{"id":881420,"date":"2025-09-03T08:44:38","date_gmt":"2025-09-03T12:44:38","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target\/"},"modified":"2025-09-03T08:44:38","modified_gmt":"2025-09-03T12:44:38","slug":"cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target\/","title":{"rendered":"Cognition Therapeutics Study of Zervimesine (CT1812) in Early Alzheimer\u2019s Disease Reaches 75% Enrollment Target"},"content":{"rendered":"
\n

PURCHASE, N.Y., Sept. 03, 2025 (GLOBE NEWSWIRE) — Cognition Therapeutics, Inc.<\/a>, (the Company or Cognition) (NASDAQ: CGTX), a clinical stage company developing drugs that treat neurodegenerative disorders, announced that the Phase 2 \u2018START\u2019 Study has reached the 75% enrollment mark. The START Study is enrolling approximately 540 individuals with mild cognitive impairment (MCI) and early Alzheimer\u2019s disease who will be treated with zervimesine (CT1812) or placebo for 18 months. Cognition is conducting the study in collaboration with the Alzheimer\u2019s Clinical Trials Consortium (ACTC) with funding from the National Institute of Aging (NIA) at the National Institutes of Health.<\/p>\n

\u201cWe believe the strong enrollment pace in the START Study is due to interest on the part of patients and investigators in the potential of a convenient, once-daily oral medication,\u201d stated Lisa Ricciardi<\/a>, Cognition\u2019s president and CEO. \u201cThe START Study is our largest Phase 2 trial to date and our second in Alzheimer\u2019s disease. In 2024 we reported results from the SHINE Study in patients with mild-to-moderate Alzheimer’s disease, which showed zervimesine slows cognitive deterioration in patients with lower levels of p-tau217. In the START study, we are testing zervimesine in people at earlier stages of disease progression. We look forward to building an understanding of zervimesine\u2019s potential across the Alzheimer\u2019s spectrum.\u201d<\/p>\n

\n About the START Study<\/strong>
\n
The START Study (NCT05531656<\/a>) is designed to measure the efficacy and tolerability of once-daily oral zervimesine in individuals with mild cognitive impairment (MCI) or early Alzheimer\u2019s disease who have elevated A\u03b2, as measured by PET or CSF. Participants are randomized to receive zervimesine or placebo for 18 months. The study will assess cognition and executive function using validated tools including the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) and ADAS-Cog rating scales, as well as biomarker and safety findings.<\/p>\n

The START Study is supported by an $81 million grant from the National Institute of Aging (NIA) at the National Institutes of Health (R01AG065248). The study is being conducted in collaboration with the Alzheimer\u2019s Clinical Trials Consortium (ACTC), an NIA-funded (grant number U24AG057437) clinical trial network of 35 leading academic sites with expertise in clinical trials in Alzheimer\u2019s disease.<\/p>\n

\n About the SHINE Study<\/strong>
\n
The COG0201 \u2018SHINE\u2019 Study<\/a> was a double-blind, placebo-controlled Phase 2 study that enrolled 153 adults with mild-to-moderate Alzheimer\u2019s disease. The study met its primary endpoints of safety and tolerability. Changes in cognition (ADAS-Cog 11, cognitive composite and MMSE) and function (ADCS-ADL and ADCS-CGIC) were also measured. Participants were evenly randomized to receive either placebo or one of two doses of CT1812 (100 mg or 300 mg), which was taken orally daily for six months.<\/p>\n

The SHINE Study was supported by two grant awards from the National Institute on Aging of the National Institutes of Health (NIH) totaling approximately $30 million. More information may be found at clinicaltrials.gov under trial ID NCT03507790<\/a>.<\/p>\n

\n About Zervimesine (CT1812)<\/strong>
\n
Zervimesine (CT1812) is an investigational, oral, once-daily pill in development for the treatment of CNS diseases such as Alzheimer\u2019s disease and dementia with Lewy bodies (DLB). While these diseases have different symptoms, both are associated with the buildup of certain proteins in the brain \u2013 A\u03b2 and \u0251-synuclein. As these proteins bind to neurons, they can damage and ultimately destroy the neurons. This results in a progressive loss in a person\u2019s ability to learn, recall memories, move efficiently, or communicate. These diseases progress relentlessly and ultimately result in death. If zervimesine can interrupt the toxic effects of these proteins, it may be able to slow progression of disease and improve the lives of those suffering from Alzheimer\u2019s and DLB. Zervimesine has been generally well tolerated in clinical studies to date.<\/p>\n

The USAN Council has adopted zervimesine as the United States Adopted Name (USAN) for CT1812.<\/p>\n

\n About Cognition Therapeutics, Inc.\u00a0\u00a0 <\/strong>
\n
\n Cognition Therapeutics, Inc.<\/a>, is a clinical-stage biopharmaceutical company discovering and developing innovative, small molecule therapeutics targeting age-related degenerative disorders of the central nervous system. We recently completed Phase 2 studies of our lead candidate, zervimesine (CT1812) in dementia with Lewy bodies (DLB), mild-to-moderate Alzheimer\u2019s disease and geographic atrophy secondary to dry AMD. The Phase 2 START Study (NCT05531656<\/a>) in early Alzheimer\u2019s disease is ongoing. We believe zervimesine can regulate pathways that are impaired in these diseases through its interaction with the sigma-2 receptor, a mechanism that is functionally distinct from other approaches for the treatment of degenerative diseases. More about Cognition Therapeutics and our pipeline can be found at https:\/\/cogrx.com<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>\u00a0
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. All statements contained in this press release or made during the conference, other than statements of historical facts or statements that relate to present facts or current conditions, including but not limited to, statements regarding our product candidates, including zervimesine (CT1812), and any expected or implied benefits or results, including that initial clinical results observed with respect to zervimesine will be replicated in later trials and our clinical development plans, including statements regarding our clinical studies of zervimesine, any analyses of the results therefrom and our expectations regarding the development programs for zervimesine, are forward-looking statements. These statements, including statements relating to the timing and expected results of our clinical trials involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance, or achievements to be materially different from any future results, performance, or achievements expressed or implied by the forward-looking statements. In some cases, you can identify forward-looking statements by terms such as \u201cmay,\u201d \u201cmight,\u201d \u201cwill,\u201d \u201cshould,\u201d \u201cexpect,\u201d \u201cplan,\u201d \u201caim,\u201d \u201cseek,\u201d \u201canticipate,\u201d \u201ccould,\u201d \u201cintend,\u201d \u201ctarget,\u201d \u201cproject,\u201d \u201ccontemplate,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cpredict,\u201d \u201cforecast,\u201d \u201cpotential\u201d or \u201ccontinue\u201d or the negative of these terms or other similar expressions. We have based these forward-looking statements largely on our current expectations and projections about future events and financial trends that we believe may affect our business, financial condition, and results of operations. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions, some of which cannot be predicted or quantified and some of which are beyond our control. Factors that may cause actual results to differ materially from current expectations include, but are not limited to: competition; our ability to secure new (and retain existing) grant funding; our ability to grow and manage growth, maintain relationships with suppliers and retain our management and key employees; our ability to successfully advance our current and future product candidates through development activities, preclinical studies and clinical trials and costs related thereto; uncertainties inherent in the results of preliminary data, pre-clinical studies and earlier-stage clinical trials being predictive of the results of early or later-stage clinical trials; the timing, scope and likelihood of regulatory filings and approvals, including regulatory approval of our product candidates; changes in applicable laws or regulations; the possibility that we may be adversely affected by other economic, business or competitive factors, including ongoing economic uncertainty; our estimates of expenses and profitability; the evolution of the markets in which we compete; our ability to implement our strategic initiatives and continue to innovate our existing products; our ability to defend our intellectual property; the impacts of ongoing global and regional conflicts on our business, supply chain and labor force; and the risks and uncertainties described more fully in the \u201cRisk Factors\u201d section of our annual and quarterly reports filed with the\u00a0Securities & Exchange Commission and are available at <\/em>www.sec.gov<\/em>. These risks are not exhaustive and we face both known and unknown risks. You should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in our forward-looking statements may not be achieved or occur, and actual results could differ materially from those projected in the forward-looking statements. Moreover, we operate in a dynamic industry and economy. New risk factors and uncertainties may emerge from time to time, and it is not possible for management to predict all risk factors and uncertainties that we may face. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.<\/em><\/p>\n\n\n
\n Contact Information:<\/strong>\u00a0\u00a0\u00a0
Cognition Therapeutics, Inc.\u00a0 \u00a0\u00a0
info@cogrx.com<\/a>\u00a0\u00a0<\/td>\n		Mike Moyer (investors)\u00a0
LifeSci Advisors\u00a0
mmoyer@lifesciadvisors.com<\/a><\/td>\n<\/tr>\n<\/table>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

PURCHASE, N.Y., Sept. 03, 2025 (GLOBE NEWSWIRE) — Cognition Therapeutics, Inc., (the Company or Cognition) (NASDAQ: CGTX), a clinical stage company developing drugs that treat neurodegenerative disorders, announced that the Phase 2 \u2018START\u2019 Study has reached the 75% enrollment mark. The START Study is enrolling approximately 540 individuals with mild cognitive impairment (MCI) and early Alzheimer\u2019s disease who will be treated with zervimesine (CT1812) or placebo for 18 months. Cognition is conducting the study in collaboration with the Alzheimer\u2019s Clinical Trials Consortium (ACTC) with funding from the National Institute of Aging (NIA) at the National Institutes of Health. \u201cWe believe the strong enrollment pace in the START Study is due to interest on the part of patients and investigators in … <\/p>\n

Continue reading “Cognition Therapeutics Study of Zervimesine (CT1812) in Early Alzheimer\u2019s Disease Reaches 75% Enrollment Target”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-881420","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nCognition Therapeutics Study of Zervimesine (CT1812) in Early Alzheimer\u2019s Disease Reaches 75% Enrollment Target - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cognition Therapeutics Study of Zervimesine (CT1812) in Early Alzheimer\u2019s Disease Reaches 75% Enrollment Target - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"PURCHASE, N.Y., Sept. 03, 2025 (GLOBE NEWSWIRE) — Cognition Therapeutics, Inc., (the Company or Cognition) (NASDAQ: CGTX), a clinical stage company developing drugs that treat neurodegenerative disorders, announced that the Phase 2 \u2018START\u2019 Study has reached the 75% enrollment mark. 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The START Study is enrolling approximately 540 individuals with mild cognitive impairment (MCI) and early Alzheimer\u2019s disease who will be treated with zervimesine (CT1812) or placebo for 18 months. Cognition is conducting the study in collaboration with the Alzheimer\u2019s Clinical Trials Consortium (ACTC) with funding from the National Institute of Aging (NIA) at the National Institutes of Health. \u201cWe believe the strong enrollment pace in the START Study is due to interest on the part of patients and investigators in … Continue reading \"Cognition Therapeutics Study of Zervimesine (CT1812) in Early Alzheimer\u2019s Disease Reaches 75% Enrollment Target\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target\/","og_site_name":"Market Newsdesk","article_published_time":"2025-09-03T12:44:38+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTUyMjIxMSM3MTI3MTY4IzIwODQ4NzU=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Cognition Therapeutics Study of Zervimesine (CT1812) in Early Alzheimer\u2019s Disease Reaches 75% Enrollment Target","datePublished":"2025-09-03T12:44:38+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target\/"},"wordCount":1391,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTUyMjIxMSM3MTI3MTY4IzIwODQ4NzU=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/cognition-therapeutics-study-of-zervimesine-ct1812-in-early-alzheimers-disease-reaches-75-enrollment-target\/","name":"Cognition Therapeutics Study of Zervimesine (CT1812) in Early Alzheimer\u2019s Disease Reaches 75% Enrollment Target - 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