{"id":897328,"date":"2025-10-18T03:26:50","date_gmt":"2025-10-18T07:26:50","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\/"},"modified":"2025-10-18T03:26:50","modified_gmt":"2025-10-18T07:26:50","slug":"kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\/","title":{"rendered":"Kura Oncology Announces Preliminary Data from Its Farnesyl Transferase Inhibitor (FTI) Programs at the 2025 European Society for Medical Oncology (ESMO) Congress"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>FTI<\/em><br \/>\n        <em>mechanism addresses innate and adaptive resistance pathways common to targeted oncology therapies<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>Early clinical and preclinical data support darlifarnib\u2019s potential to enhance clinical benefit of PI3K\u03b1<\/em><br \/>\n        <em>-, KRAS- and tyrosine kinase inhibitors<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>50% objective response rate and 80% disease control rate in renal cell carcinoma (RCC) cohort of darlifarnib plus cabozantinib in ongoing dose-escalation clinical trial<\/em><br \/>\n        \n      <\/p>\n<p align=\"center\">\n        <em>Kura Oncology to host a virtual investor event today, October 18, 2025, at 10:30 a.m. PT<\/em><br \/>\n        <em>\u00a0\/\u00a0<\/em><br \/>\n        <em>1:30 p.m. ET \/ 7:30 p.m. CEST<\/em>\n      <\/p>\n<p>SAN DIEGO, Oct.  18, 2025  (GLOBE NEWSWIRE) &#8212; Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, today announced new preliminary data from its farnesyl transferase inhibitor (FTI) programs \u2013 darlifarnib (KO-2806) and tipifarnib \u2013 presented at the 2025 European Society for Medical Oncology (ESMO) Congress in Berlin, Germany, from October 17 \u2013 21, 2025.<\/p>\n<p>\u201cKura Oncology is pioneering the use of FTIs in combination with tyrosine kinase inhibitors (TKIs), PI3K\u03b1 inhibitors and KRAS inhibitors to address mechanisms of innate and adaptive resistance, thereby enhancing and extending the clinical benefit of these single-agent targeted therapies,\u201d said Troy Wilson, Ph.D., J.D., President and Chief Executive Officer of Kura Oncology. \u201cThe clinical data reported here at ESMO 2025 build on our preclinical presentation from last month and underscore darlifarnib\u2019s transformative potential as a versatile combination partner to major classes of precision medicines.\u201d<\/p>\n<p>\n        <strong>Darlifarnib as Monotherapy in Advanced Solid Tumors \u2013 FIT-001 Phase 1 Trial<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>\n          <em>HRAS<\/em>-mutant (<em>HRAS<\/em>-m) tumors are sensitive to FTIs<\/li>\n<li>Manageable safety and tolerability profile at doses from 3 to 10 mg per day<\/li>\n<li>Encouraging antitumor activity in advanced <em>HRAS<\/em>-m solid tumors across multiple dose levels, demonstrating on-target activity and a broad therapeutic window<\/li>\n<li>Data support further evaluation of KO-2806 in combinations across tumor types\n<\/li>\n<\/ul>\n<p>\n        <strong>Darlifarnib + Cabozantinib in Renal Cell Carcinoma \u2013 FIT-001 Phase 1 Trial<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>FTI mechanism blocks hyperactivated mTORC1 signaling in tumor endothelial cells<\/li>\n<li>Manageable safety profile in RCC patients across multiple doses, including at the full label dose of cabozantinib<\/li>\n<li>Antitumor activity observed across all doses in RCC, including in prior cabozantinib-exposed patients\n<ul type=\"circle\">\n<li>ORR: 33%\u201350% in ccRCC (17-50% in patients with prior cabozantinib exposure)<\/li>\n<li>DCR: 80%\u2013100% in ccRCC<\/li>\n<\/ul>\n<\/li>\n<li>Dose-escalation study ongoing and Phase 1b dose-expansion planned to assess optimal biologically active dose for combination\n<\/li>\n<\/ul>\n<p>\n        <strong>Tipifarnib + Alpelisib in <\/strong><br \/>\n        <strong><br \/>\n          <em>PIK3CA<\/em><br \/>\n        <\/strong><br \/>\n        <strong>-altered Head and Neck Squamous Cell Carcinoma \u2013 KURRENT-HN Phase 1 Trial<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>FTI mechanism blocks hyperactivated mTORC1 signaling in squamous tumor cells<\/li>\n<li>Manageable safety profile in HNSCC patients across multiple doses<\/li>\n<li>Robust antitumor activity was observed in heavily pretreated patients with relapsed or metastatic HNSCC with <em>PIK3CA<\/em> alterations\n<ul type=\"circle\">\n<li>ORR: 47% was observed at a daily dose of tipifarnib 1200 mg + alpelisib 250 mg<\/li>\n<li>Alpelisib monotherapy provides modest clinical benefit (ORR: 0%; BOR: SD)<sup>1<\/sup> and tipifarnib monotherapy not expected to provide clinical benefit in this population<\/li>\n<\/ul>\n<\/li>\n<li>Data generation options for darlifarnib + PI3K\u03b1 inhibitor combinations in solid tumors are being assessed\n<\/li>\n<\/ul>\n<p>\u201cThese results highlight the potential of FTIs to meaningfully enhance the clinical activity of PI3K\u03b1 inhibitors in molecularly selected patients,\u201d said Glenn Hanna, M.D., Director, Center for Cancer Therapeutic Innovation, Medical Oncologist, Center for Head &amp; Neck Oncology, Dana-Farber Cancer Institute, and Associate Professor of Medicine, Harvard Medical School \u2013 an investigator on both the FIT-001 and KURRENT-HN trials. \u201cDarlifarnib demonstrates robust activity in <em>HRAS<\/em>-mutant solid tumors, which are typically very challenging to treat using existing therapies. In addition, the combination of tipifarnib and alpelisib demonstrated robust antitumor activity in heavily pretreated patients with relapsed or metastatic HNSCC with PIK3CA alterations \u2014 a population where monotherapy alpelisib provides only modest clinical benefit. These combination data are very exciting and set the stage for combining darlifarnib with PI3K\u03b1 inhibitors.\u201d<\/p>\n<ol style=\"list-style-type:decimal\">\n<li>Juric et al.\u00a0<em>J Clin Oncol<\/em>\u00a02018;36(13):1291-9.\u00a0\n<\/li>\n<\/ol>\n<p>\n        <strong>Presentations<\/strong><br \/>\n        <br \/>The presentations are available on Kura\u2019s website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=I4jZo8WfWAfkjG0f7TmVPk5KEQP-Ghyg4wqV_Jb6lEzjn2bqN0pFyCk40STwat_YWmobJz6oTDECUsE0FsRgKzkP6f8LbWxFmIKhpP2PmMQ=\" rel=\"nofollow\" target=\"_blank\">www.kuraoncology.com<\/a> under the Posters and Presentations tab in the <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ySB6IqE0upV9OvcCeyuVdFEz2feua1aGUD6J0Aujp1teTAH4xsYtWsz5ibsAOgGWNxQ_XW8scacYDGkQkFMpY83LqjDn4Rr6BzpyfUBUD35H2DhqdqG7WX9h2aeGmmSNwo_WcVH4qlD8wrxYum8FCFrhP0pqApgGpR0DGHJRmojB9E_Qf34Bk-o05iNKEZVKKvXKMqKHCcH-bPwU7uTGtA==\" rel=\"nofollow\" target=\"_blank\">Farnesyl Transferase Inhibition<\/a> section, and in the ESMO Congress 2025 online program.<\/p>\n<p>\n        <strong>Virtual Investor Event<\/strong><br \/>\n        <br \/>Kura will host a webcast and conference call today, October 18, 2025, at\u00a010:30 a.m. PT \/ 1:30 p.m. ET \/ 7:30 p.m. CEST featuring management and Glenn A. Hanna, M.D., Director, Center for Cancer Therapeutic Innovation Medical Oncologist, Center for Head &amp; Neck Oncology, Dana-Farber Cancer Institute and Associate Professor of Medicine, Harvard Medical School.<\/p>\n<p>The live webcast and replay will be available on the Company\u2019s website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=I4jZo8WfWAfkjG0f7TmVPk5KEQP-Ghyg4wqV_Jb6lEyovJfPeBqF-6PSU-MfmTmkq2Mo2Wy4QqtUx5NlBckmrCBxoGzdu9Ermd7Bc2oQ_cQ=\" rel=\"nofollow\" target=\"_blank\">www.kuraoncology.com<\/a> under the Investors tab in the <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Qq7hPV8flRaI7fyjw-alInbaQI45x6MMSXnDNP4hvxIAONF2HB__dqg4qkvrStXEI3EzPRugdH2G9yY0LKDXrsVELGpTlK2bBqJIfLanZCoOvsufxffPJbxt8JwTls88piiBmVM090lnLj0CAnxSYg==\" rel=\"nofollow\" target=\"_blank\">Events and Presentations<\/a> section.<\/p>\n<p>\n        <strong>About\u00a0Kura Oncology<\/strong><br \/>\n        <br \/>Kura Oncology is a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer. The Company\u2019s pipeline of small molecule drug candidates is designed to target cancer signaling pathways and address high-need hematologic malignancies and solid tumors. Kura is developing ziftomenib, a menin inhibitor targeting certain genetic drivers of acute myeloid leukemias, and continues to pioneer advancements in menin inhibition for acute leukemias and solid tumors and in farnesyl transferase inhibition to address mechanisms of adaptive and innate resistance in the treatment of solid tumors. For additional information, please visit the Kura website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=t9h_sqcxU34dBxQijwm2Qbxj0R6NaoyM9Ky3hAvcu3R21qg1yooEeWTTxXS246Ia3aJGvhcsUlTCpeo7YPb9BNFYUlvGBr7QiSMvoghRTRA=\" rel=\"nofollow\" target=\"_blank\">https:\/\/kuraoncology.com\/<\/a>\u00a0and follow us on\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=RG0_4y3RBjJ5Y4-W6QXCxrQJBoyeDXom0E902L-7MKr3wre7_I0WwCal-MOEHxTVJ8X5qYZEbRsMC0bpC5wwbQ==\" rel=\"nofollow\" target=\"_blank\">X<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=2RG5XTogNvV5G00dYvtEhi8YIif1IbjjI7cXvL97eqOzf9Nq59WjXIph-JefQBRHF3_0B0G8sBE69loSzRmUaxiz-Z50atNeVtvlLx_zHJ-xfnbWoZF19zT3FrbY-mwl\" rel=\"nofollow\" target=\"_blank\">LinkedIn<\/a>.<\/p>\n<p>\n        <strong>Forward-Looking Statements\u00a0<\/strong><br \/>\n        <br \/>This news release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. Such forward-looking statements include, among other things, statements regarding the potential of FTIs to address resistance mechanisms in cancer, the potential benefits of combining FTIs with\u00a0targeted therapies,\u00a0and the potential of FTIs to impact patients with cancer. Factors that may cause actual results to differ materially include the risk that compounds that appeared promising in early research or clinical trials do not demonstrate safety and\/or efficacy in later preclinical studies or clinical trials, the risk that Kura may not obtain approval to market its product candidates, uncertainties associated with performing clinical trials, regulatory filings, and other interactions with regulatory bodies, and other risks associated with the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. You are urged to consider statements that include the words \u201cmay,\u201d \u201cwill,\u201d \u201cwould,\u201d \u201ccould,\u201d \u201cshould,\u201d \u201cbelieves,\u201d \u201cestimates,\u201d \u201cprojects,\u201d \u201cpromise,\u201d \u201cpotential,\u201d \u201cexpects,\u201d \u201cplans,\u201d \u201canticipates,\u201d \u201cintends,\u201d \u201ccontinues,\u201d \u201cdesigned,\u201d \u201cgoal,\u201d or the negative of those words or other comparable words to be uncertain and forward-looking. For a further list and description of the risks and uncertainties Kura faces, please refer to Kura\u2019s periodic and other filings with the Securities and Exchange Commission, which are available at www.sec.gov. Such forward-looking statements are current only as of the date they are made, and Kura assumes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.\u00a0<\/p>\n<p>\n        <strong>Conflict of Interest Disclosure<\/strong><br \/>\n        <br \/>Dr. Hanna&#8217;s disclosures include institutional research support and an advisory role with Kura Oncology, Inc.<\/p>\n<p>\n        <strong>Kura Contact<\/strong><br \/>\n        <br \/>Investors and Media:<br \/>Greg Mann<br \/>858-987-4046<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=8K9WtiqnuL0FLd0Jgxw6NCYxtYYUxFEwo0S2ddvYFOJsQD8X1q9NREh6y3vFCLbUnbNvqLpT5goBpRdqoRtnu1EFScIjvMgsI2ZhKef9dGM=\" rel=\"nofollow\" target=\"_blank\">gmann@kuraoncology.com<\/a><\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU0NzkzOCM3MjAyNjAyIzIwMTcxOTU=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/NjA4OGQxMDMtMzQ3YS00NzYzLTgwMjMtNDk0ZDI0ZTJjYTVmLTEwMjg3NjgtMjAyNS0xMC0xOC1lbg==\/tiny\/Kura-Oncology-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>FTI mechanism addresses innate and adaptive resistance pathways common to targeted oncology therapies Early clinical and preclinical data support darlifarnib\u2019s potential to enhance clinical benefit of PI3K\u03b1 -, KRAS- and tyrosine kinase inhibitors 50% objective response rate and 80% disease control rate in renal cell carcinoma (RCC) cohort of darlifarnib plus cabozantinib in ongoing dose-escalation clinical trial Kura Oncology to host a virtual investor event today, October 18, 2025, at 10:30 a.m. PT \u00a0\/\u00a0 1:30 p.m. ET \/ 7:30 p.m. CEST SAN DIEGO, Oct. 18, 2025 (GLOBE NEWSWIRE) &#8212; Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, today announced new preliminary data from its farnesyl transferase &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Kura Oncology Announces Preliminary Data from Its Farnesyl Transferase Inhibitor (FTI) Programs at the 2025 European Society for Medical Oncology (ESMO) Congress&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-897328","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Kura Oncology Announces Preliminary Data from Its Farnesyl Transferase Inhibitor (FTI) Programs at the 2025 European Society for Medical Oncology (ESMO) Congress - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kura Oncology Announces Preliminary Data from Its Farnesyl Transferase Inhibitor (FTI) Programs at the 2025 European Society for Medical Oncology (ESMO) Congress - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"FTI mechanism addresses innate and adaptive resistance pathways common to targeted oncology therapies Early clinical and preclinical data support darlifarnib\u2019s potential to enhance clinical benefit of PI3K\u03b1 -, KRAS- and tyrosine kinase inhibitors 50% objective response rate and 80% disease control rate in renal cell carcinoma (RCC) cohort of darlifarnib plus cabozantinib in ongoing dose-escalation clinical trial Kura Oncology to host a virtual investor event today, October 18, 2025, at 10:30 a.m. PT \u00a0\/\u00a0 1:30 p.m. ET \/ 7:30 p.m. CEST SAN DIEGO, Oct. 18, 2025 (GLOBE NEWSWIRE) &#8212; Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, today announced new preliminary data from its farnesyl transferase &hellip; Continue reading &quot;Kura Oncology Announces Preliminary Data from Its Farnesyl Transferase Inhibitor (FTI) Programs at the 2025 European Society for Medical Oncology (ESMO) Congress&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-18T07:26:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU0NzkzOCM3MjAyNjAyIzIwMTcxOTU=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Kura Oncology Announces Preliminary Data from Its Farnesyl Transferase Inhibitor (FTI) Programs at the 2025 European Society for Medical Oncology (ESMO) Congress\",\"datePublished\":\"2025-10-18T07:26:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\\\/\"},\"wordCount\":1165,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTU0NzkzOCM3MjAyNjAyIzIwMTcxOTU=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/kura-oncology-announces-preliminary-data-from-its-farnesyl-transferase-inhibitor-fti-programs-at-the-2025-european-society-for-medical-oncology-esmo-congress\\\/\",\"name\":\"Kura Oncology Announces Preliminary Data from Its Farnesyl Transferase Inhibitor (FTI) Programs at the 2025 European Society for Medical Oncology (ESMO) Congress - 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