{"id":888227,"date":"2025-09-22T08:45:06","date_gmt":"2025-09-22T12:45:06","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\/"},"modified":"2025-09-22T08:45:06","modified_gmt":"2025-09-22T12:45:06","slug":"jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\/","title":{"rendered":"Jazz Pharmaceuticals Showcases Phase 4 Data Demonstrating Xywav\u00ae (calcium, magnesium, potassium, and sodium oxybates) Oral Solution Treatment Effects and Real-World Evidence at World Sleep and Psych Congresses"},"content":{"rendered":"<div class=\"xn-newslines\">\n<p class=\"xn-distributor\">PR Newswire<\/p>\n<\/p><\/div>\n<div class=\"xn-content\">\n<p class=\"prntac\">\n        <i>20 abstracts presented across World Sleep and Psych Congresses showcase Jazz&#8217;s leadership in sleep medicine<\/i>\n      <\/p>\n<p class=\"prntac\">\n        <i>Novel results from the Phase 4 DUET trial underscore the significance of appropriate treatment options in adults with narcolepsy or idiopathic hypersomnia<\/i>\n      <\/p>\n<p>\n        <i>For U.S. media and investors only<\/i>\n      <\/p>\n<p>\n        <span class=\"legendSpanClass\"><br \/>\n          <span class=\"xn-location\">DUBLIN<\/span><br \/>\n        <\/span>, <span class=\"legendSpanClass\"><span class=\"xn-chron\">Sept. 22, 2025<\/span><\/span> \/PRNewswire\/ &#8212; Jazz\u00a0Pharmaceuticals\u00a0plc\u00a0(Nasdaq:\u00a0JAZZ) today\u00a0announced new real-world evidence and Phase 4\u00a0data reinforcing the value of Xywav<sup>\u00ae<\/sup> (calcium, magnesium, potassium, and sodium oxybates) oral solution treatment outcomes in adults with narcolepsy or idiopathic hypersomnia (IH) were presented at World Sleep 2025, held in <span class=\"xn-location\">Singapore<\/span> from <span class=\"xn-chron\">September 5-10, 2025<\/span>, as well as the 38<sup>th<\/sup> annual Psych Congress, held in <span class=\"xn-location\">San Diego<\/span> from <span class=\"xn-chron\">September 17-21, 2025<\/span>. Notable Phase 4 data included new results from the DUET (Develop hypersomnia Understanding by Evaluating low-sodium oxybate Treatment) trial, showing treatment effects of low-sodium <i>Xywav <\/i>on daytime and nighttime symptoms of narcolepsy or IH. The DUET trial is a Phase 4, prospective, single-arm, open-label study to assess the effect of <i>Xywav <\/i>treatment on excessive daytime sleepiness, polysomnography parameters, and functional outcomes in adults with narcolepsy or IH.<\/p>\n<p>&#8220;These new DUET data presented by Jazz continue to show the importance of measuring and understanding the impact of treatment in both daytime and nighttime symptoms, as well as other functional outcomes in people living with narcolepsy or idiopathic hypersomnia,&#8221; said <span class=\"xn-person\">Logan Schneider<\/span>, MD, adjunct clinical associate professor of sleep medicine, Stanford Sleep Center and Consultant Neurologist, Standford\/VA Alzheimer&#8217;s Center. &#8220;These results further reflect the positive implications that an appropriate treatment can have on patients&#8217; sleep outcomes, holistic health and their daily functioning.&#8221;<\/p>\n<p>&#8220;We are leveraging both the power of Phase 4 clinical trials and real-world evidence to provide clinically meaningful, high-quality research for the global sleep community, which informs the health complexities of people living with narcolepsy and idiopathic hypersomnia,&#8221; said Kelvin Tan, MB BCh, MRCPCH, chief medical affairs officer of Jazz Pharmaceuticals. &#8220;These robust data continue to expand our understanding of sleep disorders and the challenges patients living with these conditions face while further reinforcing the value of low-sodium <i>Xywav<\/i> treatment.&#8221;<\/p>\n<p>Presentation highlights include:<\/p>\n<ul type=\"disc\">\n<li>\n          <b><br \/>\n            <i>Xywav <\/i><br \/>\n          <\/b><br \/>\n          <b>DUET Sleep Actigraphy Results (World Sleep Poster #97):<\/b> Novel analysis of DUET data examining the impact of <i>Xywav <\/i>treatment on actigraphy measures found participants with narcolepsy experienced fewer awakenings and decreased wake after sleep onset, suggesting improved sleep measures. Similarly, participants with IH treated with <i>Xywav <\/i>experienced fewer awakenings, suggesting improved sleep measures, as well as decreased nocturnal sleep time.<\/li>\n<li>\n          <b><br \/>\n            <i>Xywav <\/i><br \/>\n          <\/b><br \/>\n          <b>DUET Sleep Inertia and Components of Daytime Sleepiness Results (World Sleep Poster #92):<\/b> Analysis of DUET data evaluating Psychomotor Vigilance Test (PVT) lapses and Karolinska Sleepiness Scale (KSS) ratings among participants with IH receiving optimized <i>Xywav <\/i>treatment, demonstrated reduced sleep inertia magnitude by subjective and objective measures, subjective reduction in sleepiness upon waking and objective improvement in impaired alertness.<\/li>\n<li>\n          <b>Real-World Risk of Sodium-Associated Negative Clinical Outcomes Results (World Sleep Poster #101 and #186):<\/b> Real-world analysis assessing the risk of sodium-associated negative clinical outcomes (NCOs) showed individuals with narcolepsy or IH have an elevated risk of development or progression of cardiovascular, cardiometabolic and renal NCOs relative to those without these conditions. These results emphasized the need to reduce sodium intake to mitigate the risk of NCOs among those living with these conditions.<\/li>\n<li>\n          <b><br \/>\n            <i>Xywav <\/i><br \/>\n          <\/b><br \/>\n          <b>DUET &gt;9 Gram Cohort (<span class=\"xn-person\">Psych Congress Poster<\/span> #125):<\/b> Complete cohort (n=48) analysis of top-line efficacy and safety data from DUET trial participants with narcolepsy taking 9-12 grams of <i>Xywav <\/i>nightly experienced additional symptom benefits, with reductions in Epworth Sleepiness Scale, Narcolepsy Severity Scale scores and cataplexy attacks, as compared to taking 9 grams per night at baseline. The <i>Xywav<\/i> label recommends a nightly dose of 6-9 grams per night for adults with narcolepsy. Overall, treatment-emergent adverse events were consistent with the known safety profile of <i>Xywav <\/i>at dosages less than 9 grams per night.<\/li>\n<\/ul>\n<p>The abstracts presented at World Sleep 2025 are available online at <a href=\"https:\/\/edge.prnewswire.com\/c\/link\/?t=0&amp;l=en&amp;o=4513646-1&amp;h=3961104205&amp;u=https%3A%2F%2Fws2025.abstractserver.com%2Fprogram%2F%23%2Fprogram%2F3%2Fhorizontal&amp;a=ws2025.abstractserver.com%2Fprogram\" target=\"_blank\" rel=\"nofollow\">ws2025.abstractserver.com\/program<\/a>.<\/p>\n<p>The Psych Congress presentations are available on-demand through the conference mobile application. Abstracts and posters will also be published on HMP Global&#8217;s <a href=\"https:\/\/edge.prnewswire.com\/c\/link\/?t=0&amp;l=en&amp;o=4513646-1&amp;h=4154032539&amp;u=https%3A%2F%2Fwww.hmpgloballearningnetwork.com%2Fsite%2Fpsychbehav&amp;a=Psychiatry+%26+Behavioral+Health+Learning+Network\" target=\"_blank\" rel=\"nofollow\">Psychiatry &amp; Behavioral Health Learning Network<\/a>\u00a030-60 days after the congress ends.<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tr>\n<td class=\"prnpr2 prnpl2 prnvat prncbts prnbrbrs prnbbbs prnbsbls\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presentation Title<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Lead Author<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presentation Details\u00a0<br \/><\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"3\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">World Sleep Congress<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Risk of New-onset <br \/>Cardiovascular and <br \/>Cardiometabolic Conditions in <br \/>Narcolepsy: An Analysis of the <br \/><i>All of Us <\/i>Research Program<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">SC Markt<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 212<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: SC\u00a0Markt<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Real-world Risk of Sodium-<br \/>Associated Negative Clinical <br \/>Outcomes Among Individuals <br \/>With Narcolepsy in the United<br \/>States<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">SC Markt<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 186<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: SC\u00a0Markt<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Risk of Sodium-Associated <br \/>Negative Clinical Outcomes in<br \/>Individuals With Idiopathic<br \/>Hypersomnia in the United <br \/>States: A Real-world Analysis<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">SC Markt<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 101<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: SC\u00a0Markt<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Association Between Sodium<br \/>Intake and Systolic and <br \/>Diastolic Blood Pressure: A <br \/>Systematic Literature Review <br \/>and Meta-analysis<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">C Drachenberg<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 237<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: C\u00a0Drachenberg<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Association Between Sodium<br \/>Intake and Risk of <br \/>Hypertension, Heart Failure, <br \/>Stroke, and Myocardial<br \/>Infarction: A Systematic <br \/>Literature Review and Meta-<br \/>analysis<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">C Drachenberg<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 211<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: J Sacks<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Prevalence and Incidence of <br \/>Comorbidities in individuals <br \/>With Narcolepsy or Idiopathic <br \/>Hypersomnia: A Systematic <br \/>Literature Review<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">C Drachenberg<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 193<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: C\u00a0Drachenberg<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Estimating the Economic and <br \/>Clinical Effects of High- and <br \/>Low-Sodium Oxybate Agents<br \/>among the US Population with <br \/>Narcolepsy: Microsimulation <br \/>Cost Analysis<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">L Pinto<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 177<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: C\u00a0Drachenberg<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Sleep Architecture With Low-<br \/>Sodium Oxybate Treatment in<br \/>Narcolepsy:<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Results From the DUET Study<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">CM Ruoff<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 184<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: DA Nichols<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Sleep Architecture With Low-<br \/>sodium Oxybate Treatment In<br \/>Idiopathic Hypersomnia: <br \/>Results From The DUET Study<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">A Cairns<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 120<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: DA Nichols<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Sleep Actigraphy in <br \/>Participants With Narcolepsy or<br \/>Idiopathic Hypersomnia Taking<br \/>Low-Sodium Oxybate: Results <br \/>From the DUET Study<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">N Foldvary-<br \/>Schaefer<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 097<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter:\u00a0JK Alexander<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Reduction in Sleep Inertia and <br \/>Components of Daytime <br \/>Sleepiness in Idiopathic <br \/>Hypersomnia With Low-Sodium<br \/>Oxybate Treatment in the<br \/>Phase 4 DUET Study<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">H Van Dongen<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 092<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: H Van\u00a0Dongen<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Impact of Switching From High- <br \/>to Low-Sodium Oxybate on <br \/>Ambulatory Blood Pressure in <br \/>People With Narcolepsy<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Y Dauvilliers<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 216<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: Y\u00a0Dauvilliers<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"3\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Psych Congress<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Effectiveness and Safety of <br \/>Low-Sodium Oxybate in<br \/>Participants With Idiopathic<br \/>Hypersomnia With or Without <br \/>Psychiatric Comorbidities: <br \/>Results From the Phase 4 <br \/>DUET Study<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">DT Plante<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 123<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: DT\u00a0Plante<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Improvement in Bothersome <br \/>Mood, Cognitive, and <br \/>Functional Impacts of <br \/>Idiopathic Hypersomnia After<br \/>Low-Sodium Oxybate <br \/>Treatment in the DUET Study<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">DT Plante<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 124<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: DT\u00a0Plante<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Impact of Sleep Inertia on <br \/>Cognition in People\u00a0With<br \/>Idiopathic Hypersomnia<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">SC Markt<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 128<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: AT\u00a0Togun<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Evaluating the Impact of <br \/>Switching From High-Sodium<br \/>Oxybate to Low-Sodium <br \/>Oxybate on Ambulatory Blood<br \/>Pressure in People With <br \/>Narcolepsy<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">VK Somers<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 129<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: DA Nichols<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Greater Than 9 Gram Dosage <\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">of Low-Sodium\u00a0Oxybate in Study <\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Participants With Narcolepsy: <\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Effectiveness and Safety Results <\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">From the DUET Study<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">JK Simmons<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 125<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter:\u00a0JK Alexander<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Effectiveness and Safety of <br \/>Low-Sodium Oxybate in <br \/>Participants With Narcolepsy <br \/>With or Without Psychiatric <br \/>Comorbidities: Results From<br \/>the Phase 4 DUET Study\u00a0<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">CM Ruoff<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 120<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: DA Nichols<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Self-Reported Cognitive <br \/>Complaints and Work <br \/>Productivity in Participants With <br \/>Narcolepsy After Low-Sodium<br \/>Oxybate Treatment: Results <br \/>From the Phase 4 DUET Study<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">LD Schneider<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 126<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter:\u00a0JK Alexander<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Clinical Characteristics and <br \/>Productivity Losses Among<br \/>Individuals Diagnosed With<br \/>Narcolepsy or Idiopathic<br \/>Hypersomnia<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">AT Togun<\/span>\n              <\/p>\n<\/td>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Poster #: 113<\/span>\n              <\/p>\n<p class=\"prnml4\">\n                <span class=\"prnews_span\">Presenter: AT\u00a0Togun<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<\/table><\/div>\n<p>\n        <b>About Narcolepsy<br \/><\/b>Narcolepsy is a chronic, debilitating neurologic sleep disorder characterized by the inability to maintain continuous sleep at night and sustained wakefulness throughout the day. This leads to symptoms that can include fragmented or disrupted nighttime sleep, excessive daytime sleepiness, and cataplexy.<sup>1<\/sup> Patients with EDS due to narcolepsy experience sleep attacks and, despite fighting the urge to sleep, may unintentionally fall asleep for short periods.<sup>2,3<\/sup>\u00a0These sleep attacks may happen at inappropriate or potentially dangerous times such as during driving, cycling, eating, or mid-conversation.<sup>4<\/sup><\/p>\n<p>There is no cure for narcolepsy; the symptoms are lifelong and have a substantial negative impact on a person&#8217;s ability to function psychologically, socially and professionally.<sup>5<\/sup>\u00a0Patients with narcolepsy are at increased risk for\u00a0hypertension, cardiometabolic morbidity,\u00a0stroke, myocardial infarction, heart failure, cardiac arrest, and death.<sup>6,7,8,9<\/sup> As narcolepsy is a chronic condition that requires lifelong treatment, early access to an effective treatment can help reduce the impact of narcolepsy symptoms on a person&#8217;s physical and mental health, and long-term impacts of the treatment on cardiovascular health should be considered.<sup>5<\/sup><\/p>\n<p>\n        <b>About Idiopathic Hypersomnia\u00a0<\/b><br \/>\n        <br \/>Idiopathic hypersomnia is an often debilitating, neurologic sleep disorder that goes beyond chronic excessive daytime sleepiness.<sup>10,11,12,13<\/sup>\u00a0Idiopathic hypersomnia is a 24-hour sleep disorder, and symptoms may include non-restorative sleep with or without long sleep time (main, nighttime, sleep episode of more than 9 hours, or a sleep duration of 11 hours or longer over a 24-hour period); severe sleep inertia (prolonged difficulty waking, with frequent reentries into sleep, confusion, and irritability); long and unrefreshing naps; cognitive impairment and brain fog, or the inability to focus for long periods of time.<sup>10,11,12,13,14\u00a0<\/sup>Although there are some overlapping clinical features with narcolepsy, idiopathic hypersomnia is a condition with its own specific diagnostic criteria.<sup>13,15<\/sup>\u00a0<\/p>\n<p>Idiopathic hypersomnia is an often debilitating illness that can significantly affect social, educational, and occupational functioning.<sup>16,17<\/sup>\u00a0In the\u00a0U.S., approximately 37,000 adult patients have been diagnosed with idiopathic hypersomnia and are actively seeking healthcare.<sup>18<\/sup>\u00a0This low number of people may be due to the many difficulties in identifying and diagnosing idiopathic hypersomnia, as well as distinguishing it from other similar sleep disorders. It is estimated that far fewer patients are currently receiving pharmacological treatment for their idiopathic hypersomnia.<sup>18,19,20,21<\/sup><\/p>\n<p>\n        <b>About Xywav<sup>\u00ae<\/sup>\u00a0(calcium, magnesium, potassium, and sodium oxybates) oral solution<\/b><br \/>\n        <br \/>\n        <i>Xywav<\/i>\u00a0is the only low-sodium oxybate approved by the\u00a0U.S. Food and Drug Administration\u00a0(FDA) for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy. The FDA recognized seven years of Orphan Drug Exclusivity for\u00a0<i>Xywav<\/i>\u00a0for the treatment of cataplexy or EDS in patients 7 years of age and older with narcolepsy. The Office of Orphan Product Development (OOPD) at the FDA also published its summary of clinical superiority findings for\u00a0<i>Xywav<\/i>\u00a0for the treatment of cataplexy or EDS in patients 7 years of age and older with narcolepsy by means of greater cardiovascular safety compared to Xyrem<sup>\u00ae<\/sup>\u00a0(sodium oxybate) oral solution. The decision of the OOPD is based on the FDA findings that\u00a0<i>Xywav<\/i>\u00a0provides a greatly reduced chronic sodium burden compared to\u00a0<i>Xyrem<\/i>.\u00a0<i>Xywav\u00a0<\/i>has 131 mg of sodium at the maximum recommended nightly dose\u00a0whereas other high sodium oxybates have 1640 mg at the equivalent dose.\u00a0<i>Xywav<\/i>\u00a0is comprised of a unique composition of cations resulting in 92% less sodium, or a reduction of approximately 1,000 to 1,500 mg\/night at the recommended dose range of 6 g to 9 g\/night.\u00a0<i>Xywav<\/i>\u00a0is the only oxybate therapy that does not carry a warning in the label related to use in patients sensitive to high sodium intake.<\/p>\n<p>\n        <i>Xywav\u00a0<\/i>is also the first and only\u00a0U.S.\u00a0FDA-approved treatment option for idiopathic hypersomnia in adults. The FDA recognized seven years of Orphan Drug Exclusivity for\u00a0<i>Xywav<\/i>\u00a0for the treatment of idiopathic hypersomnia in adults.\u00a0<i>Xywav<\/i>\u00a0is the only FDA-approved treatment studied across the multiple symptoms of idiopathic hypersomnia, such as EDS, sleep inertia (severe grogginess or confusion when waking up), long sleep duration and cognitive impairment.\u00a0<i>Xywav<\/i>\u00a0can be administered as a twice- or once-nightly regimen for the treatment of idiopathic hypersomnia in adults.<\/p>\n<p>The exact mechanism of action of\u00a0<i>Xywav<\/i>\u00a0in the treatment of adults with idiopathic hypersomnia and of cataplexy and EDS in narcolepsy is unknown. It is hypothesized that the therapeutic effects of\u00a0<i>Xywav<\/i>\u00a0are mediated through GABA<sub>B<\/sub>\u00a0actions during sleep at noradrenergic and dopaminergic neurons, as well as thalamocortical neurons.<sup>22<\/sup>\u00a0The\u00a0U.S.\u00a0Drug Enforcement Agency\u00a0(DEA) has designated\u00a0<i>Xywav\u00a0<\/i>as a Schedule III medicine. The DEA defines Schedule III drugs, substances, or chemicals as drugs with a moderate to low potential for physical and psychological dependence.<sup>22,23\u00a0<\/sup>Because of the risks of central nervous system (CNS) depression and abuse and misuse,\u00a0<i>Xywav<\/i>\u00a0is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the XYWAV and XYREM REMS.<\/p>\n<p>\n        <b>Important Safety Information for Xywav<\/b>\n      <\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tr>\n<td class=\"prnpr2 prnpl2 prnvab prncbts prnbrbrs prnbbbs prnbsbls\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml50\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>WARNING: CENTRAL NERVOUS SYSTEM DEPRESSION and ABUSE AND MISUSE.<\/b><br \/>\n                <\/span>\n              <\/p>\n<ul type=\"disc\">\n<li class=\"prnews_li\">\n                  <b><br \/>\n                    <u>Central Nervous System Depression<\/u><br \/>\n                  <\/b><br \/>\n                  <br \/>\n                  <b>XYWAV is a CNS depressant. Clinically significant respiratory depression and obtundation may occur in patients treated with XYWAV at recommended doses. Many patients who received XYWAV during clinical trials in narcolepsy and idiopathic hypersomnia were receiving CNS stimulants.<\/b><\/p>\n<\/li>\n<li class=\"prnews_li\">\n                  <b><br \/>\n                    <u>Abuse and Misuse<\/u><br \/>\n                  <\/b><br \/>\n                  <br \/>\n                  <b>The active moiety of XYWAV is oxybate or gamma-hydroxybutyrate (GHB). Abuse or misuse of illicit GHB, either alone or in combination with other CNS depressants, is associated with CNS adverse reactions, including seizure, respiratory depression, decreases in the level of consciousness, coma, and death.<\/b>\n                <\/li>\n<\/ul>\n<p class=\"prnml6\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>Because of the risks of CNS depression and abuse and misuse, XYWAV is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the XYWAV and XYREM REMS.<\/b><br \/>\n                <\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<\/table><\/div>\n<p>\n        <b><br \/>\n          <u>Contraindications<\/u><br \/>\n        <\/b><br \/>\n        <br \/>XYWAV\u00a0is\u00a0contraindicated<\/p>\n<ul type=\"disc\">\n<li>in combination with sedative hypnotics or alcohol and<\/li>\n<li>in patients with\u00a0succinic\u00a0semialdehyde\u00a0dehydrogenase\u00a0deficiency.<\/li>\n<\/ul>\n<p>\n        <b><br \/>\n          <u>Warnings and Precautions<\/u><br \/>\n        <\/b><br \/>\n        <br \/>\n        <b>Central Nervous System Depression<br \/><\/b>The concurrent use of XYWAV with other CNS depressants, including but not limited to opioid analgesics, benzodiazepines, sedating antidepressants or antipsychotics, sedating anti-epileptic drugs, general anesthetics, muscle relaxants, and\/or illicit CNS depressants, may increase the risk of respiratory depression, hypotension, profound sedation, syncope, and death. If use of these CNS depressants in combination with XYWAV is required, dose reduction or discontinuation of one or more CNS depressants (including XYWAV) should be considered. In addition, if short-term use of an opioid (e.g., post- or perioperative) is required, interruption of treatment with XYWAV should be considered.<\/p>\n<p>After\u00a0first initiating treatment\u00a0and until certain that\u00a0XYWAV\u00a0does not affect\u00a0them\u00a0adversely (e.g., impair\u00a0judgment, thinking,\u00a0or motor skills), caution\u00a0patients against\u00a0hazardous\u00a0activities\u00a0requiring complete\u00a0mental alertness\u00a0or motor\u00a0coordination\u00a0such as operating\u00a0hazardous\u00a0machinery, including\u00a0automobiles\u00a0or airplanes. Also caution patients against these hazardous activities for at least 6 hours after taking\u00a0XYWAV. Patients\u00a0should be queried\u00a0about CNS depression-related events\u00a0upon initiation\u00a0of XYWAV\u00a0therapy\u00a0and\u00a0periodically\u00a0thereafter.<\/p>\n<p>\n        <b>Abuse and Misuse<\/b><br \/>\n        <br \/>XYWAV is a Schedule Ill controlled substance. The active moiety of XYWAV is oxybate, also known as\u00a0gamma-hydroxybutyrate (GHB), a Schedule\u00a0I controlled substance. Abuse of illicit GHB, either alone or in combination with other CNS depressants, is associated with CNS adverse reactions, including seizure, respiratory depression, decreases in the level of consciousness, coma, and death. The rapid onset of sedation, coupled with the amnestic features of\u00a0GHB particularly when combined with alcohol, has proven to be dangerous for the voluntary and involuntary user (e.g., assault victim). Physicians should carefully evaluate patients for a history of drug abuse and follow such patients closely.<\/p>\n<p>\n        <b>XYWAV<\/b>\u00a0<b>and<\/b>\u00a0<b>XYREM<\/b>\u00a0<b>REMS<\/b><br \/>Because of the risks of central nervous system depression and abuse and misuse,\u00a0XYWAV is available only through a restricted distribution program called the XYWAV and XYREM REMS.<\/p>\n<p>Notable\u00a0requirements\u00a0of\u00a0the\u00a0XYWAV\u00a0and\u00a0XYREM\u00a0REMS\u00a0include the\u00a0following:<\/p>\n<ul type=\"disc\">\n<li>Healthcare Providers who prescribe\u00a0XYWAV\u00a0are\u00a0specially certified<\/li>\n<li>XYWAV\u00a0will\u00a0be\u00a0dispensed\u00a0only\u00a0by\u00a0the\u00a0central\u00a0pharmacy that\u00a0is\u00a0specially\u00a0certified<\/li>\n<li>XYWAV\u00a0will be dispensed\u00a0and shipped\u00a0only to patients\u00a0who are enrolled in the XYWAV and\u00a0XYREM\u00a0REMS\u00a0with\u00a0documentation\u00a0of\u00a0safe\u00a0use<\/li>\n<\/ul>\n<p>Further\u00a0information\u00a0is available\u00a0at\u00a0<a href=\"https:\/\/edge.prnewswire.com\/c\/link\/?t=0&amp;l=en&amp;o=4513646-1&amp;h=3237309510&amp;u=https%3A%2F%2Fwww.xywavxyremrems.com%2F&amp;a=www.XYWAVXYREMREMS.com\" target=\"_blank\" rel=\"nofollow\">www.XYWAVXYREMREMS.com<\/a>\u00a0or\u00a01-866-997-3688.<\/p>\n<p>\n        <b>Respiratory Depression and Sleep-Disordered Breathing<\/b><br \/>\n        <br \/>XYWAV may impair respiratory drive, especially in patients with compromised respiratory function. In\u00a0overdoses\u00a0of oxybate\u00a0and\u00a0with illicit\u00a0use of GHB, life-threatening respiratory depression\u00a0has been\u00a0reported. Increased apnea and reduced oxygenation may occur with XYWAV administration in adult and\u00a0pediatric\u00a0patients. A significant increase\u00a0in the\u00a0number\u00a0of central apneas\u00a0and clinically significant\u00a0oxygen\u00a0desaturation\u00a0may occur\u00a0in patients with obstructive\u00a0sleep apnea\u00a0treated with XYWAV. Prescribers should be aware that sleep-related breathing disorders tend to be more prevalent in obese patients, in men, in postmenopausal women not on hormone replacement therapy, and among patients with narcolepsy.<\/p>\n<p>\n        <b>Depression and\u00a0Suicidality<\/b><br \/>\n        <br \/>In Study 1, the randomized-withdrawal clinical trial in adult patients with narcolepsy (n=201), depression\u00a0and depressed mood were reported in 3% and 4%, respectively,\u00a0of patients treated with XYWAV. Two patients\u00a0(1%)\u00a0discontinued\u00a0XYWAV because\u00a0of depression. In most cases, no change in XYWAV treatment was required.\u00a0<\/p>\n<p>In Study 2, the randomized-withdrawal clinical trial in adult patients with idiopathic hypersomnia (n=154), depression and depressed mood were reported in 1% and 3%, respectively, of patients treated with XYWAV. All patients continued XYWAV treatment.<\/p>\n<p>Two suicides and two attempted suicides occurred in adult clinical trials with oxybate (same active moiety as XYWAV). One patient experienced suicidal ideation and two patients reported depression in a pediatric clinical trial with oxybate. These events occurred in patients with and without previous histories of depressive disorders. The emergence\u00a0of\u00a0depression\u00a0in patients treated\u00a0with XYWAV requires careful and immediate\u00a0evaluation. Monitor patients for the emergence of increased\u00a0depressive\u00a0symptoms and\/or suicidality\u00a0while\u00a0taking\u00a0XYWAV.<\/p>\n<p>\n        <b>Other Behavioral or Psychiatric Adverse Reactions<\/b><br \/>\n        <br \/>In Study 1, confusion and anxiety occurred in 1% and 5% of patients with narcolepsy treated with XYWAV, respectively. One patient experienced visual hallucinations and confusion after ingesting approximately 9 grams of XYWAV.<\/p>\n<p>In Study 2, confusion and anxiety occurred in 3% and 16% of patients with idiopathic hypersomnia, respectively.\u00a0One patient experienced visual hallucinations, which led to discontinuation of XYWAV.\u00a0<\/p>\n<p>Other\u00a0neuropsychiatric\u00a0reactions reported\u00a0with oxybate\u00a0(same\u00a0active\u00a0moiety as XYWAV)\u00a0in adult or pediatric clinical\u00a0trials\u00a0and in the postmarketing setting include hallucinations, paranoia, psychosis, aggression, agitation, confusion and anxiety. The emergence or increase in the occurrence of behavioral or psychiatric events in patients taking XYWAV should\u00a0be\u00a0carefully monitored.<\/p>\n<p>\n        <b>Parasomnias<\/b><br \/>\n        <br \/>Parasomnias\u00a0can\u00a0occur\u00a0in\u00a0patients\u00a0taking\u00a0XYWAV.<\/p>\n<p>In Study 1 and Study 2,\u00a0parasomnias, including sleepwalking, were reported in 6% and 5% of adult patients treated with\u00a0XYWAV, respectively.\u00a0<\/p>\n<p>In\u00a0a\u00a0clinical trial\u00a0of\u00a0XYREM\u00a0(same\u00a0active moiety\u00a0as\u00a0XYWAV) in adult patients with narcolepsy, five instances of sleepwalking with potential injury or significant injury were reported. Parasomnias, including sleepwalking, have been reported in a pediatric clinical trial with sodium oxybate\u00a0(same\u00a0active\u00a0moiety\u00a0as\u00a0XYWAV) and\u00a0in\u00a0postmarketing\u00a0experience\u00a0with\u00a0sodium\u00a0oxybate.<\/p>\n<p>Episodes\u00a0of\u00a0sleepwalking\u00a0should\u00a0be\u00a0fully\u00a0evaluated\u00a0and\u00a0appropriate\u00a0interventions\u00a0considered.<\/p>\n<p>\n        <b><br \/>\n          <u>Most Common Adverse Reactions<\/u><br \/>\n        <\/b><br \/>\n        <br \/>The\u00a0most\u00a0common adverse\u00a0reactions (occurring in \u22655% of XYWAV-treated patients in adult clinical trials in either narcolepsy or IH) were nausea, headache,\u00a0dizziness, anxiety, insomnia, decreased appetite,\u00a0hyperhidrosis, vomiting, diarrhea, dry mouth, parasomnia, somnolence, fatigue, and tremor.\u00a0<\/p>\n<p>In\u00a0the\u00a0pediatric clinical\u00a0trial\u00a0with\u00a0XYREM\u00a0(same\u00a0active\u00a0moiety\u00a0as\u00a0XYWAV) that included pediatric patients 7 to 17 years of age with narcolepsy, the most common adverse reactions (\u22655%) were nausea (20%), enuresis (19%), vomiting (18%), headache (17%), weight decreased (13%), decreased appetite (9%), dizziness (8%), and sleepwalking (6%). The overall adverse reaction profile of\u00a0XYREM in the pediatric\u00a0clinical trial was similar to that seen in the adult clinical trial\u00a0program. The safety profile in pediatric patients\u00a0with XYWAV is expected\u00a0to be similar\u00a0to that\u00a0of adult\u00a0patients treated\u00a0with XYWAV and to that of pediatric patients treated with XYREM.<\/p>\n<p>\n        <b><br \/>\n          <u>Additional Adverse Reactions<\/u><br \/>\n        <\/b><br \/>\n        <br \/>Adverse reactions that occurred in\u00a02-&lt;5% of adult patients treated with XYWAV in the Open Label Titration and Stable Dose Periods of the randomized-withdrawal study in adult patients with narcolepsy with cataplexy (Study 1) were fatigue, dry mouth, depressed mood, enuresis, irritability, paresthesia, depression, tremor, somnolence, and muscle spasms. Adverse reactions occurring in 2-&lt;5% of patients treated with\u00a0XYWAV in the IH study include balance disorder, muscle spasms, fall, paresthesia,\u00a0snoring, weight decreased, bruxism, confusional state, depressed mood, feeling drunk, and irritability.<\/p>\n<p>Adverse reactions that occurred in\u00a0\u22652% of patients in clinical studies with oxybate (but not in\u00a0Study\u00a01)\u00a0and\u00a0which\u00a0may\u00a0be\u00a0relevant for\u00a0XYWAV,\u00a0were\u00a0pain,\u00a0feeling drunk,\u00a0pain\u00a0in\u00a0extremity,\u00a0cataplexy, disturbance\u00a0in\u00a0attention,\u00a0sleep\u00a0paralysis,\u00a0and\u00a0disorientation.<\/p>\n<p>Discontinuation: In Study 1, 9 of 201 patients (4%) reported adverse reactions that led to withdrawal from the study (anxiety, decreased appetite, depressed mood, depression, fatigue, headache, irritability, nausea, pain in extremity, parasomnia, somnolence, and vomiting). The most common adverse reaction leading to discontinuation was nausea (1.5%). In Study 2, 17 of 154 (11%) patients across all study periods (excluding placebo during the DB\u00a0RWP) (up to 42\u00a0weeks) reported adverse reactions that led to withdrawal from the study (anxiety, nausea, insomnia, vomiting, fatigue, feeling abnormal, fall, decreased\u00a0appetite, dizziness, paresthesia, tremor, parasomnia, confusional state, hallucination visual, and irritability). The most common adverse reaction leading to discontinuation was anxiety (3.2%). In Study 1 and Study 2, the majority of adverse reactions leading to discontinuation began during the first few weeks of treatment.<\/p>\n<p>In the pediatric clinical trial with XYREM (same active moiety as XYWAV), 7 of 104 patients reported adverse reactions that led to withdrawal from the study (hallucination, tactile; suicidal ideation; weight decreased; sleep apnea syndrome; affect lability; anger, anxiety, depression; and headache).<\/p>\n<p>\n        <b><br \/>\n          <u>Drug Interactions<\/u><br \/>\n        <\/b><br \/>\n        <br \/>XYWAV is contraindicated in combination with alcohol or sedative hypnotics. Use of other CNS depressants\u00a0may\u00a0potentiate\u00a0the\u00a0CNS-depressant\u00a0effects of\u00a0XYWAV.<\/p>\n<p>Concomitant\u00a0use of sodium\u00a0oxybate with divalproex\u00a0sodium\u00a0results in an increase in systemic\u00a0exposure to\u00a0GHB, which was shown to cause a greater impairment on some tests of attention and working memory in a clinical study. A similar increase in exposure is expected with concomitant use of\u00a0XYWAV and divalproex\u00a0sodium; therefore, an initial dose reduction of XYWAV is recommended when used concomitantly with\u00a0divalproex\u00a0sodium. Prescribers\u00a0are advised\u00a0to monitor\u00a0patient\u00a0response closely and adjust dose accordingly\u00a0if\u00a0concomitant\u00a0use\u00a0of\u00a0XYWAV\u00a0and\u00a0divalproex\u00a0sodium\u00a0is\u00a0warranted.<\/p>\n<p>\n        <b><br \/>\n          <u>Pregnancy and Lactation<\/u><br \/>\n        <\/b><br \/>\n        <br \/>There are no adequate data on the developmental risk associated with the use of XYWAV or sodium\u00a0oxybate\u00a0in pregnant women. XYWAV should be used during pregnancy\u00a0only if the potential benefit\u00a0justifies\u00a0the\u00a0potential\u00a0risk\u00a0to\u00a0the\u00a0fetus.\u00a0GHB is excreted in human milk after oral administration of sodium\u00a0oxybate.\u00a0There is insufficient\u00a0information\u00a0on the risk to a breastfed infant, and there is insufficient\u00a0information\u00a0on milk\u00a0production\u00a0in nursing\u00a0mothers.\u00a0The\u00a0developmental\u00a0and\u00a0health\u00a0benefits of\u00a0breastfeeding should be\u00a0considered along with the mother&#8217;s clinical need for XYWAV and any potential adverse effects on the breastfed infant\u00a0from XYWAV\u00a0or\u00a0from\u00a0the\u00a0underlying maternal\u00a0condition.<\/p>\n<p>\n        <b><br \/>\n          <u>Pediatric Use<\/u><br \/>\n        <\/b><br \/>\n        <br \/>The safety and effectiveness of XYWAV for the treatment of cataplexy or excessive daytime sleepiness in pediatric patients 7 years of age and older with narcolepsy have been established. XYWAV has not been studied in a pediatric clinical trial for narcolepsy or IH. Use of XYWAV in pediatric patients 7 years of age and older with narcolepsy is supported by evidence from an adequate and well-controlled study of sodium oxybate in pediatric patients 7 to 17 years of age, a study in adults showing a treatment effect of XYWAV similar to that observed with sodium oxybate, pharmacokinetic data\u00a0of sodium oxybate from adult and pediatric patients, and pharmacokinetic data\u00a0of XYWAV\u00a0from\u00a0healthy\u00a0adult\u00a0volunteers.<\/p>\n<p>Safety\u00a0and\u00a0effectiveness\u00a0of\u00a0XYWAV\u00a0in\u00a0pediatric\u00a0patients below\u00a0the\u00a0age\u00a0of\u00a07\u00a0years\u00a0with narcolepsy have\u00a0not\u00a0been\u00a0established.<\/p>\n<p>Safety and effectiveness of XYWAV for the treatment of idiopathic hypersomnia in pediatric patients have not been established.<\/p>\n<p>\n        <b><br \/>\n          <u>Geriatric Use<\/u><br \/>\n        <\/b><br \/>\n        <br \/>In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the\u00a0dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of\u00a0concomitant\u00a0disease or\u00a0other\u00a0drug\u00a0therapy.<\/p>\n<p>\n        <b><br \/>\n          <u>Hepatic Impairment<\/u><br \/>\n        <\/b><br \/>\n        <br \/>The\u00a0starting\u00a0dose\u00a0of\u00a0XYWAV\u00a0should\u00a0be\u00a0reduced\u00a0in\u00a0patients\u00a0with\u00a0liver\u00a0impairment.<\/p>\n<p>\n        <b>Dosage Modification in Patients with Hepatic Impairment:\u00a0<\/b>The recommended starting dosage in patients with hepatic impairment is one-half of the original dosage per night, administered orally, divided into two doses.<\/p>\n<p>\n        <b><br \/>\n          <u>Dependence and Tolerance<\/u><br \/>\n        <\/b><br \/>\n        <br \/>There\u00a0have\u00a0been\u00a0case\u00a0reports\u00a0of\u00a0withdrawal,\u00a0ranging\u00a0from\u00a0mild\u00a0to\u00a0severe,\u00a0following\u00a0discontinuation\u00a0of\u00a0illicit use of GHB\u00a0at frequent\u00a0repeated\u00a0doses\u00a0(18\u00a0g to 250 g per day)\u00a0in excess\u00a0of the recommended\u00a0dosage range. Signs and symptoms\u00a0of GHB withdrawal following abrupt discontinuation included insomnia, restlessness, anxiety, psychosis, lethargy, nausea, tremor, sweating, muscle cramps, tachycardia, headache, dizziness, rebound fatigue and sleepiness, confusion, and, particularly in the case of severe withdrawal, visual hallucinations, agitation, and delirium. These symptoms generally abated in 3 to 14 days. In cases of severe withdrawal, hospitalization may be required.<\/p>\n<p>In the clinical trial experience\u00a0with\u00a0XYREM in narcolepsy\/cataplexy patients at recommended doses, two patients reported anxiety and one reported insomnia following abrupt discontinuation at the termination of the clinical trial; in the two patients with anxiety, the frequency of cataplexy had increased markedly at the same time. In the\u00a0XYWAV clinical trial in adult narcolepsy\/cataplexy patients at recommended doses,\u00a0one patient\u00a0reported insomnia\u00a0following\u00a0abrupt\u00a0discontinuation\u00a0of\u00a0XYWAV. In the XYWAV clinical trial in adult idiopathic hypersomnia patients at recommended doses, six patients reported insomnia, two patients reported early insomnia, and one patient reported visual and auditory hallucinations following abrupt discontinuation of XYWAV<i>.<\/i><\/p>\n<p>Tolerance to XYWAV has not been systematically studied in controlled clinical trials. There have been\u00a0some case reports of symptoms of tolerance developing after illicit use at dosages far in excess of the recommended XYWAV dosage regimen.<\/p>\n<p>Please see full Prescribing Information, including BOXED Warning here:\u00a0<a href=\"https:\/\/edge.prnewswire.com\/c\/link\/?t=0&amp;l=en&amp;o=4513646-1&amp;h=2967276791&amp;u=https%3A%2F%2Fpp.jazzpharma.com%2Fpi%2Fxywav.en.USPI.pdf&amp;a=https%3A%2F%2Fpp.jazzpharma.com%2Fpi%2Fxywav.en.USPI.pdf\" target=\"_blank\" rel=\"nofollow\">https:\/\/pp.jazzpharma.com\/pi\/xywav.en.USPI.pdf<\/a><\/p>\n<p>\n        <b>About Jazz Pharmaceuticals<br \/><\/b>Jazz Pharmaceuticals plc (Nasdaq: JAZZ) is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing potentially life-changing medicines for people with serious diseases \u2014 often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in\u00a0Dublin, Ireland\u00a0with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit <a href=\"https:\/\/edge.prnewswire.com\/c\/link\/?t=0&amp;l=en&amp;o=4513646-1&amp;h=747931084&amp;u=http%3A%2F%2Fwww.jazzpharmaceuticals.com%2F&amp;a=www.jazzpharmaceuticals.com\" target=\"_blank\" rel=\"nofollow\">www.jazzpharmaceuticals.com<\/a> for more information.<\/p>\n<p>\n        <b>Contacts:<\/b>\n      <\/p>\n<p>\n        <b>Media:<\/b><br \/>\n        <br \/>\n        <span class=\"xn-person\">Kristin Bhavnani<\/span><br \/>\n        <br \/>Head of Global Corporate Communications<br \/>Jazz Pharmaceuticals plc<br \/><a href=\"mailto:CorporateAffairsMediaInfo@jazzpharma.com\" target=\"_blank\" rel=\"nofollow\">CorporateAffairsMediaInfo@jazzpharma.com<\/a><br \/><span class=\"xn-location\">Ireland<\/span> +353 1 637 2141<br \/>U.S. +1 215 867 4948<\/p>\n<p>\n        <b>Investors:<\/b><br \/>\n        <br \/>\n        <span class=\"xn-person\">Jack Spinks<\/span><br \/>\n        <br \/>Executive Director, Investor Relations<br \/>Jazz Pharmaceuticals plc<br \/><a href=\"mailto:InvestorInfo@jazzpharma.com\" target=\"_blank\" rel=\"nofollow\">InvestorInfo@jazzpharma.com<br \/><\/a><span class=\"xn-location\">Ireland<\/span> +353 1 634 3211<br \/>U.S. +1 650 496 2717<\/p>\n<p>\n        <b>References<\/b>:<\/p>\n<ol type=\"1\">\n<li>Sateia, M. J. (2023). International Classification of Sleep Disorders-Third Edition, Text Revision (ICSD-3-TR). Chest, 146(5), 1387\u20131394. PubMed. <a href=\"https:\/\/doi.org\/10.1378\/chest.14-0970\" rel=\"nofollow\">https:\/\/doi.org\/10.1378\/chest.14-0970<\/a>.<\/li>\n<li>\u200cDauvilliers Y, Arnulf I, Mignot E. Narcolepsy with cataplexy. <i>Lancet<\/i>. 2007;369(9560):499-511.<\/li>\n<li>Colten HR, Altevogt BM, Institute of Medicine (US) Committee on Sleep Medicine and Research, eds. <i>Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem<\/i>. <span class=\"xn-location\">Washington<\/span> (DC): National Academies Press (US); 2006.<\/li>\n<li>Peacock J,\u00a0Benca RM. Narcolepsy: clinical features, co-morbidities &amp; treatment. <i>Indian Journal of Medical Research<\/i>. 2010;131(2):338-349.<\/li>\n<li>National Health Service. Narcolepsy \u2013 Overview. 2019.\u00a0<a href=\"https:\/\/edge.prnewswire.com\/c\/link\/?t=0&amp;l=en&amp;o=4513646-1&amp;h=3030120707&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D4291477-1%26h%3D4280082168%26u%3Dhttps%253A%252F%252Fwww.nhs.uk%252Fconditions%252Fnarcolepsy%252F%26a%3Dhttps%253A%252F%252Fwww.nhs.uk%252Fconditions%252Fnarcolepsy%252F&amp;a=https%3A%2F%2Fwww.nhs.uk%2Fconditions%2Fnarcolepsy%2F\" target=\"_blank\" rel=\"nofollow\">https:\/\/www.nhs.uk\/conditions\/narcolepsy\/<\/a>. Accessed <span class=\"xn-chron\">August 2025<\/span>.<\/li>\n<li>Ben-Joseph\u00a0RH, Saad R, Black J, et al. Cardiovascular burden of narcolepsy disease (CV-BOND): a real-world evidence study. Presented at: 2022 AAN Annual Meeting; <span class=\"xn-chron\">April 2-7<\/span>; <span class=\"xn-location\">Seattle, Washington<\/span>. Poster 1203.<\/li>\n<li>Black J,\u00a0Reaven NL, Funk SE, et al. Medical comorbidity in narcolepsy: findings from the Burden of Narcolepsy Disease (BOND) study. <i>Sleep Med<\/i>. 2017;33:13-18.<\/li>\n<li>Ohayon MM, Black J, Lai C, et al. Increased mortality in narcolepsy. <i>Sleep<\/i>. 2014;37(3):439-444.<\/li>\n<li>Ohayon MM. Narcolepsy is complicated by high medical and psychiatric comorbidities: a comparison with the general population. <i>Sleep Med<\/i>. 2013;14(6):488-492.<\/li>\n<li>Billiard M,\u00a0Sonka K. Idiopathic hypersomnia. Sleep Med Rev. 2016;29:23-33.<\/li>\n<li>Trotti LM. Idiopathic hypersomnia. Sleep Med Clin. 2017;12(3):331-344.<\/li>\n<li>American Academy of Sleep Medicine. The International Classification of Sleep Disorders. Third Edition (ICSD-3). 2014.<\/li>\n<li>Khan Z,\u00a0Trotti LM. Central disorders of hypersomnolence: focus on the narcolepsies and idiopathic hypersomnia. Chest. 2015 Jul;148(1):262-273.<\/li>\n<li>American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition (DSM-5). 2020.<\/li>\n<li>Jazz Pharmaceuticals, Inc, Data on file. JZP258-2020-047-29 Oct 2020.<\/li>\n<li>Evangelista E, Lopez R, Dauvilliers Y. Update on treatment for idiopathic hypersomnia. Expert Opin Investig Drugs. 2018;27(2):187-192.<\/li>\n<li>Ozaki A, Inoue Y, Hayashida K, et al. Quality of life in patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time: comparison between patients on psychostimulants, drug-na\u00efve patients and the general Japanese population. Sleep Med. 2012;13(2):200-206.<\/li>\n<li>Jazz Pharmaceuticals, Inc, Data on file.<\/li>\n<li>Anderson\u00a0KN, Pilsworth S, Sharples LD, et al. Idiopathic hypersomnia: a study of 77 cases. Sleep. 2007;30(10):1274-1281.<\/li>\n<li>Masri TJ, Gonzales CG, Kushida CA. Idiopathic hypersomnia. Sleep Med Clin. 2012;7(2):283-289.<\/li>\n<li>Trotti LM, Arnulf I. Idiopathic hypersomnia and other hypersomnia syndromes. Neurotherapeutics. 2021;18(1):20-31.<\/li>\n<li>Xywav (calcium, magnesium, potassium and sodium\u00a0oxybates) oral solution. Prescribing Information. <span class=\"xn-location\">Palo Alto, CA<\/span>: Jazz Pharmaceuticals, Inc. 2021.<\/li>\n<li>United States Drug Enforcement Agency. Drug Scheduling.\u00a0https:\/\/www.dea.gov\/drug-information\/drug-scheduling. Accessed <span class=\"xn-chron\">August 2025<\/span>.<\/li>\n<\/ol>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder3609\">\n<p>\n          <a href=\"https:\/\/mma.prnewswire.com\/media\/272253\/Jazz_Pharmaceuticals_New_Logo.html\" target=\"_blank\" rel=\"nofollow\"><br \/>\n            <img decoding=\"async\" src=\"https:\/\/mma.prnewswire.com\/media\/272253\/Jazz_Pharmaceuticals_New_Logo.jpg\" title=\"Jazz Pharmaceuticals Logo (PRNewsFoto\/Jazz Pharmaceuticals plc) (PRNewsFoto\/Jazz Pharmaceuticals plc)\" alt=\"Jazz Pharmaceuticals Logo (PRNewsFoto\/Jazz Pharmaceuticals plc) (PRNewsFoto\/Jazz Pharmaceuticals plc)\" \/><br \/>\n          <\/a>\n        <\/p>\n<\/p><\/div>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\"><\/div>\n<p id=\"PURL\">\n        <img loading=\"lazy\" decoding=\"async\" title=\"Cision\" width=\"12\" height=\"12\" alt=\"Cision\" src=\"https:\/\/edge.prnewswire.com\/c\/img\/favicon.png?sn=SF78002&amp;sd=2025-09-22\" \/> View original content to download multimedia:<a id=\"PRNURL\" rel=\"nofollow\" href=\"https:\/\/www.prnewswire.com\/news-releases\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-psych-congresses-302562421.html\" target=\"_blank\">https:\/\/www.prnewswire.com\/news-releases\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-psych-congresses-302562421.html<\/a><\/p>\n<p>SOURCE  Jazz Pharmaceuticals plc<\/p>\n<\/p><\/div>\n<p>    <img decoding=\"async\" alt=\"\" src=\"https:\/\/rt.prnewswire.com\/rt.gif?NewsItemId=SF78002&amp;Transmission_Id=202509220745PR_NEWS_USPR_____SF78002&amp;DateId=20250922\" style=\"border:0px;width:1px;height:1px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PR Newswire 20 abstracts presented across World Sleep and Psych Congresses showcase Jazz&#8217;s leadership in sleep medicine Novel results from the Phase 4 DUET trial underscore the significance of appropriate treatment options in adults with narcolepsy or idiopathic hypersomnia For U.S. media and investors only DUBLIN , Sept. 22, 2025 \/PRNewswire\/ &#8212; Jazz\u00a0Pharmaceuticals\u00a0plc\u00a0(Nasdaq:\u00a0JAZZ) today\u00a0announced new real-world evidence and Phase 4\u00a0data reinforcing the value of Xywav\u00ae (calcium, magnesium, potassium, and sodium oxybates) oral solution treatment outcomes in adults with narcolepsy or idiopathic hypersomnia (IH) were presented at World Sleep 2025, held in Singapore from September 5-10, 2025, as well as the 38th annual Psych Congress, held in San Diego from September 17-21, 2025. Notable Phase 4 data included new results from &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Jazz Pharmaceuticals Showcases Phase 4 Data Demonstrating Xywav\u00ae (calcium, magnesium, potassium, and sodium oxybates) Oral Solution Treatment Effects and Real-World Evidence at World Sleep and Psych Congresses&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-888227","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jazz Pharmaceuticals Showcases Phase 4 Data Demonstrating Xywav\u00ae (calcium, magnesium, potassium, and sodium oxybates) Oral Solution Treatment Effects and Real-World Evidence at World Sleep and Psych Congresses - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jazz Pharmaceuticals Showcases Phase 4 Data Demonstrating Xywav\u00ae (calcium, magnesium, potassium, and sodium oxybates) Oral Solution Treatment Effects and Real-World Evidence at World Sleep and Psych Congresses - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"PR Newswire 20 abstracts presented across World Sleep and Psych Congresses showcase Jazz&#8217;s leadership in sleep medicine Novel results from the Phase 4 DUET trial underscore the significance of appropriate treatment options in adults with narcolepsy or idiopathic hypersomnia For U.S. media and investors only DUBLIN , Sept. 22, 2025 \/PRNewswire\/ &#8212; Jazz\u00a0Pharmaceuticals\u00a0plc\u00a0(Nasdaq:\u00a0JAZZ) today\u00a0announced new real-world evidence and Phase 4\u00a0data reinforcing the value of Xywav\u00ae (calcium, magnesium, potassium, and sodium oxybates) oral solution treatment outcomes in adults with narcolepsy or idiopathic hypersomnia (IH) were presented at World Sleep 2025, held in Singapore from September 5-10, 2025, as well as the 38th annual Psych Congress, held in San Diego from September 17-21, 2025. Notable Phase 4 data included new results from &hellip; Continue reading &quot;Jazz Pharmaceuticals Showcases Phase 4 Data Demonstrating Xywav\u00ae (calcium, magnesium, potassium, and sodium oxybates) Oral Solution Treatment Effects and Real-World Evidence at World Sleep and Psych Congresses&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-22T12:45:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mma.prnewswire.com\/media\/272253\/Jazz_Pharmaceuticals_New_Logo.jpg\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"23 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Jazz Pharmaceuticals Showcases Phase 4 Data Demonstrating Xywav\u00ae (calcium, magnesium, potassium, and sodium oxybates) Oral Solution Treatment Effects and Real-World Evidence at World Sleep and Psych Congresses\",\"datePublished\":\"2025-09-22T12:45:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\\\/\"},\"wordCount\":4643,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mma.prnewswire.com\\\/media\\\/272253\\\/Jazz_Pharmaceuticals_New_Logo.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/jazz-pharmaceuticals-showcases-phase-4-data-demonstrating-xywav-calcium-magnesium-potassium-and-sodium-oxybates-oral-solution-treatment-effects-and-real-world-evidence-at-world-sleep-and-ps\\\/\",\"name\":\"Jazz Pharmaceuticals Showcases Phase 4 Data Demonstrating Xywav\u00ae (calcium, magnesium, potassium, and sodium oxybates) Oral Solution Treatment Effects and Real-World Evidence at World Sleep and Psych Congresses - 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