{"id":895496,"date":"2025-10-14T08:50:16","date_gmt":"2025-10-14T12:50:16","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/"},"modified":"2025-10-14T08:50:16","modified_gmt":"2025-10-14T12:50:16","slug":"fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/","title":{"rendered":"Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>\u2015 Preclinical data of FTX-6274 suggests potential for the treatment of castration resistant prostate cancer \u2015<\/em>\n      <\/p>\n<p>CAMBRIDGE, Mass., Oct.  14, 2025  (GLOBE NEWSWIRE) &#8212; Fulcrum Therapeutics, Inc.<sup>\u00ae <\/sup>(Fulcrum) (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases, today announced that it will present preclinical data for FTX-6274, an oral embryonic ectoderm development, or EED, inhibitor, in castration-resistant prostate cancer. Fulcrum will present these data at the ESMO Congress 2025 being held October 17-21, 2025, in Berlin, Germany.<\/p>\n<p>\u201cWe are encouraged by these findings, which highlight the potential of EED inhibition beyond our current hematology programs,\u201d said Jeff Jacobs, Chief Scientific Officer. \u201cGiven Fulcrum\u2019s strategic focus on non-malignant hematologic diseases, a strategic partnership may provide the best path to advance FTX-6274 for oncology indications.\u201d<\/p>\n<p>Presentation details are as follows:<\/p>\n<p>\n        <strong>Title:<\/strong> FTX-6274, an EED Inhibitor, Demonstrates Robust Efficacy in Castration Resistant Prostate Cancer (CRPC)<br \/><strong>Poster ID:<\/strong> 2504P<br \/><strong>Format:<\/strong> Poster<br \/><strong>First Author:<\/strong> Suchi Raghunathan, Senior Scientist, In Vivo Pharmacology<br \/><strong>Presentation Date and Time:<\/strong> Saturday, October 18, 2025, between 12:00-12:45 PM CEST<\/p>\n<p>Following congress publication, the poster will be available on the Publications &amp; Presentations Page of Fulcrum\u2019s website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=SSS2I774zl8pa52Y4tyb5cO8mpoRiLNGko_hcy5l00-GjBmAF0WvrQkRj5ZCQDqwvYAnTTuiU2k7fxuCPvDTW64SamVtwhY03rOMhPQFTe4=\" rel=\"nofollow\" target=\"_blank\">https:\/\/www.fulcrumtx.com<\/a>.<\/p>\n<p>\n        <strong>About Fulcrum Therapeutics<\/strong><br \/>\n        <br \/>Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum\u2019s lead clinical program is pociredir, a small molecule designed to increase expression of fetal hemoglobin (HbF) for the treatment of sickle cell disease (SCD). Fulcrum uses proprietary technology to identify drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. For more information, visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=b1nRji5-Bx_RkV3XO5IXqjSjZgxrFisHi-7q57KVFDtMdcUcrdVGSBWwNrAzW3TnOgnbImfHwU9Ncpox1iq79LEHapk2zTHQ_YNi9QztYlc=\" rel=\"nofollow\" target=\"_blank\">www.fulcrumtx.com<\/a> and follow us on Twitter\/X (@FulcrumTx) and LinkedIn.<\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong><br \/>\n        <br \/>This press release contains \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this press release are forward-looking statements, including express or implied statements regarding Fulcrum\u2019s research and development strategy; the potential of FTX-6274 for the treatment of cancer or other diseases; Fulcrum\u2019s plans to seek a partner for FTX-6274; and the continued development and therapeutic potential of Fulcrum\u2019s clinical-stage program, pociredir, for sickle cell disease, among others. The words \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccould,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cplan,\u201d \u201cpotential,\u201d \u201cshould,\u201d \u201cwill,\u201d and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements are based on management\u2019s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in, or implied by, such forward-looking statements. These risks and uncertainties include, but are not limited to, risks associated with Fulcrum\u2019s ability to continue to advance its product candidates in research and clinical development; obtaining and maintaining necessary approvals from the FDA and other regulatory authorities; replicating in clinical trials positive results found in preclinical studies and\/or earlier-stage clinical trials; obtaining, maintaining or protecting intellectual property rights related to its product candidates; managing expenses;; and raising the substantial additional capital needed to achieve its business objectives, among others. For a discussion of other risks and uncertainties, and other important factors, any of which could cause Fulcrum\u2019s actual results to differ from those contained in the forward-looking statements, see the \u201cRisk Factors\u201d section, as well as discussions of potential risks, uncertainties, and other important factors, in Fulcrum\u2019s most recent filings with the Securities and Exchange Commission. In addition, the forward-looking statements included in this press release represent Fulcrum\u2019s views as of the date hereof and should not be relied upon as representing Fulcrum\u2019s views as of any date subsequent to the date hereof. Fulcrum anticipates that subsequent events and developments will cause Fulcrum\u2019s views to change. However, while Fulcrum may elect to update these forward-looking statements at some point in the future, Fulcrum specifically disclaims any obligation to do so.<\/p>\n<p>\n        <strong>Contact: <\/strong><br \/>\n        <br \/>Kevin Gardner<br \/>LifeSci Advisors, LLC<br \/>kgardner@lifesciadvisors.com<br \/>617-283-2856<\/p>\n<p>      <img decoding=\"async\" alt=\"\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU0MzcyNSM3MTkwMzcxIzIxODM1NDI=\" \/><br \/>\n      <br \/>\n      <img decoding=\"async\" alt=\"\" src=\"https:\/\/ml.globenewswire.com\/media\/MTYwMmE0ODYtYjg0YS00Zjc5LWI1NjUtYjMxOTBkZTEzNTllLTExOTUxMDAtMjAyNS0xMC0xNC1lbg==\/tiny\/Fulcrum-Therapeutics-Inc-.png\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u2015 Preclinical data of FTX-6274 suggests potential for the treatment of castration resistant prostate cancer \u2015 CAMBRIDGE, Mass., Oct. 14, 2025 (GLOBE NEWSWIRE) &#8212; Fulcrum Therapeutics, Inc.\u00ae (Fulcrum) (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases, today announced that it will present preclinical data for FTX-6274, an oral embryonic ectoderm development, or EED, inhibitor, in castration-resistant prostate cancer. Fulcrum will present these data at the ESMO Congress 2025 being held October 17-21, 2025, in Berlin, Germany. \u201cWe are encouraged by these findings, which highlight the potential of EED inhibition beyond our current hematology programs,\u201d said Jeff Jacobs, Chief Scientific Officer. \u201cGiven Fulcrum\u2019s strategic focus on non-malignant &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-895496","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"\u2015 Preclinical data of FTX-6274 suggests potential for the treatment of castration resistant prostate cancer \u2015 CAMBRIDGE, Mass., Oct. 14, 2025 (GLOBE NEWSWIRE) &#8212; Fulcrum Therapeutics, Inc.\u00ae (Fulcrum) (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases, today announced that it will present preclinical data for FTX-6274, an oral embryonic ectoderm development, or EED, inhibitor, in castration-resistant prostate cancer. Fulcrum will present these data at the ESMO Congress 2025 being held October 17-21, 2025, in Berlin, Germany. \u201cWe are encouraged by these findings, which highlight the potential of EED inhibition beyond our current hematology programs,\u201d said Jeff Jacobs, Chief Scientific Officer. \u201cGiven Fulcrum\u2019s strategic focus on non-malignant &hellip; Continue reading &quot;Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-14T12:50:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU0MzcyNSM3MTkwMzcxIzIxODM1NDI=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025\",\"datePublished\":\"2025-10-14T12:50:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\\\/\"},\"wordCount\":707,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTU0MzcyNSM3MTkwMzcxIzIxODM1NDI=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\\\/\",\"name\":\"Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025 - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/","og_locale":"en_US","og_type":"article","og_title":"Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025 - Market Newsdesk","og_description":"\u2015 Preclinical data of FTX-6274 suggests potential for the treatment of castration resistant prostate cancer \u2015 CAMBRIDGE, Mass., Oct. 14, 2025 (GLOBE NEWSWIRE) &#8212; Fulcrum Therapeutics, Inc.\u00ae (Fulcrum) (Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases, today announced that it will present preclinical data for FTX-6274, an oral embryonic ectoderm development, or EED, inhibitor, in castration-resistant prostate cancer. Fulcrum will present these data at the ESMO Congress 2025 being held October 17-21, 2025, in Berlin, Germany. \u201cWe are encouraged by these findings, which highlight the potential of EED inhibition beyond our current hematology programs,\u201d said Jeff Jacobs, Chief Scientific Officer. \u201cGiven Fulcrum\u2019s strategic focus on non-malignant &hellip; Continue reading \"Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/","og_site_name":"Market Newsdesk","article_published_time":"2025-10-14T12:50:16+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU0MzcyNSM3MTkwMzcxIzIxODM1NDI=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025","datePublished":"2025-10-14T12:50:16+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/"},"wordCount":707,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTU0MzcyNSM3MTkwMzcxIzIxODM1NDI=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/fulcrum-therapeutics-to-present-preclinical-data-for-eed-inhibitor-ftx-6274-at-european-society-for-medical-oncology-esmo-congress-2025\/","name":"Fulcrum Therapeutics to Present Preclinical Data for EED Inhibitor FTX-6274 at European Society for Medical Oncology (ESMO) Congress 2025 - 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