{"id":888218,"date":"2025-09-22T08:19:05","date_gmt":"2025-09-22T12:19:05","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/"},"modified":"2025-09-22T08:19:05","modified_gmt":"2025-09-22T12:19:05","slug":"plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/","title":{"rendered":"Plus Therapeutics Announces Additional $1.9 Million Advance Payment from CPRIT \u00a0\u00a0"},"content":{"rendered":"
\n

\n Non-dilutive payment is part of $17.6 million award granted for the Company\u2019s leptomeningeal cancer targeted radiotherapeutic development program<\/em>\n <\/p>\n

HOUSTON, Sept. 22, 2025 (GLOBE NEWSWIRE) — Plus Therapeutics, Inc.<\/a> (Nasdaq:\u00a0PSTV<\/a>) (the \u201cCompany\u201d), a clinical-stage pharmaceutical company developing targeted radiotherapeutics with advanced platform technologies for central nervous system (CNS) cancers, announces that the Company received notice of an additional advance payment from the Cancer Prevention and Research Institute of Texas (CPRIT), the second-largest public cancer research funder globally. This $1.9 million payment is part of the Company\u2019s previously awarded $17.6 million grant and is the second non-dilutive financing received from CPRIT following the $1.6 million receipt announced in July 2025.<\/p>\n

“Continued payments from CPRIT are supportive to our radiotherapeutic development initiatives, with a further $1.9 million in funding expected over the next 12 months, providing a steady source of significant non-dilutive financing,\u201d said Andrew Sims, Plus Therapeutics Chief Financial Officer. \u201cThe support from CPRIT builds on our active National Institutes of Health and Department of Defense grants, reflecting strong commitment for our clinical programs from strategic institutions. We continue to actively pursue additional grant opportunities to strengthen our capital position.\u201d<\/p>\n

The funding supports and accelerates the Company\u2019s clinical development of REYOBIQ\u2122 for the ReSPECT-LM<\/a> dose optimization trial and further develops the Company\u2019s CNSide LM diagnostic test as a key pivotal trial endpoint.<\/p>\n

\n About LM<\/strong>
\n
Leptomeningeal metastases (LM) are a rare but severe complication of advanced cancer, affecting the fluid-lined structures of the central nervous system. LM occurs in approximately 5% of patients with metastatic cancer, with breast cancer, lung cancer, and melanoma being the most common sources. Median survival is typically 2-6 months, and effective treatment options are limited, highlighting the urgent need for novel therapies.<\/p>\n

\n About REYOBIQ\u2122 (rhenium Re186 obisbemeda)<\/strong>
\n
REYOBIQ (rhenium Re186 obisbemeda) is a novel injectable radiotherapy specifically formulated to deliver direct targeted high dose radiation in CNS tumors in a safe, effective, and convenient manner to optimize patient outcomes. REYOBIQ has the potential to reduce off target risks and improve outcomes for CNS cancer patients, versus currently approved therapies, with a more targeted and potent radiation dose. Rhenium-186 is an ideal radioisotope for CNS therapeutic applications due to its short half-life, beta energy for destroying cancerous tissue, and gamma energy for real-time imaging. REYOBIQ is being evaluated for the treatment of recurrent glioblastoma, leptomeningeal metastases, and pediatric brain cancer in the ReSPECT-GBM, ReSPECT-LM, and ReSPECT-PBC clinical trials. ReSPECT-GBM is supported by an award from the National Cancer Institute (NCI), part of the U.S. National Institutes of Health (NIH), and ReSPECT-LM is funded by a three-year $17.6M grant by the Cancer Prevention & Research Institute of Texas (CPRIT). The Company\u2019s ReSPECT-PBC clinical trial for pediatric brain cancer is supported by a $3 million grant from the U.S. Department of Defense\u2019s Peer Reviewed Cancer Research Program.<\/p>\n

\n About Cancer Prevention & Research Institute of Texas (CPRIT)<\/strong>
\n
The Cancer Prevention & Research Institute of Texas (CPRIT) is a $6 billion cancer research and prevention initiative legislated in Texas. CPRIT accepts applications and award grants for a wide variety of innovative cancer-related research and product development and for the delivery of evidence-based cancer prevention programs and services by public and private entities located in Texas. CPRIT is the largest state cancer research investment in the history of the United States and the second largest cancer research and prevention program in the world with a three-part mission, established by the Texas Legislature, to invest in the research prowess of Texas universities and research organizations; create and expand life science infrastructure across the state; and expedite innovation in research and enhance the potential of breakthroughs in prevention and cures.<\/p>\n

\n About CNSide Diagnostic, LLC<\/strong>
\n
CNSide Diagnostics, LLC is a wholly owned subsidiary of Plus Therapeutics, Inc. that develops and commercializes proprietary laboratory-developed tests, such as CNSide\u00ae, designed to identify tumor cells that have metastasized to the central nervous system in patients with carcinomas and melanomas. The CNSide\u00ae CSF Assay Platform enables quantitative analysis and molecular characterization of tumor cells and circulating tumor DNA in the cerebrospinal fluid that inform and improve the management of patients with leptomeningeal metastases.<\/p>\n

\n About Plus Therapeutics<\/strong>
\n
Headquartered in Houston, Texas, Plus Therapeutics, Inc. is a clinical-stage pharmaceutical company developing targeted radiotherapeutics for difficult-to-treat cancers of the central nervous system with the potential to enhance clinical outcomes. Combining image-guided local beta radiation and targeted drug delivery approaches, the Company is advancing a pipeline of product candidates with lead programs in leptomeningeal metastases (LM) and recurrent glioblastoma (GBM). The Company has built a supply chain through strategic partnerships that enable the development, manufacturing, and future potential commercialization of its products. For more information, visit https:\/\/www.plustherapeutics.com<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>
\n
This press release contains statements that may be deemed \u201cforward-looking statements\u201d within the meaning of U.S. securities laws, including statements regarding clinical trials, expected operations and upcoming developments. All statements in this press release other than statements of historical fact are forward-looking statements. These forward-looking statements may be identified by future verbs, as well as terms such as \u201cexpect\u201d \u201cpotential,\u201d \u201canticipating,\u201d \u201cplanning\u201d and similar expressions or the negatives thereof. Such statements are based upon certain assumptions and assessments made by management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate.<\/p>\n

The forward-looking statements included in this press release could differ materially from those expressed or implied by these forward-looking statements because of risks, uncertainties, and other factors that include, but are not limited to, the following: the Company\u2019s ability to maintain the listing of its common stock on Nasdaq; risks related to a halt in trading or delisting of the Company\u2019s common stock on Nasdaq; Medicare and private payors may not provide coverage and reimbursement or may breach, rescind or modify their contracts or reimbursement policies or delay payments; the risk that our products and services may not perform as expected; the early stage of the Company\u2019s product candidates and therapies; the results of the Company\u2019s research and development activities, including uncertainties relating to the clinical trials of its product candidates and therapies; the Company\u2019s liquidity and capital resources and its ability to raise additional cash; the outcome of the Company\u2019s partnering\/licensing efforts, risks associated with laws or regulatory requirements applicable to it; market conditions, product performance, litigation or potential litigation, and competition within the cancer diagnostics and therapeutics field; ability to develop and protect proprietary intellectual property or obtain licenses to intellectual property developed by others on commercially reasonable and competitive terms; challenges associated with radiotherapeutic manufacturing, production and distribution capabilities necessary to support the Company\u2019s clinical trials and any commercial level product demand; and material security breach or cybersecurity attack affecting the Company\u2019s operations or property. This list of risks, uncertainties, and other factors is not complete. Plus Therapeutics discusses some of these matters more fully, as well as certain risk factors that could affect Plus Therapeutics\u2019 business, financial condition, results of operations, and prospects, in its reports filed with the SEC, including Plus Therapeutics\u2019 annual report on Form 10-K for the fiscal year ended December 31, 2024, quarterly reports on Form 10-Q, and current reports on Form 8-K. These filings are available for review through the SEC\u2019s website at www.sec.gov. Any or all forward-looking statements Plus Therapeutics makes may turn out to be wrong and can be affected by inaccurate assumptions Plus Therapeutics might make or by known or unknown risks, uncertainties, and other factors, including those identified in this press release. Accordingly, you should not place undue reliance on the forward-looking statements made in this press release, which speak only as of its date. The Company assumes no responsibility to update or revise any forward-looking statements to reflect events, trends or circumstances after the date they are made unless the Company has an obligation under U.S. federal securities laws to do so.<\/p>\n

\n Investor Contact<\/strong>
\n
CORE IR
investor@plustherapeutics.com<\/a>\u00a0<\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Non-dilutive payment is part of $17.6 million award granted for the Company\u2019s leptomeningeal cancer targeted radiotherapeutic development program HOUSTON, Sept. 22, 2025 (GLOBE NEWSWIRE) — Plus Therapeutics, Inc. (Nasdaq:\u00a0PSTV) (the \u201cCompany\u201d), a clinical-stage pharmaceutical company developing targeted radiotherapeutics with advanced platform technologies for central nervous system (CNS) cancers, announces that the Company received notice of an additional advance payment from the Cancer Prevention and Research Institute of Texas (CPRIT), the second-largest public cancer research funder globally. This $1.9 million payment is part of the Company\u2019s previously awarded $17.6 million grant and is the second non-dilutive financing received from CPRIT following the $1.6 million receipt announced in July 2025. “Continued payments from CPRIT are supportive to our radiotherapeutic development initiatives, with … <\/p>\n

Continue reading “Plus Therapeutics Announces Additional $1.9 Million Advance Payment from CPRIT \u00a0\u00a0“<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-888218","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nPlus Therapeutics Announces Additional $1.9 Million Advance Payment from CPRIT \u00a0\u00a0 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Plus Therapeutics Announces Additional $1.9 Million Advance Payment from CPRIT \u00a0\u00a0 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Non-dilutive payment is part of $17.6 million award granted for the Company\u2019s leptomeningeal cancer targeted radiotherapeutic development program HOUSTON, Sept. 22, 2025 (GLOBE NEWSWIRE) — Plus Therapeutics, Inc. (Nasdaq:\u00a0PSTV) (the \u201cCompany\u201d), a clinical-stage pharmaceutical company developing targeted radiotherapeutics with advanced platform technologies for central nervous system (CNS) cancers, announces that the Company received notice of an additional advance payment from the Cancer Prevention and Research Institute of Texas (CPRIT), the second-largest public cancer research funder globally. This $1.9 million payment is part of the Company\u2019s previously awarded $17.6 million grant and is the second non-dilutive financing received from CPRIT following the $1.6 million receipt announced in July 2025. “Continued payments from CPRIT are supportive to our radiotherapeutic development initiatives, with … Continue reading "Plus Therapeutics Announces Additional $1.9 Million Advance Payment from CPRIT \u00a0\u00a0"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-22T12:19:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTUzMjQ5NSM3MTU2OTMwIzIwMDQ4MDU=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Plus Therapeutics Announces Additional $1.9 Million Advance Payment from CPRIT \u00a0\u00a0\",\"datePublished\":\"2025-09-22T12:19:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\\\/\"},\"wordCount\":1333,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=OTUzMjQ5NSM3MTU2OTMwIzIwMDQ4MDU=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\\\/\",\"name\":\"Plus Therapeutics Announces Additional $1.9 Million Advance Payment from CPRIT \u00a0\u00a0 - 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(Nasdaq:\u00a0PSTV) (the \u201cCompany\u201d), a clinical-stage pharmaceutical company developing targeted radiotherapeutics with advanced platform technologies for central nervous system (CNS) cancers, announces that the Company received notice of an additional advance payment from the Cancer Prevention and Research Institute of Texas (CPRIT), the second-largest public cancer research funder globally. This $1.9 million payment is part of the Company\u2019s previously awarded $17.6 million grant and is the second non-dilutive financing received from CPRIT following the $1.6 million receipt announced in July 2025. “Continued payments from CPRIT are supportive to our radiotherapeutic development initiatives, with … Continue reading \"Plus Therapeutics Announces Additional $1.9 Million Advance Payment from CPRIT \u00a0\u00a0\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/","og_site_name":"Market Newsdesk","article_published_time":"2025-09-22T12:19:05+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTUzMjQ5NSM3MTU2OTMwIzIwMDQ4MDU=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Plus Therapeutics Announces Additional $1.9 Million Advance Payment from CPRIT \u00a0\u00a0","datePublished":"2025-09-22T12:19:05+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/"},"wordCount":1333,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTUzMjQ5NSM3MTU2OTMwIzIwMDQ4MDU=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/plus-therapeutics-announces-additional-1-9-million-advance-payment-from-cprit\/","name":"Plus Therapeutics Announces Additional $1.9 Million Advance Payment from CPRIT \u00a0\u00a0 - 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