMjc=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/cytomx-therapeutics-to-present-cx-801-phase-1-monotherapy-biomarker-data-at-the-society-for-immunotherapy-of-cancer-sitc-annual-meeting\/","name":"CytomX Therapeutics to Present CX-801 Phase 1 Monotherapy Biomarker Data at the Society for Immunotherapy of Cancer (SITC) Annual Meeting - 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