{"id":863570,"date":"2025-06-25T08:43:31","date_gmt":"2025-06-25T12:43:31","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting\/"},"modified":"2025-06-25T08:43:31","modified_gmt":"2025-06-25T12:43:31","slug":"opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting\/","title":{"rendered":"OPKO Health and Entera Bio Abstract for First-in-Class Dual GLP-1\/Glucagon Tablet Candidate for Patients with Obesity and Metabolic Disorders Selected for Presentation at the ENDO 2025 Annual Meeting"},"content":{"rendered":"
\n

MIAMI and JERUSALEM, June 25, 2025 (GLOBE NEWSWIRE) — OPKO Health, Inc. (NASDAQ: OPK) and Entera Bio Ltd. (NASDAQ: ENTX) (\u201cEntera\u201d) today announced that new pharmacologic and pharmacokinetic in vivo<\/em> data for investigational oral OPK-88006 tablet treatment has been selected for presentation at the ENDO 2025 annual meeting of the Endocrine Society, taking place July 12-15, 2025 in San Francisco, CA, USA.<\/p>\n

Oral OPK-88006 is being developed pursuant to a collaboration and license agreement between OPKO and Entera whereby the companies are advancing a proprietary novel dual agonist GLP-1\/glucagon peptide as a once-daily tablet treatment and as a weekly subcutaneous injection for patients with obesity, metabolic and fibrotic disorders. The oral program combines OPKO\u2019s proprietary long-acting oxyntomodulin analog (OPK-88006) and Entera\u2019s proprietary N-Tab\u2122 technology.<\/p>\n

\u201cOral peptides remain rare in metabolic therapy, and having both tablet and injectable formats with our partner OPKO should allow us to tailor induction and maintenance regimens to each patient to optimize outcomes,\u201d said Miranda Toledano, Chief Executive Officer of Entera. \u201cOur once-daily tablet may be simpler to titrate and offer tolerability benefits. Our joint program prioritizes durable, sustainable weight loss to help prevent or mitigate comorbidities such as severe fatty liver, sleep apnea, and other metabolic disorders.\u201d<\/p>\n

OPKO and Entera expect to file an Investigational New Drug application with the U.S. Food and Drug Administration later this year for both oral OPK-88006 tablet and a weekly injectable variant of the same molecule, which OPKO intends to develop independently. Phase 1 clinical studies are being planned.<\/p>\n

\n Abstract Title<\/strong>:\u00a0First-in-Class Oral Dual GLP-1\/Glucagon Agonist for Patients with Obesity and Metabolic Disorders: In Vivo Pharmacokinetic and Pharmacodynamic Results
Presentation Number<\/strong>:\u00a0 SUN-680
Session Date\/Time<\/strong>:\u00a0Sunday, July 13, 2025, 12:00 \u2013 01:30 PM\u00a0Pacific time<\/p>\n

\n About Entera Bio<\/strong>\n <\/p>\n

Entera is a clinical stage company focused on developing oral peptide and protein replacement therapies for significant unmet medical needs where an oral tablet form holds the potential to transform the standard of care. The Company leverages on a disruptive and proprietary technology platform (N-Tab\u2122) and its pipeline of first-in-class oral peptide programs targeting PTH(1-34), GLP-1 and GLP-2. The Company\u2019s most advanced product candidate, EB613 (oral PTH(1-34)), is being developed as the first oral, osteoanabolic (bone building) once-daily\u00a0tablet treatment for post-menopausal women with low BMD and high-risk osteoporosis. A placebo controlled, dose ranging Phase 2 study of EB613 tablets (n=161) met primary (PD\/bone turnover biomarker) and secondary endpoints (BMD). Entera is preparing to initiate a Phase 3 registrational study for EB613 pursuant to the FDA\u2019s qualification of a quantitative BMD endpoint. The EB612 program is being developed as the first oral PTH(1-34) tablet peptide replacement therapy for hypoparathyroidism. Entera is also developing the first oral oxyntomodulin, a dual targeted GLP1\/glucagon peptide, in tablet form for the treatment of obesity; and the first oral GLP-2 peptide tablet as an injection-free alternative for patients suffering from rare malabsorption conditions such as short bowel syndrome in collaboration with OPKO Health. For more information on Entera Bio, visit www.enterabio.com<\/a> or follow us on LinkedIn<\/a>, Twitter<\/a>, Facebook<\/a>, Instagram<\/a>.<\/p>\n

\n About OPKO Health<\/strong>\n <\/p>\n

OPKO Health is a multinational biopharmaceutical and diagnostics company that seeks to establish industry-leading positions in large, rapidly growing markets by leveraging its discovery, development and commercialization expertise, and its novel and proprietary technologies. For more information, visit\u00a0www.opko.com<\/a>.<\/p>\n

\n Cautionary Statement Regarding Forward Looking Statements<\/strong>\n <\/p>\n

Various statements in this presentation are \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995. All statements (other than statements of historical facts) in this presentation regarding our prospects, plans, financial position, business strategy and expected financial and operational results may constitute forward-looking statements. Words such as, but not limited to, \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccan,\u201d \u201ccould,\u201d \u201cexpect,\u201d \u201cestimate,\u201d \u201cdesign,\u201d \u201cgoal,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cmight,\u201d \u201cobjective,\u201d \u201cplan,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201ctarget,\u201d \u201clikely,\u201d \u201cshould,\u201d \u201cwill,\u201d and \u201cwould,\u201d or the negative of these terms and similar expressions or words, identify forward-looking statements. Forward-looking statements are based upon current expectations that involve risks, changes in circumstances, assumptions and uncertainties. Forward-looking statements should not be read as a guarantee of future performance or results and may not be accurate indications of when such performance or results will be achieved.<\/p>\n

Important factors that could cause actual results to differ materially from those reflected in Entera\u2019s and OPKO\u2019s forward-looking statements include, among others: results of our clinical trials; unexpected changes in our ongoing and planned preclinical development and clinical trials, the timing of and our ability to make regulatory filings and obtain and maintain regulatory approvals for our product candidates; the anticipated benefits of both the daily tablet and an injectable form; Entera\u2019s and OPKO\u2019s expectations regarding licensing, business transactions, including OPKO\u2019s development efforts should Entera opt-out, and strategic collaborations; and other factors that are described in the \u201cCautionary Statements Regarding Forward-Looking Statements,\u201d \u201cRisk Factors\u201d and \u201cManagement\u2019s Discussion and Analysis of Financial Condition and Results of Operations\u201d sections of each of Entera\u2019s and OPKO\u2019s most recent Annual Reports on Form 10-K filed with the SEC, as well as the companies\u2019 respective subsequently filed Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. There can be no assurance that the actual results or developments anticipated by Entera and OPKO will be realized or, even if substantially realized, that they will have the expected consequences to, or effects on, Entera or OPKO, as applicable. Therefore, no assurance can be given that the outcomes stated or implied in such forward-looking statements and estimates will be achieved. Entera and OPKO caution investors not to rely on the forward-looking statements made in this press release. The information in this press release is provided only as of the date of this press release, and neither Entera nor OPKO undertakes any obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, except to the extent required by law.<\/p>\n

\n Contacts: <\/strong>\n <\/p>\n

\n Entera Bio<\/strong>
\n
Miranda Toledano
Chief Executive Officer
miranda@enterabio.com<\/a>\u00a0\u00a0<\/p>\n

\n OPKO Health<\/strong>
\n
Alliance Advisors IR
Yvonne Briggs, 310-691-7100<\/u>
ybriggs@allianceadvisors.com<\/a>\u00a0
\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 or\u00a0
Bruce Voss, 310-691-7100<\/u>\u00a0
bvoss@allianceadvisors.com<\/a><\/p>\n

\"\"
\n
\n \"\"\n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

MIAMI and JERUSALEM, June 25, 2025 (GLOBE NEWSWIRE) — OPKO Health, Inc. (NASDAQ: OPK) and Entera Bio Ltd. (NASDAQ: ENTX) (\u201cEntera\u201d) today announced that new pharmacologic and pharmacokinetic in vivo data for investigational oral OPK-88006 tablet treatment has been selected for presentation at the ENDO 2025 annual meeting of the Endocrine Society, taking place July 12-15, 2025 in San Francisco, CA, USA. Oral OPK-88006 is being developed pursuant to a collaboration and license agreement between OPKO and Entera whereby the companies are advancing a proprietary novel dual agonist GLP-1\/glucagon peptide as a once-daily tablet treatment and as a weekly subcutaneous injection for patients with obesity, metabolic and fibrotic disorders. The oral program combines OPKO\u2019s proprietary long-acting oxyntomodulin analog (OPK-88006) and … <\/p>\n

Continue reading “OPKO Health and Entera Bio Abstract for First-in-Class Dual GLP-1\/Glucagon Tablet Candidate for Patients with Obesity and Metabolic Disorders Selected for Presentation at the ENDO 2025 Annual Meeting”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-863570","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nOPKO Health and Entera Bio Abstract for First-in-Class Dual GLP-1\/Glucagon Tablet Candidate for Patients with Obesity and Metabolic Disorders Selected for Presentation at the ENDO 2025 Annual Meeting - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"OPKO Health and Entera Bio Abstract for First-in-Class Dual GLP-1\/Glucagon Tablet Candidate for Patients with Obesity and Metabolic Disorders Selected for Presentation at the ENDO 2025 Annual Meeting - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"MIAMI and JERUSALEM, June 25, 2025 (GLOBE NEWSWIRE) — OPKO Health, Inc. 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(NASDAQ: OPK) and Entera Bio Ltd. (NASDAQ: ENTX) (\u201cEntera\u201d) today announced that new pharmacologic and pharmacokinetic in vivo data for investigational oral OPK-88006 tablet treatment has been selected for presentation at the ENDO 2025 annual meeting of the Endocrine Society, taking place July 12-15, 2025 in San Francisco, CA, USA. Oral OPK-88006 is being developed pursuant to a collaboration and license agreement between OPKO and Entera whereby the companies are advancing a proprietary novel dual agonist GLP-1\/glucagon peptide as a once-daily tablet treatment and as a weekly subcutaneous injection for patients with obesity, metabolic and fibrotic disorders. The oral program combines OPKO\u2019s proprietary long-acting oxyntomodulin analog (OPK-88006) and … Continue reading \"OPKO Health and Entera Bio Abstract for First-in-Class Dual GLP-1\/Glucagon Tablet Candidate for Patients with Obesity and Metabolic Disorders Selected for Presentation at the ENDO 2025 Annual Meeting\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting\/","og_site_name":"Market Newsdesk","article_published_time":"2025-06-25T12:43:31+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQ4NDA4MiM3MDE3MDA2IzIwMjU5NDE=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"OPKO Health and Entera Bio Abstract for First-in-Class Dual GLP-1\/Glucagon Tablet Candidate for Patients with Obesity and Metabolic Disorders Selected for Presentation at the ENDO 2025 Annual Meeting","datePublished":"2025-06-25T12:43:31+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting\/"},"wordCount":1037,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=OTQ4NDA4MiM3MDE3MDA2IzIwMjU5NDE=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/opko-health-and-entera-bio-abstract-for-first-in-class-dual-glp-1-glucagon-tablet-candidate-for-patients-with-obesity-and-metabolic-disorders-selected-for-presentation-at-the-endo-2025-annual-meeting\/","name":"OPKO Health and Entera Bio Abstract for First-in-Class Dual GLP-1\/Glucagon Tablet Candidate for Patients with Obesity and Metabolic Disorders Selected for Presentation at the ENDO 2025 Annual Meeting - 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