{"id":904332,"date":"2025-11-03T11:29:06","date_gmt":"2025-11-03T16:29:06","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\/"},"modified":"2025-11-03T11:29:06","modified_gmt":"2025-11-03T16:29:06","slug":"cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\/","title":{"rendered":"Cogent Biosciences Announces Multiple Presentations at the 67th Annual American Society of Hematology (ASH) Meeting"},"content":{"rendered":"
\n

\n SUMMIT data for bezuclastinib in NonAdvSM selected for two oral presentations which will describe its best-in-class potential<\/em>\n <\/p>\n

\n Novel JAK2 V617F mutant-selective inhibitor announced as Cogent\u2019s newest preclinical program; on-track for IND in 2026<\/em>\n <\/p>\n

WALTHAM, Mass. and BOULDER, Colo., Nov. 03, 2025 (GLOBE NEWSWIRE) — Cogent Biosciences, Inc.<\/u><\/a>\u00a0(Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, today announced three presentations featuring bezuclastinib, including two oral presentations in NonAdvanced Systemic Mastocytosis (NonAdvSM), at the 67th<\/sup> Annual Meeting of the American Society of Hematology (ASH) being held December 6-9, 2025 in Orlando, FL. Cogent also announced today plans to describe its novel JAK2 V617F mutant-selective inhibitor as part of a poster presentation at the 2025 ASH annual meeting.<\/p>\n

\u201cOn behalf of our clinical trial investigators, Cogent is honored to announce multiple presentations from the SUMMIT trial at this year\u2019s annual ASH meeting, including two oral presentations which will highlight the exciting results that bezuclastinib demonstrated in NonAdvSM patients,\u201d said Andrew Robbins, the company\u2019s President and Chief Executive Officer. \u201cThese data support our conviction that based on bezuclastinib\u2019s potential to fundamentally modify the disease in NonAdvSM patients, it has the potential to become the preferred standard of care in this patient population. In addition, at ASH we look forward to sharing preclinical data from our newest research program, a novel JAK2 V617F mutant-selective inhibitor which we believe has best-in-class potential based on its potency and selectivity.\u201d<\/p>\n

\n
\n Bezuclastinib Oral Presentations<\/u>
\n <\/strong>\n <\/p>\n

\n Efficacy and safety results from the primary analysis of the pivotal Summit trial: Bezuclastinib in adults with non-advanced systemic mastocytosis<\/strong>\n <\/p>\n

\n Session Name: <\/strong>634. Myeloproliferative Syndromes: Clinical and Epidemiological: Expanding the Therapeutic and Prognostic Landscape in Myeloproliferative Neoplasms, Mastocytosis and Hypereosinophilic Syndrome\u00a0
Presenter: <\/strong>Lindsay Rein, MD, Associate Professor of Medicine\u202fin the Division of Hematologic Malignancies and Cellular Therapy at Duke University\u00a0
Session Date and Time: <\/strong>December 6, 2025, 9:30 AM – 11:00 AM ET\u00a0
Presentation Time: <\/strong>9:45 AM – 10:00 AM ET\u00a0
Location: – <\/strong>Room – W414CD\u00a0<\/p>\n

\n The effect of bezuclastinib on the pathobiology of mastocytosis: Changes in BM mast cells, tryptase, and KIT p.D816V variant allele frequency from the pivotal Summit trial<\/strong>\n <\/p>\n

\n Session Name: <\/strong>634. Myeloproliferative Syndromes: Clinical and Epidemiological: Drivers and Mast Cells and Blasts, Oh My! – Insights and Treatments for MPNs and Mastocytosis.\u00a0
Presenter: <\/strong>Dr. Tracy George, MD, President and Chief Scientific Officer at ARUP Laboratories, Professor of Pathology at the University of Utah School of Medicine \u00a0
Session Date and Time: <\/strong>December 8, 2025, 4:30 PM – 6:00 PM ET\u00a0
Presentation Time: <\/strong>5:00 PM – 5:15 PM ET\u00a0
Location: – <\/strong>West Hall D2<\/p>\n

\n
\n Bezuclastinib Poster Presentation<\/u>
\n <\/strong>
\n
\n Relationship between KIT inhibition by bezuclastinib and effects on disease burden in mouse models of systemic mastocytosis<\/strong>\n <\/p>\n

\n Session Name: <\/strong>631. Myeloproliferative Syndromes and Chronic Myeloid Leukemia: Basic and Translational: Poster III\u00a0
Session Date and Time: <\/strong>December 8, 2025, 6:00 PM – 8:00 PM ET\u00a0
Location: – <\/strong>West Halls B3-B4<\/p>\n

\n
\n JAK2 Poster Presentation<\/u>
\n <\/strong>
\n
\n Preclinical characterization of a novel, wild-type-sparing, JAK2 V617F mutant-selective inhibitor<\/strong>\n <\/p>\n

\n Session Name: <\/strong>631. Myeloproliferative Syndromes and Chronic Myeloid Leukemia: Basic and Translational: Poster II\u00a0
Session Date and Time: <\/strong>December 7, 2025, 6:00 PM – 8:00 PM ET\u00a0
Location: <\/strong>West Halls B3-B4<\/p>\n

Full abstracts will be available for online viewing via the ASH Annual Meeting website: https:\/\/www.hematology.org\/meetings\/annual-meeting<\/u><\/a>.\u00a0\u00a0<\/p>\n

\n
\n About Cogent Biosciences, Inc.<\/u>
\n <\/strong>
\n
Cogent Biosciences is a biotechnology company focused on developing precision therapies for genetically defined diseases. The most advanced clinical program, bezuclastinib, is a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation as well as other mutations in KIT exon 17. KIT D816V is responsible for driving systemic mastocytosis, a serious disease caused by unchecked proliferation of mast cells. Exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. In addition to bezuclastinib, the Cogent Research Team is developing a portfolio of novel targeted therapies to help patients fighting serious, genetically driven diseases initially targeting mutations in FGFR2\/3, ErbB2, PI3K\u03b1, KRAS and JAK2. Cogent Biosciences is based in Waltham, MA and Boulder, CO. Visit our website for more information at www.cogentbio.com<\/a>. Follow Cogent Biosciences on social media:\u00a0X<\/a>\u00a0(formerly known as Twitter)\u00a0and\u00a0LinkedIn<\/a>. Information that may be important to investors will be routinely posted on our website and\u00a0X<\/a>.\u00a0<\/p>\n

\n
\n Forward Looking Statements<\/u>
\n <\/strong>
\n
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding: bezuclastinib\u2019s best-in-class potential for patients with NonAdvSM; the potential for bezuclastinib to fundamentally modify the disease in NonAdvSM patients and to become the preferred standard of care for this patient population; the best-in-class potential for the company\u2019s novel JAK2 V617F mutant-selective inhibitor and the company\u2019s plans to submit an NDA in 2026 for this program. The use of words such as, but not limited to, “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” or “would” and similar words expressions are intended to identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, our clinical results, the rate of enrollment in our clinical trials and other future conditions. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements. We may not actually achieve the forecasts or milestones disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Such forward-looking statements are subject to a number of material risks and uncertainties including but not limited to those set forth under the caption “Risk Factors” in Cogent’s most recent Quarterly Report on Form 10-Q filed with the\u00a0SEC. Any forward-looking statement speaks only as of the date on which it was made. Neither we, nor our affiliates, advisors or representatives, undertake any obligation to publicly update or revise any forward-looking statement, whether as result of new information, future events or otherwise, except as required by law. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date hereof.<\/p>\n

\n Contact:<\/strong>
\n
Christi Waarich
Senior Director, Investor Relations
christi.waarich@cogentbio.com<\/a>
617-830-1653<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

SUMMIT data for bezuclastinib in NonAdvSM selected for two oral presentations which will describe its best-in-class potential Novel JAK2 V617F mutant-selective inhibitor announced as Cogent\u2019s newest preclinical program; on-track for IND in 2026 WALTHAM, Mass. and BOULDER, Colo., Nov. 03, 2025 (GLOBE NEWSWIRE) — Cogent Biosciences, Inc.\u00a0(Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, today announced three presentations featuring bezuclastinib, including two oral presentations in NonAdvanced Systemic Mastocytosis (NonAdvSM), at the 67th Annual Meeting of the American Society of Hematology (ASH) being held December 6-9, 2025 in Orlando, FL. Cogent also announced today plans to describe its novel JAK2 V617F mutant-selective inhibitor as part of a poster presentation at the 2025 ASH annual meeting. … <\/p>\n

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Cogent also announced today plans to describe its novel JAK2 V617F mutant-selective inhibitor as part of a poster presentation at the 2025 ASH annual meeting. … Continue reading "Cogent Biosciences Announces Multiple Presentations at the 67th Annual American Society of Hematology (ASH) Meeting"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-11-03T16:29:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU2Njg3MSM3MjM4Nzg5IzIwODUxMjc=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Cogent Biosciences Announces Multiple Presentations at the 67th Annual American Society of Hematology (ASH) Meeting\",\"datePublished\":\"2025-11-03T16:29:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\\\/\"},\"wordCount\":1073,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTU2Njg3MSM3MjM4Nzg5IzIwODUxMjc=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\\\/\",\"name\":\"Cogent Biosciences Announces Multiple Presentations at the 67th Annual American Society of Hematology (ASH) Meeting - 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Cogent also announced today plans to describe its novel JAK2 V617F mutant-selective inhibitor as part of a poster presentation at the 2025 ASH annual meeting. … Continue reading \"Cogent Biosciences Announces Multiple Presentations at the 67th Annual American Society of Hematology (ASH) Meeting\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\/","og_site_name":"Market Newsdesk","article_published_time":"2025-11-03T16:29:06+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU2Njg3MSM3MjM4Nzg5IzIwODUxMjc=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Cogent Biosciences Announces Multiple Presentations at the 67th Annual American Society of Hematology (ASH) Meeting","datePublished":"2025-11-03T16:29:06+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\/"},"wordCount":1073,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU2Njg3MSM3MjM4Nzg5IzIwODUxMjc=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/cogent-biosciences-announces-multiple-presentations-at-the-67th-annual-american-society-of-hematology-ash-meeting\/","name":"Cogent Biosciences Announces Multiple Presentations at the 67th Annual American Society of Hematology (ASH) Meeting - 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